56 research outputs found
Rhodium catalysed asymmetric hydroformylation with diphosphite ligands based on sugar backbones
Caracterização quĂmica e perfil de ĂĄcidos graxos em cultivares de nogueira-macadĂąmia
EficiĂȘncia da farinha desengordurada de gergelim como complemento protĂ©ico da farinha extrudada de caupi1
Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volume
The concept of age acceleration, the difference between biological age and chronological age, is of growing interest, particularly with respect to age-related disorders, such as Alzheimerâs Disease (AD). Whilst studies have reported associations with AD risk and related phenotypes, there remains a lack of consensus on these associations. Here we aimed to comprehensively investigate the relationship between five recognised measures of age acceleration, based on DNA methylation patterns (DNAm age), and cross-sectional and longitudinal cognition and AD-related neuroimaging phenotypes (volumetric MRI and Amyloid-ÎČ PET) in the Australian Imaging, Biomarkers and Lifestyle (AIBL) and the Alzheimerâs Disease Neuroimaging Initiative (ADNI). Significant associations were observed between age acceleration using the Hannum epigenetic clock and cross-sectional hippocampal volume in AIBL and replicated in ADNI. In AIBL, several other findings were observed cross-sectionally, including a significant association between hippocampal volume and the Hannum and Phenoage epigenetic clocks. Further, significant associations were also observed between hippocampal volume and the Zhang and Phenoage epigenetic clocks within Amyloid-ÎČ positive individuals. However, these were not validated within the ADNI cohort. No associations between age acceleration and other Alzheimerâs disease-related phenotypes, including measures of cognition or brain Amyloid-ÎČ burden, were observed, and there was no association with longitudinal change in any phenotype. This study presents a link between age acceleration, as determined using DNA methylation, and hippocampal volume that was statistically significant across two highly characterised cohorts. The results presented in this study contribute to a growing literature that supports the role of epigenetic modifications in ageing and AD-related phenotypes
Estudo dos mĂ©todos de extração de carotenĂłides em cenoura por fluido supercrĂtico (efs) e convencional
Highly-parallelized simulation of a pixelated LArTPC on a GPU
The rapid development of general-purpose computing on graphics processing units (GPGPU) is allowing the implementation of highly-parallelized Monte Carlo simulation chains for particle physics experiments. This technique is particularly suitable for the simulation of a pixelated charge readout for time projection chambers, given the large number of channels that this technology employs. Here we present the first implementation of a full microphysical simulator of a liquid argon time projection chamber (LArTPC) equipped with light readout and pixelated charge readout, developed for the DUNE Near Detector. The software is implemented with an end-to-end set of GPU-optimized algorithms. The algorithms have been written in Python and translated into CUDA kernels using Numba, a just-in-time compiler for a subset of Python and NumPy instructions. The GPU implementation achieves a speed up of four orders of magnitude compared with the equivalent CPU version. The simulation of the current induced on 10^3 pixels takes around 1 ms on the GPU, compared with approximately 10 s on the CPU. The results of the simulation are compared against data from a pixel-readout LArTPC prototype
Determination of the water content of foods : Indirect determination of water in potato starch by means of phosphorus pentoxide as a reference method and in serial analysis
Determination of the water content of foods: I. Indirect determination of the water content
The indirect determination of the water content of foods is dealt witli on the basis of tlie following general considerations:
A. The absolute vapour pressure of the water in the substance to be desiccated ;
B. The absolute vapour pressure of the water in the surrounding air,
C. Behaviour of the non-water components of the substance to be desicented,
D. Special causes of errors, viz.:
Retardation in the establishment of equihbrium;
Retardation due to title structure of the substancc to be desiccated,
Crust formation;
Analytical errors.
E. Rate of desiccation: reference methods and rapid routine methods.
We prefer to consider the problems relating to the indirect determination of the water content on the basis of absolute water vapour pressures. The advantages and disadvantages of this method of treatment have been indicated
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