Enabling service-level agreement renegotiation through extending WS-Agreement specification

WS-Agreement is a language and protocol designed for creating service-level agreements (SLAs) based on initial offers, and for monitoring those offers at runtime. The definition of WS-Agreement protocol is very general and does not contemplate the possibility of changing an agreement at runtime. This paper presents extensions of the WS-Agreement specification to support the dynamic nature of SLAs by allowing the possibility of SLA renegotiation at runtime. The extended WS-Agreement specification has been implemented and tested. Within this implementation, the concept of renegotiation is demonstrated through the ability to create more than one SLA at runtime. An evaluation is conducted to examine the profits a service provider may gain through renegotiation, as well the savings resulting from rescuing the SLA from violations as a consequence of avoiding paying penalties. The results show that making the SLA terms adaptable and changeable is a viable mechanism that provides flexibility to the service provider and service consumer

Mindfulness Training and Practice in Physician Assistant Education

Purpose: The purpose of this study was to integrate mindfulness, as a compassionate pedagogy, into a physician assistant (PA) program and assess its effects on student depression, anxiety, and stress at the conclusion of the first semester. Method: Fifty-five of 60 first-semester students provided consent. Mindfulness instruction and practice began with a six-hour intensive workshop spread over two days during the first week of the semester. This was followed by seven, brief, 10 to15 minute mindfulness practices integrated across one course. Students completed a demographic questionnaire at the beginning of the project and the DASS 21 survey which measures a range of symptoms common to depression, anxiety, and stress at weeks 1 and 16 of the semester. After the course concluded, 10 students were randomly selected from those who had identified as interested in participating in a focus group to discuss their experiences and offer suggestions for improvement. Results: DASS 21 subscale scores revealed no change in depression, anxiety, nor stress. In contrast, the focus group results revealed that student anxiety and stress levels diminished through learning about mindfulness and practicing mindful meditations. Conclusions: The incorporation of mindfulness training was generally well received by first-semester PA students. Students in the focus group reported decreased levels of anxiety and stress, while the DASS 21 revealed no change. The authors suggest that the experience could be strengthened by modifying the workshop material and extending the mindfulness practice across the didactic and clinical years to allow students more opportunities to develop their personal mindfulness practice and integrate it throughout their career

Nanosized rods agglomerates as a new approach for formulation of a dry powder inhaler

HF Salem1 ME Abdelrahim2 K Abo Eid3 MA Sharaf3,41Department of Pharmaceutics, 2Department of Clinical Pharmacy, Faculty of Pharmacy, The University of Beni Suef, Beni Suef; 3Department of Chemistry, Helwan University, Ain Helwan, Helwan, Egypt; 4Department of Chemistry, The American University in Cairo, New Cairo, Helwan 11835, EgyptBackground: Nanosized dry powder inhalers provide higher stability for poorly water-soluble drugs as compared with liquid formulations. However, the respirable particles must have a diameter of 1–5 µm in order to deposit in the lungs. Controlled agglomeration of the nanoparticles increases their geometric particle size so they can deposit easily in the lungs. In the lungs, they fall apart to reform nanoparticles, thus enhancing the dissolution rate of the drugs. Theophylline is a bronchodilator with poor solubility in water.Methods: Nanosized theophylline colloids were formed using an amphiphilic surfactant and destabilized using dilute sodium chloride solutions to form the agglomerates.Results: The theophylline nanoparticles thus obtained had an average particle size of 290 nm and a zeta potential of −39.5 mV, whereas the agglomerates were 2.47 µm in size with a zeta potential of −28.9 mV. The release profile was found to follow first-order kinetics (r2 > 0.96). The aerodynamic characteristics of the agglomerated nanoparticles were determined using a cascade impactor. The behavior of the agglomerate was significantly better than unprocessed raw theophylline powder. In addition, the nanoparticles and agglomerates resulted in a significant improvement in the dissolution of theophylline.Conclusion: The results obtained lend support to the hypothesis that controlled agglomeration strategies provide an efficient approach for the delivery of poorly water-soluble drugs into the lungs.Keywords: theophylline, nanoparticles, agglomerates, dry powder inhale

Gustoća i viskoznost poluvodičkog spoja AgGaSe2 u čvrstom i tekućem stanju

The density and kinematic viscosity of AgGaSe2 were investigated in the solid and liquid states in the temperature range 690 - 930 °C. Density and dynamic viscosity measurements were carried out using the thermometer method and the rotating cylinder method. Experimental data show that the dependence of viscosity on temperature has an activation character and that logarithm of viscosity vs. reciprocal absolute temperature can be approximated by two straight lines corresponding to activation energies 0.36 eV and 0.19 eV in the solid and liquid states, respectively. The temperature dependence of the free volume was calculated and it was found that it decreases linearly with temperature. The results are explained on the basis of the free-volume model.Istraživali smo gustoću i kinematičku viskoznost AgGaSe2 u čvrstom i tekućem stanju na temperaturama 690 – 930 ◦C. U mjerenjima gustoće i viskoznosti primijenili smo termometrijsku metodu odnosno metodu rotirajućeg valjka. Mjerni podaci ukazuju da ovisnost viskoznosti η o temperaturi ima aktivacijske značajke, te se ovisnost log η o temperaturi može aproksimirati pravcima koji odgovaraju aktivacijskim energijama 0.36 eV and 0.19 eV za čvrsto odnosno tekuće stanje. Izveli smo i temperaturnu ovisnost slobodnog volumena i našli da se linerno smanjuje s temperaturom. Ishodi mjerenja tumače se na osnovi modela slobodnog volumena

A network-aware framework for energy-efficient data acquisition in wireless sensor networks

Wireless sensor networks enable users to monitor the physical world at an extremely high fidelity. In order to collect the data generated by these tiny-scale devices, the data management community has proposed the utilization of declarative data-acquisition frameworks. While these frameworks have facilitated the energy-efficient retrieval of data from the physical environment, they were agnostic of the underlying network topology and also did not support advanced query processing semantics. In this paper we present KSpot+, a distributed network-aware framework that optimizes network efficiency by combining three components: (i) the tree balancing module, which balances the workload of each sensor node by constructing efficient network topologies; (ii) the workload balancing module, which minimizes data reception inefficiencies by synchronizing the sensor network activity intervals; and (iii) the query processing module, which supports advanced query processing semantics. In order to validate the efficiency of our approach, we have developed a prototype implementation of KSpot+ in nesC and JAVA. In our experimental evaluation, we thoroughly assess the performance of KSpot+ using real datasets and show that KSpot+ provides significant energy reductions under a variety of conditions, thus significantly prolonging the longevity of a WSN

Vitamin D Level in Relation to Depression Symptoms During Adolescence

BACKGROUND: This study aimed to investigate the association between 25-hydroxyvitamin D (25(OH)D) and depression symptoms among adolescents in Kuwait, a country with a high prevalence of vitamin D deficiency. METHODS: A school based cross-sectional study was conducted on randomly selected 704 adolescents in middle schools. Data on depression symptoms were collected using the Children\u27s Depression Inventory (CDI). Data on covariates were collected from the parents by self-administered questionnaire and from adolescents by face-to-face interview. Blood samples were analyzed in an accredited laboratory; and 25(OH)D was measured using liquid chromatography-tandem mass spectrometry. RESULTS: Of 704 adolescents, 94 (13.35%; 95%CI:10.35-17.06%) had depression symptom (a score of 19 or more on the CDI). There was no significant difference in the median CDI score between different vitamin D status (p = 0.366). There was also no significant correlation between serum 25(OH)D concentration and CDI score (Spearman\u27s rank correlation = 0.01; p = 0.825).There was no significant association between 25(OH)D and depression symptoms whether 25(OH)D was fitted as a continuous variable (crude odds ratio (OR) 0 .99 [95%CI: 0.98, 1.01], p = 0.458 and adjusted OR 1.01 [95%CI: 0.99, 1.02], p = 0.233), categorical variable as per acceptable cut-of points (crude analysis p = 0.376 and adjusted analysis p = 0.736), or categorical variable as quartiles (crude analysis p = 0.760 and adjusted analysis p = 0.549). CONCLUSION: Vitamin D status does not seem to be associated with depression symptoms among adolescents in our setting. Nevertheless, it is important to have sufficient vitamin D levels during adolescence for several other health benefits

Transesophageal Echocardiograph Findings in Patients with Cardiovascular Disorders at Al-Thawrah General Hospital, Sana’a, Yemen

ABSTRACT Objectives: To determine the frequency distribution of different cardiovascular disorders and to describe their associated morphological abnormalities by transesophageal echocardiography among patients referred to the Transesophageal Echocardiography Laboratory of Al-Thawrah General Hospital, Sana’a, in the period 2009– 2011. Methods: This was a retrospective descriptive study of 856 patients with suspected cardiovascular disorders and referred for transesophageal echocardiography over a two-year period. Data about patients’ sex, their refer- ral site and transesophageal echocardiography findings were collected and analyzed according to the type of cardiovascular disorders, valvular affections and lesions, complications and recommended treatments. Results: Of the 856 patients, 63.4% were females and 36.6% were males. The majority of patients diagnosed by transesophageal echocardiography (82.4%) were referred from outpatient departments. Rheumatic heart dis- ease was the most frequent cardiovascular disorder (87.1%), followed by tricuspid valve lesions (62.8%), of which 54% (329/606) were tricuspid regurgitation and 62.6% (114/182) were aortic valve regurgitation. Re- garding the type of valvular lesions detected, mitral valve disease was the most frequent, being found in 69.2% (214/309) of patients. Regarding the severity of valvular lesions, 73.1% (19/26) of mitral valve stenosis cases were severe while 83.3% (35/62) of aortic stenosis cases were mild. Moderate pulmonary hypertension was seen mostly secondary to rheumatic heart disease. The majority of cardiovascular disorder patients (33.6%; 284/844) were recommended for balloon mitral valvotomy. Mitral valve surgery was the most frequently per- formed surgical intervention for affected valves of patients with cardiovascular disorders; being used for the treatment of 31.4% (80/255) of valvular lesions. Conclusions: Transesophageal echocardiography revealed that rheumatic heart disease is the most frequent cardiovascular disorder among Yemeni patients and poses a major health problem. In addition, a high propor- tion of patients with cardiovascular disorders have valvular lesions of the mild degree that require surgical in- tervention