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    Four-Component Domino Strategy for the Combinatorial Synthesis of Novel 1,4-Dihydropyrano[2,3‑<i>c</i>]pyrazol-6-amines

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    An efficient one-pot four-component domino protocol for the combinatorial synthesis of novel 1,4-dihydropyrano­[2,3-<i>c</i>]­pyrazol-6-amines has been achieved. This transformation presumably occurs via cyclization–Knoevenagel condensation–Michael addition–tautomerism–intramolecular <i>O</i>-cyclization–elimination sequence of reactions. The significant features of this reaction include expedient one-pot process, short reaction time, no column chromatographic purification, excellent yield, and readily available starting materials
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