311 research outputs found
Diffusion-emission theory of photon enhanced thermionic emission solar energy harvesters
Numerical and semi-analytical models are presented for
photon-enhanced-thermionic-emission (PETE) devices. The models take diffusion
of electrons, inhomogeneous photogeneration, and bulk and surface recombination
into account. The efficiencies of PETE devices with silicon cathodes are
calculated. Our model predicts significantly different electron affinity and
temperature dependence for the device than the earlier model based on a
rate-equation description of the cathode. We show that surface recombination
can reduce the efficiency below 10% at the cathode temperature of 800 K and the
concentration of 1000 suns, but operating the device at high injection levels
can increase the efficiency to 15%.Comment: 5 pages, 4 figure
The Impact of Aortic Occlusion Balloon on Mortality After Endovascular Repair of Ruptured Abdominal Aortic Aneurysms: A Meta-analysis and Meta-regression Analysis
INTRODUCTION:We aimed to investigate whether the use of aortic occlusion balloon (AOB) has an impact on mortality of patients undergoing endovascular repair of ruptured abdominal aortic aneurysms (RAAAs).METHODS:A meta-analysis of the English-language literature was undertaken through February 2013. Articles reporting data on outcome after endovascular repair of RAAAs were identified and information regarding the use of AOB was sought.RESULTS:Included in this meta-analysis were 39 eligible studies reporting 1277 patients. The pooled perioperative mortality was 21.6% (95% CI 18.1-25.1%). There was significant within-study heterogeneity (I(2) 50.2%, P < 0.001). A total of 200 patients required AOB with an estimated pooled proportion of 14.1% (8.9-19.3%). Individual random-effects meta-regression investigating the effect of AOB and other risk factors on mortality revealed a significant linear association of hemodynamic instability, bifurcated endograft approach, and primary conversion to open repair with mortality and a nonlinear (second degree polynomial) association of AOB with mortality. On multivariable meta-regression models, both hemodynamic instability and AOB were found to be statistically significant, independent predictors of mortality. In particular, there was a statistically significant negative correlation between AOB and mortality and a positive effect of hemodynamic instability on mortality. In practical terms, mortality was significantly higher in studies with a higher proportion of hemodynamically unstable patients and lower in studies with a higher rate of AOB use.CONCLUSION:This study provides meta-analytical evidence that the use of an AOB in unstable RAAA patients undergoing endovascular repair may improve the results
Monthly average daily global and diffuse solar radiation based on sunshine duration and clearness index for Brasov, Romania
The main objective of this study is to develop single location appropriate models for the estimation of the monthly average daily global and diffuse horizontal solar radiation for Brasov, Romania. The study focuses particularly on models based on the sunshine duration and clearness index. The data used for the calibration of the models were collected during a period of 4 yr, between November 2008 and October 2012, at the Transilvania University of Brasov. The testing and validation of the models was carried out using data from the online SoDa database for Brasov for the year 2005. Different statistical error tests were applied to evaluate the accuracy of the models. The predicted values are also compared with values from three other known models concerning the global and diffuse solar radiation. A new mixed model was developed for the estimation of monthly average daily global horizontal solar radiation. The data processing was performed by means of a real-time interface developed with LabVIEW graphical programming language. The parameters taken into account were the relative sunshine, the clearness index, the extraterrestrial radiation, the latitude and the longitude. The methodology is simple and effective and may be applied for any region. Its effectiveness was proven through comparison with global models
A Safety Transport Model for Validation of UK Coach Operators for School Journeys
Coaches are considered to be one of the safest modes of transport for children in the UK. In the last 10 years alone, 1191 children were injured in 371 coach crashes. Though the government has strict regulations to maintain road worthiness of the coaches, operator non-compliance was the major reason for these accidents. In last year alone, 137 coach operator licenses have been revoked due to operator non-compliance in the UK. Currently, there is no process to reliably mitigate the safety risks of children travelling by coaches. This has created a requirement to validate all the coach operators before using their coaches for school trips. This paper proposes a novel safety model for validation of coach operators prior to commencement of coach journeys
Conditions determining the morphology and nanoscale magnetism of Co nanoparticles: Experimental and numerical studies
Co-based nanostructures ranging from core-shell to hollow nanoparticles were
produced by varying the reaction time and the chemical environment during the
thermal decomposition of Co2(CO)8. Both structural characterization and kinetic
model simulation illustrate that the diffusivities of Co and oxygen determine
the growth ratio and the final morphology of the nanoparticles. Exchange
coupling between Co and Co-oxide in core/shell nanoparticles induced a shift of
field-cooled hysteresis loops that is proportional to the shell thickness, as
verified by numerical studies. The increased nanocomplexity when going from
core/shell to hollow particles, also leads to the appearance of hysteresis
above 300 K due to an enhancement of the surface anisotropy resulting from the
additional spin-disordered surfaces.Comment: 29 pages including 11 figures embedded. Submitted to Phys. Rev.
Rapid Millifluidic Synthesis of Stable High Magnetic Moment FexCy Nanoparticles for Hyperthermia
A millifluidic reactor with a 0.76 mm internal diameter was utilized for the synthesis of monodisperse, high magnetic moment, iron carbide (FexCy) nanoparticles by thermal decomposition of iron pentacarbonyl (Fe(CO)5) in 1-octadecene in the presence of oleylamine at 22 min nominal residence time. The effect of reaction conditions (temperature and pressure) on the size, morphology, crystal structure, and magnetic properties of the nanoparticles was investigated. The system developed facilitated the thermal decomposition of precursor at reaction conditions (up to 265 °C and 4 bar) that cannot be easily achieved in conventional batch reactors. The degree of carbidization was enhanced by operating at elevated temperature and pressure. The nanoparticles synthesized in the flow reactor had size 9–18 nm and demonstrated high saturation magnetization (up to 164 emu/gFe). They further showed good stability against oxidation after 2 months of exposure in air, retaining good saturation magnetization values with a change of no more than 10% of the initial value. The heating ability of the nanoparticles in an alternating magnetic field was comparable with other ferrites reported in the literature, having intrinsic loss power values up to 1.52 nHm2 kg–1
MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer
Prostate cancer (PCa) shows strong dependence on the androgen receptor (AR) pathway. Here, we show that squalene epoxidase (SQLE), an enzyme of the cholesterol biosynthesis pathway, is overexpressed in advanced PCa and its expression correlates with poor survival. SQLE expression is controlled by micro-RNA 205 (miR-205), which is significantly downregulated in advanced PCa. Restoration of miR-205 expression or competitive inhibition of SQLE led to inhibition of de novo cholesterol biosynthesis. Furthermore, SQLE was essential for proliferation of AR-positive PCa cell lines, including abiraterone or enzalutamide resistant derivatives, and blocked transactivation of the AR pathway. Inhibition of SQLE with the FDA approved antifungal drug terbinafine also efficiently blocked orthotopic tumour growth in mice. Finally, terbinafine reduced levels of prostate specific antigen (PSA) in three out of four late-stage PCa patients. These results highlight SQLE as a therapeutic target for the treatment of advanced PCa
High coercivity cobalt carbide nanoparticles processed via polyol reaction: A new permanent magnet material
Cobalt carbide nanoparticles were processed using polyol reduction chemistry
that offers high product yields in a cost effective single-step process.
Particles are shown to be acicular in morphology and typically assembled as
clusters with room temperature coercivities greater than 4 kOe and maximum
energy products greater than 20 KJ/m3. Consisting of Co3C and Co2C phases, the
ratio of phase volume, particle size, and particle morphology all play
important roles in determining permanent magnet properties. Further, the
acicular particle shape provides an enhancement to the coercivity via dipolar
anisotropy energy as well as offering potential for particle alignment in
nanocomposite cores. While Curie temperatures are near 510K at temperatures
approaching 700 K the carbide powders experience an irreversible dissociation
to metallic cobalt and carbon thus limiting operational temperatures to near
room temperature.Comment: Total 28 pages, 10 figures, and 1 tabl
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