Ergasiophytes in the urban flora of Belgorod (Russia)

Having been reinforced recently economic links between regions create conditions for the emerging of the role of the adventive element of the synanthropic flora. Active introduction of different species of plants made by city residents in the yards, garden-plots, garden patches and grave yards contributes to it as well as the activities of various municipal forestry firms and botanic garden, which is situated in Belgoro

Peculiarities in plant communities’ formation in crop plantings in the south-eastern part of the Central Russian Upland

The article describes a study of plant communities of the south-western part of the Central Russian Upland that form in batches of various crops. Field studies employed the methods of reconnaissance floristic survey. Species diversity of the plant complexes and plant communities were studied with the morphological-ecological-geographical metho

Nucleophilic Addition of Indoles to Carborancarboxaldehyde – a Convinient Synthetic Strategy Towards Novel Boron-Enriched 3-Indolylmethanols

This work was supported by Russian Science Foundation (Project 18-13-00365)

HDL apoprotein immunization induces T cell-mediated venulitis and inflammation in aorta

The hypothesis that atherosclerotic processes are mostly caused by immune (autoimmune) mechanisms has recently been gaining attraction. At the same time, the autoimmune hypothesis of atherogenesis has not become generally accepted and requires additional evidence. Previously, we were able to induce changes in the aortic wall similar to those observed in the early stages of human atherosclerosis, and also to produce visceral obesity in normocholesterolaemic Wistar rats by a single immunization with human native high- or low-density lipoproteins. We also found that the immune response to native human HDL causes atherosclerosis-like lesions in the rabbit aorta, such as adipocyte and chondrocyte metaplasia, proteoglycan deposits, and leukocyte infiltration. Atherosclerosis-like lesions developed in the aorta of hnHDL-immunized rabbits against a background of normal blood LDL-cholesterol level. Thus, an immune response against HDL or LDL may be an independent cause of atherogenesis. The aim of this study was to test whether immunization with human HDL apoproteins (apoA1 and apoE proteins) would induce atherosclerosis-like lesions in the aorta of normocholesterolemic Wistar rats. HDL apoproteins were isolated from human or rat plasma. Wistar rats (n = 5) aged 2 months were used for immunization with human HDL apoproteins. HDL apoproteins were administered as a single intradermal injection of 100 mg per rat in incomplete Freund’s adjuvant. Control rats were injected subcutaneously with incomplete Freund’s adjuvant (n = 5). Rats were dissected 25 weeks after immunization. Rat aorta sections were stained with hematoxylin and eosin for light microscopy. T lymphocytes infiltration was determined by immunohistochemical staining with FITC-labeled antibodies specific to rat CD3. CD3+T lymphocytes were detected using an Olympus BX53 fluorescent microscope. The level of antibodies to human and rat HDL apoproteins was determined by indirect enzyme-linked immunosorbent assay. Immunization with HDL apoproteins induced a T cell mediated immune response without production of autoantibodies to HDL apoproteins. The aortic intima and adventitia were infiltrated with T lymphocytes in rats immunized with HDL apoproteins. Pronounced T lymphocytic infiltration was found in all layers of the vein wall in rats immunized with human HDL apoproteins. Thus, immunization with HDL apoproteins causes T cell mediated inflammation of the aorta and venulitis

Torsion of the cyst of the right ovary in a pregnant woman and tactics of warfare

The tactics of management and treatment of patients with uterine appendages torsion fully depends on the duration of pregnancy, as well as concomitant pathology, both from the mother and the fetus.Тактика ведения и лечения пациенток при перекруте придатков матки в полной мере зависит от срока беременности и сопутствующей патологии, как со стороны матери, так и плода

Torsion of the cyst of the right ovary in a pregnant woman and tactics of warfare

The tactics of management and treatment of patients with uterine appendages torsion fully depends on the duration of pregnancy, as well as concomitant pathology, both from the mother and the fetus.Тактика ведения и лечения пациенток при перекруте придатков матки в полной мере зависит от срока беременности и сопутствующей патологии, как со стороны матери, так и плода

The first search for bosonic super-WIMPs with masses up to 1 MeV/c2^2 with GERDA

We present the first search for bosonic super-WIMPs as keV-scale dark matter candidates performed with the GERDA experiment. GERDA is a neutrinoless double-beta decay experiment which operates high-purity germanium detectors enriched in $^{76}$Ge in an ultra-low background environment at the Laboratori Nazionali del Gran Sasso (LNGS) of INFN in Italy. Searches were performed for pseudoscalar and vector particles in the mass region from 60 keV/c$^2$ to 1 MeV/c$^2$. No evidence for a dark matter signal was observed, and the most stringent constraints on the couplings of super-WIMPs with masses above 120 keV/c$^2$ have been set. As an example, at a mass of 150 keV/c$^2$ the most stringent direct limits on the dimensionless couplings of axion-like particles and dark photons to electrons of $g_{ae} < 3 \cdot 10^{-12}$ and ${\alpha'}/{\alpha} < 6.5 \cdot 10^{-24}$ at 90% credible interval, respectively, were obtained.Comment: 6 pages, 3 figures, submitted to Physical Review Letters, added list of authors, updated ref. [21

West Nile Fever: Results of Monitoring over the Causative Agent in the Russian Federation in 2021, the Incidence Forecast for 2022

The epidemiological situation on West Nile fever (WNF) in Russia in 2021 was characterized by an increase in the incidence relative to 2020 (more than 6-fold increase). The peculiarities of the WNF epidemic process have been determined: the territorial distribution of cases (75 % – in the constituent entities of the Central Federal District), the expansion of the causative agent’s areal with the involvement of new territories (official registration of cases in Moscow and the Tula Region for the first time ever), the early end of the epidemic season. An increase in the proportion of neuroinvasive forms, an increase in the share of male patients and the age group of 30–39 years, a decrease in the proportion of the population in contact with the pathogen in natural places of mass recreation were observed in the incidence structure. According to the results of the monitoring studies carried out by the Reference Center, intensive circulation of the pathogen was established on the territory of the Central Federal District, Southern Federal District, and the North Caucasian Federal District. The low reported incidence was due to insufficient detection of WNF patients. The results of moleculargenetic study showed that in the European part of Russia, WNV lineage 2 circulated in both epizootic and epidemic cycles, lineage 2 in the south of Western Siberia (Omsk Region) and lineage 4 in the Volgograd Region – in the epizootic cycle only. Phylogenetic analysis revealed that strains isolated from the Astrakhan, Volgograd, Rostov, Voronezh Regions and the Republic of Dagestan in 2021 belong to the genovariant of WNV lineage 2 not registered in Russia previously.  The topology of the phylogenetic tree indicates the possible African origin of the isolates, probably imported into Russia by migratory birds across the coast of the Caspian Sea. In the Volgograd Region, WNV of both the entrenched clade of lineage 2 (since 2007) and new genovariant circulated. The specialists of the Reference Center developed a forecast of WNF epidemiological situation development in the Volgograd Region in 2022 on the basis of the neural network modeling technique, according to which an increase in the incidence is expected, comparable to that in 2010 and 2012. Based on the climate projections, an increase in the incidence is possible in all Federal Districts of the European part of Russia, the southern territories of the Urals, Western Siberia, and the Far East

Epizooty of Tularemia, Detected in the Population of the Common Vole in the Natural Focus of Steppe Type in the South-East of the Rostov Region in 2020

The aim of study was to conduct epizootiological monitoring of natural tularemia foci of the steppe type and investigate epizootic activity in the south-east of the Rostov Region.Materials and methods. An epizootiological survey was carried out on the territory of Remontnensky, Sal’sky and Peschanokopsky districts of the Rostov Region in 2019–2021. To capture and collect mammals, Ixodidae ticks and to study the samples of field material conventional methods were used.Results and discussion. Habitation of 16 species of small mammals, 6 species of Ixodidae ticks has been found. Molecular-genetic analysis of the voles has revealed the presence of the species Microtus arvalis obscurus in the studied area of the region. The circulation of the tularemia agent has been established in the population of common and social voles, forest mouse, hare, rook, Dermacentor marginatus, Hyalomma marginatum, removed from rooks. In May 2020, a high increase in the number of the social vole in the Remontnensky district (up to 21 %), in July 2020 – the common vole in the agrocenoses of the Sal’sky district (up to 33 %) was observed. An extensive epizooty of tularemia was detected in the population of common vole in the south-east of the Rostov Region and in adjacent territories in the Republic of Kalmykia and the Stavropol territory. Two cultures of the pathogen were isolated from the fallen and captured social voles, and four cultures – from the common vole. The isolated strains belong to the Holarctic subspecies of Francisella tularensis EryR. The results obtained attest to the activation of the natural tularemia focus in the south-east of the Rostov Region and its high epizootic activity