1,559 research outputs found
Verwirklichung einer vollkommenen GlĂŒcksmöglichkeit/A perfect bliss-potential realized: âWunsch, Indianer zu werdenâ im Lichte des Dao Kafkas ĂŒbersetzend gelesen/Transreading âWish, to Become Indianâ in light of Kafkaâs Dao
Walking an unexplored path, Huiwen Helen Zhang contextualizes Kafka's pithy and cryptic parable, âWish, to Become Indianâ in his transplantation of Daoist philosophyâan astonishing cross-cultural enigma that Zhang terms âKafka's Daoââand parses it through a micro-level approach that Zhang terms âtransreading.â Contextualizing âWish, to Become Indianâ in Kafka's dialogue with ancient Chinese philosophers such as Laozi, Liezi, and Zhuangzi enables the reader to comprehend a series of otherwise incomprehensible puzzles. Zhang's scrutiny of Kafka's Dao shows how, through creative writing, Kafka not only penetrates esoteric Daoist classics, but also furthers their spirit in a way that transcends Richard Wilhelm, the pioneer European Sinologist. Transreading âWish, to Become Indianâ illuminates nuances that otherwise might have been overlooked. Wordplay, punctuational oddity, syntactic complexity, lyric density, and the curiously interlaced tenses and cases are all part of the idiosyncratic delivery of Kafka's message. Integrating the four activities of transreadingâlento reading demanded and enhanced by cultural hermeneutics, creative writing required and inspired by poetic translationâunravels Kafka's riddle as a historical-cultural phenomenon.publishedVersio
JT9D engine diagnostics. Task 2: Feasibility study of measuring in-service flight loads
The feasibility of measuring JT9D propulsion system flight inertia loads on a 747 airplane is studied. Flight loads background is discussed including the current status of 747/JT9D loads knowledge. An instrumentation and test plan is formulated for an airline-owned in-service airplane and the Boeing-owned RA001 test airplane. Technical and cost comparisons are made between these two options. An overall technical feasibility evaluation is made and a cost summary presented. Conclusions and recommendations are presented in regard to using existing inertia loads data versus conducting a flight test to measure inertia loads
Time-resolved measurement of single pulse femtosecond laser-induced periodic surface structure formation
Time-resolved diffraction microscopy technique has been used to observe the
formation of laser-induced periodic surface structures (LIPSS) from the
interaction of a single femtosecond laser pulse (pump) with a nano-scale groove
mechanically formed on a single-crystal Cu substrate. The interaction dynamics
(0-1200 ps) was captured by diffracting a time-delayed, frequency-doubled pulse
from nascent LIPSS formation induced by the pump with an infinity-conjugate
microscopy setup. The LIPSS ripples are observed to form sequentially outward
from the groove edge, with the first one forming after 50 ps. A 1-D analytical
model of electron heating and surface plasmon polariton (SPP) excitation
induced by the interaction of incoming laser pulse with the groove edge
qualitatively explains the time-evloution of LIPSS formation.Comment: 4 pages, 5 figure
Comparative analysis of US real-world dosing patterns and direct infusion-related costs for matched cohorts of rheumatoid arthritis patients treated with infliximab or intravenous golimumab.
Purpose: The objectives of this study were to evaluate and compare treatment patterns and infusion-related health care resource expenditures for rheumatoid arthritis (RA) patients initiating golimumab for intravenous use (GLM-IV) and infliximab (IFX) therapy and to assess cost implications from the commercial perspective.
Methods: Adult RA patients with a new episode of GLM-IV or IFX treatment between January 1, 2014 and March 31, 2016 were identified from MarketScan databases and evaluated for maintenance infusion intervals and related costs of treatment. IFX and GLM-IV patients were matched 1:1 on index medication treatment duration, gender, payer type, prior biologic use, and post-index methotrexate use. Paid amounts for drugs and associated administration costs were applied to treatment group dosing patterns.
Results: Final matched treatment groups included 547 GLM-IV and 547 IFX patients (mean age = 55-56 years). Mean (SD) follow-up was 609 (161) days for GLM-IV and 613 (163) days for IFX. Treatment duration was 396 (240) days for GLM-IV and 397 (239) days for IFX. Overall, 80% of GLM-IV and 39% of IFX maintenance infusions were given approximately every 8 weeks; and 6% of GLM-IV and 53% of IFX maintenance infusions occurred more frequently than every 8 weeks (P\u3c0.001). When weighting of the maintenance infusion interval was applied, the mean number of induction plus maintenance infusions during the first year of treatment was estimated at 7.03 for GLM-IV and 9.48 for IFX. From the commercial perspective, drug plus administration costs per infusion were 5,444 for IFX with total annual cost of therapy for GLM-IV patients costing 6,774 less than that for IFX patients in subsequent years.
Conclusion: Annual GLM-IV drug plus administration costs for commercial health plans were significantly less than IFX in RA patients due to differences in real-world dosing and administration. © 2019 Ellis et al
Patient-reported outcome assessment of inflammatory arthritis patient experience with intravenously administered biologic therapy
Objective: To evaluate patient perspectives regarding utilization of intravenous (IV) therapy for inflammatory arthritis (IA). Methods: This was a single-center, non-interventional, patient questionnaire-based study of adult IA patients currently receiving IV biologics. At a single visit, patients completed the questionnaire comprising 30 questions centered on their experience receiving an intravenously administered therapy to treat their IA. The questionnaire included questions on patient demographics, disease characteristics, and previous biologic treatment for IA (subcutaneous [SC] and IV). Patients rated their level of agreement with statements regarding satisfaction with current IV biologic therapy and potential advantages and disadvantages of IV biologic therapy using a 5-point Likert scale (1= strongly disagree, 5= strongly agree). Results: One hundred patients were enrolled and completed the survey; 66% were female and the mean age was 58 years. Before IV treatment, 97% of patients received information regarding therapy options. Ninety patients ranked their satisfaction with current IV therapy as 4 or 5. The proportion of patients with an âextremely favorableâ perception of IV therapy increased from 33% to 71% following initiation of their current medication. Thirty-one patients had previously received SC therapies to treat their IA. Conclusion: These results demonstrated an overall favorable perception of IV therapy among this patient population. Patients previously treated with SC therapy also had a positive shift in the perception of IV therapy after initiating IV therapy. Patientsâ perception and preference for treatment options should be highly considered by the treating physician during or as part of a shared decision-making process. © 2017 Gaylis et al
"Dark Matter" in Accretion Disks
Using Spitzer Space Telescope photometric observations of the eclipsing,
interacting binary WZ Sge, we have discovered that the accretion disk is far
more complex than previously believed. Our 4.5 and 8 micron time series
observations reveal that the well known gaseous accretion disk is surrounded by
an asymmetric disk of dusty material with a radius approximately 15 times
larger than the gaseous disk. This dust ring contains only a small amount of
mass and is completely invisible at optical and near-IR wavelengths, hence
consisting of "dark matter". We have produced a model dust ring using 1 micron
spherical particles with a density of 3 g/cm and with a temperature profile
ranging from 700-1500K. Our discovery about the accretion disk structure and
the presence of a larger, outer dust ring have great relevance for accretion
disks in general, including those in other interacting binary systems, pre-main
sequence stars, and active galaxies.Comment: 34 pages, 8 figures (3 in color). Accepted to Ap
The Dwarf Nova Outbursts of Nova Her 1960 (=V446 Her)
V446 Her is the best example of an old nova which has developed dwarf nova
eruptions in the post-nova state. We report on observed properties of the
long-term light curve of V446 Her, using photometry over 19 years. Yearly
averages of the outburst magnitudes shows a decline of ~0.013 mag/yr,
consistent with the decline of other post-novae that do not have dwarf nova
outbursts. Previous suggestions of bimodal distributions of the amplitudes and
widths of the outbursts are confirmed. The outbursts occur at a mean spacing of
18 days but the range of spacings is large (13-30 days). From simulations of
dwarf nova outbursts it has been predicted that the outburst spacing in V446
Her will increase as M-dot from the red dwarf companion slowly falls following
the nova; however the large intrinsic scatter in the spacings serves to hide
any evidence of this effect. We do find a systematic change in the outburst
pattern in which the brighter, wider type of outbursts disappeared after late
2003, and this phenomenon is suggested to be due to falling M-dot following the
nova.Comment: To appear at the Astronomical Journal; 7 pages, 1 table, 11 figure
Recent atmospheric neutrino results from Soudan 2
An updated measurement of the atmospheric nu_mu/nu_e ratio-of-ratios,
0.68+-0.11+-0.06, has been obtained using a 4.6-kty exposure of the Soudan-2
iron tracking calorimeter. The L/E distributions have been analyzed for effects
of nu_mu -> nu_x oscillations, and an allowed region in the Delta m^2 vs. sin^2
2 theta plane has been determined.Comment: 3 pages, 4 figures; presented at TAUP99, the 6th Int. Workshop on
Topics in Astroparticle and Underground Physics, Sept. 6-10, 1999, College de
France, Paris, Franc
The Factory and The Beehive II. Activity and Rotation in Praesepe and the Hyades
Open clusters are collections of stars with a single, well-determined age,
and can be used to investigate the connections between angular-momentum
evolution and magnetic activity over a star's lifetime. We present the results
of a comparative study of the relationship between stellar rotation and
activity in two benchmark open clusters: Praesepe and the Hyades. As they have
the same age and roughly solar metallicity, these clusters serve as an ideal
laboratory for testing the agreement between theoretical and empirical
rotation-activity relations at 600 Myr. We have compiled a sample of
720 spectra --- more than half of which are new observations --- for 516
high-confidence members of Praesepe; we have also obtained 139 new spectra for
130 high-confidence Hyads. We have collected rotation periods () for
135 Praesepe members and 87 Hyads. To compare emission, an indicator
of chromospheric activity, as a function of color, mass, and Rossby number
, we first calculate an expanded set of values, with which we can
obtain the to bolometric luminosity ratio, ,
even when spectra are not flux-calibrated and/or stars lack reliable distances.
Our values cover a broader range of stellar masses and colors (roughly
equivalent to spectral types from K0 to M9), and exhibit better agreement
between independent calculations, than existing values. We find no difference
between the two clusters in their equivalent width or
distributions, and therefore take the merged
and data to be representative of 600-Myr-old stars. Our analysis
shows that activity in these stars is saturated for
. Above that value activity declines as a
power-law with slope , before dropping off rapidly
at ...Comment: 17 pages, 15 figures, Accepted by Ap
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