Propagation of Bose-Einstein condensates in a magnetic waveguide

Gaseous Bose-Einstein condensates of 2-3 million atoms were loaded into a microfabricated magnetic trap using optical tweezers. Subsequently, the condensates were released into a magnetic waveguide and propagated 12 mm. Single-mode propagation was observed along homogeneous segments of the waveguide. Inhomogeneities in the guiding potential arose from geometric deformations of the microfabricated wires and caused strong transverse excitations. Such deformations may restrict the waveguide physics that can be explored with propagating condensates.Comment: 5 pages, 4 figure

Eliminating the mean-field shift in multicomponent Bose-Einstein condensates

We demonstrate that the nonlinear mean-field shift in a multi-component Bose-Einstein condensate may be eliminated by controlling the two-body interaction coefficients. This modification is achieved by, e.g., suitably engineering the environment of the condensate. We consider as an example the case of a two-component condensate in a tightly confining atom waveguide. Modification of the atom-atom interactions is then achieved by varying independently the transverse wave function of the two components. Eliminating the density dependent phase shift in a high-density atomic beam has important applications in atom interferometry and precision measurement

Bohr-Sommerfeld Quantization of Periodic Orbits

We show, that the canonical invariant part of $\hbar$ corrections to the Gutzwiller trace formula and the Gutzwiller-Voros spectral determinant can be computed by the Bohr-Sommerfeld quantization rules, which usually apply for integrable systems. We argue that the information content of the classical action and stability can be used more effectively than in the usual treatment. We demonstrate the improvement of precision on the example of the three disk scattering system.Comment: revte

A Storage Ring for Neutral Atoms

We have demonstrated a storage ring for ultra-cold neutral atoms. Atoms with mean velocities of 1 m/s corresponding to kinetic energies of ~100 neV are confined to a 2 cm diameter ring by magnetic forces produced by two current-carrying wires. Up to 10^6 atoms are loaded at a time in the ring, and 7 revolutions are clearly observed. Additionally, we have demonstrated multiple loading of the ring and deterministic manipulation of the longitudinal velocity distribution of the atoms using applied laser pulses. Applications of this ring include large area atom interferometers and cw monochromatic atomic beam generation.Comment: 4 pages, 5 figure

Spatial Transferability of an Agent‑Based Model to Simulate Taenia solium control interventions

Background Models can be used to study and predict the impact of interventions aimed at controlling the spread of infectious agents, such as Taenia solium, a zoonotic parasite whose larval stage causes epilepsy and economic loss in many rural areas of the developing nations. To enhance the credibility of model estimates, calibration against observed data is necessary. However, this process may lead to a paradoxical dependence of model parameters on location-specific data, thus limiting the model’s geographic transferability. Methods In this study, we adopted a non-local model calibration approach to assess whether it can improve the spatial transferability of CystiAgent, our agent-based model of local-scale T. solium transmission. The calibration dataset for CystiAgent consisted of cross-sectional data on human taeniasis, pig cysticercosis and pig serology collected in eight villages in Northwest Peru. After calibration, the model was transferred to a second group of 21 destination villages in the same area without recalibrating its parameters. Model outputs were compared to pig serology data collected over a period of 2 years in the destination villages during a trial of T. solium control interventions, based on mass and spatially targeted human and pig treatments. Results Considering the uncertainties associated with empirical data, the model produced simulated pre-intervention pig seroprevalences that were successfully validated against data collected in 81% of destination villages. Furthermore, the model outputs were able to reproduce validated pig seroincidence values in 76% of destination villages when compared to the data obtained after the interventions. The results demonstrate that the CystiAgent model, when calibrated using a non-local approach, can be successfully transferred without requiring additional calibration. Conclusions This feature allows the model to simulate both baseline pre-intervention transmission conditions and the outcomes of control interventions across villages that form geographically homogeneous regions, providing a basis for developing large-scale models representing T. solium transmission at a regional level

A new cell primo-culture method for freshwater benthic diatom communities

A new cell primo-culture method was developed for the benthic diatom community isolated from biofilm sampled in rivers. The approach comprised three steps: (1) scraping biofilm from river pebbles, (2) diatom isolation from biofilm, and (3) diatom community culture. With a view to designing a method able to stimulate the growth of diatoms, to limit the development of other microorganisms, and to maintain in culture a community similar to the original natural one, different factors were tested in step 3: cell culture medium (Chu No 10 vs Freshwater “WC” medium modified), cell culture vessel, and time of culture. The results showed that using Chu No 10 medium in an Erlenmeyer flask for cell culture was the optimal method, producing enough biomass for ecotoxicological tests as well as minimising development of other microorganisms. After 96 h of culture, communities differed from the original communities sampled in the two rivers studied. Species tolerant of eutrophic or saprobic conditions were favoured during culture. This method of diatom community culture affords the opportunity to assess, in vitro, the effects of different chemicals or effluents (water samples andindustrial effluents) on diatom communities, as well as on diatom cells, from a wide range of perspectives

Mach's Principle and the Origin of Inertia

The current status of Mach's principle is discussed within the context of general relativity. The inertial properties of a particle are determined by its mass and spin, since these characterize the irreducible unitary representations of the inhomogeneous Lorentz group. The origin of the inertia of mass and intrinsic spin are discussed and the inertia of intrinsic spin is studied via the coupling of intrinsic spin with rotation. The implications of spin-rotation coupling and the possibility of history dependence and nonlocality in relativistic physics are briefly mentioned.Comment: 14 pages. Dedicated to Carl Brans in honor of his 80th birthday. To appear in the Brans Festschrift; v2: typo corrected, published in: At the Frontier of Spacetime, edited by T. Asselmeyer-Maluga (Springer, 2016), Chapter 10, pp. 177-18

Physics with Coherent Matter Waves

This review discusses progress in the new field of coherent matter waves, in particular with respect to Bose-Einstein condensates. We give a short introduction to Bose-Einstein condensation and the theoretical description of the condensate wavefunction. We concentrate on the coherence properties of this new type of matter wave as a basis for fundamental physics and applications. The main part of this review treats various measurements and concepts in the physics with coherent matter waves. In particular we present phase manipulation methods, atom lasers, nonlinear atom optics, optical elements, interferometry and physics in optical lattices. We give an overview of the state of the art in the respective fields and discuss achievements and challenges for the future

Selective nanomanipulation using optical forces

We present a detailed theoretical study of the recent proposal for selective nanomanipulation of nanometric particles above a substrate using near-field optical forces [Chaumet {\it et al.} Phys. Rev. Lett. {\bf 88}, 123601 (2002)]. Evanescent light scattering at the apex of an apertureless near-field probe is used to create an optical trap. The position of the trap is controlled on a nanometric scale via the probe and small objects can be selectively trapped and manipulated. We discuss the influence of the geometry of the particles and the probe on the efficiency of the trap. We also consider the influence of multiple scattering among the particles on the substrate and its effect on the robustness of the trap.Comment: 12 pages, 17 figure

Homozygosity for a missense mutation in the 67 kDa isoform of glutamate decarboxylase in a family with autosomal recessive spastic cerebral palsy: parallels with Stiff-Person Syndrome and other movement disorders

Background Cerebral palsy (CP) is an heterogeneous group of neurological disorders of movement and/or posture, with an estimated incidence of 1 in 1000 live births. Non-progressive forms of symmetrical, spastic CP have been identified, which show a Mendelian autosomal recessive pattern of inheritance. We recently described the mapping of a recessive spastic CP locus to a 5 cM chromosomal region located at 2q24-31.1, in rare consanguineous families. Methods Here we present data that refine this locus to a 0.5 cM region, flanked by the microsatellite markers D2S2345 and D2S326. The minimal region contains the candidate gene GAD1, which encodes a glutamate decarboxylase isoform (GAD67), involved in conversion of the amino acid and excitatory neurotransmitter glutamate to the inhibitory neurotransmitter γ-aminobutyric acid (GABA). Results A novel amino acid mis-sense mutation in GAD67 was detected, which segregated with CP in affected individuals. Conclusions This result is interesting because auto-antibodies to GAD67 and the more widely studied GAD65 homologue encoded by the GAD2 gene, are described in patients with Stiff-Person Syndrome (SPS), epilepsy, cerebellar ataxia and Batten disease. Further investigation seems merited of the possibility that variation in the GAD1 sequence, potentially affecting glutamate/GABA ratios, may underlie this form of spastic CP, given the presence of anti-GAD antibodies in SPS and the recognised excitotoxicity of glutamate in various contexts