NANOTECHNOLOGY IN NOVEL DRUG DELIVERY SYSTEM

Nanotechnology is novel and having full scope of contribution in the field of human health care. Recent advances suggest that nanotechnology will have a profound impact on diseases prevention, diagnosis and treatment. It will allow faster drug absorption, controlled dose release with minimized side-effects. Nanotechnology plays a crucial role in revolutionizing the field of surgery, detection of disease like cancer. Drugs with high toxic potential can be given with a better safety profile with the utility of nanotechnology. It is an ideal targeting system should have long circulating time, it should be present at appropriate Concentrations at the target site, and it should not lose its activity or therapeutic efficacy while in circulation. Our aim is to review the potential applications and various drug delivery system of nanotechnology. Keywords: Nanotechnology, health care, side-effects, revolutionizing, concentrations

Lawnermis acid: A new anticomplementary triterpenoid from Lawsonia inermis seeds

252-25

A U.S. Partnership with India and Poland to Track Acute Chemical Releases to Serve Public Health

We describe a collaborative effort between the U.S., India, and Poland to track acute chemical releases during 2005–2007. In all three countries, fixed facility events were more common than transportation-related events; manufacturing and transportation/warehousing were the most frequently involved industries; and equipment failure and human error were the primary contributing factors. The most commonly released nonpetroleum substances were ammonia (India), carbon monoxide (U.S.) and mercury (Poland). More events in India (54%) resulted in victims compared with Poland (15%) and the U.S. (9%). The pilot program showed it is possible to successfully conduct international surveillance of acute hazardous substances releases with careful interpretation of the findings

Synthesis and antileishmanial activity of some chromon-8-ylalkanoic acids and their methyl esters

553-55

International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways.

Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wide association studies of European subjects (n=2,764 cases and 10,475 controls) followed by validation genotyping in an independent cohort (n=3,716 cases and 4,261 controls). We discover and validate six previously unknown risk loci for PBC (Pcombined<5 × 10(-8)) and used pathway analysis to identify JAK-STAT/IL12/IL27 signalling and cytokine-cytokine pathways, for which relevant therapies exist

INTERNATIONAL JOURNAL OF PHARMACY &amp; LIFE SCIENCES Neuroactive steroids and neuropharmacological disorder

Abstract The brain, like the adrenals, gonads and the placenta, is a steroidogenic tissue. However, unlike classic steroidogenic tissues, the synthesis of steroids in the nervous system requires coordinated expression and regulation of genes encoding the steroidogenic enzymes in several different cell types (neurons and glia) at different locations in the nervous system, often at some distance from the cell bodies. Furthermore, the synthesis of these steroids might be developmentally regulated and related to their functions in the developing brain. The steroids synthesized by the brain and nervous system, given the name &apos;neurosteroids&apos;, have a wide variety of diverse functions. In general, they mediate their actions not through classic steroid hormone nuclear receptors, but through other mechanisms, such as ion-gated neurotransmitter receptors or direct/indirect modulation of other neurotransmitter receptors. We summarize the biochemistry of the enzymes involved in the biosynthesis of neurosteroids, their pharmacological properties and modes of action. The physiological relevance and potential uses of neurosteroids in certain human diseases are discussed