2,004 research outputs found
Acceptability of temporary suspension of visiting during norovirus outbreaks:investigating patient, visitor and public opinion
Background
Noroviruses are a leading cause of outbreaks globally and the most common cause of service disruption due to ward closures. Temporary suspension of visiting (TSV) is increasingly a recommended public health measure to reduce exposure, transmission and impact during norovirus outbreaks; however, preventing patientâvisitor contact may contravene the ethos of person-centred care, and public acceptability of this measure is not known.
Aim
To investigate the acceptability of TSV during norovirus outbreaks from the perspectives of patients, visitors and the wider public.
Methods
Cross-sectional survey of patients (NÂ =Â 153), visitors (NÂ =Â 175) and the public (NÂ =Â 224) in three diverse areas in Scotland. Health Belief Model constructs were applied to understand ratings of acceptability of TSV during norovirus outbreaks, and to determine associations between these levels and various predictor variables.
Findings
The majority (84.6%) of respondents indicated that the possible benefits of TSV are greater than the possible disadvantages. Conversely, the majority (70%) of respondents disagreed that TSV âis wrong as it ignores people's rights to have contact with family and friendsâ. The majority (81.6%) of respondents agreed that TSV would be more acceptable if exceptions were made for seriously ill or dying patients. Correlational analysis demonstrated that overall acceptability was positively related to perceived severity (r = 0.65), identified benefits (r = 0.54) and implementing additional communication strategies (r = 0.60); acceptability was negatively related to potential barriers (r = â0.49).
Conclusions
There is greater service user and public support for the use of TSV than concerns around impinging upon patients' rights to have visitors. TSV should be considered as an acceptable infection control measure that could be implemented consistently during norovirus outbreaks
Plasma zonulin levels in childhood nephrotic syndrome
© 2019 Trachtman, Gipson, Lemley, Troost, Faul, Morrison, Vento, Ahn and Goldberg. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Objective: We conducted this study to test the hypothesis that plasma zonulin levels are elevated in pediatric patients with nephrotic syndrome compared to healthy controls. Study Design: Plasma zonulin levels were measured by ELISA in 114 children enrolled in the NEPTUNE study. Clinical and laboratory data were retrieved from the NEPTUNE database. Results: The median age of the patients was 10 (IQR = 5 to 14) years, 59 were male, 64 had minimal change disease, 47 focal segmental glomerulosclerosis, median eGFR was 96 (IQR = 80 to 114) ml/min/1.73 m2, and median urine protein:creatinine ratio was 0.5 (IQR = 0.1 to 3.4) (g:g). The plasma zonulin level was 14.2 ± 5.0 vs. 10.2 ± 2.5 ng/ml in healthy adults in a report using the same assay kit, P = 0.0025. These findings were confirmed in an independent cohort of children with nephrotic syndrome compared to healthy age-matched controls, P = 0.01. Zonulin concentrations did not differ in children with minimal change disease vs. focal segmental glomerulosclerosis, frequently relapsing vs. steroid-dependent vs. steroid-resistant clinical course, and were not influenced by the immunosuppressive treatment regimen. There was no relationship between plasma zonulin levels and the absolute or percentage change in proteinuria from enrollment until the time of the zonulin assay. Conclusion: Plasma zonulin levels are elevated in childhood nephrotic syndrome regardless of level of proteinuria or specific treatment. The cause of the high plasma zonulin levels and whether zonulin contributes to glomerular injury requires further study
The hind- and midfoot alignment analyzed after a medializing calcaneal osteotomy using a 3D weight bearing CT
Geochemical analysis of bulk marine sediment by Inductively Coupled PlasmaâAtomic Emission Spectroscopy on board the JOIDES Resolution
Geochemical analyses on board the JOIDES Resolution have been enhanced with the addition of a Jobin-Yvon Ultrace inductively coupled plasma-atomic emission spectrometer (ICP-AES) as an upgrade from the previous X-ray fluorescence facility. During Leg 199, we sought to both challenge and utilize the capabilities of the ICP-AES in order to provide an extensive bulk-sediment geochemical database during the cruise. These near real-time analyses were then used to help characterize the recovered sedimentary sequences, calculate mass accumulation rates of the different sedimentary components, and assist with cruise and postcruise sampling requests. The general procedures, sample preparation techniques, and basic protocol for ICP-AES analyses on board ship are outlined by Murray et al. (2000) in Ocean Drilling Program Tech Note, 29. We expand on those concepts and offer suggestions for ICP-AES methodology, calibration by standard reference materials, data reduction procedures, and challenges that are specific to the analysis of bulk-sediment samples. During Leg 199, we employed an extensive bulk-sediment analytical program of ~600 samples of varying lithologies, thereby providing several opportunities for refinement of techniques. We also discuss some difficulties and challenges that were faced and suggest how to alleviate such occurrences for sedimentary chemical analyses during future legs
On reminder effects, drop-outs and dominance: evidence from an online experiment on charitable giving
We present the results of an experiment that (a) shows the usefulness of screening out drop-outs and (b) tests whether different methods of payment and reminder intervals affect charitable giving. Following a lab session, participants could make online donations to charity for a total duration of three months. Our procedure justifying the exclusion of drop-outs consists in requiring participants to collect payments in person flexibly and as known in advance and as highlighted to them later. Our interpretation is that participants who failed to collect their positive payments under these circumstances are likely not to satisfy dominance. If we restrict the sample to subjects who did not drop out, but not otherwise, reminders significantly increase the overall amount of charitable giving. We also find that weekly reminders are no more effective than monthly reminders in increasing charitable giving, and that, in our three months duration experiment, standing orders do not increase giving relative to one-off donations
Photonuclear Reactions of Three-Nucleon Systems
We discuss the available data for the differential and the total cross
section for the photodisintegration of He and H and the corresponding
inverse reactions below MeV by comparing with our calculations
using realistic interactions. The theoretical results agree within the
errorbars with the data for the total cross sections. Excellent agreement is
achieved for the angular distribution in case of He, whereas for H a
discrepancy between theory and experiment is found.Comment: 11 pages (twocolumn), 12 postscript figures included, uses psfig,
RevTe
Radiative decay of a massive particle and the non-thermal process in primordial nucleosynthesis
We consider the effects on big bang nucleosynthesis (BBN) of the radiative
decay of a long-lived massive particle. If high-energy photons are emitted
after the BBN epoch ( sec), they may change the abundances of
the light elements through photodissociation processes, which may result in a
significant discrepancy between standard BBN and observation. Taking into
account recent observational and theoretical developments in this field, we
revise our previous study constraining the abundance of the
radiatively-decaying particles. In particular, on the theoretical side, it was
recently claimed that the non-thermal production of Li, which is caused by
the photodissociation of \hefour, most severely constrains the abundance of
the radiatively-decaying particle. We will see, however, it is premature to
emphasize the importance of the non-thermal production of Li because (i)
the theoretical computation of the Li abundance has large uncertainty due
to the lack of the precise understanding of the Li production cross
section, and (ii) the observational data of Li abundance has large errors.Comment: 15 pages, using REVTeX and 3 postscript figure
Influence of Gamma-Ray Emission on the Isotopic Composition of Clouds in the Interstellar Medium
We investigate one mechanism of the change in the isotopic composition of
cosmologically distant clouds of interstellar gas whose matter was subjected
only slightly to star formation processes. According to the standard
cosmological model, the isotopic composition of the gas in such clouds was
formed at the epoch of Big Bang nucleosynthesis and is determined only by the
baryon density in the Universe. The dispersion in the available cloud
composition observations exceeds the errors of individual measurements. This
may indicate that there are mechanisms of the change in the composition of
matter in the Universe after the completion of Big Bang nucleosynthesis. We
have calculated the destruction and production rates of light isotopes (D, 3He,
4He) under the influence of photonuclear reactions triggered by the gamma-ray
emission from active galactic nuclei (AGNs). We investigate the destruction and
production of light elements depending on the spectral characteristics of the
gamma-ray emission. We show that in comparison with previous works, taking into
account the influence of spectral hardness on the photonuclear reaction rates
can increase the characteristic radii of influence of the gamma-ray emission
from AGNs by a factor of 2-8. The high gamma-ray luminosities of AGNs observed
in recent years increase the previous estimates of the characteristic radii by
two orders of magnitude. This may suggest that the influence of the emission
from AGNs on the change in the composition of the medium in the immediate
neighborhood (the host galaxy) has been underestimated.Comment: 13 pages, 13 figures, 3 table
The threshold for the McGurk effect in audio-visual noise decreases with development
Across development, vision increasingly infuences audio-visual perception. This is evidenced in illusions such as the McGurk efect, in which a seen mouth movement changes the perceived sound. The current paper assessed the efects of manipulating the clarity of the heard and seen signal upon the McGurk efect in children aged 3â6 (n=29), 7â9 (n=32) and 10â12 (n=29) years, and adults aged 20â35 years (n=32). Auditory noise increased, and visual blur decreased, the likelihood of vision changing auditory perception. Based upon a proposed developmental shift from auditory to visual dominance we predicted that younger children would be less susceptible to McGurk responses, and that adults would continue to be infuenced by vision in higher levels of visual noise and with less auditory noise. Susceptibility to the McGurk efect was higher in adults compared with 3â6-year-olds and 7â9-yearolds but not 10â12-year-olds. Younger children required more auditory noise, and less visual noise, than adults to induce McGurk responses (i.e. adults and older children were more easily infuenced by vision). Reduced susceptibility in childhood supports the theory that sensory dominance shifts across development and reaches adult-like levels by 10 years of age
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