52 research outputs found
Group Size and Population Structure of Vulnerable Gaur in an Isolated Tropical Deciduous Forest of Eastern India
Numerical simulation of blood flow through a capillary using a non-linear viscoelastic model
Responses of tiger (Panthera tigris) and their prey to removal of anthropogenic influences in Rajaji National Park, India
Snapshots of Dirac fermions near the Dirac point in topological insulators
ABSTRACT: The recent focus on topological insulators i
Snapshots of Dirac fermions near the Dirac point in topological insulators
ABSTRACT: The recent focus on topological insulators i
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Longitudinal Weight Change During CKD Progression and Its Association With Subsequent Mortality.
BackgroundFew studies have investigated the changes in weight that may occur over time among adults with the progression of chronic kidney disease (CKD). Whether such weight changes are independently associated with death after the onset of end-stage renal disease has also not been rigorously examined.Study designProspective cohort study.Setting & participantsWe studied 3,933 participants of the Chronic Renal Insufficiency Cohort (CRIC) Study, a longitudinal cohort of patients with CKD. We also performed similar analyses among 1,067 participants of the African American Study of Kidney Disease and Hypertension (AASK).PredictorsEstimated glomerular filtration rate (eGFR) and weight change during CKD.OutcomeWeight and all-cause mortality after dialysis therapy initiation.ResultsDuring a median follow-up of 5.7 years in CRIC, weight change was not linear. Weight was stable until cystatin C-based eGFR (eGFRcys) decreased to <35mL/min/1.73m2; thereafter, weight declined at a mean rate of 1.45 kg (95% CI, 1.19-1.70) for every 10 mL/min/1.73m2 decline in eGFRcys. Among the 770 CRIC participants who began hemodialysis or peritoneal dialysis therapy during follow-up, a >5% annualized weight loss after eGFR decreased to <35mL/min/1.73m2 was associated with a 54% higher risk for death after dialysis therapy initiation (95% CI, 1.17-2.03) compared with those with more stable weight (annualized weight changes within 5% of baseline) in adjusted analysis. Similar findings were observed in the AASK.LimitationsInclusion of research participants only; inability to distinguish intentional versus unintentional weight loss.ConclusionsSignificant weight loss began relatively early during the course of CKD and was associated with a substantially higher risk for death after dialysis therapy initiation. Further studies are needed to determine whether interventions to optimize weight and nutritional status before the initiation of dialysis therapy will improve outcomes after end-stage renal disease
Hierarchical NiO@NiS@graphene nanocomposite as a sustainable counter electrode for Pt free dye-sensitized solar cell
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