2,538 research outputs found

    Engineering physiology

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    InAs-AlSb quantum wells in tilted magnetic fields

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    InAs-AlSb quantum wells are investigated by transport experiments in magnetic fields tilted with respect to the sample normal. Using the coincidence method we find for magnetic fields up to 28 T that the spin splitting can be as large as 5 times the Landau splitting. We find a value of the g-factor of about 13. For small even-integer filling factors the corresponding minima in the Shubnikov-de Haas oscillations cannot be tuned into maxima for arbitrary tilt angles. This indicates the anti-crossing of neighboring Landau and spin levels. Furthermore we find for particular tilt angles a crossover from even-integer dominated Shubnikov-de Haas minima to odd-integer minima as a function of magnetic field

    Ergonomic Models of Anthropometry, Human Biomechanics and Operator-Equipment Interfaces

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    The Committee on Human Factors was established in October 1980 by the Commission on Behavioral and Social Sciences and Education of the National Research Council. The committee is sponsored by the Office of Naval Research, the Air Force Office of Scientific Research, the Army Research Institute for the Behavioral and Social Sciences, the National Aeronautics and Space Administration, and the National Science Foundation. The workshop discussed the following: anthropometric models; biomechanical models; human-machine interface models; and research recommendations. A 17-page bibliography is included

    Anodic respiration of Pseudomonas putida KT2440 in a stirred-tank bioreactor

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    Anodic batch production of para-hydroxybenzoic acid (pHBA) from citric acid with a genetically modified Pseudomonas putida KT2440 strain was studied in a bio-electrochemical system (BES) based on a standard lab-scale stirred-tank bioreactor at fully controlled anaerobic reaction conditions. Electron transfer to the anode was mediated by addition of KFe(CN) to the medium. Effects of varying anode surface areas (graphite rod, felt and brush), power input (stirrer speed) and mediator concentrations were investigated. The obligate aerobic P. putida grew anaerobically with mediated anodic respiration and pHBA production was observed. Anodic respiration was best applying the graphite rod electrode which showed a maximal current density of 12.5 mA cm. This is the highest measured for non-porous electrodes in BES until now. Increasing the power input to 2.93 W L (700 rpm) and online control of the redox potential E at 225 mV (vs. Ag/AgCl) in the medium by controlled addition of mediator resulted in a maximal pHBA yield of 9.91 mmolC molC which exceeds pHBA yields in the aerobic batch process by 69 % (5.87 mmolC molC )

    Cholesterol, C-Reactive Protein, and Periodontitis: HMG-CoA-Reductase Inhibitors (Statins) as Effect Modifiers

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    Common risk factors of periodontitis and cardiovascular diseases fuel the debate on interrelationships between them. The aim is to prove whether statins may influence periodontal parameters by affecting either of these factors. Out of the 4,290 subjects of SHIP (Study of Health in Pomerania), we included subjects aged >30 years (219 with statins, 2937 without) and excluded edentulous. We determined periodontal measures, cholesterol fractions, and inflammation markers. Statin use and periodontal risk factors were assessed. Gingival plaque and periodontal attachment loss were associated with systemic LDL cholesterol (P < 0.001) and C-reactive protein CRP (P = 0.019) revealing interaction with statin use. When adjusted for age, sex, smoking, diabetes, education, and dental service, statins were identified as effect modifiers abolishing the relationship between attachment loss and LDL and between gingival plaque and LDL (interactions P < 0.001). No statin-related interaction was detected with increase in CRP. The interaction supports the view of inter-relationships between periodontal and systemic inflammatory mediators

    Bim and Bmf Synergize To Induce Apoptosis in Neisseria Gonorrhoeae Infection

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    Bcl-2 family proteins including the pro-apoptotic BH3-only proteins are central regulators of apoptotic cell death. Here we show by a focused siRNA miniscreen that the synergistic action of the BH3-only proteins Bim and Bmf is required for apoptosis induced by infection with Neisseria gonorrhoeae (Ngo). While Bim and Bmf were associated with the cytoskeleton of healthy cells, they both were released upon Ngo infection. Loss of Bim and Bmf from the cytoskeleton fraction required the activation of Jun-N-terminal kinase-1 (JNK-1), which in turn depended on Rac-1. Depletion and inhibition of Rac-1, JNK-1, Bim, or Bmf prevented the activation of Bak and Bax and the subsequent activation of caspases. Apoptosis could be reconstituted in Bim-depleted and Bmf-depleted cells by additional silencing of antiapoptotic Mcl-1 and Bcl-X-L, respectively. Our data indicate a synergistic role for both cytoskeletal-associated BH3-only proteins, Bim, and Bmf, in an apoptotic pathway leading to the clearance of Ngo-infected cells

    Stationary states and phase diagram for a model of the Gunn effect under realistic boundary conditions

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    A general formulation of boundary conditions for semiconductor-metal contacts follows from a phenomenological procedure sketched here. The resulting boundary conditions, which incorporate only physically well-defined parameters, are used to study the classical unipolar drift-diffusion model for the Gunn effect. The analysis of its stationary solutions reveals the presence of bistability and hysteresis for a certain range of contact parameters. Several types of Gunn effect are predicted to occur in the model, when no stable stationary solution exists, depending on the value of the parameters of the injecting contact appearing in the boundary condition. In this way, the critical role played by contacts in the Gunn effect is clearly stablished.Comment: 10 pages, 6 Post-Script figure

    Newton's law for Bloch electrons, Klein factors and deviations from canonical commutation relations

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    The acceleration theorem for Bloch electrons in a homogenous external field is usually presented using quasiclassical arguments. In quantum mechanical versions the Heisenberg equations of motion for an operator k^(t)\hat {\vec k}(t) are presented mostly without properly defining this operator. This leads to the surprising fact that the generally accepted version of the theorem is incorrect for the most natural definition of k^\hat {\vec k}. This operator is shown not to obey canonical commutation relations with the position operator. A similar result is shown for the phase operators defined via the Klein factors which take care of the change of particle number in the bosonization of the field operator in the description of interacting fermions in one dimension. The phase operators are also shown not to obey canonical commutation relations with the corresponding particle number operators. Implications of this fact are discussed for Tomonaga-Luttinger type models.Comment: 9 pages,1 figur

    Andreev magnetotransport in low-dimensional proximity structures: Spin-dependent conductance enhancement

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    We study the excess conductance due to the superconducting proximity effect in a ballistic two-dimensional electron system subject to an in-plane magnetic field. We show that under certain conditions the interplay of the Zeeman spin splitting and the effect of a screening supercurrent gives rise to a spin-selective Andreev enhancement of the conductance and anomalies in its voltage, temperature and magnetic field characteristics. The magnetic-field influence on Andreev reflection is discussed in the context of using superconducting hybrid junctions for spin detection.Comment: 4 pages, 5 figure
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