Point-by-point inscription of first-order fiber Bragg grating for C-band applications

The influence of the fiber geometry on the point-by-point inscription of fiber Bragg gratings using a femtosecond laser is highlighted. Fiber Bragg gratings with high spectral quality and strong first-order Bragg resonances within the C-band are achieved by optimizing the inscription process. Large birefringence (1.2x10-4) and high degree of polarizationdependent index modulation are observed in these gratings. Potential applications of these gratings in resonators are further illustrated. © 2007 Optical Society of America

Fabrication of high-rejection, low-loss filters by the concatenation of broadly chirped fibre Bragg gratings

Single- and multiple-bandpass filters with broad, high- rejection stopbands and narrow, low-loss passbands are significant components for fiber networks. Hitherto, this combination of characteristics has proved elusive using in- fiber grating techniques. Here, we report the realization of practical single-passband filters synthesized from concatenated chirped broadband fiber gratings written holographically in a highly photosensitive fiber. Practical, low-loss (< 2 dB), single-passband fiber Bragg grating transmission filters have been fabricated with greater than 30 dB out-of-band rejection over a 25 nm spectral width. ©2005 Copyright SPIE - The International Society for Optical Engineering

The cardiomyocyte "redox rheostat": Redox signalling via the AMPK-mTOR axis and regulation of gene and protein expression balancing survival and death.

Reactive oxygen species (ROS) play a key role in development of heart failure but, at a cellular level, their effects range from cytoprotection to induction of cell death. Understanding how this is regulated is crucial to develop novel strategies to ameliorate only the detrimental effects. Here, we revisited the fundamental hypothesis that the level of ROS per se is a key factor in the cellular response by applying different concentrations of H2O2 to cardiomyocytes. High concentrations rapidly reduced intracellular ATP and inhibited protein synthesis. This was associated with activation of AMPK which phosphorylated and inhibited Raptor, a crucial component of mTOR complex-1 that regulates protein synthesis. Inhibition of protein synthesis by high concentrations of H2O2 prevents synthesis of immediate early gene products required for downstream gene expression, and such mRNAs (many encoding proteins required to deal with oxidant stress) were only induced by lower concentrations. Lower concentrations of H2O2 promoted mTOR phosphorylation, associated with differential recruitment of some mRNAs to the polysomes for translation. Some of the upregulated genes induced by low H2O2 levels are cytoprotective. We identified p21Cip1/WAF1 as one such protein, and preventing its upregulation enhanced the rate of cardiomyocyte apoptosis. The data support the concept of a "redox rheostat" in which different degrees of ROS influence cell energetics and intracellular signalling pathways to regulate mRNA and protein expression. This sliding scale determines cell fate, modulating survival vs death

A dynamically extending exclusion process

An extension of the totally asymmetric exclusion process, which incorporates a dynamically extending lattice is explored. Although originally inspired as a model for filamentous fungal growth, here the dynamically extending exclusion process (DEEP) is studied in its own right, as a nontrivial addition to the class of nonequilibrium exclusion process models. Here we discuss various mean-field approximation schemes and elucidate the steady state behaviour of the model and its associated phase diagram. Of particular note is that the dynamics of the extending lattice leads to a new region in the phase diagram in which a shock discontinuity in the density travels forward with a velocity that is lower than the velocity of the tip of the lattice. Thus in this region the shock recedes from both boundaries.Comment: 20 pages, 12 figure

Embedding low loss polymer optical fibre Bragg gratings:two different approaches

In this paper, we present two different ways to embed polymer fibre Bragg gratings (FBGs) into polymer matrices. In the first experiment, we embedded the FBG into a 3D printed polymer structure, whereas in the second experiment, the coating was polymerized around the fibre. In both cases, the response of the grating was unchanged, without any loss or distortion of the FBG signal compared with the bare fibre response. The design of the polymer coating was optimised for the measurement of a single measurand. We highlighted two possible applications: surface bend deformation monitoring and improved-sensitivity temperature sensing

Boron isotope insights into the origin of subduction signatures in continent-continent collision zone volcanism

We present the first boron abundance and δ11B data for young (1.5-0 Ma) volcanic rocks formed in an active continent-continent collision zone. The δ11B of post-collisional volcanic rocks (−5 to +2‰) from the Armenian sector of the Arabia-Eurasia collision zone are heavier than mid-ocean ridge basalts (MORB), confirming trace element and isotope evidence for their derivation from a subduction-modified mantle source. Based on the low B/Nb (0.03-0.25 vs 0.2-90 in arc magmas), as well as low Ba/Th and Pb/Ce, this source records a subduction signature which is presently fluid-mobile element depleted relative to most arc settings. The heavier than MORB δ11B of post-collision volcanic rocks argues against derivation of their subduction signature from a stalled slab, which would be expected to produce a component with a lighter than MORB δ11B, due to previous fluid depletion. Instead, the similarity of δ11B in Plio-Pleistocene post-collision to 41 Ma alkaline igneous rocks also from Armenia (and also presented in this study), suggests that the subduction signature is inherited from Mesozoic-Paleogene subduction of Neotethys oceanic slabs. The slab component is then stored in the mantle lithosphere in amphibole, which is consistent with the low [B] in both Armenian volcanic rocks and metasomatic amphibole in mantle xenoliths. Based on trace element and radiogenic isotope systematics, this slab component is thought to be dominated by sediment melts (or supercritical fluids). Previously published δ11B of metasediments suggests a sediment-derived metasomatic agent could produce the B isotope composition observed in Armenian volcanic rocks. The lack of evidence for aqueous fluids preserved over the 40 Myr since initial collision supports observations that this latter component is transitory, while the lifetime of sediment melts/supercritical fluids can be extended to >40 Myr

3D-printed PMMA preform for hollow-core POF drawing

In this paper we report the first, to our knowledge, 3D-printed hollow-core poly(methyl methacrylate) (PMMA) preform for polymer optical fibre drawing. It was printed of commercial PMMA by means of fused deposition modelling technique. The preform was drawn to cane, proving good enough quality of drawing process and the PMMA molecular weight to be appropriate for drawing. This ascertains that the manufacturing process provides preforms suitable for hollow-core fibre drawing. The paper focuses on maximisation of transparency of PMMA 3D printouts by optimising printing process parameters: nozzle temperature, printing speed and infill

A model of hyphal tip growth involving microtubule-based transport

We propose a simple model for mass transport within a fungal hypha and its subsequent growth. Inspired by the role of microtubule-transported vesicles, we embody the internal dynamics of mass inside a hypha with mutually excluding particles progressing stochastically along a growing one-dimensional lattice. The connection between long range transport of materials for growth, and the resulting extension of the hyphal tip has not previously been addressed in the modelling literature. We derive and analyse mean-field equations for the model and present a phase diagram of its steady state behaviour, which we compare to simulations. We discuss our results in the context of the filamentous fungus, Neurospora crassa.Comment: 5 pages, 5 figure