Evolution of Heat Flow, Hydrothermal Circulation and Permeability on the Young Southern Flank of the Costa Rica Rift

We analyze 67 new conductive heat flow measurements on the southern flank of the Costa Rica Rift (CRR). Heat flow measurements cover five sites ranging in oceanic crustal age between approximately 1.6 and 5.7 Ma, and are co-located with a high-resolution multi-channel seismic line that extends from slightly north of the first heat flow site (1.6 Ma) to beyond ODP Hole 504B in 6.9 Ma crust. For the five heat flow sites, the mean observed conductive heat flow is ≈ 85 mWm−2. This value is approximately 30 per cent of the mean lithospheric heat flux expected from a half-space conductive cooling model, indicating that hydrothermal processes account for about 70 per cent of the heat loss. The advective heat loss fraction varies from site to site and is explained by a combination of outcrop to outcrop circulation through exposed basement outcrops and discharge through faults. Super-critical convection in Layer 2A extrusives occurs between 1.6 and 3.5 Ma, and flow through a thinly-sedimented basement high occurs at 4.6 Ma. Advective heat loss diminishes rapidly between ≈ 4.5 and ≈ 5.7 Ma, which contrasts with plate cooling reference models that predict a significant deficit in conductive heat flow up to ages ≈ 65 ± 10 Ma. At ≈ 5.7 Ma the CRR topography is buried under sediment with an average thickness ≈ 150 m, and hydrothermal circulation in the basement becomes sub-critical or perhaps marginally critical. The absence of significant advective heat loss at ≈ 5.7 Ma at the CRR is thus a function of both burial of basement exposure under the sediment load and a reduction in basement permeability that possibly occurs as result of mineral precipitation and original permeability at the time of formation. Permeability is a non-monotonic function of age along the southern flank of the CRR, in general agreement with seismic velocity tomography interpretations that reflect variations in the degree of ridge-axis magma supply and tectonic extension. Hydrothermal circulation in the young oceanic crust at southern flank of CRR is affected by the interplay and complex interconnectedness of variations in permeability, sediment thickness, topographical structure, and tectonic and magmatic activities with age

Eclipsing Binaries in Open Clusters

Detached eclipsing binaries are very useful objects for calibrating theoretical stellar models and checking their predictions. Detached eclipsing binaries in open clusters are particularly important because of the additional constraints on their age and chemical composition from their membership of the cluster. I compile a list containing absolute parameters of well-studied eclipsing binaries in open clusters, and present new observational data on the B-type systems V1481 Cyg and V2263 Cyg which are members of the young open cluster NGC 7128.Comment: 4 pages, 2 colour figures. Poster presentation for IAUS 240 (Binary Stars as Critical Tools and Tests in Contemporary Astrophysics), Prague, August 2006. The poster itself can be dowloaded in ppt and pdf versions from http://www.astro.keele.ac.uk/~jkt/pubs.htm

Electromagnetic shielding with polypyrrole-coated fabrics

Several shielding applications, to protect human health and electronic devices against dangerous effects of electromagnetic radiation, require solutions that fabrics can suitably fulfill. Here, we will investigate the electromagnetic interference shielding effectiveness of polypyrrole-coated polyester textiles, in the frequency range 100-1000 MHz. Insertion losses for several conductive fabrics with different surface resistivity ranging from 40 Ohm till the very low value of 3 Ohm were evaluated with a dual-tem cell. Correlations between the shielding effectiveness and the conductivity of composites are also discussed.Comment: 6 pages, 6 figure

Cosmogenic nuclides constrain surface fluctuations of an East Antarctic outlet glacier since the Pliocene

Understanding past changes in the Antarctic ice sheets provides insight into how they might respond to future climate warming. During the Pliocene and Pleistocene, geological data show that the East Antarctic Ice Sheet responded to glacial and interglacial cycles by remaining relatively stable in its interior, but oscillating at its marine-based margin. It is currently not clear how outlet glaciers, which connect the ice sheet interior to its margin, responded to these orbitally-paced climate cycles. Here we report new ice surface constraints from Skelton Glacier, an outlet of the East Antarctic ice sheet, which drains into the Ross Ice Shelf. Our multiple-isotope (10Be and 26Al) cosmogenic nuclide data indicate that currently ice-free areas adjacent to the glacier underwent substantial periods of exposure and ice cover in the past. We use an exposure-burial model driven by orbitally-paced glacial–interglacial cycles to determine the probable ice surface history implied by our data. This analysis shows that: 1) the glacier surface has likely fluctuated since at least the Pliocene; 2) the ice surface was >200 m higher than today during glacial periods, and the glacier has been thicker than present for ∼75–90% of each glacial–interglacial cycle; and 3) ice cover at higher elevations possibly occurred for a relatively shorter time per Pliocene cycle than Pleistocene cycle. Our multiple-nuclide approach demonstrates the magnitude of ice surface fluctuations during the Pliocene and Pleistocene that are linked to marine-based ice margin variability

Preceding rule induction with instance reduction methods

A new prepruning technique for rule induction is presented which applies instance reduction before rule induction. An empirical evaluation records the predictive accuracy and size of rule-sets generated from 24 datasets from the UCI Machine Learning Repository. Three instance reduction algorithms (Edited Nearest Neighbour, AllKnn and DROP5) are compared. Each one is used to reduce the size of the training set, prior to inducing a set of rules using Clark and Boswell's modification of CN2. A hybrid instance reduction algorithm (comprised of AllKnn and DROP5) is also tested. For most of the datasets, pruning the training set using ENN, AllKnn or the hybrid significantly reduces the number of rules generated by CN2, without adversely affecting the predictive performance. The hybrid achieves the highest average predictive accuracy

Experimental Evidence of Giant Electron - Gamma Bursts Generated by Extensive Atmospheric Showers in Thunderclouds

The existence of a new phenomena - giant electron-gamma bursts is established. The bursts are generated in thunderclouds as a result of the combined action of runaway breakdown and extensive atmosphere showers (RB-EAS). The experiments were fulfilled at the Tien Shan Mountain Scientific Station using EAS-Radio installation. This specially constructed installation consists of a wide spread EAS trigger array and a high time resolution radiointerferometer.Comment: 30 pages, 16 figure

Effect of Intralipid infusion on peripheral blood T cells and plasma cytokines in women undergoing assisted reproduction treatment

Objectives: Intravenous infusion of Intralipid is an adjunct therapy in assisted reproduction treatment (ART) when immune-associated infertility is suspected. Here, we evaluated the effect of Intralipid infusion on regulatory T cells (Treg cells), effector T cells and plasma cytokines in peripheral blood of women undertaking IVF. Methods: This prospective, observational pilot study assessed Intralipid infusion in 14 women exhibiting recurrent implantation failure, a clinical sign of immune-associated infertility. Peripheral blood was collected immediately prior to and 7 days after intravenous administration of Intralipid. Plasma cytokines were measured by Luminex, and T-cell subsets were analysed by flow cytometry. Results: A small increase in conventional CD8+ T cells occurred after Intralipid infusion, but no change was seen in CD4+ Treg cells, or naïve, memory or effector memory T cells. Proliferation marker Ki67, transcription factors Tbet and RORγt, and markers of suppressive capacity CTLA4 and HLA-DR were unchanged. Dimensionality-reduction analysis using the tSNE algorithm confirmed no phenotype shift within Treg cells or other T cells. Intralipid infusion increased plasma CCL2, CCL3, CXCL8, GM-CSF, G-CSF, IL-6, IL-21, TNF and VEGF. Conclusion: Intralipid infusion elicited elevated pro-inflammatory cytokines, and a minor increase in CD8+ T cells, but no change in pro-tolerogenic Treg cells. Notwithstanding the limitation of no placebo control, the results do not support Intralipid as a candidate intervention to attenuate the Treg cell response in women undergoing ART. Future placebo-controlled studies are needed to confirm the potential efficacy and clinical significance of Intralipid in attenuating cytokine induction and circulating CD8+ T cells.Kerrie L Foyle, David J Sharkey, Lachlan M Moldenhauer, Ella S Green, Jasmine J Wilson, Cassandra J Roccisano ... et al

Collision times in pi-pi and pi-K scattering and spectroscopy of meson resonances

Using the concept of collision time (time delay) introduced by Eisenbud and Wigner and its connection to on-shell intermediate unstable states, we study mesonic resonances in pi-pi and pi-K scattering. The time-delay method proves its usefulness by revealing the spectrum of the well-known rho- and K*-mesons and by supporting some speculations on rho-mesons in the 1200 MeV region. We use this method further to shed some light on more speculative meson resonances, among others the enigmatic scalars. We confirm the existence of chiralons below 1 GeV in the unflavoured and strange meson sector.Comment: 22 pages LaTex, 8 figure

Towards liver-directed gene therapy: Retrovirus-mediated gene transfer into human hepatocytes

Liver-directed gene therapy is being considered in the treatment of inherited metabolic diseases. One approach we are considering is the transplantation of autologous hepatocytes that have been genetically modified with recombinant retroviruses ex vivo. We describe, in this report, techniques for isolating human hepatocytes and efficiently transducing recombinant genes into primary cultures. Hepatocytes were isolated from tissue of four different donors, plated in primary culture, and exposed to recombinant retroviruses expressing either the LacZ reporter gene or the cDNA for rabbit LDL receptor. The efficiency of gene transfer under optimal conditions, as determined by Southern blot analysis, varied from a maximum of one proviral copy per cell to a minimum of 0.1 proviral copy per cell. Cytochemical assays were used to detect expression of the recombinant derived proteins, E. coli β-galactosidase and rabbit LDL receptor. Hepatocytes transduced with the LDL receptor gene expressed levels of receptor protein that exceeded the normal endogenous levels. The ability to isolate and genetically modify human hepatocytes, as described in this report, is an important step towards the development of liver-directed gene therapies in humans.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45540/1/11188_2005_Article_BF01233625.pd

Ecological Invasion, Roughened Fronts, and a Competitor's Extreme Advance: Integrating Stochastic Spatial-Growth Models

Both community ecology and conservation biology seek further understanding of factors governing the advance of an invasive species. We model biological invasion as an individual-based, stochastic process on a two-dimensional landscape. An ecologically superior invader and a resident species compete for space preemptively. Our general model includes the basic contact process and a variant of the Eden model as special cases. We employ the concept of a "roughened" front to quantify effects of discreteness and stochasticity on invasion; we emphasize the probability distribution of the front-runner's relative position. That is, we analyze the location of the most advanced invader as the extreme deviation about the front's mean position. We find that a class of models with different assumptions about neighborhood interactions exhibit universal characteristics. That is, key features of the invasion dynamics span a class of models, independently of locally detailed demographic rules. Our results integrate theories of invasive spatial growth and generate novel hypotheses linking habitat or landscape size (length of the invading front) to invasion velocity, and to the relative position of the most advanced invader.Comment: The original publication is available at www.springerlink.com/content/8528v8563r7u2742