Seasonal symptom variation in patients with chronic fatigue: Comparison with major mood disorders

The psychobiology of idiopathic fatigue has received renewed interest in the medical literature in recent years. In order to examine the relation between chronic, idiopathic fatigue and specific subtypes of depressive illness, we characterized the pattern and severity of seasonal symptom variation in 73 patients with chronic, idiopathic fatigue, compared to patients with major depression (n = 55), a typical depression (n = 35), and seasonal affective disorder (n = 16). Fifty of the fatigued subjects also met the specific Centers for Disease Control and Prevention case criteria for chronic fatigue syndrome, though this definition was unable to discriminate a distinct subgroup of patients, based on their seasonality scores alone. As a group, the fatigued subjects reported the lowest levels of symptom seasonality of any of the study groups. Further, even in those fatigued subjects with scores in the range of those seen in patients with seasonal affective disorder, seasonality was not reported to be a subjectively distressing problem. These findings lend support to the idea that although chronic fatigue shares some clinical features with certain mood disorders, they are not the same illnesses. These data are also consistent with the emerging view that chronic fatigue represents a heterogeneously determined clinical condition.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/31850/1/0000799.pd

Anatomy and essential oil composition of Salvia marashica A. İlçim, F. Celep & Doğan

Türkiye'ye endemik bir tür olan Salvia marashica'nın morfolojisi, anatomisi ve uçucu yağ bileşenleri incelenmiştir. Dikdörtgen gövde anatomisi, ekzodermal yapı, unifasiyal yapraklar, belirgin büyük bir iletim demetinin varlığı ve küçük yanal demetlerin olmadığı anatomik karakterler gözlenmiştir. Salvia marashica'nın hidrodistillenmesiyle elde edilen uçucu yağların kimyasal bileşimi GC ve GC-MS ile araştırılmıştır. Yetmiş bileşen, α-pinen (%27.01), β-Pinen (%5.72), Sabinen (%5.26), Limonen (%17.09), β-Karyofillen (15.08), Terpinen (2.04) ve 1,8 sineol (%7.87' si) Salvia marashica'nın esansiyel yağlarından elde edilmiştirThe morphology, anatomy and essential oil components of the aerial parts of Salvia marashica an endemic species in Turkey, were studied. Some anatomical characters such as rectangular stem anatomy, exodermal structure, unifasial leaves, one large obvious vascular bundle in the center, and anatomic characteristics without small lateral bundles were observed. The chemical composition of essential oils obtained by hydrodistillation of Salvia marashica was investigated by GC and GCMS. Seventy constituents, α-pinene (27.01%), β-Pinene (5.72%), Sabinene (5.26%), Limonene (17.09%), β-Caryophyllene (15.08), Terpinene (2.04) and 1, 8 cineole (7.87%) were obtained the essential oil extracted from the Salvia marashica

An Investigation into the Protective Effects of Various Doses of Boric Acid on Liver, Kidney, and Brain Tissue Damage Caused by High Levels of Acute Alcohol Consumption.

Acute high-dose alcohol consumption can lead to oxidative stress, which can cause harm to organs. In this study we aim to determine whether administering boric acid (BA) can protect certain organs (liver, kidney, and brain) from the damaging effects of alcohol by reducing oxidative stress. We used 50 and 100 mg/kg of BA. Thirty-two Sprague Dawley (12–14-week-old) male rats in our study were separated into four groups (n=8); control, ethanol, ethanol+50 mg/kg BA, and ethanol+100 mg/kg BA groups. Acute ethanol was given to rats by gavage at 8 g/kg. BA doses were given by gavage 30 min before ethanol administration. Alanine transaminase (ALT) and aspartate transaminase (AST) measurements were made in blood samples. The total antioxidant status (TAS), total oxidant status (TOS), OSI (oxidative stress index) (TOS/TAS), malondialdehyde (MDA) levels and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities were measured to determine the oxidative stress induced by high-dose acute ethanol in the liver, kidney, and brain tissue, and the antioxidant effects of BA doses. According to our biochemical results, acute high-dose ethanol increases oxidative stress in liver, kidney, and brain tissues, while BA reduces the damage in tissues with its antioxidant effect. For the histopathological examinations, hematoxylin-eosin staining was performed. As a result, we found that the effect of alcohol-induced oxidative stress on liver, kidney, and brain tissues was different, and that giving boric acid reduces the increased oxidative stress in tissues due to its antioxidant effect. It was found that 100mg/kg BA administration had a higher antioxidant effect than in the 50mg/kg group.</p

The Use of Oxalic Acid as a Chelating Agent in the Dissolution Reaction of Calcium Molybdate

In this study, the dissolution behavior of calcium molybdate (CaMoO4) was investigated in oxalic acid (H2C2O4) solution. The effects of stirring speed, temperature, H2C2O4 concentration, and particle size on the dissolution reaction of CaMoO4 were determined. The dissolved quantities of molybdenum and calcium were analyzed quantitatively by ICP-OES. Fractional conversion of CaMoO4 vs time and concentration of calcium vs time diagrams were plotted. It was observed that at constant temperatures and lower H2C2O4 concentrations, the dissolution increased by increasing H2C2O4 concentration, but at higher H2C2O4 concentrations, the effect of H2C2O4 concentrations was negligible. The dissolution reaction of CaMoO4 in H2C2O4 solution was performed in two steps as series-parallel type reaction. In the first step, CaMoO4 reacted with H2C2O4 to form the water-soluble calcium aqua oxalato molybdate (Ca[MoO3(C2O4)(H2O)]) intermediate chelate product. In the second step, the intermediate chelate, Ca[MoO3(C2O4)(H2O)], reacted with the reactant, H2C2O4, to yield water-soluble hydrogen oxalato dimolybdate chelate (H-2[(MoO3)(2)(C2O4)]) and insoluble CaC2O4H2O as final products. It was found that 500 rpm was enough to eliminate the resistance of liquid film layer that surrounds the solid particles. It was concluded that the optimum temperature was 313 K (40 A degrees C) and the optimum concentration of H2C2O4 was 1 kmol m(-3) to obtain high conversion during the dissolution of CaMoO4