984 research outputs found
Novel Phases in the Field Induced Spin Density Wave State in (TMTSF)_2PF_6
Magnetoresistance measurements on the quasi one-dimensional organic conductor
(TMTSF)_2PF_6 performed in magnetic fields B up to 16T, temperatures T down to
0.12K and under pressures P up to 14kbar have revealed new phases on its P-B-T
phase diagram. We found a new boundary which subdivides the field induced spin
density wave (FISDW) phase diagram into two regions. We showed that a
low-temperature region of the FISDW diagram is characterized by a hysteresis
behavior typical for the first order transitions, as observed in a number of
studies. In contrast to the common believe, in high temperature region of the
FISDW phase diagram, the hysteresis and, hence, the first order transitions
were found to disappear. Nevertheless, sharp changes in the resistivity slope
are observed both in the low and high temperature domains indicating that the
cascade of transitions between different subphases exists over all range of the
FISDW state. We also found that the temperature dependence of the resistance
(at a constant B) changes sign at about the same boundary. We compare these
results with recent theoretical models.Comment: LaTex, 4 pages, 4 figure
Spin-density-wave instabilities in the organic conductor (TMTSF)_2ClO_4: Role of anion ordering
We study the spin-density-wave instabilities in the quasi-one-dimensional
conductor (TMTSF)_2ClO_4. The orientational order of the anions ClO_4 doubles
the unit cell and leads to the presence of two electrnic bands at the Fermi
level. From the Ginzburg-Landau expansion of the free energy, we determine the
low-temperature phase diagram as a function of the strength of the Coulomb
potential due to the anions. Upon increasing the anion potential, we first find
a SDW phase corresponding to an interband pairing. This SDW phase is rapidly
supressed, the metallic phase being then stable down to zero temperature. The
SDW instability is restored when the anion potential becomes of the order of
the hopping amplitude. The metal-SDW transition corresponds to an intraband
pairing which leaves half of the Fermi surface metallic. At lower temperature,
a second transition, corresponding to the other intraband pairing, takes place
and opens a gap on the whole Fermi surface. We discuss the consequences of our
results for the experimental phase diagram of (TMTSF)_2ClO_4 at high magnetic
field.Comment: 13 pages, 10 figures, Version 2 with minor correction
EPS09 - a New Generation of NLO and LO Nuclear Parton Distribution Functions
We present a next-to-leading order (NLO) global DGLAP analysis of nuclear
parton distribution functions (nPDFs) and their uncertainties. Carrying out an
NLO nPDF analysis for the first time with three different types of experimental
input -- deep inelastic +A scattering, Drell-Yan dilepton production in
p+ collisions, and inclusive pion production in d+Au and p+p collisions at
RHIC -- we find that these data can well be described in a conventional
collinear factorization framework. Although the pion production has not been
traditionally included in the global analyses, we find that the shape of the
nuclear modification factor of the pion -spectrum at
midrapidity retains sensitivity to the gluon distributions, providing evidence
for shadowing and EMC-effect in the nuclear gluons. We use the Hessian method
to quantify the nPDF uncertainties which originate from the uncertainties in
the data. In this method the sensitivity of to the variations of the
fitting parameters is mapped out to orthogonal error sets which provide a
user-friendly way to calculate how the nPDF uncertainties propagate to any
factorizable nuclear cross-section. The obtained NLO and LO nPDFs and the
corresponding error sets are collected in our new release called {\ttfamily
EPS09}. These results should find applications in precision analyses of the
signatures and properties of QCD matter at the LHC and RHIC.Comment: 34 pages, 16 figures. The version accepted for publicatio
Pharmacokinetic and exposure-response analysis of pertuzumab in patients with HER2-positive metastatic gastric or gastroesophageal junction cancer
Purpose: To characterize the pharmacokinetics (PK) of pertuzumab and trastuzumab in patients with HER2-positive metastatic gastric or gastroesophageal junction cancer in the randomized, double-blind, phase III JACOB study (NCT01774786), and to evaluate the appropriateness of the pertuzumab regimen in these patients. Methods: Patients received 840 mg intravenous pertuzumab or placebo plus trastuzumab q3w and chemotherapy. Pertuzumab and trastuzumab were administered until disease progression or unacceptable toxicity. Chemotherapy was administered for up to six cycles or disease progression or unacceptable toxicity. Serum concentrations of pertuzumab and trastuzumab were measured. Pertuzumab PK was characterized across treatment cycles. The impact of anti-drug antibodies (ADAs) on pertuzumab PK and the impact of pertuzumab on trastuzumab PK were assessed. An exploratory exposure-efficacy analysis was also conducted. Results: In total, 374 patients in the pertuzumab arm had evaluable PK data. The mean observed pertuzumab steady-state serum trough (minimum) concentration (C) ± standard deviation was 114 ± 51.8 μg/mL. The target pertuzumab C of ≥ 20 μg/mL was reached in 99.3% of patients at Cycle 5 (steady state) and beyond. Greater than 90% of patients were above the PK target right after the first pertuzumab dose. There was no apparent impact of ADAs on pertuzumab PK nor of pertuzumab on trastuzumab PK. There were no differences in overall survival across Cycle 1 pertuzumab (C) or Cycle 5 pertuzumab (C) exposure quartiles. Conclusions: Pertuzumab exposure in JACOB was consistent with prior studies in advanced gastric cancer and breast cancer. The 840 mg q3w dose allowed the majority of patients in JACOB to achieve target pertuzumab concentrations and appears to be an appropriate dose selectio
Magnetothemopower study of quasi two-dimensional organic conductor -(BEDT-TTF)KHg(SCN)
We have used a low-frequency magneto-thermopower (MTEP) method to probe the
high magnetic field ground state behavior of
-(BEDT-TTF)KHg(SCN) along all three principal crystallographic
axes at low temperatures. The thermopower tensor coefficients (
and ) have been measured to 30 T, beyond the anomalous low temperature,
field-induced transition at 22.5 T. We find a significant anisotropy in the
MTEP signal, and also observe large quantum oscillations associated with the de
Haas - van Alphen effect. The anisotropy indicates that the ground state
properties are clearly driven by mechanisms that occur along specific
directions for the in-plane electronic structure. Both transverse and
longitudinal magnetothermopower show asymptotic behavior in field, which can be
explained in terms of magnetic breakdown of compensated closed orbits.Comment: 9 pages, 10 figure
From bi-layer to tri-layer Fe nanoislands on Cu3Au(001)
Self assembly on suitably chosen substrates is a well exploited root to
control the structure and morphology, hence magnetization, of metal films. In
particular, the Cu3Au(001) surface has been recently singled out as a good
template to grow high spin Fe phases, due to the close matching between the
Cu3Au lattice constant (3.75 Angstrom) and the equilibrium lattice constant for
fcc ferromagnetic Fe (3.65 Angstrom). Growth proceeds almost layer by layer at
room temperature, with a small amount of Au segregation in the early stage of
deposition. Islands of 1-2 nm lateral size and double layer height are formed
when 1 monolayer of Fe is deposited on Cu3Au(001) at low temperature. We used
the PhotoElectron Diffraction technique to investigate the atomic structure and
chemical composition of these nanoislands just after the deposition at 140 K
and after annealing at 400 K. We show that only bi-layer islands are formed at
low temperature, without any surface segregation. After annealing, the Fe atoms
are re-aggregated to form mainly tri-layer islands. Surface segregation is
shown to be inhibited also after the annealing process. The implications for
the film magnetic properties and the growth model are discussed.Comment: Revtex, 5 pages with 4 eps figure
Current constraints on Cosmological Parameters from Microwave Background Anisotropies
We compare the latest observations of Cosmic Microwave Background (CMB)
Anisotropies with the theoretical predictions of the standard scenario of
structure formation. Assuming a primordial power spectrum of adiabatic
perturbations we found that the total energy density is constrained to be
while the energy density in baryon and Cold Dark
Matter (CDM) are and ,
(all at 68% C.L.) respectively. The primordial spectrum is consistent with
scale invariance, () and the age of the universe is
Gyrs. Adding informations from Large Scale Structure and
Supernovae, we found a strong evidence for a cosmological constant
and a value of the Hubble parameter
. Restricting this combined analysis to flat universes, we put
constraints on possible 'extensions' of the standard scenario. A gravity waves
contribution to the quadrupole anisotropy is limited to be (95%
c.l.). A constant equation of state for the dark energy component is bound to
be (95% c.l.). We constrain the effective relativistic degrees
of freedom and the neutrino chemical potential and (massless neutrinos).Comment: The status of cosmological parameters before WMAP. In press on Phys.
Rev. D., Rapid Communication, 6 pages, 5 figure
Transverse Momentum Dependent Parton Distribution/Fragmentation Functions at an Electron-Ion Collider
We present a summary of a recent workshop held at Duke University on Partonic
Transverse Momentum in Hadrons: Quark Spin-Orbit Correlations and Quark-Gluon
Interactions. The transverse momentum dependent parton distribution functions
(TMDs), parton-to-hadron fragmentation functions, and multi-parton correlation
functions, were discussed extensively at the Duke workshop. In this paper, we
summarize first the theoretical issues concerning the study of partonic
structure of hadrons at a future electron-ion collider (EIC) with emphasis on
the TMDs. We then present simulation results on experimental studies of TMDs
through measurements of single spin asymmetries (SSA) from semi-inclusive
deep-inelastic scattering (SIDIS) processes with an EIC, and discuss the
requirement of the detector for SIDIS measurements. The dynamics of parton
correlations in the nucleon is further explored via a study of SSA in D (`D)
production at large transverse momenta with the aim of accessing the unexplored
tri-gluon correlation functions. The workshop participants identified the SSA
measurements in SIDIS as a golden program to study TMDs in both the sea and
valence quark regions and to study the role of gluons, with the Sivers
asymmetry measurements as examples. Such measurements will lead to major
advancement in our understanding of TMDs in the valence quark region, and more
importantly also allow for the investigation of TMDs in the sea quark region
along with a study of their evolution.Comment: 44 pages 23 figures, summary of Duke EIC workshop on TMDs accepted by
EPJ
Simulation techniques for cosmological simulations
Modern cosmological observations allow us to study in great detail the
evolution and history of the large scale structure hierarchy. The fundamental
problem of accurate constraints on the cosmological parameters, within a given
cosmological model, requires precise modelling of the observed structure. In
this paper we briefly review the current most effective techniques of large
scale structure simulations, emphasising both their advantages and
shortcomings. Starting with basics of the direct N-body simulations appropriate
to modelling cold dark matter evolution, we then discuss the direct-sum
technique GRAPE, particle-mesh (PM) and hybrid methods, combining the PM and
the tree algorithms. Simulations of baryonic matter in the Universe often use
hydrodynamic codes based on both particle methods that discretise mass, and
grid-based methods. We briefly describe Eulerian grid methods, and also some
variants of Lagrangian smoothed particle hydrodynamics (SPH) methods.Comment: 42 pages, 16 figures, accepted for publication in Space Science
Reviews, special issue "Clusters of galaxies: beyond the thermal view",
Editor J.S. Kaastra, Chapter 12; work done by an international team at the
International Space Science Institute (ISSI), Bern, organised by J.S.
Kaastra, A.M. Bykov, S. Schindler & J.A.M. Bleeke
Search for and Using Genetic Programming Event Selection
We apply a genetic programming technique to search for the double Cabibbo
suppressed decays and .
We normalize these decays to their Cabibbo favored partners and find
\Lambda_c^+ \to p K^+ \pi^-\Lambda_c^+ \to p K^-
\pi^+ and D_s^+ \to K^+ K^+
\pi^-D_s^+ \to K^+ K^- \pi^+ where
the first errors are statistical and the second are systematic. Expressed as
90% confidence levels (CL), we find and respectively.
This is the first successful use of genetic programming in a high energy
physics data analysis.Comment: 10 page
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