Winter Survival and Resource Use of Translocated Northern Bobwhite in the Mid-Atlantic United States

Northern bobwhite (Colinus virginianus; hereafter, bobwhite) in the Mid-Atlantic United States have been experiencing precipitous population declines due to a combination of habitat deterioration, urban and suburban sprawl, change in forest management regimes, and farming practices. In recent years, restocking of bobwhite through translocation efforts has gained interest to rebuild local populations. However, empirical studies are warranted to understand the limitations of translocation as it relates to its potential use for long-term population recovery and persistence in this region. Further, few studies nation-wide have evaluated resource use and survival during the non-breeding season on translocated sites. As such, we translocated 360 bobwhites from source populations from southern latitudes during March–April 2015–2017 into 2 different landscape types similar to the source population vegetative communities (agricultural cropland dominated in Maryland, USA versus pine forest dominated in New Jersey, USA) and tested the effects of habitat fragmentation on survival and habitat use during the subsequent non-breeding season. We found habitat fragmentation negatively affecting survival and resource use among translocated bobwhite on fragmented cropland-dominated sites as compared to larger unfragmented forested sites. Survival was lower on cropland sites compared to forested sites such that bobwhite in cropland-dominated landscapes were \u3e125 times less likely to survive the winter than those on forested sites. In our examination of resource use, bobwhite in structurally complex forested sites used cut pine, early-successional woody, early-successional herbaceous, and thinned pine more than what was available on the landscape. On the cropland sites bobwhite used food plots, early-successional woody, and mixed woods more than what was available on the landscape and only food plots at the home range scale. While larger unfragmented forested bobwhite habitat ultimately provided a more successful translocation landscape, birds still had large home ranges and relatively low survival. Therefore, proper pine management may be necessary to optimize habitat availability during the non-breeding season. Our findings provide rare information on demographic resiliency and resource use for translocated bobwhite during the non-breeding season. Further, this research provides valuable information to improve future translocation efforts in the Mid-Atlantic

TRADEOFF ANALYSIS OF BACKUP POWER GENERATION SOLUTIONS FOR MILITARY BASES

Energy security is becoming increasingly important as the DOD relies on energy to build and project combat power from military installations. Installation energy managers currently ensure uninterrupted power to mission-critical facilities through emergency stand-alone diesel generators. Research has recently indicated that networks of smaller diesel generators offer greater energy security benefits than a network of a few large diesel generators. However, existing research has not compared or analyzed the cost and resilience between the two strategies. This capstone examines the cost and resilience of centralized and decentralized power architectures by developing a general methodology to capture comprehensive life-cycle costs and metrics. It examines resilience for various configurations of networked diesel generators. Installation power managers can apply this method to quantitatively compare life-cycle cost and resilience of emergency diesel generator solutions to improve energy security within the unique constraints of an installation. The capstone then applied this methodology to the aging diesel generator power plant at Naval Station, Rota, Spain, which demonstrated that decentralized architecture was the most cost-effective strategy for resilience. Finally, the capstone presents these findings and general methodology for future application.Navy Shore Energy Technology Transition and Integration (NSETTI), Naval Facilities (NAVFAC) Engineering and Expeditionary Warfare Center (EXWC), Port Hueneme, CA, 93043Captain, United States ArmyMajor, United States ArmyMajor, United States ArmyCaptain, United States ArmyCaptain, United States ArmyApproved for public release. Distribution is unlimited

Winter Survival and Habitat Selection by Translocated Northern Bobwhite in the New Jersey Pine Barrens: Preliminary Results

Northern bobwhite (Colinus virginianus) populations have been experiencing precipitous range-wide declines for more than 50 years; some of the steepest declines occurring in the Mid-Atlantic states. These declines are largely attributed to habitat deterioration from urban sprawl, change in forest management, and intensive farming. This ongoing study aims to evaluate the efficacy of translocating wild bobwhites into the New Jersey Pine Barrens as a means to restore their historic populations. Translocation has proven relatively successful in augmenting bobwhite populations in other regions as well as restoring populations of gallinaceous species. This portion of the study aims to investigate what bobwhites require during winter months (October—March) in the Mid-Atlantic to survive until summer for reproduction. The study site, Pine Island Cranberry Company, is the largest privately owned tract of land (6,800 hectares) in New Jersey, with habitat comprised of pitch pine (Pinus rigida), shortleaf pine (Pinus echinata), scrub oak (Quercus ilicifolia), and early successional forbs and grasses. For three consecutive years (2015—2017) prior to breeding season, we will translocate 80 radio-collared bobwhites (40 male, 40 female) to Pine Island from wild populations in southwest Georgia. These bobwhites are radio-located 3—5 times per week throughout the year while this portion of the study focuses on the winter months. We are collecting microhabitat measurements (e.g., basal density, groundcover, understory, and canopy closure) from 30 random telemetry location points, per covey, per habitat type to characterize winter habitat use. Survival is estimated using staggered-entry Kaplan-Meier analyses and a Cox proportional hazard model in R to determine covariates of daily mortality. We are reporting on the first 2 years of results

Summer Survival of Translocated Northern Bobwhite in the New Jersey Pine Barrens: Preliminary Results

Northern bobwhite (Colinus virginianus) have declined precipitously since the 1960s, largely due to habitat deterioration and changes in land use; some of the highest declines have been observed in the Mid-Atlantic States. In other regions, attempts to augment bobwhite populations have been relatively successful using translocation. As part of a long-term restocking program, focal areas for translocation in the mid-Atlantic region were identified by biologists at a National Bobwhite Conservation Initiative (NBCI) workshop. The objective of this project is to evaluate translocation to restore bobwhite populations in the New Jersey Pine Barrens, a focal area designated with a high ranking for potential bobwhite recovery. The study site, Pine Island Cranberry Co., is the largest privately owned land tract (\u3e6,000 hectares) in New Jersey, with a mix of shortleaf pine (Pinus echinata), pitch pine (P. rigida), scrub oak (Quercus ilicifolia), and early successional forbes and grasses. For three consecutive years (2015—2017) prior to breeding season, we are translocating eighty radio-collared bobwhite (40 male, 40 female) from wild populations in southwest Georgia. These individuals are radio-located 3-5 times per week, year round. We are collecting microhabitat measurements (e.g., groundcover, understory, and canopy closure) and monitoring nests to characterize habitat use, nest site selection, and nest fate. Survival is estimated using staggered-entry Kaplan-Meier analyses and a Cox proportional hazard model in R to determine covariates of daily mortality. Six of 14 nests were successful in summer 2015 (66 known hatches), and 0 of 12 nests were successful in summer 2016. Snake depredation was the cause of 41.7% of failed nests in 2016. Preliminary analyses produce a five-month adult survival rate of 0.455 (SE = 0.138) for summer 2015 and 0.270 (SE = 0.0516) for 2016. Our planned third summer (2017) of data collection will increase our understanding of these disparate survival estimates

Can grapheme-color synesthesia be induced by hypnosis?

Grapheme-color synesthesia is a perceptual experience where graphemes, letters or words evoke a specific color, which are experienced either as spatially coincident with the grapheme inducer (projector sub-type) or elsewhere, perhaps without a definite spatial location (associator sub-type). Here, we address the question of whether synesthesia can be rapidly produced using a hypnotic color suggestion to examine the possibility of “hypnotic synesthesia”, i.e., subjectively experienced color hallucinations similar to those experienced by projector synesthetes. We assess the efficacy of this intervention using an “embedded figures” test, in which participants are required to detect a shape (e.g., a square) composed of local graphemic elements. For grapheme-color synesthetes, better performance on the task has been linked to a higher proportion of graphemes perceived as colored.We found no performance benefits on this test when using a hypnotic suggestion, as compared to a no-suggestion control condition. The same result was found when participants were separated according to the degree to which they were susceptible to the suggestion (number of colored trials perceived). However, we found a relationship between accuracy and subjective reports of color in those participants who reported a large proportion of colored trials: trials in which the embedded figure was accurately recognized (relative to trials in which it was not) were associated with reports of more intense colors occupying a greater spatial extent. Collectively, this implies that hypnotic color was only perceived after shape detection rather than aiding in shape detection via color-based perceptual grouping. The results suggest that hypnotically induced colors are not directly comparable to synesthetic ones

Current advances in experimental and computational approaches to enhance CAR T cell manufacturing protocols and improve clinical efficacy

Since the FDA’s approval of chimeric antigen receptor (CAR) T cells in 2017, significant improvements have been made in the design of chimeric antigen receptor constructs and in the manufacturing of CAR T cell therapies resulting in increased in vivo CAR T cell persistence and improved clinical outcome in certain hematological malignancies. Despite the remarkable clinical response seen in some patients, challenges remain in achieving durable long-term tumor-free survival, reducing therapy associated malignancies and toxicities, and expanding on the types of cancers that can be treated with this therapeutic modality. Careful analysis of the biological factors demarcating efficacious from suboptimal CAR T cell responses will be of paramount importance to address these shortcomings. With the ever-expanding toolbox of experimental approaches, single-cell technologies, and computational resources, there is renowned interest in discovering new ways to streamline the development and validation of new CAR T cell products. Better and more accurate prognostic and predictive models can be developed to help guide and inform clinical decision making by incorporating these approaches into translational and clinical workflows. In this review, we provide a brief overview of recent advancements in CAR T cell manufacturing and describe the strategies used to selectively expand specific phenotypic subsets. Additionally, we review experimental approaches to assess CAR T cell functionality and summarize current in silico methods which have the potential to improve CAR T cell manufacturing and predict clinical outcomes

Guidelines for the assessment of efficacy of clinical hypnosis applications

Research on the efficacy of hypnosis applications continues to grow, but there remain major gaps between the science and clinical practice. One challenge has been a lack of consensus on which applications of hypnosis are efficacious based on research evidence. In 2018, 6 major hypnosis organizations collaborated to form the Task Force for Establishing Efficacy Standards for Clinical Hypnosis. This paper describes a Guideline for the Assessment of Efficacy of Clinical Hypnosis Applications developed by the Task Force, which makes 10 specific recommendations. The guideline is intended to be a tool for those who want to assess the quality of existing evidence on the efficacy of clinical hypnosis for any particular indication. The paper also discusses methodological issues in the interpretation and implementation of these guidelines. Future papers will report on the other products of the Hypnosis Efficacy Task Force, such as best practice recommendations for outcomes research in hypnosis and an international survey of researchers and clinicians on current practice and attitudes about hypnosis

A simple clinical scoring system to improve the sensitivity and standardization of the diagnosis of mycosis fungoides type cutaneous T-cell lymphoma: logistic regression of clinical and laboratory data

Background  The diagnosis of mycosis fungoides (MF) is notoriously difficult to establish because in the early stages, histological features may be nonspecific or merely suggestive. Objectives  To standardize the diagnosis of MF. Methods  We studied 138 patients with suspected MF referred over a 7-year period to a university department of a dermatology-based cutaneous lymphoma clinic. Six diagnostic criteria were evaluated: clinical morphology, clinical distribution, skin biopsy T-cell receptor gene rearrangement (TCR-GR), skin biopsy pan T-cell marker loss ≥ 2, skin biopsy CD4/CD8 ratio ≥ 6, and skin biopsy diffuse epidermal HLA-DR expression. These six clinical and laboratory criteria were compared by logistic regression analysis in patients with histologically diagnosed MF and those with benign disease. Results  Of the 138 patients, 74 had histology of MF, 47 of benign dermatoses and 17 were indeterminate. Close associations were found between a histological diagnosis of MF and TCR-GR (odds ratio 14·4), classical morphology (7·5), classical distribution (2·5) and diffuse epidermal HLA-DR expression (2·8). Logistic regression models were developed depending on the availability of data (either TCR-GR or HLA-DR). Probabilities for correctly diagnosing MF compared with histology as the ‘gold standard’ were derived from these logistic regression models. A scoring system assigning point values based on these probabilities was then created in order to assist the clinician in making the diagnosis. If using TCR-GR data, a positive TCR-GR = 2·5 points, the presence of classical morphology = 2·0 points, and the presence of classical distribution = 1·5 points. A total score of ≥ 3·5 points assigns a high probability (> 85%) of having MF. If using HLA-DR expression, then the presence of classical morphology = 2·5 points, a positive diffuse epidermal HLA-DR expression = 2·0 points, and the presence of classical distribution = 1·5 points. In this case, a total score of ≥ 4·0 points assigns a high probability (> 85%) of MF. Conclusions  The logistic regression models and scoring systems integrate clinical and laboratory assessments, allow rapid probability estimation, and provide a threshold for the diagnosis of MF in an objective, standardized manner.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75520/1/j.1365-2133.2003.05458.x.pd

Zinc intake, status and indices of cognitive function in adults and children: a systematic review and meta-analysis

In developing countries, deficiencies of micronutrients are thought to have a major impact on child development; however, a consensus on the specific relationship between dietary zinc intake and cognitive function remains elusive. The aim of this systematic review was to examine the relationship between zinc intake, status and indices of cognitive function in children and adults. A systematic literature search was conducted using EMBASE, MEDLINE and Cochrane Library databases from inception to March 2014. Included studies were those that supplied zinc as supplements or measured dietary zinc intake. A meta-analysis of the extracted data was performed where sufficient data were available. Of all of the potentially relevant papers, 18 studies met the inclusion criteria, 12 of which were randomised controlled trials (RCTs; 11 in children and 1 in adults) and 6 were observational studies (2 in children and 4 in adults). Nine of the 18 studies reported a positive association between zinc intake or status with one or more measure of cognitive function. Meta-analysis of data from the adult’s studies was not possible because of limited number of studies. A meta-analysis of data from the six RCTs conducted in children revealed that there was no significant overall effect of zinc intake on any indices of cognitive function: intelligence, standard mean difference of <0.001 (95% confidence interval (CI) –0.12, 0.13) P=0.95; executive function, standard mean difference of 0.08 (95% CI, –0.06, 022) P=0.26; and motor skills standard mean difference of 0.11 (95% CI –0.17, 0.39) P=0.43. Heterogeneity in the study designs was a major limitation, hence only a small number (n=6) of studies could be included in the meta-analyses. Meta-analysis failed to show a significant effect of zinc supplementation on cognitive functioning in children though, taken as a whole, there were some small indicators of improvement on aspects of executive function and motor development following supplementation but high-quality RCTs are necessary to investigate this further