A preliminary laboratory study on the salinity and temperature tolerances of some medusae from the São Paulo coast, Brazil

The salinity and temperature tolerances of some species of medusae were studied in the laboratory. The results showed the following order of tolerances in diluted seawater: Cirrholovenia tetranema, Clytia cylindrica and Eucheilota duodecimalis > Proboscidactyla ornata and Obelia spp. > Euphysora gracilis, Ectopleura dumortieri, Liriope tetraphylla and Cunina octonaria. In relation to the decrease of temperature, the following results were obtained: Ectopleura dumortieri, Euphysora gracilis, Obelia spp. and Proboscidactyla ornata > Liriope tetraphylla > Cunina octonaria > Clytia cylindrica and Eucheilota duodecimalis. The results obtained in laboratory were discussed in relation to the distribution of the species in nature.A tolerância de varias espécies de medusas a valores decrescentes de salinidade e temperatura foi estudada em laboratório. Os resultados mostraram a seguinte ordem de tolerância em relação á água do mar diluída: Cirrholovenia tetranema, Clytia cylindrica e Eucheilota duodecimalis > Proboscidactyla ornata e Obelia spp. > Euphysora gracilis, Ectopleura dumortieri, Liriope tetraphylla e Cunina octonaria. Em relação á diminuição de temperatura, os seguintes resultados foram obtidos: Ectopleura dwrortieri, Euphysora gracilis, Obelia spp. e Proboscidactyla ornata > Liriope tetraphylla > Cunina octonaria > Clytia cylindrica e Eucheilota duodecimalis. Estes resultados obtidos em laboratório foram discutidos levando-se em conta a distribuição dessas espécies na natureza

Sport coaches' experiences of athlete injury : the development and regulation of guilt

This study sought to examine coaches’ stories of guilt in the specific context of athlete injury. Using narrative interviews with a diverse group of ten coaches, guilt was found to be a commonly experienced emotion that the participants also sought to regulate. The coaches’ experiences of the embodiment and management of guilt is primarily, although not exclusively, interrogated using the mainstream psychological theorising of Kubany and Watson (2003). The article concludes by connecting the coaches’ experiences of guilt with critiques of the prevailing deontological approach used to define what it means to be a ‘good’ sport coach. Here we suggest that dominant perspectives in coach education may be instrumental in entrenching coaches’ experience of guilt

Mu2e Technical Design Report

The Mu2e experiment at Fermilab will search for charged lepton flavor violation via the coherent conversion process mu- N --> e- N with a sensitivity approximately four orders of magnitude better than the current world's best limits for this process. The experiment's sensitivity offers discovery potential over a wide array of new physics models and probes mass scales well beyond the reach of the LHC. We describe herein the preliminary design of the proposed Mu2e experiment. This document was created in partial fulfillment of the requirements necessary to obtain DOE CD-2 approval.Comment: compressed file, 888 pages, 621 figures, 126 tables; full resolution available at http://mu2e.fnal.gov; corrected typo in background summary, Table 3.

Meta-analysis of type 2 Diabetes in African Americans Consortium

Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is known about the genetic risk in African Americans despite the recent identification of more than 70 T2D loci primarily by genome-wide association studies (GWAS) in individuals of European ancestry. In order to investigate the genetic architecture of T2D in African Americans, the MEta-analysis of type 2 DIabetes in African Americans (MEDIA) Consortium examined 17 GWAS on T2D comprising 8,284 cases and 15,543 controls in African Americans in stage 1 analysis. Single nucleotide polymorphisms (SNPs) association analysis was conducted in each study under the additive model after adjustment for age, sex, study site, and principal components. Meta-analysis of approximately 2.6 million genotyped and imputed SNPs in all studies was conducted using an inverse variance-weighted fixed effect model. Replications were performed to follow up 21 loci in up to 6,061 cases and 5,483 controls in African Americans, and 8,130 cases and 38,987 controls of European ancestry. We identified three known loci (TCF7L2, HMGA2 and KCNQ1) and two novel loci (HLA-B and INS-IGF2) at genome-wide significance (4.15 × 10(-94)<P<5 × 10(-8), odds ratio (OR)  = 1.09 to 1.36). Fine-mapping revealed that 88 of 158 previously identified T2D or glucose homeostasis loci demonstrated nominal to highly significant association (2.2 × 10(-23) < locus-wide P<0.05). These novel and previously identified loci yielded a sibling relative risk of 1.19, explaining 17.5% of the phenotypic variance of T2D on the liability scale in African Americans. Overall, this study identified two novel susceptibility loci for T2D in African Americans. A substantial number of previously reported loci are transferable to African Americans after accounting for linkage disequilibrium, enabling fine mapping of causal variants in trans-ethnic meta-analysis studies.Peer reviewe