The influence of state on the capacity of driven piles in sands

The prime objective of the thesis was to study the influence of state on the capacity of driven piles in sand. The work was prompted by findings of recent laboratory based research on the mechanics of granular soils (Coop & Lee, 1993 and Jovicic & Coop, 1997) which showed that, as for clays, a principal controlling factor of soil behaviour is the stress-volume state. The work started in November 1996 and was funded buy the EPSRC under contract GR/L16590. Centrifuge testing was used to investigate the behaviour of driven piles in sands. A new actuator and strongbox package were designed and constructed taking full advantage of the centrifuge facilities. A fully instrumented model pile was developed, which consisted of eleven segments and allowed five independent measurements of shaft friction, four of radial stress and one of end bearing to be taken during installation. The pile was jacked into samples of two sands of varying densities at accelerations of between 50-200g, simulating piles of up to 70 min length and 3.2 m in diameter. The two sands used in the investigation were a carbonate sand and a quartz sand, chosen for the diversity of their geological origins and behaviour. A series of triaxial tests was conducted in order to characterise the behaviour of each sand, and in particular to locate precisely their critical state lines in stress-volume space. The centrifuge model tests showed that neither the end bearing nor the shaft friction could be adequately predicted using methods based on relative density of the sand such as APIRP2A (1993), but that the controlling factor for both was the state of the soil relative to the location of the critical state line, which should be quantified not only by the density of the soil, but also the effective stress level. The radial stress was found to be highest approximately seven pile diameters above the pile tip and not at the pile tip as assumed in recent design methods (e. g. Randolph et al., 1994 and Jardine & Chow, 1996). The friction angles mobilised on the model pile were found to be significantly lower than those that were measured by means of interface shear box tests, and it was found that the correct friction angle could only be measured by interface ring shear tests taken to very large displacements. An examination of the literature showed clearly that available field data support the new framework, although the data were both very scattered and very limited in extent, particularly because even the most extensive field tests rarely included even the basic laboratory tests required to apply the new method of analysis. The work therefore highlights severe limitations with many current pile design methods for piles in sands and suggests how new methods should be based on correct quantification of state

Characterization of [3H][^3H]Phenobarbital Binding to Rat Brain Membranes

The binding of $[^3H]$phenobarbital to rat brain membranes was studied in order to determine its characteristics and specificity. The binding reaction was rapid and occurred at sites of low affinity. $(K_d = 700 μM)$ and very high density $(B_{max} = 2.7 nmoll/mg protein)$. It was unaffected by temperature changes from O°C to 95°C and was maximal at pH 5. Detergents in low concentrations markedly decreased the binding, apparently without solubilizing the binding sites. It is concluded that the binding of $[^3H]$ phenobarbital is a rather non-specific interaction with the plasma membrane

Alteration in elemental and functional composition of heated peat humic acids

The article analyzes the effect of thermal modification of different-type peat on the alteration of elemental and functional composition of peat humic acids. Based on the data of IR-spectra and readings of electron paramagnetic resonance, structural alterations are identified. It is shown that the impact of peat characteristics on humic acids is preserved after thermal modification. It is revealed that the strongest alteration of humic acid composition and properties caused by peat heating are typical to humic acid samples extracted from the peat with low decomposition degree

Electrophysiological activation by masked primes: Independence of prime-related and target-related activities

Visual stimuli that are made invisible by metacontrast masking (primes) have a marked influence on behavioral and psychophysiological measures such as reaction time (RT) and the lateralized readiness potential (LRP). 4 experiments are reported that shed light on the effects that masked primes have on the LRP. Participants had a go-nogo task in which the prime was associated with 1 of 2 responses even if the target required participants to refrain from responding. To analyze the electrophysiological responses, we computed the LRP and applied an averaging method separating the activation due to the prime and the target. The results demonstrated that (a) masked primes activate responses even in a nogo situation, (b) this prime-related activation is independent of masking, (c) and is also independent of whether prime and target require the same responses (congruent condition) or different responses (incongruent condition)

Frustration - how it can be measured

A misfit parameter is used to characterize the degree of frustration of ordered and disordered systems. It measures the increase of the ground-state energy due to frustration in comparison with that of a relevant reference state. The misfit parameter is calculated for various spin-glass models. It allows one to compare these models with each other. The extension of this concept to other combinatorial optimization problems with frustration, e.g. p-state Potts glasses, graph-partitioning problems and coloring problems is given.Comment: 10 pages, 1 table, no figures, uses revtex.st

Reduction of Steady-State Valproate Levels by Other Antiepileptic Drugs

Steady-state plasma valproate (VPA) levels were analyzed in 37 children after 6 weeks of VPA therapy. Twenty-six patients were receiving other antiepileptic drugs in addition to VPA (experimental group). Eleven patients who received VPA alone served as controls. The mean VPA dose was not statistically different for the two groups (experimental group, 35.4 mg/kg/ day, 11.6 SD; control group, 31.1 mg/kg/day, SD 6.6) The mean plasma VPA level was significantly lower for the experimental group (63.0 Μg/m1, SD 21.8) than for the control (99.3 Μg/m1), SD 23.3) ( p < 0.01). VPA levelrdose ratio (LDR) was also reduced in the experimental group (1.92, SD 0.75) as compared to controls (3.26, SD 0.65) ( p < 0.01). Within the experimental group the VPA levels and VPA LDR were significantly reduced in patients receiving either phenytoin or phenobarbital. The data suggest that other antiepileptic drugs significantly alter the steady-state level to dose relationship for VPA. RÉSUMÉ Le taux plasmatique À l'Équilibre du valproate de sodium (VPA) a ÉtÉÉtudiÉ chez 37 enfants aprÈs 6 semaines de thÉrapeutique. Vingt six patients reÇoivent d'autres mÉdicaments antiÉpileptiques associÉs au VPA (groupe expÉrimental) alors que 11 sujets tÉmoins ne reÇoivent que le VPA seul. La posologie moyenne du VPA n'est pas significativement diffÉrente entre les deux groupes (35,4 mg/kg/jour ± 11,6 centre 31,1 mg/kg/jour ± 6,6). Le taux plasmatique de VPA est significativement plus bas dans le groupe experimental (63,0 Μg/ml ± 21,8) contre 99,3 Μg/ml ± 23,3 dans le groupe tÉmoin ( p < 0,01). Le rapport taux plasmatique/posologie (LDR) a ÉtÉ diminuÉ dans le groupe expÉrimental (1,92 ± 0,75) par rapport au groupe tÉmoin (3,26 ± 0,65), p < 0,01 en particulier chez les malades recevant de la phÉnytoÏne ou du phÉnobarbital. La posologie moyenne du VPA n'Étant pas significativement diffÉrente dans les deux groupes, les faits observÉs suggÈrent que l'addition d'autres antiÉpileptiques est capable de modifier le taux À l'Équilibre du VPA plasmatique en fonction de la dose administrÉe. RESUMEN Se analizaron los niveles estables de valproato en plasma (VPA) en 37 niÑos despuÉs de 6 semanas de terapia con VPA. Ventiseis pacientes recibÍan otros fÁrmacos ademÁs de VPA (grupo experimental) y once sÓlo tomaban VPA y sirvieron como controles. La dosis media de VPA no fue significativamente distinta en los dos grupos (grupo experimental: 35,4 mg/kg/dÍa, DS 11,6; grupo control: 31.1 mg/kg/dÍa, DS 6,6). El nivel plasmÁtico medio de VPA fue significativamente inferior en el grupo experimental (63,0 Μg/ml, DS 21,8) que en el control (99,3 Μg/ml, DS 23,3), p < 0,01. La relaciÓn nivel de VPA: dosis (LDR) estaba tambiÉn reducida en el grupo experimental (1,92, DS 0,75) al compararla con los controles (3,26, DS 0,65), p < 0,01. Dentro del grupo experimental los niveles de VPA y la LDR estaban significativamente reducidos en pacientes que tomaban fenitoÍna o fenobarbital. La dosis media no fue diferente entre los grupos experimental y control. Estos datos sugieren que la ingestiÓn de otros fÁrmacos alteran de modo significativo los niveles estables de VPA en relaciÓn con la dosis. ZUSAMMENFASSUNG In steady-state befindliche Plasma Valproatspiegel (VPA) wurden bei 37 Kindern nach 6 wÖchiger VPA-Therapie analysiert. 26 Patienten erhielten zusÄtzlich zum VPA andere Antiepileptika (experimentelle Gruppe). 11 Patienten, die VPA alleine bekamen, dienten als Kontrollen. Die mittlere VPA-Dosis war in beiden Gruppen nicht signifikant Vunterschiedlich (experimentelle Gruppe 35,4 mg/kg pro Tag, 11,6 SD; Kontrollgruppe 31,1 mg/kg pro Tag, SD 6,6). Der mittlere Plasma VPA-Spiegel war signifikant niedriger in der experimentellen Gruppe (63,0 Μg/ml, SD 21,8) als in der Kontrollgruppe (99,3 Μg/m1, SD 23,3), p < 0.01. Das VerhÄltnis VPA-Spiegel: Dosis (LDR) war in der experimentellen Gruppe ebenfalls reduziert (1,92, SD 0,75) gegenuber der Kontrollgruppe (3,26, SD 0,65), p < 0.01. Innerhalb der experimentellen Gruppe waren die VPA-Spiegel und die VPA/LDR bei Patienten, die entweder Phenytoin oder Phenobarbital bekamen, signifikant erniedrigt. Die mittlere VPA-Dosis war nicht signifikant unterschiedlich in der experimentellen und in der Kontrollgruppe. Diese Daten lassen vermuten, daß andere Antiepileptika signifikanterweise den Steady-state-Spiegel im Hinblick auf die verabfolgte Dosis VPA Ändern.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66058/1/j.1528-1157.1981.tb06154.x.pd

Visual similarity in masking and priming: The critical role of task relevance

Cognitive scientists use rapid image sequences to study both the emergence of conscious perception (visual masking) and the unconscious processes involved in response preparation (masked priming). The present study asked two questions: (1) Does image similarity influence masking and priming in the same way? (2) Are similarity effects in both tasks governed by the extent of feature overlap in the images or only by task-relevant features? Participants in Experiment 1 classified human faces using a single dimension even though the faces varied in three dimensions (emotion, race, sex). Abstract geometric shapes and colors were tested in the same way in Experiment 2. Results showed that similarity reduced the visibility of the target in the masking task and increased response speed in the priming task, pointing to a double-dissociation between the two tasks. Results also showed that only task-relevant (not objective) similarity influenced masking and priming, implying that both tasks are influenced from the beginning by intentions of the participant. These findings are interpreted within the framework of a reentrant theory of visual perception. They imply that intentions can influence object formation prior to the separation of vision for perception and vision for action

Rise and fall of the X-ray flash 080330: an off-axis jet?

Original article can be found at: http://www.aanda.org/ Copyright The European Southern Observatory (ESO). DOI: 10.1051/0004-6361/200911719Context. X-ray flashes (XRFs) are a class of gamma-ray bursts (GRBs) with a peak energy of the time-integrated spectrum, , typically below 30 keV, whereas classical GRBs have of a few hundreds of keV. Apart from and the systematically lower luminosity, the properties of XRFs, such as their duration or spectral indices, are typical of the classical GRBs. Yet, the nature of XRFs and their differences from GRBs are not understood. In addition, there is no consensus on the interpretation of the shallow decay phase observed in most X-ray afterglows of both XRFs and GRBs. Aims. We examine in detail the case of XRF 080330 discovered by Swift at redshift 1.51. This burst is representative of the XRF class and exhibits an X-ray shallow decay. The rich broadband (from NIR to UV) photometric data set we collected during this phase makes it an ideal candidate for testing the off-axis jet interpretation proposed to explain both the softness of XRFs and the shallow decay phase. Methods. We present prompt -ray, early and late NIR/visible/UV and X-ray observations of the XRF 080330. We derive a spectral energy distribution from NIR to X-ray bands across the shallow/plateau phase and describe the temporal evolution of the multi-wavelength afterglow within the context of the standard afterglow model. Results. The multiwavelength evolution of the afterglow is achromatic from ~102 s to ~8104 s. The energy spectrum from NIR to X-ray is reproduced well by a simple power-law, , with = 0.790.01 and negligible rest-frame dust extinction. The light curve can be modelled by either a piecewise power-law or the combination of a smoothly broken power law with an initial rise up to ~600 s, a plateau lasting up to ~2 ks, followed by a gradual steepening to a power-law decay index of ~2 until 82 ks. At this point, a bump appears to be modelled well with a second component, while the corresponding optical energy spectrum, , reddens by = 0.260.06. Conclusions. A single-component jet viewed off-axis can explain the light curve of XRF 080330, the late-time reddening being due to the reverse shock of an energy injection episode and its being an XRF. Other possibilities, such as the optical rise marking the pre-deceleration of the fireball within a wind environment, cannot be excluded definitely, but appear to be contrived. We exclude the possibility of a dust decreasing column density being swept up by the fireball as explaining the rise of the afterglow.Peer reviewe

Electronic structure of the quasi-one-dimensional organic conductor TTF-TCNQ

We study the electronic structure of the quasi-one-dimensional organic conductor TTF-TCNQ by means of density-functional band theory, Hubbard model calculations, and angle-resolved photoelectron spectroscopy (ARPES). The experimental spectra reveal significant quantitative and qualitative discrepancies to band theory. We demonstrate that the dispersive behavior as well as the temperature-dependence of the spectra can be consistently explained by the finite-energy physics of the one-dimensional Hubbard model at metallic doping. The model description can even be made quantitative, if one accounts for an enhanced hopping integral at the surface, most likely caused by a relaxation of the topmost molecular layer. Within this interpretation the ARPES data provide spectroscopic evidence for the existence of spin-charge separation on an energy scale of the conduction band width. The failure of the one-dimensional Hubbard model for the {\it low-energy} spectral behavior is attributed to interchain coupling and the additional effect of electron-phonon interaction.Comment: 18 pages, 9 figure