Recent advances in minimally invasive colorectal cancer surgery

Laparoscopy has improved surgical treatment of various diseases due to its limited surgical trauma and has developed as an interesting therapeutic alternative for the resection of colorectal cancer. Despite numerous clinical advantages (faster recovery, less pain, fewer wound and systemic complications, faster return to work) the laparoscopic approach to colorectal cancer therapy has also resulted in unusual complications, i.e. ureteral and bladder injury which are rarely observed with open laparotomy. Moreover, pneumothorax, cardiac arrhythmia, impaired venous return, venous thrombosis as well as peripheral nerve injury have been associated with the increased intraabdominal pressure as well as patient's positioning during surgery. Furthermore, undetected small bowel injury caused by the grasping or cauterizing instruments may occur with laparoscopic surgery. In contrast to procedures performed for nonmalignant conditions, the benefits of laparoscopic resection of colorectal cancer must be weighed against the potential for poorer long-term outcomes of cancer patients that still has not been completely ruled out. In laparoscopic colorectal cancer surgery, several important cancer control issues still are being evaluated, i.e. the extent of lymph node dissection, tumor implantation at port sites, adequacy of intraperitoneal staging as well as the distance between tumor site and resection margins. For the time being it can be assumed that there is no significant difference in lymph node harvest between laparoscopic and open colorectal cancer surgery if oncological principles of resection are followed. As far as the issue of port site recurrence is concerned, it appears to be less prevalent than first thought (range 0-2.5%), and the incidence apparently corresponds with wound recurrence rates observed after open procedures. Short-term (3-5 years) survival rates have been published by a number of investigators, and survival rates after laparoscopic surgery appears to compare well with data collected after conventional surgery for colorectal cancer. However, long-term results of prospective randomized trials are not available. The data published so far indicate that the oncological results of laparoscopic surgery compare well with the results of the conventional open approach. Nonetheless, the limited information available from prospective studies leads us to propose that minimally invasive surgery for colorectal cancer surgery should only be performed within prospective trials

Investigation into the limits of perturbation theory at low Q^2 using HERA deep inelastic scattering data

A phenomenological study of the final combined HERA data on inclusive deep inelastic scattering (DIS) has been performed. The data are presented and investigated for a kinematic range extending from values of the four-momentum transfer, $Q^2$, above 10$^4$ GeV$^2$ down to the lowest values observable at HERA of $Q^2$ = 0.045 GeV$^2$ and Bjorken $x$, $x_{\rm Bj}$ = 6 $\cdot$ 10$^{-7}$. The data are well described by fits based on perturbative quantum chromodynamics (QCD) using collinear factorisation and evolution of the parton densities encompassed in the DGLAP formalism from the highest $Q^2$ down to $Q^2$ of a few GeV$^2$. The Regge formalism can describe the data up to $Q^2 \approx$ 0.65 GeV$^2$. The complete data set can be described by a new fit using the ALLM parameterisation. The region between the Regge and the perturbative QCD regimes is of particular interest.Comment: 38 pages, 13 figure

Comorbidity of respiratory and cardiovascular diseases among the elderly residing close to mine dumps in South Africa: A cross-sectional study

Background. Pollution arising from mine dumps in South Africa (SA) has been a source of concern to nearby communities.Objective. To investigate whether comorbidity of respiratory and cardiovascular diseases among elderly persons (≥55 years) was associated with proximity to mine dumps.Methods. Elderly persons in communities 1 - 2 km (exposed) and ≥5 km (unexposed) from five preselected mine dumps in Gauteng and North West provinces in SA were included in a cross-sectional study.Results. Exposed elderly persons had a significantly higher prevalence of cardiovascular and respiratory diseases than those who were unexposed. Multiple logistic regression analysis indicated that living close to mine dumps was significantly associated with asthma + hypertension (odds ratio (OR) 1.67; 95% confidence interval (CI) 1.22 - 2.28), asthma + pneumonia (OR 1.86; 95% CI 1.14 - 3.04), emphysema + arrhythmia (OR 1.38; 95% CI 1.07 - 1.77), emphysema + myocardial infarction (OR 2.01; 95% CI 1.73 - 2.54), emphysema + pneumonia (OR 3.36; 95% CI 1.41 - 7.98), hypertension + myocardial infarction (OR 1.60; 95% CI 1.04 - 2.44) and hypertension + pneumonia (OR 1.34; 95% CI 1.05 - 1.93).Conclusion. Detrimental associations between comorbidity of the health outcomes and proximity to mine dumps were observed among the elderly in SA

Single-Particle Diffusion-Coefficient on Surfaces with Ehrlich-Schwoebel-Barriers

The diffusion coefficient of single particles in the presence of Ehrlich-Schwoebel barriers (ESB)is considered. An exact expression is given for the diffusion coefficient on linear chains with random arrangements of ESB. The results are extended to surfaces having ESB with uniform extension in one or both directions. All results are verified by Monte Carlo simulations.Comment: 11 pages, LaTeX2e, 6 eps-figure

L-arginine: A unique amino acid for improving depressed wound immune function following hemorrhage

Objective: To determine whether L-arginine has any salutary effects on wound immune cell function following trauma-hemorrhage. Background. Depressed wound immune function contributes to an increased incidence of wound infections following hemorrhage. Although administration of L-arginine has been shown to restore depressed cell-mediated immune responses following hemorrhage potentially by maintaining organ blood flow, it remains unknown whether Larginine has any salutary effects on the depressed local immune response at the wound site. Methods: Male mice were subjected to a midline laparotomy and polyvinyl sponges were implanted subcutaneously in the abdominal wound prior to hemorrhage (35 +/- 5 mm Hg for 90 min and resuscitation) or sham operation. During resuscitation mice received 300 mg/kg body weight L-arginine or saline (vehicle). Sponges were harvested 24 h thereafter, wound fluid collected and wound immune cells cultured for 24 h in the presence of LPS. Pro- (IL-1beta, IL-6) and anti-inflammatory (IL-10) cytokines were determined in the supernatants and the wound fluid. In addition, wounds were stained for IL-6 immunohistochemically. In a separate set of animals, skin and muscle blood flow was determined by microspheres. Results: The capacity of wound immune cells to release IL-1beta and IL-6 in vitro was significantly depressed in hemorrhaged mice receiving vehicle. Administration of L-arginine, however, improved wound immune cell function. In contrast, in vivo the increased IL-6 release at the wound site was decreased in L-arginine-treated mice following hemorrhage. Moreover, IL-10 levels were significantly increased in the wound fluid in hemorrhaged animals receiving L-arginine compared to vehicle-treated mice. In addition, the depressed skin and muscle blood flow after hemorrhage was restored by L-arginine. Conclusions: Thus, L-arginine might improve local wound cell function by decreasing the inflammatory response at the wound site. Since L-arginine protected wound immune cell function this amino acid might represent a novel and useful adjunct to fluid resuscitation for decreasing wound complications following hemorrhage. Copyright beta 2002 S. Karger AG, Basel

Near-Infrared Studies of V1280 Sco (Nova Scorpii 2007)

We present spectroscopic and photometric results of Nova V1280 Sco which was discovered in outburst in early 2007 February. The large number of spectra obtained of the object leads to one of the most extensive, near-infrared spectral studies of a classical nova. The spectra evolve from a P-Cygni phase to an emission-line phase and at a later stage is dominated by emission from the dust that formed in this nova. A detailed model is computed to identify and study characteristics of the spectral lines. Inferences from the model address the vexing question of which novae have the ability to form dust. It is demonstrated, and strikingly corroborated with observations, that the presence of lines in the early spectra of low-ionization species like Na and Mg - indicative of low temperature conditions - appear to be reliable indicators that dust will form in the ejecta. It is theoretically expected that mass loss during a nova outburst is a sustained process. Spectroscopic evidence for such a sustained mass loss, obtained by tracing the evolution of a P-Cygni feature in the Brackett gamma line, is presented here allowing a lower limit of 25-27 days to be set for the mass-loss duration. Photometric data recording the nova's extended 12 day climb to peak brightness after discovery is used to establish an early fireball expansion and also show that the ejection began well before maximum brightness. The JHK light curves indicate the nova had a fairly strong second outburst around 100 days after the first.Comment: Accepted in MNRAS. The paper contains 8 figures and 4 tables. Few typographical errors were correcte

New triple systems in the RasTyc sample of stellar X-ray sources

During the study of a large set of late-type stellar X-ray sources, we discovered a large fraction of multiple systems. In this paper we investigate the orbital elements and kinematic properties of three new spectroscopic triple systems as well as spectral types and astrophysical parameters (T_eff, log g, vsin i, log N(Li)) of their components. We conducted follow-up optical observations, both photometric and spectroscopic at high resolution, of these systems. We used a synthetic approach and the cross-correlation method to derive most of the stellar parameters. We estimated reliable radial velocities and deduced the orbital elements of the inner binaries. The comparison of the observed spectra with synthetic composite ones, obtained as the weighted sum of three spectra of non-active reference stars, allowed us to determine the stellar parameters for each component of these systems. We found all are only composed of main sequence stars. These three systems are certainly stable hierarchical triples composed of short-period inner binaries plus a tertiary component in a long-period orbit. From their kinematics and/or Lithium content, these systems result to be fairly young.Comment: Accepted for publication in A&A (on July 22, 2008

Eclipsing Binaries in the OGLE Variable Star Catalog. IV. The Pre-Contact, Equal-Mass Systems

We used the database of eclipsing binaries detected by the OGLE microlensing project in the pencil-beam search volume toward Baade's Window to define a sample of 74 detached, equal-mass, main-sequence binary stars with short orbital periods in the range 0.19<P<8 days. The logarithmic slope of the period distribution, logN propto (-0.8 pm 0.2) logP, was used to infer the angular-momentum-loss (AML) efficiency for the late, rapidly-rotating members of close binaries. It is very likely that the main cause of the negative slope is a discovery selection bias that progressively increases with the orbital period length. Assuming a power-law dependence for the correction for the bias: bias propto -C logP (with C ge 0), the AML braking-efficiency exponent alpha in dH/dt = P^-alpha can take any value alpha = (-1.1 pm 0.2) + C. Very simple considerations of discovery biases suggest C simeq 4/3, which would give an AML braking law very close to the "saturated" one, with no dependence on the period. However, except for plausibility arguments, we have no firm data to support this estimate of C, so that alpha remains poorly constrained. The results signal the utmost importance of the detection bias evaluation for variable star databases used in analyses similar to the one presented in this study.Comment: accepted by AJ, October 1999. AASTEX-4. 9 PS figures and 3 table