Effect of Zofenopril on regeneration of sciatic nerve crush injury in a rat model

<p>Abstract</p> <p>Background</p> <p>Zofenopril is an antioxidant agent which has been shown to have beneficial effects in hypertension and heart failure. The aim of this study was to test the effects of Zofenopril on nerve regeneration and scarring in a rat model of peripheral nerve crush injury.</p> <p>Methods</p> <p>Twenty-one adult Sprague-Dawley rats underwent a surgical procedure involving right sciatic nerve crush injury. 15 mg/kg Zofenopril was administered orally to seven rats in group Z for seven days. Seven rats in group S received saline orally for seven days. Seven rats in the control group C received no drug after crush injury. Fourteenth and 42nd days after injury, functional and electromyography assessments of nerves were performed. Functional recovery was analyzed using a walking track assessment, and quantified using the sciatic functional index (SFI). After these evaluations, all rats were sacrificed and microscopic evaluations were performed.</p> <p>Results</p> <p>The Sciatic functional Index (SFI) in group Z on 14^thday is different significantly from group S and group C (p = 0.037). But on 42^ndday there was no difference between groups (p = 0.278). The statistical analyses of electromyelographic (EMG) studies showed that the latency in group Z is significantly different from group S (p = 0.006) and group C (p = 0.045). But on 42^ndday there was no difference between groups like SFI (p = 0.147). The amplitude was evaluated better in group Z than others (p < 0.05). In microscopic evaluation, we observed the highest number of nerve regeneration in the group Z and the lowest in the group C. But it was not significant statistically.</p> <p>Conclusion</p> <p>Our results demonstrate that Zofenopril promotes the regeneration of peripheral nerve injuries in rat models.</p

Fogarty® catheter dilatation of veins smaller than 2.5 mm after completion of the anastomosis during arteriovenous fistula creation

Introduction. Risk of failure after surgical creation of the AVF was linked to the diameter and flow dynamics of the vessel that is to be quantified by preoperative ultrasound mapping. We aimed to report our results using a different technique consisting of Fogarty® catheter dilatation of the cephalic vein after completion of the anastomosis. Material and methods. A total of 23 patients, aged between 35 to 70 years, with a cephalic vein diameter of ≤ 2.5 mm received a dilatation technique for arteriovenous creation. Patients having reoperations, aneurysmatic or thrombosed veins and multiple risk factors were not considered eligible and access failure within 60 days was defined as early fistula failure. Results. Mean cephalic vein diameter was 2.03 ± 0.28 mm and mean radial artery diameter was 2.33 ± 0.16 mm. At 15th day visit, 21 of 23 patients (91.3%) had patent arteriovenous fistula. Mean time of follow-up was 7.2 ± 1.67 months and was complete in 20 of 21 patients with a patent fistula. Overall patency was 18/23 (78.2%) in patients with survived AVFs. Conclusion. Fogarty® catheter dilatation of the cephalic vein after completion of the anastomosis during arteriovenous fistula creation is effective and safe in patients with small calibrated veins

Endovascular treatment of femoro-popliteal artery stenosis/obstruction using a repositionable self-expanding nitinol stent: a preliminary study

Introduction. The aim of this study was to report our preliminary results regarding the use of the repositionable self-expanding nitinol stent in a cohort of patients with femoro-popliteal artery occlusion/stenosis. Material and methods. The study groups consisted a total of 8 patients (10 extremities) between 47 and 70 years of age who presented with typical symptoms of intermittent claudication and/or critical limb ischaemia (Fontaine stage II–IV) and underwent primary elective superficial femoral artery percutaneous transluminal angioplasty and/or stenting using a Jaguar repositionable self-expanding nitinol stent in the dates of 2013–2015. Information for patency at 6th month after the stenting procedure was obtained. Results. The mean operation time was 38.56 ± 26.40 minutes. No patients had procedure-related stent fracture, distal thromboembolism, haematoma, femoral pseudoaneurysm or stent occlusion. At 6-month follow-up, at least one categorical improvement was observed in 7 patients (87.5% of intent-to-treat population). Conclusions. The Jaguar self-expanding nitinol stent has several technical advantages, and its use was associated with a low risk of complications. Further study is warranted to establish its superiority in providing good long-term patency

Mixed Bacteriological Isolation Percentages from the Uterus of Cows Slaughtered due to Infertility

Background: Intrauterine mixed infections are an important problem in cattle breeding. In this study, we aimed to determine the mixed bacteriological isolation rates from the uterus of cows with clinical metritis and to reveal the relationships between the bacteria that isolated together.Methods: For this purpose, sterile swabs were taken from 490 uterus obtained from cattle slaughtered due to infertility in three slaughterhouses and used them to perform microbiological tests. After evaluating the data, it was determined that the bacterial isolation rate from uterus with clinical metritis was 76.14% (n = 268).Results: The rates for 1, 2, 3, 4, and 5 bacteria isolated from the uterus with clinical metritis were 48.13%, 33.96%, 15.30%, 2.24%, and 0.37%, respectively. The isolation rates for Trueperella pyogenes, Fusobacterium necrophorum, and Escherichia coli alone from the uterus with clinical metritis were 27.08%, 28.00%, and 16.51%, respectively. In uterus with clinical metritis, Staphylococcus aureus (16.67%) was the most commonly isolated bacteria with T. pyogenes, Clostridium spp. (16%) co-isolated with F. necrophorum, and coagulase-negative staphylococci (16.51%) and Bacillus spp. (16.51%) were detected with E. coli.Conclusion: As a result, it was concluded that when evaluating the microbiological results for cows with clinical metritis, mixed infections should be taken into more consideration, and the characteristics of the bacteria that isolate together should be considered during the treatment of mixed infections.Keywords: Cattle; Uterine; Isolation; infertility     

Spontaneous left iliac vein rupture — case report

Spontaneous iliac vein rupture is an uncommon cause of retroperitoneal haematoma. Most common concomitant pathology reported was deep vein thrombosis or thrombophlebitis and followed by May-Thurner Syndrome. In this particular case, we observed findings parallel to literature. A 61-year-old female patient complaining of abdominal and back pain was admitted to the emergency room. She was a smoker and except that medical history revealed only chronic obstructive pulmonary disease. Also, she had no history of trauma. She suffered from sudden left abdominal and back pain without evident cause. On arrival, her vitals were normal. An abdominopelvic computed tomography (CT) showed large haematoma in the lower abdominal cavity. Retroperitoneal exploration revealed large haematoma and left external iliac vein rupture. The vein was repaired primarily. Postoperative follow-up visit at one month after surgery showed that the patient was doing well. Iliac vein rupture should be taken into account in middle-aged or elderly women with acute onset abdominal pain and acute DVT

Analysis of the Relationship Between Smartphone Addiction and Internet Addiction and Self-Esteem and Loneliness

DergiPark: 545391trakyasobedİnternetve akıllı telefon bağımlılığı gelişen teknoloji ile birlikte psikoloji alandizininde sıklıkla incelenen konuların başında gelmiştir. Sürekli internet veakıllı telefon başındaki bireyler toplumdan uzaklaşmakta ve yalnızlaşmaktadır.Bu durum bireylerin kendilerine olan saygılarında da azalmaya neden olmaktadır.Bu çalışmanın amacı akıllı telefon ve internet bağımlılığı ile benlik saygısıve yalnızlık arasındaki ilişkinin incelenmesidir. Yapılan çalışmada ilişkiseltarama modeli tercih edilmiştir. Bu amaçla yürütülen çalışmaya 137’si kadın ve93’ü erkek olmak üzere 230 kişi katılmıştır. Katılımcılara içeriğinde;demografik veri formu, akıllı telefon bağımlılığı ölçeği, Young İnternetBağımlılığı Testi Kısa Formu, Rosenberg Benlik Saygısı Ölçeği ve UCLA YalnızlıkÖlçeği’nin bulunduğu anket formu uygulanmıştır. Yapılan korelasyon analizlerisonucunda akıllı telefon bağımlılığı ile benlik saygısı ölçeği toplam puanlararasında negatif, orta düzeyde ve anlamlı; telefon bağımlılığı ile yalnızlıkölçeği toplam puanları arasında pozitif ve düşük düzeyde anlamlı bir korelasyonkatsayısı elde edilmiştir. İnternet bağımlılığı ile benlik saygısı ölçeğitoplam puanlar arasında negatif, orta düzeyde ve anlamlı bir korelasyonkatsayısı; internet bağımlılığı ile yalnızlık ölçeği toplam puanlar arasında pozitif,orta düzeyde anlamlı bir korelasyon katsayısı hesaplanmıştır. İnternetin kişiiçin önemi, benlik saygısı ve yalıtılmışlık akıllı telefon bağımlılığınıyordamaktadır. İnternetin kişi için önemi, benlik saygısı, yaş ve yalıtılmışlıkinternet bağımlılığını yordamaktadır.Internetand smart phone addiction has been one of the most frequently studied topics inthe psychology field index along with the developing technology. Individualswho constantly interest internet and smart phone move away from society andbecome lonely. This leads to a decrease in the respect of individuals forthemselves. The aim of this study is to examine the relationship between smartphone and Internet addiction and self-esteem and loneliness. In this study,relational screening model was preferred. For this purpose, 230 people, 137 ofwhom were female and 93 of them were male, participated in the study.Demographic data, Smart Phone Addiction Scale, Young Internet Addiction TestShort Form, Rosenberg Self Esteem Scale and UCLA Loneliness Scale were appliedto the participants. The results of the correlation analysis, positive, low andsignificant correlation coefficient between smart phone addiction and self-esteemscale total scores, and negative, moderate and significant correlationcoefficient between smart phone addiction loneliness subscale total scores wasfound. Between internet addiction and self-esteem scale total scores positive,moderate and significant correlation coefficient; between internet addictionand loneliness scale total scores positive, moderate and significantcorrelation coefficient was calculated. The importance of the internet for theperson, self-esteem and the isolation have been found to be predictive factorsfor smart phone addiction. The importance of the internet for the person,self-esteem, age and the isolation have been found to be predictive factors forinternet addiction

Risk factors of nasopharyngeal carcinoma in Turkey - an epidemiological survey of the anatolian society of medical oncology

Background: Nasopharyngeal carcinoma is a rare disease in most parts of the world with a multifactorial etiology involving an interaction of genetic, viral, environmental and dietary risk factors. This is the first epidemiologic study aimed to evaluate the risk factors of nasopharyngeal carcinoma in the Turkish population. Methods: We conducted a multicentric, retrospective, case-control study using a standardized questionnaire which captured age, sex, occupation, household type, blood group, dietary habits, smoking, alcohol consumption and oral hygiene. The study included 183 cases and 183 healthy controls matched by sex and age. Multiple logistic regression and univariate analysis were employed. Results: The peak age incidence was 40-50 years and the male to female ratio was 2:1. We observed significant associations between elevated nasopharyngeal carcinoma risk and low socioeconomic status, rural household type (OR:3.95, p0.05); furthermore salty foods had a borderline p value (OR:2.14, p=0.053). Blood type A increased the risk (OR:2.03, p=0.002) while blood type 0 was a protective factor (OR:0.53, p=0.009). Rare habit of teeth brushing (OR:6.17, p<0.001) and ≥10 decayed teeth before diagnosis (OR:2.17, p<0.001) increased the risk. Conclusions: The nasopharyngeal carcinoma risk factors described in the literature are also applicable for the Turkish population. People with type A blood are at risk in Turkey. Salted foods have also a border risk out of the endemic regions. This is the only study showing that poor oral hygene is a serious risk factor for nasopharyngeal carcinoma