Comparison of Protective Effects of Melatonin and Amifostine on Radiation-Induced Renal Oxidative Stress in Rats

ΔΕΝ ΔΙΑΤΙΘΕΤΑΙ ΠΕΡΙΗΨΗIn this study, we aimed to compare the protective effects of melatonin and amifostine on radiation-induced oxidative stress. Fifty female Wistar rats (3-4 months old, weighing 200±25 g) were divided into five groups (with ten rats each) and treated as follows: control (Cont), radiotherapy alone (RT), radiotherapy + amifostine (RT+AMI), radiotherapy + melatonin (RT+MEL), radiotherapy + amifostine + melatonin (RT+AMI+MEL). Rats were irradiated individually with a single dose of 8 Gy and amifostine (200 mg/kg) and melatonin (10 mg/kg) was administered to rats 30 minutes before irradiation. At the end of this follow-up period (72 hours) the rats were sacrificed. Spectrophotometric Analysis has been performed to kidney tissue samples. As a result of statistical comparison between groups after RT, total antioxidant capacity (TAC) decreased, total oxidant status (TOS) and oxidative stress index (OSI) increased, although the statistically significant change was only for OSI (p = 0.030). Addition of AMI or MEL to RT increased TAC and OSI significantly (p = 0.000), but there was no additive effect for TAC and OSI when both drugs were given together (p = 1.000, p = 0.172, respectively). In terms of TOS, statistically significant increasing was only for AMI (p = 0.000). There was protective effect when both drugs were given together against on Radiation-Induced Renal Oxidative Stress

Comparative study of the osseointegration of dental implants after different bone augmentation techniques: Vascularized femur flap, non-vascularized femur graft and mandibular bone graft

PubMedID: 21044163Objectives: The purpose of this study was to evaluate the osseointegration of the dental implants placed into the mandible augmented with different techniques in pigs. Material and methods: Four adult domestic pigs were used. Horizontal augmentation of the mandible was performed in animals by using vascularized femur flap (VFF), non-vascularized femur graft (NVFG) and monocortical mandibular block graft (MG). After 5 months of healing 10 dental implants were placed into each augmented site. The pigs were sacrificed after 3 months of healing. Undecalcified sections were prepared for histomorphometric analysis. Results: Mean bone-implant contact (BIC) values for implants placed into MG, NVFG and VFF were 57.38 ± 11.97%, 76.5 ± 7.88%, 76.53 ± 8.15%, respectively. The BIC values of NVFG and VFF group were significantly greater than MG group (P<0.001). On the other hand, there was not statistically significant difference between NVFG group and VFF group (P=0.999). Conclusion: NVFG as well as VFF can be considered as a promising method for augmentation of alveolar defects and the placement of the implants. The selection of non-vascularized graft or vascularized flap depends on the condition of the recipient site. © 2010 John Wiley & Sons A/S

Juvenile hyaline fibromatosis: A case report follow-up after 3 years and a review of the literature

PubMedID: 24506420[No abstract available

Comparative study of the osseous healing process following three different techniques of bone augmentation in the mandible: An experimental study

PubMedID: 25091894The aim of this study was to evaluate the osseointegration of three different bone grafting techniques. Forty-eight mature New Zealand rabbits were divided randomly into three groups of 16 each. Horizontal augmentation was performed on the corpus of the mandible using three different techniques: free bone graft (FBG), free periosteal bone graft (PBG), pedicled bone flap (BF). The animals were sacrificed at postoperative weeks 1, 3, or 8. Specimens were decalcified for histological examination, and histomorphometric measurements were performed. The histological evaluation demonstrated bony fusion between the grafts and the augmented mandibular bone after 8 weeks in all groups. At week 8, the bone volume was significantly greater in the BF group than in the FBG (P < 0.001) and PBG (P = 0.001) groups, and also the trabecular thickness was significantly greater than in the FBG (P = 0.015) and PBG (P = 0.015) groups. Trabecular separation was significantly lower in the BF group than in the FBG group at week 8 (P = 0.015). BF demonstrated greater osseous healing capacity compared to FBG and PBG. The preserved vascularization in BF improves the bone quality in mandibular bone augmentations. © 2014 International Association of Oral and Maxillofacial Surgeons

Molecular characterization of carbapenem-resistant Klebsiella pneumoniae in a tertiary university hospital in Turkey

The aim of this study was to identify the resistance genes and genetic relationship of carbapenemase-resistant Klebsiella pneumoniae (CRKP) identified in a tertiary university hospital in Turkey. During the study, CRKP was isolated from 137 patients. Resistance genes were studied in 94 isolates. Among these isolates, most of the CRKP produced only oxacillinase (OXA)-48 (91.5%); however, 4.3% of the isolates produced only New Delhi metallo-beta-lactamase 1 (NDM-1), 1% produced both OXA-48 and NDM-1, and 3.2% produced imipenem. This study adds Turkey to the growing list of countries with NDM-1-producing bacteria and shows that NDM-1 may easily spread worldwide. (c) 2013 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved

Tribological Behavior of New Martensitic Stainless Steels Using Scratch and Dry Wear Test

This paper focuses on the tribological characterization of new martensitic stainless steels by two different tribological methods (scratch and dry wear tests) and their comparison to the austenitic standard stainless steel AISI 316L. The scratch test allows obtaining critical loads, scratch friction coefficients, scratch hardness and specific scratch wear rate, and the dry wear test to quantify wear volumes. The damage has been studied by ex situ scanning electron microscopy. Wear resistance was related to the hardness and the microstructure of the studied materials, where martensitic stainless steels exhibit higher scratch wear resistance than the austenitic one, but higher hardness of the martensitic alloys did not give better scratch resistance when comparing with themselves. It has been proved it is possible to evaluate the scratch wear resistance of bulk stainless steels using scratch test. 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Beyond geotagged tweets: exploring the geolocalisation of tweets for transportation applications

Researchers in multiple disciplines have used Twitter to study various mobility patterns and “live” aspects of cities. In the field of transportation planning, one major area of interest has been to use Twitter data to infer movement patterns and origins and destinations of trip-makers. In the area of transportation operations, researchers have been interested in automated incident detection or event detection. Because the number of geotagged tweets pinpointing the location of the user at the time of tweeting tends to be sparse for transportation applications, there is a need to consider expanding and geolocalising the sample of non-geotagged tweets that can be associated with locations.We call this process “geolocalisation”. While geolocalisation is an active area of research associated with the geospatial semanticWeb and Geographic Information Retrieval, much of the work has focused on geolocalisation of users, or on geolocalisation of tweeting activity to fairly coarse geographical levels, whereas our work relates to street-level or even building-level geolocalisation. We will consider two different approaches to geolocalisation that make use of Points of Interest databases and a second information retrieval-based approach that trains on geotagged tweets. Our objective is to make a comprehensive assessment of the differences in spatial and content coverage between non-geotagged tweets geolocalised using different approaches compared to using geotagged tweets alone. We find that using geolocalised tweets allow discovery of a larger number of incidents and socioeconomic patterns that are not evident from using geotagged data alone, including activity throughout the metropolitan area, including deprived “Environmental Justice” (EJ) areas where the degree of social media activity detected is usually low. Conclusions are drawn on the relative usefulness of the alternative approaches