399 research outputs found
Linearized model Fokker-Planck collision operators for gyrokinetic simulations. II. Numerical implementation and tests
A set of key properties for an ideal dissipation scheme in gyrokinetic
simulations is proposed, and implementation of a model collision operator
satisfying these properties is described. This operator is based on the exact
linearized test-particle collision operator, with approximations to the
field-particle terms that preserve conservation laws and an H-Theorem. It
includes energy diffusion, pitch-angle scattering, and finite Larmor radius
effects corresponding to classical (real-space) diffusion. The numerical
implementation in the continuum gyrokinetic code GS2 is fully implicit and
guarantees exact satisfaction of conservation properties. Numerical results are
presented showing that the correct physics is captured over the entire range of
collisionalities, from the collisionless to the strongly collisional regimes,
without recourse to artificial dissipation.Comment: 13 pages, 8 figures, submitted to Physics of Plasmas; typos fixe
Saturated State of the Nonlinear Small-Scale Dynamo
We consider the problem of incompressible, forced, nonhelical, homogeneous
and isotropic MHD turbulence with no mean magnetic field and large magnetic
Prandtl number. This type of MHD turbulence is the end state of the turbulent
dynamo, which generates folded fields with small-scale direction reversals. We
propose a model in which saturation is achieved as a result of the velocity
statistics becoming anisotropic with respect to the local direction of the
magnetic folds. The model combines the effects of weakened stretching and
quasi-two-dimensional mixing and produces magnetic-energy spectra in remarkable
agreement with numerical results at least in the case of a one-scale flow. We
conjecture that the statistics seen in numerical simulations could be explained
as a superposition of these folded fields and Alfv\'en-like waves that
propagate along the folds.Comment: revtex, 4 pages, 2 figures; minor changes to match published versio
On the Origin of Cosmic Magnetic Fields
We review the literature concerning how the cosmic magnetic fields pervading
nearly all galaxies actually got started. some observational evidence involves
the chemical abundance of the light elements Be and B, while another one is
based on strong magnetic fields seen in high red shift galaxies. Seed fields,
whose strength is of order 10^{-20} gauss, easily sprung up in the era
preceding galaxy formation. Several mechanisms are proposed to amplify these
seed fields to microgauss strengths. The standard mechanism is the Alpha-Omega
dynamo theory. It has a major difficulty that makes unlikely to provide the
sole origin. The difficulty is rooted in the fact that the total flux is
constant. This implies that flux must be removed from the galactic discs. This
requires that the field and flux be separated, for otherwise interstellar mass
must be removed from the deep galactic gravitational and then their strength
increased by the alpha omega theory.Comment: 90 pages and 6 figures; accepted for publication in Reports of
Progress in Physics as an invited revie
"Author! Author!" : Shakespeare and biography
Original article can be found at: http://www.informaworld.com/smpp/title~content=t714579626~db=all Copyright Informa / Taylor & Francis Group. DOI: 10.1080/17450910902764454Since 1996, not a year has passed without the publication of at least one Shakespeare biography. Yet for many years the place of the author in the practice of understanding literary works has been problematized, and even on occasions eliminated. Criticism reads the “works”, and may or may not refer to an author whose “life” contributed to their meaning. Biography seeks the author in the works, the personality that precedes the works and gives them their characteristic shape and meaning. But the form of literary biography addresses the unusual kind of “life” that puts itself into “works”, and this is particularly challenging where the “works” predominate massively over the salient facts of the “life”. This essay surveys the current terrain of Shakespeare biography, and considers the key questions raised by the medium: can we know anything of Shakespeare's “personality” from the facts of his life and the survival of his works? What is the status of the kind of speculation that inevitably plays a part in biographical reconstruction? Are biographers in the end telling us as much about themselves as they tell us about Shakespeare?Peer reviewe
A blind detection of a large, complex, Sunyaev--Zel'dovich structure
We present an interesting Sunyaev-Zel'dovich (SZ) detection in the first of
the Arcminute Microkelvin Imager (AMI) 'blind', degree-square fields to have
been observed down to our target sensitivity of 100{\mu}Jy/beam. In follow-up
deep pointed observations the SZ effect is detected with a maximum peak
decrement greater than 8 \times the thermal noise. No corresponding emission is
visible in the ROSAT all-sky X-ray survey and no cluster is evident in the
Palomar all-sky optical survey. Compared with existing SZ images of distant
clusters, the extent is large (\approx 10') and complex; our analysis favours a
model containing two clusters rather than a single cluster. Our Bayesian
analysis is currently limited to modelling each cluster with an ellipsoidal or
spherical beta-model, which do not do justice to this decrement. Fitting an
ellipsoid to the deeper candidate we find the following. (a) Assuming that the
Evrard et al. (2002) approximation to Press & Schechter (1974) correctly gives
the number density of clusters as a function of mass and redshift, then, in the
search area, the formal Bayesian probability ratio of the AMI detection of this
cluster is 7.9 \times 10^4:1; alternatively assuming Jenkins et al. (2001) as
the true prior, the formal Bayesian probability ratio of detection is 2.1
\times 10^5:1. (b) The cluster mass is MT,200 = 5.5+1.2\times 10^14h-1M\odot.
(c) Abandoning a physical model with num- -1.3 70 ber density prior and instead
simply modelling the SZ decrement using a phenomenological {\beta}-model of
temperature decrement as a function of angular distance, we find a central SZ
temperature decrement of -295+36 {\mu}K - this allows for CMB primary
anisotropies, receiver -15 noise and radio sources. We are unsure if the
cluster system we observe is a merging system or two separate clusters.Comment: accepted MNRAS. 12 pages, 9 figure
Impact of presentation and transfer delays on complete ST-segment resolution before primary percutaneous coronary intervention: Insights from the ATLANTIC trial
Aims: The aim of this study was to identify predictors of complete ST-segment resolution (STR) pre-primary percutaneous coronary intervention (PCI) in patients enrolled in the ATLANTIC trial. Methods and results: ECGs recorded at the time of inclusion (pre-hospital [pre-H]-ECG) and in the catheterisation laboratory before angiography (pre-PCI-ECG) were analysed by an independent core laboratory. Complete STR was defined as 6570%. Complete STR occurred pre-PCI in 12.8% (204/1, 598) of patients and predicted lower 30-day composite MACCE (OR=0.10, 95% CI: 0.002-0.57, p=0.001) and total mortality (OR=0.16, 95% CI: 0.004-0.95, p=0.035). Independent predictors of complete STR included the time from index event to pre-H-ECG (OR=0.94, 95% CI: 0.89-1.00, p=0.035), use of heparins before pre- PCI-ECG (OR=1.75, 95% CI: 1.25-2.45, p=0.001) and time from pre-H-ECG to pre-PCI-ECG (OR=1.09, 95% CI: 1.03-1.16, p=0.005). In the pre-H ticagrelor group, patients with complete STR had a significantly longer delay between pre-H-ECG and pre-PCI-ECG compared to patients without complete STR (median 53 [44-73] vs. 49 [38.5-61] mins, p=0.001); however, this was not observed in the control group (in-hospital ticagrelor) (50 [40-67] vs. 49 [39-61] mins, p=0.258). Conclusions: Short patient delay, early administration of anticoagulant and ticagrelor if a long transfer delay is expected may help to achieve reperfusion prior to PCI. Pre-H treatment may be beneficial in patients with longer transfer delays, allowing the drug to become biologically active. ClinicalTrials.gov Identifier: NCT01347580
Pre-hospital administration of ticagrelor in diabetic patients with ST-elevation myocardial infarction undergoing primary angioplasty: A sub-analysis of the ATLANTIC trial
Objective: We investigated, in the contemporary era of ST-elevation myocardial infarction (STEMI) treatment, the influence of diabetes mellitus (DM) on cardiovascular outcomes, and whether pre-hospital administration of ticagrelor may affect these outcomes in a subgroup of STEMI patients with DM. Background: DM patients have high platelet reactivity and a prothrombotic condition which highlight the importance of an effective antithrombotic regimen in this high-risk population. Methods: In toal 1,630 STEMI patients enrolled in the ATLANTIC trial who underwent primary percutaneous coronary intervention (PCI) were included. Multivariate analysis was used to explore the association of DM with outcomes and potential treatment-by-diabetes interaction was tested. Results: A total of 214/1,630 (13.1%) patients had DM. DM was an independent predictor of poor myocardial reperfusion as reflected by less frequent ST-segment elevation resolution ( 6570%) after PCI (OR 0.59, 95% CI 0.43\u20130.82, P < 0.01) and was an independent predictor of the composite 30-day outcomes of death/new myocardial infarction (MI)/urgent revascularization/definite stent thrombosis (ST) (OR 2.80, 95% CI 1.62\u20134.85, P < 0.01), new MI or definite acute ST (OR 2.46, 95% CI 1.08\u20135.61, P = 0.03), and definite ST (OR 10.00, 95% CI 3.54\u201328.22, P < 0.01). No significant interaction between pre-hospital ticagrelor vs in-hospital ticagrelor administration and DM was present for the clinical, electrocardiographic and angiographic outcomes as well as for thrombolysis in myocardial infarction major bleeding. Conclusions: DM remains independently associated with poor myocardial reperfusion and worse 30-day clinical outcomes. No significant interaction was found between pre-hospital vs in-hospital ticagrelor administration and DM status. Further approaches for the treatment of DM patients are needed. CLINICAL TRIAL REGISTRATION: clinicaltrials.gov identifier: NCT01347580
Efficacy and Safety of Glycoprotein IIb/IIIa Inhibitors on Top of Ticagrelor in STEMI: A Subanalysis of the ATLANTIC Trial
BACKGROUND:
Glycoprotein IIb/IIIa inhibitors (GPIs) in combination with clopidogrel improve clinical outcome in ST-elevation myocardial infarction (STEMI); however, finding a balance that minimizes both thrombotic and bleeding risk remains fundamental. The efficacy and safety of GPI in addition to ticagrelor, a more potent P2Y12-inhibitor, have not been fully investigated.
METHODS:
1,630 STEMI patients who underwent primary percutaneous coronary intervention (PCI) were analyzed in this subanalysis of the ATLANTIC trial. Patients were divided in three groups: no GPI, GPI administration routinely before primary PCI, and GPI administration in bailout situations. The primary efficacy outcome was a composite of death, myocardial infarction, urgent target revascularization, and definite stent thrombosis at 30 days. The safety outcome was non-coronary artery bypass graft (CABG)-related PLATO major bleeding at 30 days.
RESULTS:
Compared with no GPI (n\u2009=\u2009930), routine GPI (n\u2009=\u2009525) or bailout GPI (n\u2009=\u2009175) was not associated with an improved primary efficacy outcome (4.2% no GPI vs. 4.0% routine GPI vs. 6.9% bailout GPI; p\u2009=\u20090.58). After multivariate analysis, the use of GPI in bailout situations was associated with a higher incidence of non-CABG-related bleeding compared with no GPI (odds ratio [OR] 2.96, 95% confidence interval [CI] 1.32-6.64; p\u2009=\u20090.03). However, routine GPI use compared with no GPI was not associated with a significant increase in bleeding (OR 1.78, 95% CI 0.88-3.61; p\u2009=\u20090.92).
CONCLUSION:
Use of GPIs in addition to ticagrelor in STEMI patients was not associated with an improvement in 30-day ischemic outcome. A significant increase in 30-day non-CABG-related PLATO major bleeding was seen in patients who received GPIs in a bailout situation
A model of nonlinear evolution and saturation of the turbulent MHD dynamo
The growth and saturation of magnetic field in conducting turbulent media
with large magnetic Prandtl numbers are investigated. This regime is very
common in low-density hot astrophysical plasmas. During the early (kinematic)
stage, weak magnetic fluctuations grow exponentially and concentrate at the
resistive scale, which lies far below the hydrodynamic viscous scale. The
evolution becomes nonlinear when the magnetic energy is comparable to the
kinetic energy of the viscous-scale eddies. A physical picture of the ensuing
nonlinear evolution of the MHD dynamo is proposed. Phenomenological
considerations are supplemented with a simple Fokker--Planck model of the
nonlinear evolution of the magnetic-energy spectrum. It is found that, while
the shift of the bulk of the magnetic energy from the subviscous scales to the
velocity scales may be possible, it occurs very slowly -- at the resistive,
rather than dynamical, time scale (for galaxies, this means that generation of
large-scale magnetic fields cannot be explained by this mechanism). The role of
Alfvenic motions and the implications for the fully developed isotropic MHD
turbulence are discussed.Comment: IOP latex, 19 pages, 6 figures; final published versio
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