136 research outputs found
One-by-one trap activation in silicon nanowire transistors
Flicker or 1/f noise in metal-oxide-semiconductor field-effect transistors
(MOSFETs) has been identified as the main source of noise at low frequency. It
often originates from an ensemble of a huge number of charges trapping and
detrapping. However, a deviation from the well-known model of 1/f noise is
observed for nanoscale MOSFETs and a new model is required. Here, we report the
observation of one-by-one trap activation controlled by the gate voltage in a
nanowire MOSFET and we propose a new low-frequency-noise theory for nanoscale
FETs. We demonstrate that the Coulomb repulsion between electronically charged
trap sites avoids the activation of several traps simultaneously. This effect
induces a noise reduction by more than one order of magnitude. It decreases
when increasing the electron density in the channel due to the electrical
screening of traps. These findings are technologically useful for any FETs with
a short and narrow channel.Comment: One file with paper and supplementary informatio
Only the Lonely: H I Imaging of Void Galaxies
Void galaxies, residing within the deepest underdensities of the Cosmic Web,
present an ideal population for the study of galaxy formation and evolution in
an environment undisturbed by the complex processes modifying galaxies in
clusters and groups, as well as provide an observational test for theories of
cosmological structure formation. We have completed a pilot survey for the HI
imaging aspects of a new Void Galaxy Survey (VGS), imaging 15 void galaxies in
HI in local (d < 100 Mpc) voids. HI masses range from 3.5 x 10^8 to 3.8 x 10^9
M_sun, with one nondetection with an upper limit of 2.1 x 10^8 M_sun. Our
galaxies were selected using a structural and geometric technique to produce a
sample that is purely environmentally selected and uniformly represents the
void galaxy population. In addition, we use a powerful new backend of the
Westerbork Synthesis Radio Telescope that allows us to probe a large volume
around each targeted galaxy, simultaneously providing an environmentally
constrained sample of fore- and background control sample of galaxies while
still resolving individual galaxy kinematics and detecting faint companions in
HI. This small sample makes up a surprisingly interesting collection of
perturbed and interacting galaxies, all with small stellar disks. Four galaxies
have significantly perturbed HI disks, five have previously unidentified
companions at distances ranging from 50 to 200 kpc, two are in interacting
systems, and one was found to have a polar HI disk. Our initial findings
suggest void galaxies are a gas-rich, dynamic population which present evidence
of ongoing gas accretion, major and minor interactions, and filamentary
alignment despite the surrounding underdense environment.Comment: 53 pages, 18 figures, accepted for publication in AJ. High resolution
available at http://www.astro.columbia.edu/~keejo/kreckel2010.pd
Drosophila Boi limits Hedgehog levels to suppress follicle stem cell proliferation
The Boi receptor regulates stem cell function by sequestering the diffusible hedgehog ligand
Stromal Fibroblasts in Digestive Cancer
The normal gastrointestinal stroma consists of extra-cellular matrix and a community of stromal cells including fibroblasts, myofibroblasts, smooth muscle cells, pericytes, endothelium and inflammatory cells. α-smooth muscle actin (α-SMA) positive stromal fibroblasts, often referred to as myofibroblasts or activated fibroblasts, are critical in the development of digestive cancer and help to create an environment that is permissive of tumor growth, angiogenesis and invasion. This review focusses on the contribution of activated fibroblasts in carcinogenesis and where possible directly applies this to, and draws on examples from, gastrointestinal cancer. In particular, the review expands on the definition, types and origins of activated fibroblasts. It examines the molecular biology of stromal fibroblasts and their contribution to the peritumoral microenvironment and concludes by exploring some of the potential clinical applications of this exciting branch of cancer research. Understanding the origin and biology of activated fibroblasts will help in the development of an integrated epithelial-stromal sequence to cancer that will ultimately inform cancer pathogenesis, natural history and future therapeutics
New Approaches in the Differentiation of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells toward Hepatocytes
Orthotropic liver transplantation is the only established treatment for end-stage liver diseases. Utilization of hepatocyte transplantation and bio-artificial liver devices as alternative therapeutic approaches requires an unlimited source of hepatocytes. Stem cells, especially embryonic stem cells, possessing the ability to produce functional hepatocytes for clinical applications and drug development, may provide the answer to this problem. New discoveries in the mechanisms of liver development and the emergence of induced pluripotent stem cells in 2006 have provided novel insights into hepatocyte differentiation and the use of stem cells for therapeutic applications. This review is aimed towards providing scientists and physicians with the latest advancements in this rapidly progressing field
A connectome of the adult drosophila central brain
The neural circuits responsible for behavior remain largely unknown. Previous efforts have reconstructed the complete circuits of small animals, with hundreds of neurons, and selected circuits for larger animals. Here we (the FlyEM project at Janelia and collaborators at Google) summarize new methods and present the complete circuitry of a large fraction of the brain of a much more complex animal, the fruit fly Drosophila melanogaster. Improved methods include new procedures to prepare, image, align, segment, find synapses, and proofread such large data sets; new methods that define cell types based on connectivity in addition to morphology; and new methods to simplify access to a large and evolving data set. From the resulting data we derive a better definition of computational compartments and their connections; an exhaustive atlas of cell examples and types, many of them novel; detailed circuits for most of the central brain; and exploration of the statistics and structure of different brain compartments, and the brain as a whole. We make the data public, with a web site and resources specifically designed to make it easy to explore, for all levels of expertise from the expert to the merely curious. The public availability of these data, and the simplified means to access it, dramatically reduces the effort needed to answer typical circuit questions, such as the identity of upstream and downstream neural partners, the circuitry of brain regions, and to link the neurons defined by our analysis with genetic reagents that can be used to study their functions. Note: In the next few weeks, we will release a series of papers with more involved discussions. One paper will detail the hemibrain reconstruction with more extensive analysis and interpretation made possible by this dense connectome. Another paper will explore the central complex, a brain region involved in navigation, motor control, and sleep. A final paper will present insights from the mushroom body, a center of multimodal associative learning in the fly brain
Sfrp5 Modulates Both Wnt and BMP Signaling and Regulates Gastrointestinal Organogensis in the Zebrafish, Danio rerio
Sfrp5 belongs to the family of secreted frizzled related proteins (Sfrp), secreted inhibitors of Wingless-MMTV Integration Site (Wnt) signaling, which play an important role in cancer and development. We selected sfrp5 because of its compelling expression profile in the developing endoderm in zebrafish, Danio rerio. In this study, overexpression of sfrp5 in embryos results in defects in both convergent extension (CE) by inhibition of non-canonical Wnt signaling and defects in dorsoventral patterning by inhibition of Tolloid-mediated proteolysis of the BMP inhibitor Chordin. From 25 hours post fertilization (hpf) to 3 days post fertilization (dpf), both overexpression and knockdown of Sfrp5 decrease the size of the endoderm, significantly reducing liver cell number. At 3 dpf, insulin-positive endodermal cells fail to coalesce into a single pancreatic islet. We show that Sfrp5 inhibits both canonical and non-canonical Wnt signaling during embryonic and endodermal development, resulting in endodermal abnormalities. © 2013 Stuckenholz et al
A connectome and analysis of the adult Drosophila central brain
The neural circuits responsible for animal behavior remain largely unknown. We summarize new methods and present the circuitry of a large fraction of the brain of the fruit fly Drosophila melanogaster. Improved methods include new procedures to prepare, image, align, segment, find synapses in, and proofread such large data sets. We define cell types, refine computational compartments, and provide an exhaustive atlas of cell examples and types, many of them novel. We provide detailed circuits consisting of neurons and their chemical synapses for most of the central brain. We make the data public and simplify access, reducing the effort needed to answer circuit questions, and provide procedures linking the neurons defined by our analysis with genetic reagents. Biologically, we examine distributions of connection strengths, neural motifs on different scales, electrical consequences of compartmentalization, and evidence that maximizing packing density is an important criterion in the evolution of the fly’s brain
A connectome and analysis of the adult Drosophila central brain.
The neural circuits responsible for animal behavior remain largely unknown. We summarize new methods and present the circuitry of a large fraction of the brain of the fruit fly Drosophila melanogaster. Improved methods include new procedures to prepare, image, align, segment, find synapses in, and proofread such large data sets. We define cell types, refine computational compartments, and provide an exhaustive atlas of cell examples and types, many of them novel. We provide detailed circuits consisting of neurons and their chemical synapses for most of the central brain. We make the data public and simplify access, reducing the effort needed to answer circuit questions, and provide procedures linking the neurons defined by our analysis with genetic reagents. Biologically, we examine distributions of connection strengths, neural motifs on different scales, electrical consequences of compartmentalization, and evidence that maximizing packing density is an important criterion in the evolution of the fly's brain
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