NMSS handbook for decommissioning fuel cycle and materials licensees

The US Nuclear Regulatory Commission amended its regulations to set forth the technical and financial criteria for decommissioning licensed nuclear facilities. These regulations were further amended to establish additional recordkeeping requirements for decommissioning; to establish timeframes and schedules for the decommissioning; and to clarify that financial assurance requirements must be in place during operations and updated when licensed operations cease. Reviews of the Site Decommissioning Management Plan (SDMP) program found that, while the NRC staff was overseeing the decommissioning program at nuclear facilities in a manner that was protective of public health and safety, progress in decommissioning many sites was slow. As a result NRC determined that formal written procedures should be developed to facilitate the timely decommissioning of licensed nuclear facilities. This handbook was developed to aid NRC staff in achieving this goal. It is intended to be used as a reference document to, and in conjunction with, NRC Inspection Manual Chapter (IMC) 2605, ``Decommissioning Inspection Program for Fuel Cycle and Materials Licensees.`` The policies and procedures discussed in this handbook should be used by NRC staff overseeing the decommissioning program at licensed fuel cycle and materials sites; formerly licensed sites for which the licenses were terminated; sites involving source, special nuclear, or byproduct material subject to NRC regulation for which a license was never issued; and sites in the NRC`s SDMP program. NRC staff overseeing the decommissioning program at nuclear reactor facilities subject to regulation under 10 CFR Part 50 are not required to use the procedures discussed in this handbook

The Weak Charge of the Proton and New Physics

We address the physics implications of a precision determination of the weak charge of the proton, QWP, from a parity violating elastic electron proton scattering experiment to be performed at the Jefferson Laboratory. We present the Standard Model (SM) expression for QWP including one-loop radiative corrections, and discuss in detail the theoretical uncertainties and missing higher order QCD corrections. Owing to a fortuitous cancellation, the value of QWP is suppressed in the SM, making it a unique place to look for physics beyond the SM. Examples include extra neutral gauge bosons, supersymmetry, and leptoquarks. We argue that a QWP measurement will provide an important complement to both high energy collider experiments and other low energy electroweak measurements. The anticipated experimental precision requires the knowledge of the order alpha_s corrections to the pure electroweak box contributions. We compute these contributions for QWP, as well as for the weak charges of heavy elements as determined from atomic parity violation.Comment: 22 pages of LaTeX, 5 figure

The effect of near-surface plastic deformation on the hot corrosion and high temperature corrosion-fatigue response of a nickel-based superalloy

Surface treatments such as shot peening to inhibit fatigue crack initiation are essential processes when designing gas turbine components for aerospace applications. It is therefore crucial to understand the effects of shot peening in representative service environments. Here, the influence of surface treatment on the high temperature corrosion fatigue response of a polycrystalline nickel-based superalloy is considered, an area that has not previously been explored. Two shot peening conditions; 110H 7A 200% and 330H 7A 200%, along with a polished surface were chosen. Specimens were salted and exposed to SO2 gas during fatigue testing at 700 °C. A range of novel techniques including SEM, EBSD and axial chromatism profilometry were used to analyse the near surface cold work and surface condition before and after testing. EBSD local misorientation maps, paired with an increase in corrosion-fatigue life, suggest that a greater depth of cold work produced by the smaller shot size (110H), is providing a significant benefit in terms of hot corrosion and corrosion-fatigue performance. This paper concludes that the presence of a substantial layer of cold work is required to account for any metal loss due to the effects of hot corrosion. It is also evident that cold work hinders fatigue crack initiation and delays the onset of pit to crack transition

Use of SMS texts for facilitating access to online alcohol interventions: a feasibility study

A41 Use of SMS texts for facilitating access to online alcohol interventions: a feasibility study In: Addiction Science & Clinical Practice 2017, 12(Suppl 1): A4

History of clinical transplantation

How transplantation came to be a clinical discipline can be pieced together by perusing two volumes of reminiscences collected by Paul I. Terasaki in 1991-1992 from many of the persons who were directly involved. One volume was devoted to the discovery of the major histocompatibility complex (MHC), with particular reference to the human leukocyte antigens (HLAs) that are widely used today for tissue matching.1 The other focused on milestones in the development of clinical transplantation.2 All the contributions described in both volumes can be traced back in one way or other to the demonstration in the mid-1940s by Peter Brian Medawar that the rejection of allografts is an immunological phenomenon.3,4 © 2008 Springer New York

Comparing Presenting Clinical Features in 48 Children With Microscopic Polyangiitis to 183 Children Who Have Granulomatosis With Polyangiitis (Wegener's) : an ARChiVe Cohort Study

OBJECTIVE: To uniquely classify children with microscopic polyangiitis (MPA), to describe their demographic characteristics, presenting clinical features, and initial treatments in comparison to patients with granulomatosis with polyangiitis (Wegener's) (GPA). METHODS: The European Medicines Agency (EMA) classification algorithm was applied by computation to categorical data from patients recruited to the ARChiVe (A Registry for Childhood Vasculitis: e-entry) cohort, with the data censored to November 2015. The EMA algorithm was used to uniquely distinguish children with MPA from children with GPA, whose diagnoses had been classified according to both adult- and pediatric-specific criteria. Descriptive statistics were used for comparisons. RESULTS: In total, 231 of 440 patients (64% female) fulfilled the classification criteria for either MPA (n\u2009=\u200948) or GPA (n\u2009=\u2009183). The median time to diagnosis was 1.6 months in the MPA group and 2.1 months in the GPA group (ranging to 39 and 73 months, respectively). Patients with MPA were significantly younger than those with GPA (median age 11 years versus 14 years). Constitutional features were equally common between the groups. In patients with MPA compared to those with GPA, pulmonary manifestations were less frequent (44% versus 74%) and less severe (primarily, hemorrhage, requirement for supplemental oxygen, and pulmonary failure). Renal pathologic features were frequently found in both groups (75% of patients with MPA versus 83% of patients with GPA) but tended toward greater severity in those with MPA (primarily, nephrotic-range proteinuria, requirement for dialysis, and end-stage renal disease). Airway/eye involvement was absent among patients with MPA, because these GPA-defining features preclude a diagnosis of MPA within the EMA algorithm. Similar proportions of patients with MPA and those with GPA received combination therapy with corticosteroids plus cyclophosphamide (69% and 78%, respectively) or both drugs in combination with plasmapheresis (19% and 22%, respectively). Other treatments administered, ranging in decreasing frequency from 13% to 3%, were rituximab, methotrexate, azathioprine, and mycophenolate mofetil. CONCLUSION: Younger age at disease onset and, perhaps, both gastrointestinal manifestations and more severe kidney disease seem to characterize the clinical profile in children with MPA compared to those with GPA. Delay in diagnosis suggests that recognition of these systemic vasculitides is suboptimal. Compared with adults, initial treatment regimens in children were comparable, but the complete reversal of female-to-male disease prevalence ratios is a provocative finding