DIAGNOSTIC PROBLEMS AND THEARAPEUTIC BEHAVIOUR IN CHILDREN WITH NEUROBLASTOMA

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Reduction of sanitary indicator microorganisms in anaerobic digestion of poultry litter in combination with silages

ABSTRACT: In connection with experiments aimed at optimizing anaerobic digestion of organic fertilizers, microbiological tests were performed to assess the epizootiological safety of resulting finished product to fertilize the soil by quantities of sanitary indicator microorganisms. Mixtures of substrates were composed and tested in technological parameters established for other experiments: mesophilic temperature regime 33oC, dry matter content of 7%, residence time in the digester 15 days. The substrates tested were beetroot, sugar and salad beets, corn silage and leaves of Paulownia elongata, and silage combinations of these feeds in ratio 60:40 with mulch litter from broiler chickens. It was found that significant reduction of microorganisms was realized in the final products, which were assessed as safe for soil application. The ensiling of poultry litter in combinations of these feeds had the effect of reducing the amount of microorganisms in almost all examined groups therein. The most significant was the reduction in the quantity of sanitary revealing bacteria in the manure after its ensilage with autumn leaves of P. elongata and beetroot, and the least - with the participation of sugar beet. Microbial reduction was to the greatest extent in bioslime produced by anaerobic digestion of poultry litter ensiled with corn. Of the silages from different types of beets with poultry manure, during anaerobic digestion highest decontamination was achieved in this with sugar beets. After anaerobic degradation of the studied feed without poultry litter, at least microorganisms were found in bioslimes from the three types of beet, as well from the silage from P. elongata. РЕЗЮМЕ: Във връзка с експерименти, насочени към оптимизиране на анаеробното разграждане на органични торове, са извършени микробиологични изследвания за преценка на епизоотологичната безопасност на получените крайни продукти за наторяване на почви според количествата на санитарно индикаторните микроорганизми. Съставени са смеси от субстрати при установени при други експерименти технологични параметри: мезофилен температурен режим 33оС, съдържание на сухо вещество 7%, време на престой в биореактора 15 денонощия. Изпитани са захарно, кръмно и салатно цвекло, царевичен силаж и листа от Paulownia elongata, както и силажи от комбинации на тези фуражи в съотношение 60:40 с торова постеля от пилета-бройлери. Установено е, че се осъществява значително редуциране на микроорганизмите в крайните продукти, които се преценяват като безопасни за внасяне в почвите. В най-голяма степен микробната редукция е при биошлама, получен при анаеробното разграждане на комбинацията от торова постеля с царевичен силаж. От трите вида цвекло, силажирани с птичи тор, при анаеробно разграждане се постига най-висока деконтаминация с участие на захарното цвекло. При анаеробно разграждане на изследваните фуражи без птичи тор най-малко микроорганизми се установяват в биошламовете от трите вида цвекло, както и в силажа от P. elongata

Case Report of Advanced Childhood Nasopharyngeal Carcinoma: Is Radiotherapy Dose Deescalation the Right Way in Good Responders to Induction Chemotherapy

Objectives:. Treatment of childhood NPC similar to adults consists of radiotherapy and chemotherapy, but distant failure is often observed, which led to introducing the induction chemotherapy followed by radiation or chemoradiation. The improved survival rates raised the question of late toxicity. The options for lowering the toxicity rate is the application of advanced radiotherapy techniques like IMRT and VMAT, and deescalation of the radiation dose in good responders and early NPC.Case report: We report a case of13-years old male patient with a high-risk childhood undifferentiated NPC, stage cT4 cN2b M0. He presented with unilateral swallowing at the middle third of left muscle sterenocleidomastoideus, and headache, fever, sore throat and intermittent nasal bleeding for an year. Diagnostic MRI and PET/CT showed good concordance for primary tumor extension and lymph node involvement. Three coursesinduction chemotherapy were applied according to NPC2003-GPOH protocolwith good treatment response. The restaging PET/CT found no distant metastasis. Deescalated protocol of radiotherapy alone was delivered to 50.4 Gy total dose with IGRT, VMAT irradiation technique. At three month PET/CT follow up a solitary bone lesion was detected.Conclusion: The present case proved that in high risk patients more aggressive treatment strategies should be recommended with no omission of concurrent chemotherapy even after full response. Deescalation of radiotherapy dose probably is not appropriate in this group of patients. MRI and PET CT should be used as complementary imaging modalities for early detection of locoregional or distant metastasis

Magnetic structural effect in nonequilibrium defective solids

Scientific study of the effect of structural memory of nonequilibrium defective solids about the processing in magnetic field (the magnetic structural effect (MSE) was continued in this paper. The study was aimed to reveal the universal nature of the MSE, which was investigated in several new nonequilibrium defective solids. The results of investigation of the processing in the vortical magnetic field (PVMF) and its effect on the structure of the natural magnetite Fe3O4 and the SnO2 films were presented. The methods of Mössbauer and X-ray spectroscopy were used. The PVMF reduction of a defectiveness of Fe3O4 structure in the magnetite was detected. The MSE was also observed in the Mössbauer spectra of diamagnetic tin oxide SnO2 films after the PVMF. One of the possible explanations of the MSE was given in the paper.Comment: 6 pages, 6 figures, 3 table

Microbiological evaluation of sewage sludge in terms of possibility of applications in soil as a fertilizer

The studies were carried out of sewage sludge from wastewater treatment plant for the presence of microorganisms of several main groups, containing pathogenic representatives with epizootological significance (Gram-negative aerobic bacteria, E. coli, Clostridium perfringens, the genera Pseudomonas, Staphylococcus, Enterococcus, fungi, and the total number of microorganisms), in order to assess the environmental safety of the final product. In parallel similar studies were made of fresh and composted cattle manures. A comparison of the results was made with the ready for manuring compost in order to assess the possibilities for the use of sludge for fertilizing. The quantities of microorganisms were given in CFU per 1 g of the investigated material, as well as per 1 g of dry substance for each of them. In our opinion this new approach to the reporting of the results per unit of dry matter of the investigated materials, allows for a more accurate comparison. It was found that the examined sewage sludge from wastewater treatment plant were rich in microorganisms from studied groups and their direct application in soils without prior treatment by aerobic or anaerobic digestion may represent epidemiological danger

New generalized fuzzy metrics and fixed point theorem in fuzzy metric space

In this paper, in fuzzy metric spaces (in the sense of Kramosil and Michalek (Kibernetika 11:336-344, 1957)) we introduce the concept of a generalized fuzzy metric which is the extension of a fuzzy metric. First, inspired by the ideas of Grabiec (Fuzzy Sets Syst. 125:385-389, 1989), we define a new G-contraction of Banach type with respect to this generalized fuzzy metric, which is a generalization of the contraction of Banach type (introduced by M Grabiec). Next, inspired by the ideas of Gregori and Sapena (Fuzzy Sets Syst. 125:245-252, 2002), we define a new GV-contraction of Banach type with respect to this generalized fuzzy metric, which is a generalization of the contraction of Banach type (introduced by V Gregori and A Sapena). Moreover, we provide the condition guaranteeing the existence of a fixed point for these single-valued contractions. Next, we show that the generalized pseudodistance J:X×X→[0,∞) (introduced by Włodarczyk and Plebaniak (Appl. Math. Lett. 24:325-328, 2011)) may generate some generalized fuzzy metric NJ on X. The paper includes also the comparison of our results with those existing in the literature

Typological classification of health groups of schoolboys with comorbidity and behavioural risk factors

The purpose of study is estimation of a state of health by typological classification Complex examination of 142 girls and 116 boys in the age of 14-17 years has shown, that 2,1 % of girls and 11,2% of boys have la type of the status of health without risk factors. Premorbid types (lla, lib, lie) were in 20,4% and 25,9% accordingly. Among schoolboys persons with monomorbid (40,9% and 43,0 %) and bimorbid (23,9% and 12,1%) types of the status of health (Ilia and lllb) prevailed. Comorbidity is revealed in 68,3% of girls and 52,3% of boys. A prevailing pathology were dysplasia of connective tissue.Цель исследования оценить состояние здоровья подростков в соответствии с типологической классификацией. Комплексное обследование 142 девонек и 116 мальчиков в возрасте 14-17 лет показало, что 2,1 % девочек и 11,2% мальчиков относятся к la типу статуса здоровья без факторов риска. Преморбидные типы (На, НЬ, Не) были в 20,4% и 25,9% соответственно. Среди школьников преобладали лица с мономорбидным (40,9% и 43,0%) и биморбидным (23,9% и 12,1 %) типами статуса здоровья (Ша и lllb). Коморбидная патология выявлена в 68,3% девочек и 52,3% мальчиков. Преобладающей патологией была дисплазия соединительной ткани

Phase formation and relaxor properties of lead-free perovskite ceramics on the base of sodium-bismuth titanate

The work was supported by the Russian Foundation for Basic Research (Projects 16-53-48009, 17-03-00542)

Preliminary data on COVID-19 in patients with hemoglobinopathies : A multicentre ICET-A study

Objectives: This study aims to investigate, retrospectively, the epidemiological and clinical characteristics, laboratory results, radiologic findings, and outcomes of COVID-19 in patients with transfusion-dependent β thalassemia major (TM), β-thalassemia intermedia (TI) and sickle cell disease (SCD). Design: A total of 17 Centers, from 10 countries, following 9,499 patients with hemoglobinopathies, participated in the survey. Main outcome data: Clinical, laboratory, and radiologic findings and outcomes of patients with COVID-19 were collected from medical records and summarized. Results: A total of 13 patients, 7 with TM, 3 with TI, and 3 with SCD, with confirmed COVID-19, were identified in 6 Centers from different countries. The overall mean age of patients was 33.7±12.3 years (range:13-66); 9/13 (69.2%) patients were females. Six patients had pneumonia, and 4 needed oxygen therapy. Increased C-reactive protein (6/10), high serum lactate dehydrogenase (LDH; 6/10), and erythrocyte sedimentation rate (ESR; 6/10) were the most common laboratory findings. 6/10 patients had an exacerbation of anemia (2 with SCD). In the majority of patients, the course of COVID-19 was moderate (6/10) and severe in 3/10 patients. A 30-year-old female with TM, developed a critical SARS-CoV-2 infection, followed by death in an Intensive Care Unit. In one Center (Oman), the majority of suspected cases were observed in patients with SCD between the age of 21 and 40 years. A rapid clinical improvement of tachypnea/dyspnea and oxygen saturation was observed, after red blood cell exchange transfusion, in a young girl with SCD and worsening of anemia (Hb level from 9.2 g/dl to 6.1g/dl). Conclusions: The data presented in this survey permit an early assessment of the clinical characteristics of COVID 19 in different countries. 70% of symptomatic patients with COVID-19 required hospitalization. The presence of associated co-morbidities can aggravate the severity of COVID- 19, leading to a poorer prognosis irrespective of age