Lithography-Free Route to Hierarchical Structuring of High-chi Block Copolymers on a Gradient Patterned Surface

A chemically defined patterned surface was created via a combined process of controlled evaporative self-assembly of concentric polymer stripes and the selective surface modification of polymer brush. The former process involved physical adsorption of poly (methyl methacrylate) (PMMA) segments into silicon oxide surface, thus forming ultrathin PMMA stripes, whereas the latter process was based on the brush treatment of silicon native oxide surface using a hydroxyl-terminated polystyrene (PS-OH). The resulting alternating PMMA- and PS-rich stripes provided energetically favorable regions for self-assembly of high <mml:semantics>chi</mml:semantics> polystyrene-block-polydimethylsiloxane (PS-b-PDMS) in a simple and facile manner, dispensing the need for conventional lithography techniques. Subsequently, deep reactive ion etching and oxygen plasma treatment enabled the transition of the PDMS blocks into oxidized groove-shaped nanostructures

Review-Based Domain Disentanglement without Duplicate Users or Contexts for Cross-Domain Recommendation

A cross-domain recommendation has shown promising results in solving data-sparsity and cold-start problems. Despite such progress, existing methods focus on domain-shareable information (overlapped users or same contexts) for a knowledge transfer, and they fail to generalize well without such requirements. To deal with these problems, we suggest utilizing review texts that are general to most e-commerce systems. Our model (named SER) uses three text analysis modules, guided by a single domain discriminator for disentangled representation learning. Here, we suggest a novel optimization strategy that can enhance the quality of domain disentanglement, and also debilitates detrimental information of a source domain. Also, we extend the encoding network from a single to multiple domains, which has proven to be powerful for review-based recommender systems. Extensive experiments and ablation studies demonstrate that our method is efficient, robust, and scalable compared to the state-of-the-art single and cross-domain recommendation methods

Pulsed Corona Discharge for Oxidation of Gaseous Elemental Mercury

Positive pulsed corona discharge has been applied for the oxidation of gaseous elemental mercury (Hg0) from a simulated flue gas. The oxidation of Hg0 to HgO and HgCl2 can significantly enhance the mercury removal from flue gas. At a gas condition of O2 (10%), H2O (3%), and N2 (balance), Hg0 oxidation efficiency of 84% was achieved at an input energy density of 45 J/l. The presence of NO, however, hinders Hg0 oxidation due to the preferential reaction of NO with O and O3. On the contrary, SO2 shows little effect on Hg0 oxidation due to its preferential reaction with OH. It has been also observed that the HCl in gas stream can be dissociated to Cl and Cl2 and can induce additional Hg0 oxidation to HgCl2

A new type of slumping-induced soft-sediment deformation structure: the envelope structure

The sediments of the Cretaceous Gyeokpori Formation in south-western South Korea accumulated in a lake in which mainly siliciclastic rocks were deposited, with some interbedded volcaniclastics. The nearby volcanic activity resulted in unstable lake margins inducing a dominance of gravity-flow deposits. The high sedimentation rate facilitated soft-sediment deformation on the sloping margin. The deposition of numerous gravity-flow deposits resulted in a vertically heterolithic stratification. The slumps are composed of different lithologies, which is expressed in different types of deformation due to the difference in cohesion between sandy and mussy layers within the slumps. Coarser-grained (cohesionless) slumps tend to show more chaotic deformation of their lamination or layering. The difference in slumping behaviour of the cohesive and non-cohesive examples is explained and modelled. A unique soft-sediment deformation structure is recognized. This structure has not been described before, and we call it ‘envelope structure’. It consists of a conglomerate mass that has become entirely embedded in fine-grained sediment because slope failure took place and the fine-grained material slumped down with the conglomerate ‘at its back’. The cohesive laminated mudstone formed locally slump folds that embedded the non-cohesive overlying conglomerate unit, possibly partly due to the bulldozing effect of the latter. This structure presumably can develop when the density contrast with the underlying and overlying deposits is exceptionally high. The envelope structure should be regarded as a special – and rare – type of a slumping-induced deformation structure

Characterization of germanium/silicon p-n junction fabricated by low temperature direct wafer bonding and layer exfoliation

The current transport across a p-Ge/n-Si diode structure obtained by direct wafer bonding and layer exfoliation is analysed. A low temperature anneal at 400 degrees C for 30 min was used to improve the forward characteristics of the diode with the on/off ratio at -1 V being > 8000. Post anneal, the transport mechanism has a strong tunnelling component. This fabrication technique using a low thermal budget (T <= 400 degrees C) is an attractive option for heterogeneous integration. (C) 2012 American Institute of Physics. (doi:10.1063/1.3688174

Screening of FDA-Approved Drugs Using a MERS-CoV Clinical Isolate from South Korea Identifies Potential Therapeutic Options for COVID-19

Therapeutic options for coronaviruses remain limited. To address this unmet medical need, we screened 5406 compounds, including United States Food and Drug Administration (FDA)-approved drugs and bioactives, for activity against a South Korean Middle East respiratory syndrome coronavirus (MERS-CoV) clinical isolate. Among 221 identified hits, 54 had therapeutic indexes (TI) greater than 6, representing effective drugs. The time-of-addition studies with selected drugs demonstrated eight and four FDA-approved drugs which acted on the early and late stages of the viral life cycle, respectively. Confirmed hits included several cardiotonic agents (TI > 100), atovaquone, an anti-malarial (TI > 34), and ciclesonide, an inhalable corticosteroid (TI > 6). Furthermore, utilizing the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), we tested combinations of remdesivir with selected drugs in Vero-E6 and Calu-3 cells, in lung organoids, and identified ciclesonide, nelfinavir, and camostat to be at least additive in vitro. Our results identify potential therapeutic options for MERS-CoV infections, and provide a basis to treat coronavirus disease 2019 (COVID-19) and other coronavirus-related illnesses.Peer reviewe

House of Commons Library: Briefing paper: Number 07147, 13 April 2018: School places in England: applications, allocations and appeals

Background: We previously reported that ginsenoside Re (GRe) attenuated against methamphetamine (MA)-induced neurotoxicity via anti-inflammatory and antioxidant potentials. We also demonstrated that dynorphin possesses anti-inflammatory and antioxidant potentials against dopaminergic loss, and that balance between dynorphin and substance P is important for dopaminergic neuroprotection. Thus, we examined whether GRe positively affects interactive modulation between dynorphin and substance P against MA neurotoxicity in mice. Methods: We examined changes in dynorphin peptide level, prodynorphin mRNA, and substance P mRNA, substance P-immunoreactivity, homeostasis in enzymatic antioxidant system, oxidative parameter, microglial activation, and pro-apoptotic parameter after a neurotoxic dose of MA to clarify the effects of GRe, prodynorphin knockout, pharmacological inhibition of κ-opioid receptor (i.e., nor-binaltorphimine), or neurokinin 1 (NK1) receptor (i.e., L-733,060) against MA insult in mice. Results: GRe attenuated MA-induced decreases in dynorphin level, prodynorphin mRNA expression in the striatum of wild-type (WT) mice. Prodynorphin knockout potentiated MA-induced dopaminergic toxicity in mice. The imbalance of enzymatic antioxidant system, oxidative burdens, microgliosis, and pro-apoptotic changes led to the dopaminergic neurotoxicity. Neuroprotective effects of GRe were more pronounced in prodynorphin knockout than in WT mice. Nor-binaltorphimine, a κ-opioid receptor antagonist, counteracted against protective effects of GRe. In addition, we found that GRe significantly attenuated MA-induced increases in substance P-immunoreactivity and substance P mRNA expression in the substantia nigra. These increases were more evident in prodynorphin knockout than in WT mice. Although, we observed that substance P-immunoreactivity was co-localized in NeuN-immunreactive neurons, GFAP-immunoreactive astrocytes, and Iba-1-immunoreactive microglia. NK1 receptor antagonist L-733,060 or GRe selectively inhibited microgliosis induced by MA. Furthermore, L-733,060 did not show any additive effects against GRe-mediated protective activity (i.e., antioxidant, antimicroglial, and antiapoptotic effects), indicating that NK1 receptor is one of the molecular targets of GRe. Conclusions: Our results suggest that GRe protects MA-induced dopaminergic neurotoxicity via upregulatgion of dynorphin-mediated κ-opioid receptor and downregulation of substance P-mediated NK1 R