Lupus systémique et atteinte rénale: Apport des anticorps anti-SSA

Le but de notre travail est de déterminer le profil des auto-anticorps chez 30 patients ayant un lupus systémique avec ou sans atteinte rénale afind'établir une corrélation clinico-immunologique entre la néphropathie lupique et ces auto-anticorps. Il s'agit d'une étude transversale de 30 patients atteints de lupus érythémateux systémique diagnostiqués au service de dermatologie durant la période de Décembre 2010 à Décembre 2012 et réalisée conjointement avec le laboratoire d'immunologie. Les anticorps anti-ADN étaient retrouvés chez 17 patients (56.7%) suivis des anti-SSA dans 12 cas (40%).Cinq patients (62.5%) ayant une atteinte rénale avaient des anticorps anti DNA négatifs. Parmi ces patients avec atteinte rénale, 37.5% avaient des anticorps anti SSA sans anticorps anti DNA. La moitié des patients ayant une atteinte rénale (50%) avaient desanticorps anti SSA positifs. Notre série montre l'importance des anticorps anti-SSA surtout chez des patients avec des anticorps anti-DNA négatifsnon seulement pour le diagnostic du lupus systémique mais aussi pour déceler certaines manifestations systémiques comme l'atteinte rénale

Coupled systems of fractional equations related to sound propagation: analysis and discussion

In this note we analyse the propagation of a small density perturbation in a one-dimensional compressible fluid by means of fractional calculus modelling, replacing thus the ordinary time derivative with the Caputo fractional derivative in the constitutive equations. By doing so, we embrace a vast phenomenology, including subdiffusive, superdiffusive and also memoryless processes like classical diffusions. From a mathematical point of view, we study systems of coupled fractional equations, leading to fractional diffusion equations or to equations with sequential fractional derivatives. In this framework we also propose a method to solve partial differential equations with sequential fractional derivatives by analysing the corresponding coupled system of equations

Linear Parsing Expression Grammars

PEGs were formalized by Ford in 2004, and have several pragmatic operators (such as ordered choice and unlimited lookahead) for better expressing modern programming language syntax. Since these operators are not explicitly defined in the classic formal language theory, it is significant and still challenging to argue PEGs' expressiveness in the context of formal language theory.Since PEGs are relatively new, there are several unsolved problems.One of the problems is revealing a subclass of PEGs that is equivalent to DFAs. This allows application of some techniques from the theory of regular grammar to PEGs. In this paper, we define Linear PEGs (LPEGs), a subclass of PEGs that is equivalent to DFAs. Surprisingly, LPEGs are formalized by only excluding some patterns of recursive nonterminal in PEGs, and include the full set of ordered choice, unlimited lookahead, and greedy repetition, which are characteristic of PEGs. Although the conversion judgement of parsing expressions into DFAs is undecidable in general, the formalism of LPEGs allows for a syntactical judgement of parsing expressions.Comment: Parsing expression grammars, Boolean finite automata, Packrat parsin

DIAGNOSTIC BIOLOGIQUE DE LA BRUCELLOSE HUMAINE: COMPARAISON DE DEUX TECHNIQUES DE SEROAGGLUTINATION

objective: Evaluate the technical characteristics of two agglutination techniques used for the detection of serum antibodies of Brucella. Material and methods: The search for Brucella antibodies was performed in 100 serum samples. They come from patients with brucellosis was suspected on clinical and epidemiological criteria. The average age was 31 years with a standard deviation of 1.5 and a sex ratio (M / W) is equal to 2. The two methods used are (manual): 1- BRUCELLACAPT® (Vircell,Spain) 2- ROSE BENGAL ® (Bio-Rad, France). Results: The results showed a concordance between the two techniques of 92% (80% negative results and 12% positive), and discrepancy of 8%. Conclusion: Discordant results demonstrate the need to always integrate the  approach diagnostic of a clinical and epidemiological data associated with biological data, and secondly, to take into account the  threshold value of detection of serological markers of the technique used.Objectif : Evaluer les caractéristiques de deux techniques de séroagglutination  pour la détection des anticorps sériques anti-Brucella. Matériel et méthodes : La recherche des anticorps anti Brucella a été effectuée sur 100 échantillons de sérums,  provenant de patients  chez qui la brucellose a été suspectée sur des critères cliniques et épidémiologiques. La moyenne d’âge est de 31 ans avec un écart type de 1,5 et un sex-ratio (H/F) de 2. Les deux méthodes de séroagglutination utilisées (manuelles) sont : 1- BRUCELLACAPT® (Vircell,Espagne) 2- ROSE BENGALE® (Bio Rad, France). Résultats : Les résultats  ont montré une concordance entre les deux techniques de 92% (80% négatifs et 12% positifs), et une disconcordance de 8%. Conclusion : Les résultats discordants démontrent la nécessité d’intégrer à la démarche diagnostic, les données cliniques, épidémiologiques,  l’évolution de la maladie, ainsi que les données biologiques et  de prendre en considération la valeur seuil  de détection des marqueurs sérologiques de la technique utilisée

An Inverse Method to Obtain Porosity, Fibre Diameterand Density of Fibrous Sound Absorbing Materials

Characterization of sound absorbing materials is essential to predict its acoustic behaviour. The most commonly used models to do so consider the flow resistivity, porosity, and average fibre diameter as parameters to determine the acoustic impedance and sound absorbing coefficient. Besides direct experimental techniques, numerical approaches appear to be an alternative to estimate the material's parameters. In this work an inverse numerical method to obtain some parameters of a fibrous material is presented. Using measurements of the normal incidence sound absorption coefficient and then using the model proposed by Voronina, subsequent application of basic minimization techniques allows one to obtain the porosity, average fibre diameter and density of a sound absorbing material. The numerical results agree fairly well with the experimental data.This work has been supported by the Ministerio de Educacion y Ciencia-D.G. Investigacion (BIA2007-68098-C02-01 and BIA2007-68098-C02-02) and also from the Spanish Ministry of Foreign Affairs and Cooperation through the Inter-University and Scientific Research Cooperation Program (A/023748/09).Alba Fernández, J.; Rey Tormos, RMD.; Ramis Soriano, J.; Arenas, JP. (2011). An Inverse Method to Obtain Porosity, Fibre Diameterand Density of Fibrous Sound Absorbing Materials. Archives of Acoustics. 36(3):561-574. https://doi.org/10.2478/v10168-011-0040-xS561574363Allard, J., & Champoux, Y. (1992). New empirical equations for sound propagation in rigid frame fibrous materials. The Journal of the Acoustical Society of America, 91(6), 3346-3353. doi:10.1121/1.402824Attenborough, K. (1983). Acoustical characteristics of rigid fibrous absorbents and granular materials. The Journal of the Acoustical Society of America, 73(3), 785-799. doi:10.1121/1.389045Bies, D. A., & Hansen, C. H. (1980). Flow resistance information for acoustical design. Applied Acoustics, 13(5), 357-391. doi:10.1016/0003-682x(80)90002-xChampoux, Y., Stinson, M. R., & Daigle, G. A. (1991). Air‐based system for the measurement of porosity. The Journal of the Acoustical Society of America, 89(2), 910-916. doi:10.1121/1.1894653Crocker, M. J., & Arenas, J. P. (s. f.). Use of Sound-Absorbing Materials. Handbook of Noise and Vibration Control, 696-713. doi:10.1002/9780470209707.ch57Delany, M. E., & Bazley, E. N. (1970). Acoustical properties of fibrous absorbent materials. Applied Acoustics, 3(2), 105-116. doi:10.1016/0003-682x(70)90031-9Dunn, I. P., & Davern, W. A. (1986). Calculation of acoustic impedance of multi-layer absorbers. Applied Acoustics, 19(5), 321-334. doi:10.1016/0003-682x(86)90044-7Fellah, Z. E. A., Berger, S., Lauriks, W., Depollier, C., Aristégui, C., & Chapelon, J.-Y. (2003). Measuring the porosity and the tortuosity of porous materials via reflected waves at oblique incidence. The Journal of the Acoustical Society of America, 113(5), 2424-2433. doi:10.1121/1.1567275Fellah, Z. E. A., Berger, S., Lauriks, W., Depollier, C., & Fellah, M. (2003). Measuring the porosity of porous materials having a rigid frame via reflected waves: A time domain analysis with fractional derivatives. Journal of Applied Physics, 93(1), 296-303. doi:10.1063/1.1524025Fellah, Z. E. A., Berger, S., Lauriks, W., Depollier, C., Trompette, P., & Chapelon, J. Y. (2003). Ultrasonic measurement of the porosity and tortuosity of air-saturated random packings of beads. Journal of Applied Physics, 93(11), 9352-9359. doi:10.1063/1.1572191Fellah, Z. E. A., Mitri, F. G., Fellah, M., Ogam, E., & Depollier, C. (2007). Ultrasonic characterization of porous absorbing materials: Inverse problem. Journal of Sound and Vibration, 302(4-5), 746-759. doi:10.1016/j.jsv.2006.12.007Garai, M., & Pompoli, F. (2005). A simple empirical model of polyester fibre materials for acoustical applications. Applied Acoustics, 66(12), 1383-1398. doi:10.1016/j.apacoust.2005.04.008ISO (1998), 10534-2:1998. Acoustics - determination of sound absorption coefficient and impedance in impedance tubes - Part 2: transfer-function method, International Organization for Standardization, Geneva.Miki, Y. (1990). Acoustical properties of porous materials. Modifications of Delany-Bazley models. Journal of the Acoustical Society of Japan (E), 11(1), 19-24. doi:10.1250/ast.11.19Miki, Y. (1990). Acoustical properties of porous materials. Generalizations of empirical models. Journal of the Acoustical Society of Japan (E), 11(1), 25-28. doi:10.1250/ast.11.25Ramis, J., Alba, J., Del Rey, R., Escuder, E., & Sanchís, V. J. (2010). Nuevos materiales absorbentes acústicos basados en fibra de kenaf. Materiales de Construcción, 60(299), 133-143. doi:10.3989/mc.2010.50809Shoshani, Y., & Yakubov, Y. (2000). Numerical assessment of maximal absorption coefficients for nonwoven fiberwebs. Applied Acoustics, 59(1), 77-87. doi:10.1016/s0003-682x(99)00015-8Umnova, O., Attenborough, K., Shin, H.-C., & Cummings, A. (2005). Deduction of tortuosity and porosity from acoustic reflection and transmission measurements on thick samples of rigid-porous materials. Applied Acoustics, 66(6), 607-624. doi:10.1016/j.apacoust.2004.02.005Voronina, N. (1994). Acoustic properties of fibrous materials. Applied Acoustics, 42(2), 165-174. doi:10.1016/0003-682x(94)90005-1Voronina, N. (1996). Improved empirical model of sound propagation through a fibrous material. Applied Acoustics, 48(2), 121-132. doi:10.1016/0003-682x(95)00055-eVoronina, N. (1998). An empirical model for elastic porous materials. Applied Acoustics, 55(1), 67-83. doi:10.1016/s0003-682x(97)00098-4Voronina, N. (1999). An empirical model for rigid-frame porous materials with low porosity. Applied Acoustics, 58(3), 295-304. doi:10.1016/s0003-682x(98)00076-0Voronina, N. ., & Horoshenkov, K. . (2003). A new empirical model for the acoustic properties of loose granular media. Applied Acoustics, 64(4), 415-432. doi:10.1016/s0003-682x(02)00105-6Wang, X., Eisenbrey, J., Zeitz, M., & Sun, J. Q. (2004). Multi-stage regression analysis of acoustical properties of polyurethane foams. Journal of Sound and Vibration, 273(4-5), 1109-1117. doi:10.1016/j.jsv.2003.09.039Wilson, D. K. (1997). Simple, relaxational models for the acoustical properties of porous media. Applied Acoustics, 50(3), 171-188. doi:10.1016/s0003-682x(96)00048-

The progress of early phase bone healing using porous granules produced from calcium phosphate cement

<p>Abstract</p> <p>Objective</p> <p>Bone grafting is a vital component in many surgical procedures to facilitate the repair of bone defects or fusions. Autologous bone has been the gold standard to date in spite of associated donor-site morbidity and the limited amount of available donor bone. The aim of this study was to investigate the progress of bone regeneration and material degradation of calcium phosphate granules (CPG) produced from a calcium phosphate self-setting cement powder compared to the use of autologous bone grafting in the treatment of "critical size defects" on load-bearing long bones of minipigs.</p> <p>Methods</p> <p>A critical size defect in the tibial metaphysis of 16 mini-pigs was filled either with autologous cancellous graft or with micro- and macroporous carbonated, apatic calcium phosphate granules (CPG) produced from a calcium phosphate self-setting cement powder. After 6 weeks, the specimens were assessed by X-ray and histological evaluation. The amount of new bone formation was analysed histomorphometrically.</p> <p>Results</p> <p>The semi-quantitative analysis of the radiological results showed a complete osseous bridging of the defect in three cases for the autograft group. In the same group five animals showed a beginning, but still incomplete bridging of the defect, whereas in the CPG group just two animals developed this. All other animals of the CPG group showed only a still discontinuous new bone formation. Altogether, radiologically a better osseous bridging was observed in the autograft group compared to the CPG group.</p> <p>Histomorphometrical analysis after six weeks of healing revealed that the area of new bone was significantly greater in the autograft group concerning the central area of the defect zone (p < 0.001) as well as the cortical defect zone (p < 0.002). All defects showed new bone formation, but only in the autograft group defects regenerated entirely</p> <p>Conclusions</p> <p>Within the limits of the present study it could be demonstrated that autologous cancellous grafts lead to a significantly better bone regeneration compared to the application of calcium phosphate granules (CPG) produced from a calcium phosphate self-setting cement powder after 6 weeks. In the early phase of bone-healing, the sole application of CPG appears to be inferior to the autologous cancellous grafts in an <it>in vivo </it>critical size defect on load-bearing long bones of mini-pigs.</p

The first transcriptome of Italian wall lizard, a new tool to infer about the Island Syndrome

Some insular lizards show a high degree of differentiation from their conspecific mainland populations, like Licosa island lizards, which are described as affected by Reversed Island Syndrome (RIS). In previous works, we demonstrated that some traits of RIS, as melanization, depend on a differential expression of gene encoding melanocortin receptors. To better understand the basis of syndrome, and providing raw data for future investigations, we generate the first de novo transcriptome of the Italian wall lizard. Comparing mainland and island transcriptomes, we link differences in life-traits to differential gene expression. Our results, taking together testis and brain sequences, generated 275,310 and 269,885 transcripts, 18,434 and 21,606 proteins in Gene Ontology annotation, for mainland and island respectively. Variant calling analysis identified about the same number of SNPs in island and mainland population. Instead, through a differential gene expression analysis we found some putative genes involved in syndrome more expressed in insular samples like Major Histocompatibility Complex class I, Immunoglobulins, Melanocortin 4 receptor, Neuropeptide Y and Proliferating Cell Nuclear Antigen

Glioma imaging in Europe: A survey of 220 centres and recommendations for best clinical practice

Objectives: At a European Society of Neuroradiology (ESNR) Annual Meeting 2015 workshop, commonalities in practice, current controversies and technical hurdles in glioma MRI were discussed. We aimed to formulate guidance on MRI of glioma and determine its feasibility, by seeking information on glioma imaging practices from the European Neuroradiology community. Methods: Invitations to a structured survey were emailed to ESNR members (n=1,662) and associates (n=6,400), European national radiologists’ societies and distributed via social media. Results: Responses were received from 220 institutions (59% academic). Conventional imaging protocols generally include T2w, T2-FLAIR, DWI, and pre- and post-contrast T1w. Perfusion MRI is used widely (85.5%), while spectroscopy seems reserved for specific indications. Reasons for omitting advanced imaging modalities include lack of facility/software, time constraints and no requests. Early postoperative MRI is routinely carried out by 74% within 24–72 h, but only 17% report a percent measure of resection. For follow-up, most sites (60%) issue qualitative reports, while 27% report an assessment according to the RANO criteria. A minori