Severe acute axonal neuropathy following treatment with arsenic trioxide for acute promyelocytic leukemia: a case report

Peripheral neuropathy is a common complication of arsenic toxicity. Symptoms are usually mild and reversible following discontinuation of treatment. A more severe chronic sensorimotor polyneuropathy characterized by distal axonal-loss neuropathy can be seen in chronic arsenic exposure. The clinical course of arsenic neurotoxicity in patients with coexistence of thiamine deficiency is only anecdotally known but this association may potentially lead to severe consequences. We describe a case of acute irreversible axonal neuropathy in a patient with hidden thiamine deficiency who was treated with a short course of arsenic trioxide for acute promyelocytic leukemia. Thiamine replacement therapy and arsenic trioxide discontinuation were not followed by neurological recovery and severe polyneuropathy persisted at 12-month follow-up. Thiamine plasma levels should be measured in patients who are candidate to arsenic trioxide therapy. Prophylactic administration of vitamin B1 may be advisable. The appearance of polyneuropathy signs early during the administration of arsenic trioxide should prompt electrodiagnostic testing to rule out a pattern of axonal neuropathy which would need immediate discontinuation of arsenic trioxide

Business-community relationships for extractive industries: a case study in Peru

Natural resource-based economies have long relied on foreign demand to fuel their growth. For instance, the extractive sectors in Peru have experienced a rapid expansion, driven by a rising demand for commodities. Alongside economic growth, extractive operations have triggered social and environmental concerns among the various stakeholders, thus resulting in either social conflict or a deterioration of the relationship between companies in the extractive industries and local communities. In this context, the purpose of this paper is to understand the relationships between companies in the extractive industries and rural families. This research uses the case-study method. The findings show that a trustful relationship is supported by a beneficiary-society approach that builds upon philanthropic and ethical types of relationships. Unlike the type of relationship based on economic or legal interests, a trust-based relationship offers avenues for managing social conflict that have yet to be explored

The career advancement challenge faced by female executives in Peruvian organisations

The percentage of women in Peru's workforce overall has been growing at a steady rate, but there are still few women are seen in executive positions. This qualitative study describes the challenges in women's professional career advancement in a country in which the cultural pattern of business is dominated by men and where specific roles have been assigned to women. In-depth interviews were conducted with 24 professionals, 11 women and 13 men. The interviews were analysed using qualitative data analysis software. The results show that family responsibilities were the main challenge for female executives' career advancement. Moreover, family responsibilities were linked to other challenges, such as physical mobility, educational attainment, professional experience and informal networks. Family responsibilities can be considered a transcultural challenge to the career advancement of female executives. Finally, the study shows that a country's culture is an important challenge to career advancement, as in the Peruvian context where women are still considered responsible for attending to the family and are assigned a fundamental role in raising the children

Poverty reduction through corporate social responsibility: case study of Peruvian rural families

Poverty remains one of this millennium’s main problems, which why the first objective of sustainable development is poverty reduction. Multiple actors are working on this issue: states, multilateral organisms, civil societies, and—perhaps less boldly—the private sector, through social responsibility programs. In this research, the aim was to understand how rural families perceive the contribution of CSR programs, in respect to the decrease in rural poverty. A total of 20 rural families, who were beneficiaries from CSR programs belonging to two extractive companies, were interviewed; furthermore, they were no longer poor and were currently dwelling within the highlands and jungles of Perú. The results show that the CSR strategies used by the companies directly and indirectly contribute toward a reduction in rural poverty, and particularly those more specifically related to capacity development, access to markets, and strategic philanthropy. In this study, it was also found that families mostly use the strategy of informal entrepreneurship, which is not directly linked to the companies’ actions; as such, this could serve as a basis for the future implementation of CSR actions

Acute complete heart block in dogs

A study has been conducted immediately and up to 18 days after the surgical production of complete heart block in dogs. Immediately after surgery cardiac output, coronary flow, and mean arterial pressure were reduced in rough proportion to the degree of bradycardia. In time, these measures began to return toward preoperative levels. Paralleling the diminished left ventricular work was a diminished left ventricular oxygen consumption with little consequent change in myocardial efficiency. Small rises were detected in central venous pressure. At autopsy, the only unequivocal abnormality was myocardial hypertrophy which became measurable between 2 and 18 days after operation

International markets entry strategy determinants: an exploratory study in Peru

Nowadays a progressively more dynamic and global economic environment causes a higher number of enterprises to pick an entry strategy to become international. The choice of a strategy of entry into foreign markets constitutes one of the most relevant decisions for a company, for it impacts on its performance and means it being ready to cooperate, to a greater or lesser extent, with global supply chains. The present article identifies the determining factors of the strategies of entry into international markets as implemented by Peruvian businessmen, which impact on the integration level into an international market. The companies that participated in this exploratory study have growing exportation levels within the non-traditional sector. The results allow to appreciate exporters employing entry strategies with low levels of integration, and predominantly prefer low-risk markets and high resemblance to the Peruvian market, with regards to cultural affinity and business behavior.En la actualidad, el entorno económico progresivamente más dinámico y global, genera que un mayor número de empresas elija alguna estrategia de entrada para internacionalizarse. La elección de la estrategia de entrada a mercados extranjeros constituye una de las decisiones más relevantes para la empresa, en tanto impacta en el desempeño e implica que esté dispuesta a colaborar, en menor o mayor medida, con cadenas de abastecimiento globales. En el presente artículo se identifican los factores determinantes de las estrategias de entrada a mercados internacionales implementadas por empresarios peruanos, que impactan en el nivel de integración en el mercado internacional. Las empresas que participaron en el estudio exploratorio tienen crecientes niveles de exportación en el sector no tradicional. Los resultados permiten apreciar que los exportadores emplean estrategias de entrada con bajos niveles de integración, y predominantemente prefieren mercados de bajo riesgo y alta similitud al mercado peruano en cuanto a la afinidad cultural y al comportamiento en los negocios

KETERAMPILAN GURU PENDIDIKAN AGAMA ISLAM (PAI) DALAM MENGGUNAKAN METODE DEMONSTRASI DI SEKOLAH MENENGAH PERTAMA (SMP) ISLAM TERPADU (IT) ARROYAN TAQWA PEKANBARU

Tujuan dalam penelitian ini adalah untuk mengetahui keterampilan guru pai dalam menggunakan metode demonstrasi dan faktor-faktor yang mempengaruhinya di smp Arroyan Taqwa Pekanbaru. Rumusan masalah dalam penelitian ini adalah bagaimana keterampilan guru pai dalam menggunakan metode demonstrasi dan faktor-faktor yang mempengaruhinya di smp Arroyan Taqwa Pekanbaru. Sunyek dalam penelitian ini adalah guru pai yang berjumlah tiga orang, dan yang menjadi obyek adalah keterampilan guru pai dalam menggunakan metode demonstrasi. Teknik pengumpulan data dalam penelitian ini adalah wawancara, observasi dan dokumentasi. Sedangkan teknik analisa data yang digunakan adalah teknik deskriptif kualitatif, dan penulis menggunakan rumus: X100% N F P = Adapun hasil pada penelitian yang diperoleh di lapangan, dapat disimpulkan bahwa keterampilan guru pai dalam menggunakan metode demonstrasi masih tidak terampil karena secara kualitatif persentase hanya diperoleh skor 47% hasil dari observasi terhadap guru, hal ini berdasarkan ketentuan bahwa 0%-49% dikatakan tidak terampil. Tidak terampilnya hal tersebut dikarenakan rendahnya pendidikan guru, kurangnya pengetahuan guru tentang metode, terbatasnya dana dan fasilitas yang kurang memadai serta kurang ketatnya pengawasan dari kepala sekolah

A snapshot of training practices in Peru

Organizations need well trained employees in order to maintain a competitive advantage. The purpose of this paper is to describe current training practices in Peru and to provide recommendations for improving organizational performance. This paper also aims to set priorities for future research work. Human capital theory and contributions on need assessment, and training planning, implementation and evaluation served as theoretical framework. This is a cross-sectional, exploratory study that used information from surveys conducted in 24 Peru-vian companies. The findings reveal a strong interest in training, particularly with regard to the improvement of competencies, preference for face-to-face training, and the use of reaction evaluation methods. The recommendations include, among others, improving the provisions for internal support, policies, technology, behavioral evaluation, and resources.Las organizaciones necesitan empleados bien entrenados para mantener una ventaja competitiva. El prop?sito de este art?culo es describir las pr?cticas de capacitaci?n en organizaciones en Per?, para entregar recomendaciones que mejoren el desempe?o organizacional. Este art?culo tambi?n ayuda a establecer prioridades de investigaci?n futura. La Teor?a de Capital Humano y contribuciones de evaluaci?n de necesidades, planeaci?n, implantaci?n y evaluaci?n de la capacitaci?n sirvieron como marco te?rico. Es un estudio exploratorio de corte trasversal, usando encuestas en 24 compa??as peruanas. Los resultados revelan un inter?s fuerte en capacitaci?n, particularmente en competencias, preferencia por capacitaci?n cara a cara, y uso de m?todos de evaluaci?n de reacci?n. Las recomendaciones incluyen mejor provisi?n de apoyo interno, pol?ticas, tecnolog?a, evaluaci?n de conductas y recursos

PENGARUH NON PERFORMING LOAN, NET INTEREST MARGIN, DAN LOAN TO DEPOSIT RATIO TERHADAP PROFITABILITAS (RETURN ON ASSETS) PERUSAHAAN SEKTOR PERBANKAN YANG TERDAFTAR DI BURSA EFEK INDONESIA TAHUN 2016

KETY SATIVA, 8105145126 Pengaruh Non Performing Loan, Net Interest Margin, dan Loan to Deposit Ratio terhadap Profitabilitas (Return On Assets). Fakultas Ekonomi, Universitas Negeri Jakarta, 2018. This study aims to analyze the effect of NPL, NIM, and LDR on profitability (ROA) both simultaneously and partially. This research period is the company's financial statements for 2016. This study uses secondary data in the form of annual reports of companies from the Indonesia Stock Exchange. The analysis technique used is multiple linear regression analysis and technique in sampling is random sampling and obtained 36 samples of companies listed on the Indonesia Stock Exchange. Return On Assets as the dependent variable in this study is proxied by profit before tax divided by total assets while the first independent variable is Non-Performing Loans obtained from problem loans divided by the total loans distributed. The second independent variable is Net Interest Margin which is proxied by expense income less interest expense divided by average earning assets and Loan to Deposit Ratio measured by comparing the amount of loans disbursed with the amount of third party funds. The analytical method used is descriptive statistical analysis, analysis of requirements analysis analysis, classical assumption test, multiple linear regression analysis at a significance level of 5%. Hypothesis testing is done using regression test partial (t test) and simultaneous test (Test F) and test the coefficient of determination (R2). Test results t NPL shows that the value of t count> t table or -6.667> 2.449 then H1 is accepted so that there is a negative influence between the NPL variable with ROA with significance (0.000 <0.05) so that it shows a significant influence. The results of the T NIM test obtained thitung value for the NIM variable of 3.964 and positive. This shows that the value of t count> t table or 3.964> 2.449, then H0 is rejected so that there is a positive effect between the NIM variable with ROA with significance (0.000 <0.05) so that it shows significant influence. Whereas the LDR t test shows the results of t count 5% so that H0 is accepted which means there is no influence between LDR and ROA. Whereas for F test obtained Ftable is 2,892. This means that the value of Fcount> Ftable (29,284> 3,267) then H0 is rejected so that it can be concluded that there is an influence between NPL, NIM, and LDR variables on Profitability (ROA) with significance (0,000 <0,05) so that the significant effect occurs. Multiple regression testing that has been carried out the results obtained 1,8 = 1.833 - 0.837 X1 + 0.522 X2 - 0.010 X3 .. the value of R Square (R2) of 0.708 means the influence of NPL, NIM, and LDR on Profitability (ROA) in the banking sector companies listed on the Indonesia Stock Exchange (IDX) of 0.708 or 70.8%. Kata Kunci: NPL, NIM, LDR, dan Profitabilitas (ROA