VASCOMP 2. The V/STOL aircraft sizing and performance computer program. Volume 6: User's manual, revision 3

This report describes the use of the V/STOL Aircraft Sizing and Performance Computer Program (VASCOMP II). The program is useful in performing aircraft parametric studies in a quick and cost efficient manner. Problem formulation and data development were performed by the Boeing Vertol Company and reflects the present preliminary design technology. The computer program, written in FORTRAN IV, has a broad range of input parameters, to enable investigation of a wide variety of aircraft. User oriented features of the program include minimized input requirements, diagnostic capabilities, and various options for program flexibility

A Computational Model of Aging and Calcification in the Aortic Heart Valve

The aortic heart valve undergoes geometric and mechanical changes over time. The cusps of a normal, healthy valve thicken and become less extensible over time. In the disease calcific aortic stenosis (CAS), calcified nodules progressively stiffen the cusps. The local mechanical changes in the cusps, due to either normal aging or pathological processes, affect overall function of the valve. In this paper, we propose a computational model for the aging aortic valve that connects local changes to overall valve function. We extend a previous model for the healthy valve to describe aging. To model normal/uncomplicated aging, leaflet thickness and extensibility are varied versus age according to experimental data. To model calcification, initial sites are defined and a simple growth law is assumed. The nodules then grow over time, so that the area of calcification increases from one model to the next model representing greater age. Overall valve function is recorded for each individual model to yield a single simulation of valve function over time. This simulation is the first theoretical tool to describe the temporal behavior of aortic valve calcification. The ability to better understand and predict disease progression will aid in design and timing of patient treatments for CAS

The temperature dependence of FeRh's transport properties

The finite-temperature transport properties of FeRh compounds are investigated by first-principles Density Functional Theory-based calculations. The focus is on the behavior of the longitudinal resistivity with rising temperature, which exhibits an abrupt decrease at the metamagnetic transition point, $T = T_m$ between ferro- and antiferromagnetic phases. A detailed electronic structure investigation for $T \geq 0$ K explains this feature and demonstrates the important role of (i) the difference of the electronic structure at the Fermi level between the two magnetically ordered states and (ii) the different degree of thermally induced magnetic disorder in the vicinity of $T_m$, giving different contributions to the resistivity. To support these conclusions, we also describe the temperature dependence of the spin-orbit induced anomalous Hall resistivity and Gilbert damping parameter. For the various response quantities considered the impact of thermal lattice vibrations and spin fluctuations on their temperature dependence is investigated in detail. Comparison with corresponding experimental data finds in general a very good agreement

Fluctuation-dissipation theorem and quantum tunneling with dissipation

We suggest to take the fluctuation-dissipation theorem of Callen and Welton as a basis to study quantum dissipative phenomena (such as macroscopic quantum tunneling) in a manner analogous to the Nambu-Goldstone theorem for spontaneous symmetry breakdown. It is shown that the essential physical contents of the Caldeira-Leggett model such as the suppression of quantum coherence by Ohmic dissipation are derived from general principles only, namely, the fluctuation-dissipation theorem and unitarity and causality (i.e., dispersion relations), without referring to an explicit form of the Lagrangian. An interesting connection between quantum tunneling with Ohmic dissipation and the Anderson's orthogonality theorem is also noted.Comment: To appear in Phys. Rev.

Does Young's equation hold on the nanoscale? A Monte Carlo test for the binary Lennard-Jones fluid

When a phase-separated binary ($A+B$) mixture is exposed to a wall, that preferentially attracts one of the components, interfaces between A-rich and B-rich domains in general meet the wall making a contact angle $\theta$. Young's equation describes this angle in terms of a balance between the $A-B$ interfacial tension $\gamma_{AB}$ and the surface tensions $\gamma_{wA}$, $\gamma_{wB}$ between, respectively, the $A$- and $B$-rich phases and the wall, $\gamma _{AB} \cos \theta =\gamma_{wA}-\gamma_{wB}$. By Monte Carlo simulations of bridges, formed by one of the components in a binary Lennard-Jones liquid, connecting the two walls of a nanoscopic slit pore, $\theta$ is estimated from the inclination of the interfaces, as a function of the wall-fluid interaction strength. The information on the surface tensions $\gamma_{wA}$, $\gamma_{wB}$ are obtained independently from a new thermodynamic integration method, while $\gamma_{AB}$ is found from the finite-size scaling analysis of the concentration distribution function. We show that Young's equation describes the contact angles of the actual nanoscale interfaces for this model rather accurately and location of the (first order) wetting transition is estimated.Comment: 6 pages, 6 figure

Near-Constant Mean Curvature Solutions of the Einstein Constraint Equations with Non-Negative Yamabe Metrics

We show that sets of conformal data on closed manifolds with the metric in the positive or zero Yamabe class, and with the gradient of the mean curvature function sufficiently small, are mapped to solutions of the Einstein constraint equations. This result extends previous work which required the conformal metric to be in the negative Yamabe class, and required the mean curvature function to be nonzero.Comment: 15 page

NATO and CSDP: party and public positioning in Germany and France

This is the final version. Available on open access from the NATO Defense College via the link in this recordVolkswagen Foundatio

The Constraints in Spherically Symmetric General Relativity II --- Identifying the Configuration Space: A Moment of Time Symmetry

We continue our investigation of the configuration space of general relativity begun in I (gr-qc/9411009). Here we examine the Hamiltonian constraint when the spatial geometry is momentarily static (MS). We show that MS configurations satisfy both the positive quasi-local mass (QLM) theorem and its converse. We derive an analytical expression for the spatial metric in the neighborhood of a generic singularity. The corresponding curvature singularity shows up in the traceless component of the Ricci tensor. We show that if the energy density of matter is monotonically decreasing, the geometry cannot be singular. A supermetric on the configuration space which distinguishes between singular geometries and non-singular ones is constructed explicitly. Global necessary and sufficient criteria for the formation of trapped surfaces and singularities are framed in terms of inequalities which relate appropriate measures of the material energy content on a given support to a measure of its volume. The strength of these inequalities is gauged by exploiting the exactly solvable piece-wise constant density star as a template.Comment: 50 pages, Plain Tex, 1 figure available from the authors

A short artificial antimicrobial peptide shows potential to prevent or treat bone infections.

Infection of bone is a severe complication due to the variety of bacteria causing it, their resistance against classical antibiotics, the formation of a biofilm and the difficulty to eradicate it. Antimicrobial peptides (AMPs) are naturally occurring peptides and promising candidates for treatment of joint infections. This study aimed to analyze the effect of short artificial peptides derived from an optimized library regarding (1) antimicrobial effect on different bacterial species, (2) efficacy on biofilms, and (3) effect on osteoblast‑like cells. Culturing the AMP-modifications with Escherichia coli, Enterococcus faecalis, Pseudomonas aeruginosa, Staphylococcus aureus (including clinical isolates of MRSA and MSSA) and Staphylococcus epidermidis identified one candidate that was most effective against all bacteria. This AMP was also able to reduce biofilm as demonstrated by FISH and microcalorimetry. Osteoblast viability and differentiation were not negatively affected by the AMP. A cation concentration comparable to that physiologically occurring in blood had almost no negative effect on AMP activity and even with 10% serum bacterial growth was inhibited. Bacteria internalized into osteoblasts were reduced by the AMP. Taken together the results demonstrate a high antimicrobial activity of the AMP even against bacteria incorporated in a biofilm or internalized into cells without harming human osteoblasts