18 research outputs found
Four-Component Domino Strategy for the Combinatorial Synthesis of Novel 1,4-Dihydropyrano[2,3â<i>c</i>]pyrazol-6-amines
An
efficient one-pot four-component domino protocol for the combinatorial
synthesis of novel 1,4-dihydropyranoÂ[2,3-<i>c</i>]Âpyrazol-6-amines
has been achieved. This transformation presumably occurs via cyclizationâKnoevenagel
condensationâMichael additionâtautomerismâintramolecular <i>O</i>-cyclizationâelimination sequence of reactions.
The significant features of this reaction include expedient one-pot
process, short reaction time, no column chromatographic purification,
excellent yield, and readily available starting materials