Spiritual Well-Being Scale: Mental and Physical Health Relationships (Chapter 48 of Oxford Textbook of Spirituality in Healthcare)

The existence of this handbook documents the recent increase in research on and practical attention to the role of spirituality in healthcare. One essential companion to the concept of spirituality is spiritual well-being (SWB).[1] That is, although the degree and type of spirituality per se can no doubt play an important role in how well a person faces the dilemmas related to health issues,[2,3] the degree to which a person perceives or derives a sense of wellbeing from that spirituality may be equally or more important. In this connection, SWB is an outcome indicator, or barometer, of how well a person is doing in the face of whatever the person is confronting.[4] Therefore, although SWB is not synonymous with spirituality, it is closely related to it. Similarly, SWB is not synonymous with mental health or physical health, but is likely to be related to both of them. SWB connotes one\u27s subjective perception of well-being in both the religious and/or existential dimensions in accord with whatever is implicitly or explicitly conceived of as a spiritual umbrella for the individual. The Spiritual Well-Being Scale (SWBS)* was developed in order to be a tool for self-assessment of these aspects of general perceived well-being. [ 4,5] Since its first publication in 1982, a large body of research has been done with the SWBS. In preparation for writing this chapter, a literature search documented the scale\u27s use in over 300 published articles and chapters, 190 doctoral dissertations and Masters theses, 35 posters and presentations, and 50 unpublished papers. It has also been reprinted in no less than 4 books on palliative care and counseling. [ 6-9] An exhaustive review of all of this research is beyond the scope of this chapter; the interested reader is referred to a companion review article. [ 10] Here, we focus specifically and selectively on research related to healthcare. We highlight those studies using the SWBS that are related to mental health variables or to the mental and well-being issues that are consequences or correlates of physical health conditions. In order to maximize the usefulness of this chapter, it is necessary to ( 1) summarize the intellectual roots of the concept of SWB and what the SWBS does and does not measure, (2) explain the meaning and utility of its religious well-being (RWB) and existential well-being (EWB) subscales, (3) summarize the literature with the SWBS as related to mental and physical health variables, ( 4) note any strengths and weaknesses, research directions, and applications of the SWBS, and (5) summarize implications of SWB research for healthy health care practice

Fast beam stacking using RF barriers

Two barrier RF systems were fabricated, tested and installed in the Fermilab Main Injector. Each can provide 8 kV rectangular pulses (the RF barriers) at 90 kHz. When a stationary barrier is combined with a moving barrier, injected beams from the Booster can be continuously deflected, folded and stacked in the Main Injector, which leads to doubling of the beam intensity. This paper gives a report on the beam experiment using this novel technology.Comment: 2007 Particle Accelerator Conference (PAC07

Coexpression of rat P2X2 and P2X6 subunits in Xenopus oocytes.

Transcripts for P2X(2) and P2X(6) subunits are present in rat CNS and frequently colocalize in the same brainstem nuclei. When rat P2X(2) (rP2X(2)) and rat P2X(6) (rP2X(6)) receptors were expressed individually in Xenopus oocytes and studied under voltage-clamp conditions, only homomeric rP2X(2) receptors were fully functional and gave rise to large inward currents (2-3 microA) to extracellular ATP. Coexpression of rP2X(2) and rP2X(6) subunits in Xenopus oocytes resulted in a heteromeric rP2X(2/6) receptor, which showed a significantly different phenotype from the wild-type rP2X(2) receptor. Differences included reduction in agonist potencies and, in some cases (e.g., Ap(4)A), significant loss of agonist activity. ATP-evoked inward currents were biphasic at the heteromeric rP2X(2/6) receptor, particularly when Zn(2+) ions were present or extracellular pH was lowered. The pH range was narrower for H(+) enhancement of ATP responses at the heteromeric rP2X(2/6) receptor. Also, H(+) ions inhibited ATP responses at low pH levels (<pH 6.3). The pH-dependent blocking activity of suramin was changed at this heteromeric receptor, although the potentiating effect of Zn(2+) on ATP responses was unchanged. Thus, the rP2X(2/6) receptor is a functionally modified P2X(2)-like receptor with a distinct pattern of pH modulation of ATP activation and suramin blockade. Although homomeric P2X(6) receptors function poorly, the P2X(6) subunit can contribute to functional heteromeric P2X channels and may influence the phenotype of native P2X receptors in those cells in which it is expressed

Topology optimization of geometrically nonlinear structures using an evolutionary optimization method

Iso-XFEM method is an evolutionary optimization method developed in our previous studies to enable the generation of high resolution topology optimised designs suitable for additive manufacture. Conventional approaches for topology optimization require additional post-processing after optimization to generate a manufacturable topology with clearly defined smooth boundaries. Iso-XFEM aims to eliminate this time-consuming post-processing stage by defining the boundaries using isovalues of a structural performance criterion and an extended finite element method (XFEM) scheme. In this paper, the Iso-XFEM method is further developed to enable the topology optimization of geometrically nonlinear structures undergoing large deformations. This is achieved by implementing a total Lagrangian finite element formulation and defining a structural performance criterion appropriate for the objective function of the optimization problem. The Iso-XFEM solutions for geometrically nonlinear test-cases implementing linear and nonlinear modelling are compared, and the suitability of nonlinear modelling for the topology optimization of geometrically nonlinear structures is investigated

A Study of Two Facultative Lagoons for Municipal Wastewater Treatment in Iowa

Two 2-celled facultative lagoons, comparable in design and serving small communities in rural Iowa, were studied for seven consecutive summer weeks. Chemical and physical parameters of water quality were monitored in samples taken from influent and effluent structures and at two depths and three to six locations in each cell. The composition and density of the phytoplankton was monitored, and total and fecal coliform counts were made. A diurnal study showed wide fluctuations in the chemical composition of influent wastewater. The quality of effluent water was comparable for the two lagoons although one was loaded to design capacity and the other to half capacity. During the study period, both lagoons met the Iowa standards and approached the EPA standards

Urinary ATP and visualization of intracellular bacteria: a superior diagnostic marker for recurrent UTI in renal transplant recipients?

Renal transplant recipients (RTR) are highly susceptible to urinary tract infections (UTIs) with over 50% of patients having at least one UTI within the first year. Yet it is generally acknowledged that there is considerable insensitivity and inaccuracy in routine urinalysis when screening for UTIs. Thus a large number of transplant patients with genuine urine infections may go undiagnosed and develop chronic recalcitrant infections, which can be associated with graft loss and morbidity. Given a recent study demonstrating ATP is released by urothelial cells in response to bacteria exposure, possibly acting at metabotropic P2Y receptors mediating a proinflammatory response, we have investigated alternative, and possibly more appropriate, urinalysis techniques in a cohort of RTRs.Mid-stream urine (MSU) samples were collected from 53 outpatient RTRs. Conventional leukocyte esterase and nitrite dipstick tests, and microscopic pyuria counts (in 1 ?l), ATP concentration measurements, and identification of intracellular bacteria in shed urothelial cells, were performed on fresh unspun samples and compared to ‘gold-standard’ bacterial culture results.Of the 53 RTRs, 22% were deemed to have a UTI by ‘gold-standard’ conventional bacteria culture, whereas 87%, 8% and 4% showed evidence of UTIs according to leukocyte esterase dipstick, nitrite dipstick, and a combination of both dipsticks, respectively. Intracellular bacteria were visualized in shed urothelial cells of 44% of RTRs, however only 1 of the 23 RTRs (44%) was deemed to have a UTI by conventional bacteria culture. A significant association of the ‘gold-standard’ test with urinary ATP concentration combined with visualization of intracellular bacteria in shed urothelial cells was determined using the Fisher’s exact test.It is apparent that standard bedside tests for UTIs give variable results and that seemingly quiescent bacteria in urothelial cells are very common in RTRs and may represent a focus of subclinical infection. Furthermore, our results suggest urinary ATP concentration combined with detection of intracellular bacteria in shed urinary epithelial cells may be a sensitive means by which to detect ‘occult’ infection in RTRs

Rigidity analysis of HIV-1 protease

We present a rigidity analysis on a large number of X-ray crystal structures of the enzyme HIV-1 protease using the 'pebble game' algorithm of the software FIRST. We find that although the rigidity profile remains similar across a comprehensive set of high resolution structures, the profile changes significantly in the presence of an inhibitor. Our study shows that the action of the inhibitors is to restrict the flexibility of the beta-hairpin flaps which allow access to the active site. The results are discussed in the context of full molecular dynamics simulations as well as data from NMR experiments.Comment: 4 pages, 3 figures. Conference proceedings for CMMP conference 2010 which was held at the University of Warwic

“I wouldn't survive it, as simple as that”: Syndemic vulnerability among people living with chronic non-communicable disease during the COVID-19 pandemic

The co-occurrence of COVID-19, non-communicable diseases and socioeconomic disadvantage has been identified as creating a syndemic: a state of synergistic epidemics, occurring when co-occurring health conditions interact with social conditions to amplify the burden of disease. In this study, we use the concept of illness management work to explore the impact of the COVID-19 pandemic on the lives of people living with, often multiple, chronic health conditions in a range of social circumstances. In-depth interviews were conducted between May and July 2020 with 29 participants living in a city in North East England. Qualitative data provide unique insights for those seeking to better understand the consequences for human life and wellbeing of the interacting social, physical and psychological factors that create syndemic risks in people's lives. Among this group of people at increased vulnerability to harm from COVID-19, we find that the pandemic public health response increased the work required for condition management. Mental distress was amplified by fear of infection and by the requirements of social isolation and distancing that removed participants' usual sources of support. Social conditions, such as poor housing, low incomes and the requirement to earn a living, further amplified the work of managing everyday life and risked worsening existing mental ill health. As evidenced by the experiences reported here, the era of pandemics will require a renewed focus on the connection between health and social justice if stubborn, and worsening health and social inequalities are to be addressed or, at the very least, not increased