A review on various optimization techniques of resource provisioning in cloud computing

Cloud computing is the provision of IT resources (IaaS) on-demand using a pay as you go model over the internet.It is a broad and deep platform that helps customers builds sophisticated, scalable applications. To get the full benefits, research on a wide range of topics is needed. While resource over-provisioning can cost users more than necessary, resource under provisioning hurts the application performance. The cost effectiveness of cloud computing highly depends on how well the customer can optimize the cost of renting resources (VMs) from cloud providers. The issue of resource provisioning optimization from cloud-consumer potential is a complicated optimization issue, which includes much uncertainty parameters. There is a much research avenue available for solving this problem as it is in the real-world. Here, in this paper we provide details about various optimization techniques for resource provisioning

Concurrent chemo radiation with cisplatin and bleomycin versus cisplatin alone in locally advanced squamous cell carcinoma of oral cavity: a retrospective study.

Oral cavity cancer constitutes two thirds of locally advanced head and neck cancer in India and majority presents in advanced stage. Despite aggressive treatment disease outcome is poor. The aim of this study is to compare concurrent chemo radiation with cisplatin and bleomycin versus concurrent chemo radiation with cisplatin alone in locally advanced oral cavity cancer. Materials and methods: Patients with locally advanced squamous cell carcinoma of oral cavity cancers registered at cancer institute from 2009 – 2011 were included in the study. Patients who were either taken up for initial surgery or treated with radiation therapy alone were excluded from study. Of 515 patients treated with concurrent chemo radiation, 112 � patients were treated with three weekly cisplatin along with biweekly bleomycin and 104 patients were treated with 3 weekly cisplatin alone concurrent with radiation therapy. Results: Among the patient treated with three weekly cisplatin and biweekly bleomycin there is increased two year disease free survival (45.5% versus 35.6%) and two year overall survival(60% versus 45.2%)on comparison with patients treated with three weekly cisplatin alone.(P <0.05). Three weekly cisplatin alone has lesser incidence of grade III mucositis, but comparable treatment breaks haematological toxicity, vomiting, treatment response when compared to three weekly cisplatin along with biweekly bleomycin. Conclusion: The addition bleomycin to cisplatin concurrently with radiation therapy increases disease free survival and overall survival, with manageable toxicity

Bacoside A: Role in Cigarette Smoking Induced Changes in Brain

Cigarette smoking (CS) is a major health hazard that exerts diverse physiologic and biochemical effects mediated by the components present and generated during smoking. Recent experimental studies have shown predisposition to several biological consequences from both active and passive cigarette smoke exposure. In particular, passive smoking is linked to a number of adverse health effects which are equally harmful as active smoking. A pragmatic approach should be considered for designing a pharmacological intervention to combat the adverse effects of passive smoking. This review describes the results from a controlled experimental condition, testing the effect of bacoside A (BA) on the causal role of passive/secondhand smoke exposure that caused pathological and neurological changes in rat brain. Chronic exposure to cigarette smoke induced significant changes in rat brain histologically and at the neurotransmitter level, lipid peroxidation states, mitochondrial functions, membrane alterations, and apoptotic damage in rat brain. Bacoside A is a neuroactive agent isolated from Bacopa monnieri. As a neuroactive agent, BA was effective in combating these changes. Future research should examine the effects of BA at molecular level and assess its functional effects on neurobiological and behavioral processes associated with passive smoke

RESPONSE OF AN IDEOTYPE OF CLUSTER ONION (ALLIUM CEPA L. VAR. AGGREGATUM) TO FARM AND ANIMAL WASTES

In Tamilnadu, Ariyalur district contributes a major share of cluster onion production. An ideotype popular among the growers of this locality is preferred by consumers of entire state for its size, storability and taste. Hence the present investigation was carried out the in a farmer’s field at Vennallur located in Ariyalur District during 2017. The experiment was laid out with seven treatments in randomized block design. Each treatment was replicated thrice. The treatments included three kinds of practices adopted by the farmers of the tract and four others where bulky organic manures (Vermicompost, Poultry manure) and concentrated organic manures (Neem cake and Groundnut cake) were substituted on ‘N’ equivalent basis, along with biofertilizers (Azospirillum and Phosphobacteria) and foliar spray of Panchakavya (3%). All the four treatments with organic inputs (T4 to T7) gave better results, when compared to farmer’s practice (T1 and T2). Though T3 was the best, incorporation of Poultry manure+Neem cake (T6) and Poultry manure+Groundnut cake (T7) along with Biofertilizer+Panchakavya 3 % improved the yield significantly in order

Integrated case scripts to enhance diagnostic competency

Background: The overwhelmingly high burden of disease and disorder especially in developing countries requires oral physicians to provide optimal dental treatment without complicating individuals’ general health. The opportunity for learners to extract the multiple aspects of a systemic condition and to relate them with the presenting complaint in order to devise an appropriate dental treatment plan is limited by time in chair- side teaching. To overcome the necessity of exposing students to real patients with varying degrees of underlying disease, those in medical and nursing education unanimously employ imaginary scenarios similar to real cases. However, such clinical scripts are seldom practiced in dental education, and the prospect of structured integration is almost never addressed. Objectives: To evaluate the effectiveness of applying systematic and integrated case-based discussion in dental education in terms of enhancing five essential skills to novice Indian dental students. Methods: A mixed- methods study was carried out with thirty graduating third-year students in 5focus groups. The integrated case-based focused group training occurred in 6 weeks and lasted approximately 90 minutes per discussion. Ten case scripts of hypothetical situations were discussed and five integrated modules were organized as a part of this program. Revised Bloom’s taxonomy was adopted to achieve the expected level of competency. Results: Students performance following integrated case-based discussions was improved and their acceptance to this practice is positive. Conclusions: The present study supports the need for course specific, basic science integrated seminars with concurrent case scripts discussion to enhance students’ competencies

Genetic divergence in brinjal genotypes for growth and yield parameters

Field investigations were carried out during 2019 and 2020 to study the genetic diversity among 112 brinjal genotypes. Mahalanobis’s D2 analysis was done for ten growth and nine yield attributing characters. All 112 genotypes were grouped into seven clusters. Cluster IV (23.975) registered the highest intra cluster distance, whereas cluster II (5.683) recorded the lowest cluster distance. The maximum inter cluster distance was observed for clusters I and IV (24.912). Minimum inter cluster distance was registered between clusters II and III (10.431). Fruit yield per plant, fruit girth and the number of seeds per fruit retained the highest contribution in order towards total divergence. Cluster IV registered the maximum mean for average fruit yield per plant (1647.37). Therefore, the selection of parents from the diverse clusters would yield good segregants for the improvement of yield in brinjal

Influence of season, age and breed on prevalence of haemoprotozoan diseases in cattle of Tamil Nadu, India

Aim: To assess the prevalence of haemoprotozoan diseases in cross-bred and indigenous cattle in relation to season, age and breed in Western part of Tamil Nadu, India. Materials and Methods: A total of 2637 blood smears were screened for haemoprotozoan diseases and samples were received from the college hospital and veterinary dispensaries in Western part of Tamil Nadu, India. Blood smears were stained using Giemsa's technique and examined under oil immersion. Results: Microscopic examination of blood smears revealed an overall prevalence of 16.64 %; of which theileriosis was 13 %, followed by anaplasmosis 2.64 % and then babesiosis 1.0%. Among the haemoprotozoan diseases, the prevalence of theileriosis was significantly (p<0.05) high during summer (14.4%), followed by moderate in monsoon (13.8%) and less in fair (11.5%) seasons. However, there was no significant seasonal influence on the prevalence of babesiosis and anaplasmosis. The data on influence of breed revealed that there was a significantly (p<0.05) high prevalence of haemoprotozoan diseases in Holstein Friesian (HF) and Jersey cross breeds than indigenous breed and the occurrence of these haemoprotozoan diseases was found to be high among the age groups of 2-7 years in cross-bred animals and below 2 years in indigenous animals. Conclusion: The present study suggests that Western part of Tamil Nadu is highly endemic for theileriosis and occurrence of the disease was high during summer. Cross-bred animals aged 2-7 years are highly susceptible to these haemoprotozoan diseases than indigenous animals

Extracellular Hsp72 concentration relates to a minimum endogenous criteria during acute exercise-heat exposure

Extracellular heat-shock protein 72 (eHsp72) concentration increases during exercise-heat stress when conditions elicit physiological strain. Differences in severity of environmental and exercise stimuli have elicited varied response to stress. The present study aimed to quantify the extent of increased eHsp72 with increased exogenous heat stress, and determine related endogenous markers of strain in an exercise-heat model. Ten males cycled for 90 min at 50% O2peak in three conditions (TEMP, 20°C/63% RH; HOT, 30.2°C/51%RH; VHOT, 40.0°C/37%RH). Plasma was analysed for eHsp72 pre, immediately post and 24-h post each trial utilising a commercially available ELISA. Increased eHsp72 concentration was observed post VHOT trial (+172.4%) (P<0.05), but not TEMP (-1.9%) or HOT (+25.7%) conditions. eHsp72 returned to baseline values within 24hrs in all conditions. Changes were observed in rectal temperature (Trec), rate of Trec increase, area under the curve for Trec of 38.5°C and 39.0°C, duration Trec ≥ 38.5°C and ≥ 39.0°C, and change in muscle temperature, between VHOT, and TEMP and HOT, but not between TEMP and HOT. Each condition also elicited significantly increasing physiological strain, described by sweat rate, heart rate, physiological strain index, rating of perceived exertion and thermal sensation. Stepwise multiple regression reported rate of Trec increase and change in Trec to be predictors of increased eHsp72 concentration. Data suggests eHsp72 concentration increases once systemic temperature and sympathetic activity exceeds a minimum endogenous criteria elicited during VHOT conditions and is likely to be modulated by large, rapid changes in core temperature

Polarized Neutron Reflectometry of Nickel Corrosion Inhibitors.

Polarized neutron reflectometry has been used to investigate the detailed adsorption behavior and corrosion inhibition mechanism of two surfactants on a nickel surface under acidic conditions. Both the corrosion of the nickel surface and the structure of the adsorbed surfactant layer could be monitored in situ by the use of different solvent contrasts. Layer thicknesses and roughnesses were evaluated over a range of pH values, showing distinctly the superior corrosion inhibition of one negatively charged surfactant (sodium dodecyl sulfate) compared to a positively charged example (dodecyl trimethylammonium bromide) due to its stronger binding interaction with the surface. It was found that adequate corrosion inhibition occurs at significantly less than full surface coverage.X-ray photoelectron spectra were obtained at the National Engineering and Physical Sciences Research Council (EPSRC) XPS User’s Service (NEXUS) at Newcastle University, an EPSRC midrange facility. NR data were obtained on the D17 instrument, and samples were treated in the laboratories of the Partnership for Soft Condensed Matter (PSCM) at the Institut Laue-Langevin. M.H.W. is grateful for funding from the Oppenheimer Trust.This is the final version of the article. It first appeared from the American Chemical Society via http://dx.doi.org/10.1021/acs.langmuir.5b0171