Morphodynamisme des environnements à Beach-rocks du plateau continental de Côte d’Ivoire (golfe de Guinée)

Les beach-rocks sont constituées de grains de quartz, avec une faible proportion de feldspath et de mica. Il s’agit de grès quartzeux à cimentferrugineux, parfois carbonatés. Ils sont constitués de matériaux terrigènes charriés par les cours d’eau. Ces grès ont subi un long transport et une cimentation par précipitation de l’oxyde de fer. L’absence de fraction argileuse, la faible proportion de feldspaths et de micas, et l’abondance de quartz à grains arrondis indiquent qu’ils sont matures. Eneffet, la présence de quartzs polycristallins indiquant une recristallisation et une substitution du ciment, montre que ces grès ont subi une diagenèse avancée. La fraction sableuse adjacente aux barres de grèsdu plateau continental montre des sables d’origine fluviatile, mal triés à classement médiocre présentent une asymétrie vers les plus petites tailles. Ces grès se déposeraient dans un environnement de type ligne derivage, sous l’influence de courants locaux bimodaux dus aux variations du niveau de la mer. En raison de leur résistance mécanique et de leurépaisseur, les beach-rocks constituent un obstacle au transport dessédiments.Mots-clés : Beach-rocks, sédimentologie, paléoenvironnement, plateau continental, Côte d’Ivoir

Determinan Pemanfaatan Pelayanan Program Kb pada Pasangan Usia Subur ( Pus ) di Kelurahan Babura Kecamatan Medan Sunggal Tahun 2012

One of the main demography issues in Indonesia is a higher growth rate of population. Nowadays, there are any efforts to control the growth rate of the population through the control of birth rate or fertility by using contraception involuntary by the fertile spouse. This research is a survey by Explanatory research approach to study the determinant influence the implementation of family planning (KB) program.. Population in this research is all of fertile spouse while the number of sample is 94 respondents. The data analysis applied in this research is logistic regression test on confidential level 95 %. The results of research indicates that there is influence of the society value (p=0,017), resource availibility (p=0,000), the trust to family planning (KB) service (p=0,031) to the utilization of KB program while variable that has not influence is educational level, occupation, earning, perception, and attitude of the official. It is suggested to anyone who serve the family planning (KB) provide the society with extension proactively especially to the fertile spouse to enable them understand the advantages of family planning (KB) program, the side effect of the contraception tools and to change the society paradigm to the value available in society to make them trust and use KB progra

Taphonomy of a monodominant Gryposaurus sp. bonebed from the Oldman Formation (Campanian) of Alberta, Canada

A monodominant Gryposaurus sp. bonebed in the lower unit of the Campanian Oldman Formation of southern Alberta is the oldest hadrosauroid bonebed documented in the province and the first described from the formation. The sedimentology of the locality and the taphonomy of the hadrosaurid material indicates that the bonebed represents an assemblage of juvenile-sized individuals that were probably transported only a short distance from where they died to where they were finally deposited and preserved in a fine-grained mudstone within an overbank sequence. Histological examination of six limb elements confirms that all individuals are juveniles, with two age classes (<1 and <2 years of age at the time of death) that likely died in the same event. Bone microstructure data indicate that Gryposaurus experienced rapid growth over the 2-year life spans documented, equivalent to other Late Cretaceous hadrosaurids in North America. The parautochthonous nature of the bonebed, and the lack of small neonate (newborn) material and almost complete lack of large adult material, suggests that the bonebed represents a segregated group of juveniles. This group of immature individuals may have been an autonomous unit that had separated itself from a larger social grouping, possibly in an effort to increase their survivability

Can you trust clinical practice guidelines for laparoscopic surgery? A systematic review of clinical practice guidelines for laparoscopic surgery

BACKGROUND: Clinical practice guidelines aim to support clinicians in providing clinical care and should be supported by evidence. There is currently no information on whether clinical practice guidelines in laparoscopic surgery are supported by evidence. METHODS: We performed a systematic review and identified clinical practice guidelines of laparoscopic surgery published in PubMed and Embase between March 2016 and February 2019. We performed an independent assessment of the strength of recommendation based on the evidence provided by the guideline authors. We used the 'Appraisal of Guidelines for Research & Evaluation II' (AGREE-II) Tool's 'rigour of development', 'clarity of presentation', and 'editorial independence' domains to assess the quality of the guidelines. We performed a mixed-effects generalised linear regression modelling. RESULTS: We retrieved 63 guidelines containing 1905 guideline statements. The median proportion of 'difference in rating' of strength of recommendation between the guideline authors and independent assessment was 33.3% (quartiles: 18.3%, 55.8%). The 'rigour of development' domain score (odds ratio 0.06; 95% confidence intervals 0.01-0.48 per unit increase in rigour score; P value = 0.0071) and whether the strength of recommendation was 'strong' by independent evaluation (odds ratio 0.09 (95% confidence intervals 0.06-0.13; P value < 0.001) were the only determinants of difference in rating between the guideline authors and independent evaluation. CONCLUSION: A considerable proportion of guideline statements in clinical practice guidelines in laparoscopic surgery are not supported by evidence. Guideline authors systematically overrated the strength of the recommendation (i.e., even when the evidence points to weak recommendation, guideline authors made strong recommendations)

Nuclear-Targeted Deleted in Liver Cancer 1 (DLC1) Is Less Efficient in Exerting Its Tumor Suppressive Activity Both In Vitro and In Vivo

BACKGROUND: Deleted in liver cancer 1 (DLC1) serves as an important RhoGTPase activating protein (RhoGAP) protein that terminates active RhoA signaling in human cancers. Increasing evidence has demonstrated that the tumor suppressive activity of DLC1 depends not only on RhoGAP activity, but also relies on proper focal adhesion localization through its interaction with tensin family proteins. Recently, there are reports showing that DLC1 can also be found in the nucleus; however, the existence and the relative tumor suppressive activity of nuclear DLC1 have never been clearly addressed. METHODOLOGY AND PRINCIPAL FINDINGS: We herein provide new evidence that DLC1 protein, which predominantly associated with focal adhesions and localized in cytosol, dynamically shuttled between cytoplasm and nucleus. Treatment of cells with nuclear export blocker, Leptomycin B (LMB), retained DLC1 in the nucleus. To understand the nuclear entry of DLC1, we identified amino acids 600-700 of DLC1 as a novel region that is important for its nuclear localization. The tumor suppressive activity of nuclear DLC1 was directly assessed by employing a nuclear localization signal (NLS) fusion variant of DLC1 (NLS-DLC1) with preferential nuclear localization. In SMMC-7721 HCC cells, expression of NLS-DLC1 failed to suppress colony formation and actin stress fiber formation in vitro. The abrogated tumor suppressive activity of nuclear DLC1 was demonstrated for the first time in vivo by subcutaneously injecting p53(-/-) RasV12 hepatoblasts with stable NLS-DLC1 expression in nude mice. The injected hepatoblasts with NLS-DLC1 expression effectively formed tumors when compared with the non-nuclear targeted DLC1. CONCLUSIONS/SIGNIFICANCE: Our study identified a novel region responsible for the nuclear entry of DLC1 and demonstrated the functional difference of DLC1 in different cellular compartments both in vitro and in vivo

Impact of Rumen Fluid Storage on In Vitro Feed Fermentation Characteristics

Storing rumen fluid (RF) has the potential to standardize subsequent in vitro feed fermentation studies. The first phase of this experiment aimed to evaluate the effect of two RF storage methods on gas composition and dry matter disappearance (DMD) in wheat grain and lucerne hay under in vitro fermentation. The storage methods were as follows: (1) snap-freezing RF using liquid nitrogen and then storing it at −80 °C (−80 °C); and (2) mixing RF with 5% dimethyl sulfoxide (DMSO), subsequently freezing it at −20 °C (D−20 °C), and comparing it to fresh RF on days 1, 14, and 30 post collection. The objective of the second phase was to quantify the impact of preserving the RF for 180 days at D−20 °C on the in vitro fermentation parameters. The methane composition was lower (p < 0.001) in both the preserved RFs than in the fresh RF. There was no difference (p < 0.05) in DMD values between days 14 and 30. The average cumulative gas production and DMD from the RF stored at D−20 °C was higher than that from the RF stored at −80 °C. Moreover, there was no difference between day 30 and day 180 in the total gas production and lag time when fermenting with RF preserved at D−20 °C. Therefore, storing RF at D−20 °C is preferable to storing it at −80 °C when access to fresh RF is limited

Total Cost of Ownership Driven Methodology for Predictive Maintenance Implementation in Industrial Plants

Part 4: Product and Asset Life Cycle Management in Smart Factories of Industry 4.0International audienceThis paper proposes a methodology to drive from a strategic point of view the implementation of a predictive maintenance policy within an industrial plant. The methodology integrates the evaluation of system performances, used to identify the critical components, with simulation and cost analysis. The goal is to evaluate predictive maintenance implementation scenarios based on alternative condition monitoring (CM) solutions, under the lenses of Total Cost of Ownership (TCO). This allows guiding the decision on where in the industrial system to install diagnostic solutions for monitoring of asset health, by keeping a systemic and life cycle-oriented perspective. Technical systemic performances are evaluated through Monte Carlo simulation based on the Reliability Block Diagram (RBD) model of the system. To validate the methodology, an application case study focused on a production line of a relevant Italian company in the food sector is presented

On staying grounded and avoiding Quixotic dead ends

The 15 articles in this special issue on The Representation of Concepts illustrate the rich variety of theoretical positions and supporting research that characterize the area. Although much agreement exists among contributors, much disagreement exists as well, especially about the roles of grounding and abstraction in conceptual processing. I first review theoretical approaches raised in these articles that I believe are Quixotic dead ends, namely, approaches that are principled and inspired but likely to fail. In the process, I review various theories of amodal symbols, their distortions of grounded theories, and fallacies in the evidence used to support them. Incorporating further contributions across articles, I then sketch a theoretical approach that I believe is likely to be successful, which includes grounding, abstraction, flexibility, explaining classic conceptual phenomena, and making contact with real-world situations. This account further proposes that (1) a key element of grounding is neural reuse, (2) abstraction takes the forms of multimodal compression, distilled abstraction, and distributed linguistic representation (but not amodal symbols), and (3) flexible context-dependent representations are a hallmark of conceptual processing

On Polynomial Stability of Coupled Partial Differential Equations in 1D

We study the well-posedness and asymptotic behaviour of selected PDE-PDE and PDE-ODE systems on one-dimensional spatial domains, namely a boundary coupled wave-heat system and a wave equation with a dynamic boundary condition. We prove well-posedness of the models and derive rational decay rates for the energy using an approach where the coupled systems are formulated as feedback interconnections of impedance passive regular linear systems.Comment: 12 pages, 1 figure, accepted for publication in the Proceedings of "Semigroups of Operators: Theory and Applications", Kazimierz Dolny, Poland, October 201

Mental disorder symptoms during the COVID-19 pandemic in Latin America - a systematic review and meta-analysis.

AIMS: There is a lack of evidence related to the prevalence of mental health symptoms as well as their heterogeneities during the coronavirus disease 2019 (COVID-19) pandemic in Latin America, a large area spanning the equator. The current study aims to provide meta-analytical evidence on mental health symptoms during COVID-19 among frontline healthcare workers, general healthcare workers, the general population and university students in Latin America. METHODS: Bibliographical databases, such as PubMed, Embase, Web of Science, PsycINFO and medRxiv, were systematically searched to identify pertinent studies up to August 13, 2021. Two coders performed the screening using predefined eligibility criteria. Studies were assigned quality scores using the Mixed Methods Appraisal Tool. The double data extraction method was used to minimise data entry errors. RESULTS: A total of 62 studies with 196 950 participants in Latin America were identified. The pooled prevalence of anxiety, depression, distress and insomnia was 35%, 35%, 32% and 35%, respectively. There was a higher prevalence of mental health symptoms in South America compared to Central America (36% v. 28%, p < 0.001), in countries speaking Portuguese (40%) v. Spanish (30%). The pooled prevalence of mental health symptoms in the general population, general healthcare workers, frontline healthcare workers and students in Latin America was 37%, 34%, 33% and 45%, respectively. CONCLUSIONS: The high yet heterogenous level of prevalence of mental health symptoms emphasises the need for appropriate identification of psychological interventions in Latin America