36 research outputs found
Social Influence and the Collective Dynamics of Opinion Formation
Social influence is the process by which individuals adapt their opinion,
revise their beliefs, or change their behavior as a result of social
interactions with other people. In our strongly interconnected society, social
influence plays a prominent role in many self-organized phenomena such as
herding in cultural markets, the spread of ideas and innovations, and the
amplification of fears during epidemics. Yet, the mechanisms of opinion
formation remain poorly understood, and existing physics-based models lack
systematic empirical validation. Here, we report two controlled experiments
showing how participants answering factual questions revise their initial
judgments after being exposed to the opinion and confidence level of others.
Based on the observation of 59 experimental subjects exposed to peer-opinion
for 15 different items, we draw an influence map that describes the strength of
peer influence during interactions. A simple process model derived from our
observations demonstrates how opinions in a group of interacting people can
converge or split over repeated interactions. In particular, we identify two
major attractors of opinion: (i) the expert effect, induced by the presence of
a highly confident individual in the group, and (ii) the majority effect,
caused by the presence of a critical mass of laypeople sharing similar
opinions. Additional simulations reveal the existence of a tipping point at
which one attractor will dominate over the other, driving collective opinion in
a given direction. These findings have implications for understanding the
mechanisms of public opinion formation and managing conflicting situations in
which self-confident and better informed minorities challenge the views of a
large uninformed majority.Comment: Published Nov 05, 2013. Open access at:
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.007843
Pleiotropic effects of the vacuolar ABC transporter MLT1 of Candida albicans on cell function and virulence.
Among the several mechanisms that contribute to MDR (multidrug resistance), the overexpression of drug-efflux pumps belonging to the ABC (ATP-binding cassette) superfamily is the most frequent cause of resistance to antifungal agents. The multidrug transporter proteins Cdr1p and Cdr2p of the ABCG subfamily are major players in the development of MDR in Candida albicans Because several genes coding for ABC proteins exist in the genome of C. albicans, but only Cdr1p and Cdr2p have established roles in MDR, it is implicit that the other members of the ABC family also have alternative physiological roles. The present study focuses on an ABC transporter of C. albicans, Mlt1p, which is localized in the vacuolar membrane and specifically transports PC (phosphatidylcholine) into the vacuolar lumen. Transcriptional profiling of the mlt1∆/∆ mutant revealed a down-regulation of the genes involved in endocytosis, oxidoreductase activity, virulence and hyphal development. High-throughput MS-based lipidome analysis revealed that the Mlt1p levels affect lipid homoeostasis and thus lead to a plethora of physiological perturbations. These include a delay in endocytosis, inefficient sequestering of reactive oxygen species (ROS), defects in hyphal development and attenuated virulence. The present study is an emerging example where new and unconventional roles of an ABC transporter are being identified
Foundation characteristics of edible Musa triploids revealed from allelic distribution of SSR markers
Background and Aims The production of triploid banana and plantain (Musa spp.) cultivars with improved characteristics (e.g. greater disease resistance or higher yield), while still preserving the main features of current popular cultivars (e.g. taste and cooking quality), remains a major challenge for Musa breeders. In this regard, breeders require a sound knowledge of the lineage of the current sterile triploid cultivars, to select diploid parents that are able to transmit desirable traits, together with a breeding strategy ensuring final triploidization and sterility. Highly polymorphic single sequence repeats (SSRs) are valuable markers for investigating phylogenetic relationships. Methods Here, the allelic distribution of each of 22 SSR loci across 561 Musa accessions is analysed. Key Results and ConclusionsWe determine the closest diploid progenitors of the triploid 'Cavendish' and 'Gros Michel' subgroups, valuable information for breeding programmes. Nevertheless, in establishing the likely monoclonal origin of the main edible triploid banana subgroups (i.e. 'Cavendish', 'Plantain' and 'Mutika- Lujugira'), we postulated that the huge phenotypic diversity observed within these subgroups did not result from gamete recombination, but rather from epigenetic regulations. This emphasizes the need to investigate the regulatory mechanisms of genome expression on a unique model in the plant kingdom. We also propose experimental standards to compare additional and independent genotyping data for reference. (Résumé d'auteur
Analysis of the leaf transcriptome of Musa acuminata during interaction with Mycosphaerella musicola: gene assembly, annotation and marker development
Echounterdrueckung bei HD-MAC-Uebertragungen in Kabelnetzen (A) Abschlussbericht
The research and development project 'Echo cancelling in HD-MAC-transmissions via cable-networks (A)' financed by the BMFT and worked out by RFT AG Stassfurt (RFT) in cooperation with NOKIA CONSUMER ELECTRONICS GmbH Pforzheim/Bochum (NOKIA) from 1st October 1991 to 31st March 1994 leads to the conclusion that an echo-compensation is technically possible with reasonable efforts. According to the project plan our research activities have mainly been focussed on cable-reception and front-end development of the consumer product. Due to misadjustments reflections can interfere with the transmitted data-, sound- and videosignals in HD-MAC-transmissions via cable. We have developed a tuner/IF-amplifier with a frequency response for HD-MAC-distribution and transmission according to hyperband signals with a bandwidth of 12 MHz. For comprehensive testing of the reception channel we built up a highly modificable HD-MAC-satellite system with echo-generator in the hyperband. (orig.)Available from TIB Hannover: F94B1988+a / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEBundesministerium fuer Forschung und Technologie (BMFT), Bonn (Germany); Commission of the European Communities (CEC), Brussels (Belgium)DEGerman
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SIGLETIB: RN 7920 (58) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman