535 research outputs found
Analysis of Lean Manufacturing: A Cost Saving Approach in Garments Production Unit
Sewing process is one of the most important stages in labor intensive ready-made clothing enterprises. Quality faults occurring during this process adversely affect the product quality and product efficiency, and also increase the production cost. The aim of this study is to investigate whether the knitwear production process is under control in a knitwear production enterprise and to detect the processes with highest rates of sewing faults in sewing department and finally to make suggestions for improving the quality control. Among the Statistical Process Control methods; control list, product control chart were used in the study. “Product control chart” was used to test whether the production process is controlled in the enterprise. Furthermore, the statistical methods were employed to determine the issues that need to be done in the improvement efforts and to detect the relations between the process groups supposedly effective on faults occurring in knitwear production and the amount of faults. Also, the processes with highest amounts of sewing faults and the effects of these processes on fault rates were investigated. As a result, it was concluded that the production process was statistically not under control in the ready-made clothing enterprise. In addition, this study demonstrated that the investigation of each process group by drawing their product control charts would make significant contributions to foresee the results and prepare more effective the improvement plans.
A peptide mimic of the chemotaxis inhibitory protein of Staphylococcus aureus: towards the development of novel anti-inflammatory compounds
Complement factor C5a is one of the most powerful pro-inflammatory agents involved in recruitment of leukocytes, activation of phagocytes and other inflammatory responses. C5a triggers inflammatory responses by binding to its G-protein-coupled C5a-receptor (C5aR). Excessive or erroneous activation of the C5aR has been implicated in numerous inflammatory diseases. The C5aR is therefore a key target in the development of specific anti-inflammatory compounds. A very potent natural inhibitor of the C5aR is the 121-residue chemotaxis inhibitory protein of Staphylococcus aureus (CHIPS). Although CHIPS effectively blocks C5aR activation by binding tightly to its extra-cellular N terminus, it is not suitable as a potential anti-inflammatory drug due to its immunogenic properties. As a first step in the development of an improved CHIPS mimic, we designed and synthesized a substantially shorter 50-residue adapted peptide, designated CHOPS. This peptide included all residues important for receptor binding as based on the recent structure of CHIPS in complex with the C5aR N terminus. Using isothermal titration calorimetry we demonstrate that CHOPS has micromolar affinity for a model peptide comprising residues 7–28 of the C5aR N terminus including two O-sulfated tyrosine residues at positions 11 and 14. CD and NMR spectroscopy showed that CHOPS is unstructured free in solution. Upon addition of the doubly sulfated model peptide, however, the NMR and CD spectra reveal the formation of structural elements in CHOPS reminiscent of native CHIPS
The sensitivity of real-time PCR amplification targeting invasive Salmonella serovars in biological specimens
Background:
PCR amplification for the detection of pathogens in biological material is generally considered a rapid and informative diagnostic technique. Invasive Salmonella serovars, which cause enteric fever, can be commonly cultured from the blood of infected patients. Yet, the isolation of invasive Salmonella serovars from blood is protracted and potentially insensitive.
Methods:
We developed and optimised a novel multiplex three colour real-time PCR assay to detect specific target sequences in the genomes of Salmonella serovars Typhi and Paratyphi A. We performed the assay on DNA extracted from blood and bone marrow samples from culture positive and negative enteric fever patients.
Results:
The assay was validated and demonstrated a high level of specificity and reproducibility under experimental conditions. All bone marrow samples tested positive for Salmonella, however, the sensitivity on blood samples was limited. The assay demonstrated an overall specificity of 100% (75/75) and sensitivity of 53.9% (69/128) on all biological samples. We then tested the PCR detection limit by performing bacterial counts after inoculation into blood culture bottles.
Conclusions:
Our findings corroborate previous clinical findings, whereby the bacterial load of S. Typhi in peripheral blood is low, often below detection by culture and, consequently, below detection by PCR. Whilst the assay may be utilised for environmental sampling or on differing biological samples, our data suggest that PCR performed directly on blood samples may be an unsuitable methodology and a potentially unachievable target for the routine diagnosis of enteric fever. </p
Centrality and transverse momentum dependence of elliptic flow of multi-strange hadrons and meson in Au+Au collisions at = 200 GeV
We present high precision measurements of elliptic flow near midrapidity
() for multi-strange hadrons and meson as a function of
centrality and transverse momentum in Au+Au collisions at center of mass energy
200 GeV. We observe that the transverse momentum dependence of
and is similar to that of and , respectively,
which may indicate that the heavier strange quark flows as strongly as the
lighter up and down quarks. This observation constitutes a clear piece of
evidence for the development of partonic collectivity in heavy-ion collisions
at the top RHIC energy. Number of constituent quark scaling is found to hold
within statistical uncertainty for both 0-30 and 30-80 collision
centrality. There is an indication of the breakdown of previously observed mass
ordering between and proton at low transverse momentum in the
0-30 centrality range, possibly indicating late hadronic interactions
affecting the proton .Comment: 7 pages and 4 figures, Accepted for publication in Physical Review
Letter
Energy dependence of acceptance-corrected dielectron excess mass spectrum at mid-rapidity in Au+Au collisions at and 200 GeV
The acceptance-corrected dielectron excess mass spectra, where the known
hadronic sources have been subtracted from the inclusive dielectron mass
spectra, are reported for the first time at mid-rapidity in
minimum-bias Au+Au collisions at = 19.6 and 200 GeV. The excess
mass spectra are consistently described by a model calculation with a broadened
spectral function for GeV/. The integrated
dielectron excess yield at = 19.6 GeV for
GeV/, normalized to the charged particle multiplicity at mid-rapidity, has
a value similar to that in In+In collisions at = 17.3 GeV. For
= 200 GeV, the normalized excess yield in central collisions is
higher than that at = 17.3 GeV and increases from peripheral to
central collisions. These measurements indicate that the lifetime of the hot,
dense medium created in central Au+Au collisions at = 200 GeV
is longer than those in peripheral collisions and at lower energies.Comment: 9 pages, 6 figure
Isolation of Flow and Nonflow Correlations by Two- and Four-Particle Cumulant Measurements of Azimuthal Harmonics in 200 GeV Au+Au Collisions
A data-driven method was applied to measurements of Au+Au collisions at
200 GeV made with the STAR detector at RHIC to isolate
pseudorapidity distance -dependent and -independent
correlations by using two- and four-particle azimuthal cumulant measurements.
We identified a component of the correlation that is -independent,
which is likely dominated by anisotropic flow and flow fluctuations. It was
also found to be independent of within the measured range of
pseudorapidity . The relative flow fluctuation was found to be for particles of transverse momentum
less than GeV/. The -dependent part may be attributed to
nonflow correlations, and is found to be relative to the
flow of the measured second harmonic cumulant at
Beam energy dependent two-pion interferometry and the freeze-out eccentricity of pions in heavy ion collisions at STAR
We present results of analyses of two-pion interferometry in Au+Au collisions
at = 7.7, 11.5, 19.6, 27, 39, 62.4 and 200 GeV measured in the
STAR detector as part of the RHIC Beam Energy Scan program. The extracted
correlation lengths (HBT radii) are studied as a function of beam energy,
azimuthal angle relative to the reaction plane, centrality, and transverse mass
() of the particles. The azimuthal analysis allows extraction of the
eccentricity of the entire fireball at kinetic freeze-out. The energy
dependence of this observable is expected to be sensitive to changes in the
equation of state. A new global fit method is studied as an alternate method to
directly measure the parameters in the azimuthal analysis. The eccentricity
shows a monotonic decrease with beam energy that is qualitatively consistent
with the trend from all model predictions and quantitatively consistent with a
hadronic transport model.Comment: 27 pages; 27 figure
Observation of charge asymmetry dependence of pion elliptic flow and the possible chiral magnetic wave in heavy-ion collisions
We present measurements of and elliptic flow, , at
midrapidity in Au+Au collisions at 200, 62.4, 39, 27,
19.6, 11.5 and 7.7 GeV, as a function of event-by-event charge asymmetry,
, based on data from the STAR experiment at RHIC. We find that
() elliptic flow linearly increases (decreases) with charge asymmetry
for most centrality bins at and higher.
At , the slope of the difference of
between and as a function of exhibits a
centrality dependence, which is qualitatively similar to calculations that
incorporate a chiral magnetic wave effect. Similar centrality dependence is
also observed at lower energies.Comment: 6 pages, 4 figure
Observation of Transverse Spin-Dependent Azimuthal Correlations of Charged Pion Pairs in at GeV
We report the observation of transverse polarization-dependent azimuthal
correlations in charged pion pair production with the STAR experiment in
collisions at RHIC. These correlations directly probe quark
transversity distributions. We measure signals in excess of five standard
deviations at high transverse momenta, at high pseudorapidities eta>0.5, and
for pair masses around the mass of the rho-meson. This is the first direct
transversity measurement in p+p collisions. Comparing the results to data from
lepton-nucleon scattering will test the universality of these spin-dependent
quantities.Comment: 11 pages, 5 figures, 15 tables. Submitted to PR
Azimuthal anisotropy in U+U and Au+Au collisions at RHIC
Collisions between prolate uranium nuclei are used to study how particle
production and azimuthal anisotropies depend on initial geometry in heavy-ion
collisions. We report the two- and four-particle cumulants, and
, for charged hadrons from U+U collisions at =
193 GeV and Au+Au collisions at = 200 GeV. Nearly fully
overlapping collisions are selected based on the amount of energy deposited by
spectators in the STAR Zero Degree Calorimeters (ZDCs). Within this sample, the
observed dependence of on multiplicity demonstrates that ZDC
information combined with multiplicity can preferentially select different
overlap configurations in U+U collisions. An initial-state model with gluon
saturation describes the slope of as a function of multiplicity in
central collisions better than one based on Glauber with a two-component
multiplicity model.Comment: Final paper version accepted for publication in Phys. Rev. Lett. New
version includes comparisons to a constituent quark glauber mode
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