64 research outputs found

    TINGKAT MOTIVASI BERPRESTASI ATLET DENGAN HAMBATAN FISIK NATIONAL PARALYMPIC COMMITTEE OF INDONESIA (NPCI) LEVEL KABUPATEN

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    Tujuan penelitian ini adalah untuk mengetahui motivasi berprestasi atlet dengan hambatan fisik National Paralympic Committee (NPCI) di tingkat kabupaten. Penelitian ini merupakan jenis penelitian mixed method dengan menggunakan subjek penelitian yaitu atlet pemula dengan hambatan fisik NPCI di tingkat kabupaten. Kriteria subjek penelitian adalah atlet dengan hambatan fisik pemula yang mengikuti Pemusatan Latihan Cabang (Pelatcab) dengan total 24 atlet dari 6 cabang olahraga. Instrumen penelitian yang digunakan yaitu angket motivasi berprestasi pada penelitian yang sudah ada. Angket tersebut sudah melalui uji validitas dan reliabilitas dengan 62 soal, terdapat 18 soal yang tidak valid sehingga ada 44 soal yang valid untuk digunakan sebagai instrumen penelitian. Pengambilan data dilakukan dengan memberikan lembar angket kepada atlet dengan hambatan fisik serta melakukan wawancara kepada atlet dengan hambatan fisik, para pelatih, dan beberapa pengurus. Hasil penelitian menunjukkan bahwa motivasi berprestasi atlet dengan hambatan fisik yang termasuk dalam kategori sangat tinggi 38%, kategori tinggi 58%, kategori sedang 4%, kategori rendah 0%, dan kategori sangat rendah 0%. Dengan kesimpulan mayoritas atlet dengan hambatan fisik berada pada kategori sangat tinggi hingga tinggi yang menunjukkan motivasi berprestasi atlet dengan hambatan fisik sudah sangat baik. Kata Kunci: motivasi berprestasi; atlet dengan hambatan fisik; NPC

    Implications for post critical illness trial design: sub-phenotyping trajectories of functional recovery among sepsis survivors.

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    This is a post-peer-review, pre-copyedit version of an article published in Critical Care. The final authenticated version is available online at: https://doi.org/10.1186/s13054-020-03275-wBACKGROUND: Patients who survive critical illness suffer from a significant physical disability. The impact of rehabilitation strategies on health-related quality of life is inconsistent, with population heterogeneity cited as one potential confounder. This secondary analysis aimed to (1) examine trajectories of functional recovery in critically ill patients to delineate sub-phenotypes and (2) to assess differences between these cohorts in both clinical characteristics and clinimetric properties of physical function assessment tools. METHODS: Two hundred ninety-one adult sepsis survivors were followed-up for 24 months by telephone interviews. Physical function was assessed using the Physical Component Score (PCS) of the Short Form-36 Questionnaire (SF-36) and Activities of Daily Living and the Extra Short Musculoskeletal Function Assessment (XSFMA-F/B). Longitudinal trajectories were clustered by factor analysis. Logistical regression analyses were applied to patient characteristics potentially determining cluster allocation. Responsiveness, floor and ceiling effects and concurrent validity were assessed within clusters. RESULTS: One hundred fifty-nine patients completed 24 months of follow-up, presenting overall low PCS scores. Two distinct sub-cohorts were identified, exhibiting complete recovery or persistent impairment. A third sub-cohort could not be classified into either trajectory. Age, education level and number of co-morbidities were independent determinants of poor recovery (AUROC 0.743 ((95%CI 0.659-0.826), p < 0.001). Those with complete recovery trajectories demonstrated high levels of ceiling effects in physical function (PF) (15%), role physical (RP) (45%) and body pain (BP) (57%) domains of the SF-36. Those with persistent impairment demonstrated high levels of floor effects in the same domains: PF (21%), RP (71%) and BP (12%). The PF domain demonstrated high responsiveness between ICU discharge and at 6 months and was predictive of a persistent impairment trajectory (AUROC 0.859 (95%CI 0.804-0.914), p < 0.001). CONCLUSIONS: Within sepsis survivors, two distinct recovery trajectories of physical recovery were demonstrated. Older patients with more co-morbidities and lower educational achievements were more likely to have a persistent physical impairment trajectory. In regard to trajectory prediction, the PF score of the SF-36 was more responsive than the PCS and could be considered for primary outcomes. Future trials should consider adaptive trial designs that can deal with non-responders or sub-cohort specific outcome measures more effectively

    A maritime decision support system to assess risk in the presence of environmental uncertainties: the REP10 experiment

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    The aim of this work is to report on an activity carried out during the 2010 Recognized Environmental Picture experiment, held in the Ligurian Sea during summer 2010. The activity was the first at-sea test of the recently developed decision support system (DSS) for operation planning, which had previously been tested in an artificial experiment. The DSS assesses the impact of both environmental conditions (meteorological and oceanographic) and non-environmental conditions (such as traffic density maps) on people and assets involved in the operation and helps in deciding a course of action that allows safer operation. More precisely, the environmental variables (such as wind speed, current speed and significant wave height) taken as input by the DSS are the ones forecasted by a super-ensemble model, which fuses the forecasts provided by multiple forecasting centres. The uncertainties associated with the DSS's inputs (generally due to disagreement between forecasts) are propagated through the DSS's output by using the unscented transform. In this way, the system is not only able to provide a traffic light map (run/not run the operation), but also to specify the confidence level associated with each action. This feature was tested on a particular type of operation with underwater gliders: the glider surfacing for data transmission. It is also shown how the availability of a glider path prediction tool provides surfacing options along the predicted path. The applicability to different operations is demonstrated by applying the same system to support diver operations

    Lacticacidaemia due to pyruvate dehydrogenase deficiency, with evidence of protein polymorphism in the α-subunit of the enzyme

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    In three infants with neonatal lacticacidaemia, a deficiency in the E 1 (pyruvate dehydrogenase) component of the pyruvate dehydrogenase complex was demonstrated in skin fibroblast cultures. Residual activites of the pyruvate dehydrogenase complex in the activated state were 1.6%, 3.9% and 18.8% of control values, respectively. Immunoprecipitation of extracts of cultures skin fibroblasts grown on 35 S-methionine with anti-pyruvate dehydrogenase complex antibody revealed an abnormality in the E 1 α-component of these three patients when visualised after sodium dodecyl sulphate/polyacrylamide gel electrophoresis. This component appeared to have a slightly lower molecular weight than did this protein from control cell strains. Cell strains from other patients with a deficiency of the pyruvate dehydrogenase complex did not exhibit this defect. Three patients also showed dysmorphism and developmental abnormalities of the central nervous system.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/47532/1/431_2004_Article_BF00441736.pd

    Early and Late Pathomechanisms in Alzheimer’s Disease: From Zinc to Amyloid-β Neurotoxicity

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