Impact of inflammation-based prognostic score on survival after curative thoracoscopic esophagectomy for esophageal cancer

AbstractBackgroundDespite recent improvements in early detection, progress in surgical techniques, and development of chemoradiation therapies, prognosis of esophageal cancer remains poor. The aim of the present study was to assess whether Glasgow Prognostic Score (GPS), an inflammation-based prognostic score, has prognostic value independent of conventional clinicopathological criteria in patients undergoing curative resection for esophageal cancer, even in elderly patients.MethodsWe retrospectively reviewed the database of 141 consecutive patients with histologically verified esophageal squamous cell carcinoma who underwent potentially curative surgery in our institute, between January 2006 and December 2014. GPS and neutrophil lymphocyte ratio (NLR) were calculated.ResultsOn multivariate analysis, TNM stage (p < 0.0001) and GPS (p = 0.041) were independently associated with worse prognosis in overall patients with esophageal cancer.Multivariate analysis evaluated the prognostic factors in two different patient groups: patients younger than 70 years (non-elderly) and those aged 70 years or more (elderly).Multivariate analysis demonstrated that TNM stage (p = 0.0003) was an only independent risk factor for a worse prognosis among non-elderly group. Meanwhile, multivariate analysis demonstrated that TNM stage (p = 0.001) and GPS (p = 0.043) were the independent risk factor for a worse prognosis among elderly group.ConclusionThe present study demonstrated that GPS is associated with prognosis and can be considered as an independent prognostic marker in patients who underwent esophagectomy. Moreover, the GPS has the advantage of being simple to measure, routinely available and well standardized. But the present study failed to confirm the NLR as a significant predictor of survival following resection for esophageal cancer

Adaptive Adjustable Tricycle

As a part of the Cal Poly Mechanical Engineering curriculum, all students must take part in a three quarter long senior design project. Students are presented with existing problems, select a project, and then apply the knowledge they have gained throughout their academic career to design and build a solution. The intent behind this project is to create an experience that is similar to an engineering project in industry, by applying engineering and teamwork skills to solve a problem. Team Trikeceratops’ mission was to develop an adaptive adjustable tricycle to be used in the Special Education Department of the Buena Park School District for recreational use and physical therapy. The design team was comprised of four Cal Poly mechanical engineering students and a kinesiology student-consultant who worked through three primary design phases over the course of nine months to develop a functional prototype. These phases included ideation and conception, detailed design, and manufacturing, all of which have different requirements that call for a variety of skill sets. During ideation and conception, Team Trikeceratops developed lists of requirements from sponsor input, divided the project into components, generated ideas, and refined the options to reach an overall conceptual design. This initial phase was also essential in developing a team mentality and establishing the basic rules and guidelines by which the team would operate. At the end of ideation and conception, the team had developed a full theoretical design that would meet the customer requirements. Detailed design was the second phase wherein the students took the conceptual design and applied engineering knowledge to clearly define the solution. In this phase, most of the more stereotypical engineering occurred. Students sized tubing for the frame, performed calculations and analysis on components, created manufacturing drawings, identified part numbers for acquisition, and began contacting companies for parts and services. At the end of detailed design, the team had a bill of materials, manufacturing plan, contact information for suppliers, and fully dimensioned drawings for manufacturing custom parts. The third phase of product development was manufacturing and testing. Students cut, notched, welded, and machined various custom components while simultaneously overcoming problems of improper sizing and extended lead times on ordered materials. Following this process, the students tested the tricycle to ensure that it met the customer requirements set forth in the Design Verification Plan and Report (DVPR). At the end of this phase a functioning prototype was completed and staged for delivery and the final report was compiled. This remainder of this report details Team Trikeceratops’ progress from initial concept generation to prototype realization and explores each part of the aforementioned engineering design process in depth

Hierarchically Porous ZSM-5 Synthesized by Nonionic- and Cationic-Templating Routes and Their Catalytic Activity in Liquid-Phase Esterification

Hierarchically porous MFI zeolites (ZSM-5) have been synthesized by hydrothermal treatment in the presence of trialkoxysilylated-derivatives of nonionic poly(oxyethylene) alkyl ether or alkyl quaternary ammonium cation as mesopore-generating agent, along with tetrapropylammonium cation as zeolite structure-directing agent. Powder X-ray diffraction revealed that zeolites have been crystallized, and scanning electron microscopy showed rugged surface morphology that was quite different from conventional ZSM-5. The mesoporosity was confirmed by nitrogen adsorption-desorption measurement showing type IV isotherms with narrow distribution of mesopore diameters. The catalytic activity of these mesoporous ZSM-5 was tested in liquid-phase esterification of benzyl alcohol with hexanoic acid. The conversion of benzyl alcohol on mesoporous ZSM-5 prepared via cationic-templating route was almost 100%, being much higher than on mesoporous ZSM-5 prepared with silylated nonionic surfactant as well as on conventional ZSM-5 with no mesopores. The presence of Brønsted acid sites, together with the mesopores, was responsible for this catalytic conversion, as confirmed by pyridine adsorption monitored by in situ infrared and 27Al magic angle spinning nuclear magnetic resonance spectroscopy

Quantum states and linear response in dc and electromagnetic fields for charge current and spin polarization of electrons at Bi/Si interface with giant spin-orbit coupling

An expansion of the nearly free-electron model constructed by Frantzeskakis, Pons and Grioni [Phys. Rev. B {\bf 82}, 085440 (2010)] describing quantum states at Bi/Si(111) interface with giant spin-orbit coupling is developed and applied for the band structure and spin polarization calculation, as well as for the linear response analysis for charge current and induced spin caused by dc field and by electromagnetic radiation. It is found that the large spin-orbit coupling in this system may allow resolving the spin-dependent properties even at room temperature and at realistic collision rate. The geometry of the atomic lattice combined with spin-orbit coupling leads to an anisotropic response both for current and spin components related to the orientation of the external field. The in-plane dc electric field produces only the in-plane components of spin in the sample while both the in-plane and out-of-plane spin components can be excited by normally propagating electromagnetic wave with different polarizations.Comment: 10 pages, 9 figure

Ion-dispersion and rapid electron fluctuations in the cusp: a case study

We present results from co-ordinated measurements with the low altitude REIMEI satellite and the ESR (EISCAT Svalbard Radar), together with other ground-based instruments carried out in February 2006. The results mainly relate to the dayside cusp where clear signatures of so-called ion-dispersion are seen in the satellite data. The cusp ion-dispersion is important for helping to understand the temporal and spatial structure of magnetopause reconnection. Whenever a satellite crosses boundaries of flux tubes or convection cells, cusp structures such as ion-dispersion will always be encountered. In our case we observed 3 distinct steps in the ion energy, but it includes at least 2 more steps as well, which we interpret as temporal features in relation to pulsed reconnection at the magnetopause. In addition, fast variations of the electron flux and energy occurring during these events have been studied in detail. The variations of the electron population, if interpreted as structures crossed by the REIMEI satellite, would map near the magnetopause to similar features as observed previously with the Cluster satellites. These were explained as Alfvén waves originating from an X-line of magnetic reconnection