79 research outputs found
Magnetic Diode Effect in Double Barrier Tunnel Junctions
A quantum statistical theory of spin-dependent tunneling through asymmetric
magnetic double barrier junctions is presented which describes ballistic
and diffuse tunneling by a single analytical expression. It is evidenced that
the key parameter for the transition between these two tunneling regimes is the
electron scattering. For these junctions a strong asymmetric behaviour in the
I-V characteristics and the tunnel magnetoresistance (TMR) is predicted which
can be controlled by an applied magnetic field. This phenomenon relates to the
quantum well states in the middle metallic layer. The corresponding resonances
in the current and the TMR are drastically phase shifted under positive and
negative voltage.Comment: 10 pages, 4 Postscript figures, submitted to Europhys. Let
Oxidation process of AlOx-based magnetic tunnel junctions studied by photoconductance
The oxidation process of Co/AlOx/Co magnetic tunnel junctions has been investigated by photoconductance, in addition to traditional transport measurements. The shape of the photoconductance curves is explained within the framework of a simple qualitative model, assuming an oxidation time dependent imbalance of the incident forward and reverse hot electron fluxes, as well as inelastic scattering processes in the oxide. Due to the large sensitivity of the technique, the presence of unoxidized Al beneath the barrier layer can be monitored very accurately. The disappearance of a negative contribution to the photocurrent indicates the complete oxidation of the barrier layer, which coincides with the maximum magnetoresistance. From a Fowler analysis, the barrier height is determined as a function of oxidation time. The observed disagreement of the effective barrier heights determined by this technique and those found by Simmons fits demonstrates the added value of photoconductance studies
Magnetization Vorticity and Exchange Bias Phenomena in Arrays of Small Asymmetric Magnetic Rings
Arrays of nanoscopic magnetic asymmetric rings, 150 nm in outer diameter, are
fabricated using the techniques of electron-beam lithography, angular
deposition and ion-beam etching. Magnetic measurements for cobalt asymmetric
rings at room temperature verifies previous reports of vortex magnetic state
formation of a desired circulation direction for the application of external
magnetic field along the asymmetry axis of the rings. However, the main theme
of this article is the observation of exchange bias phenomena when the ring
samples are cooled down to low temperature in the presence of a positive
magnetic field. Very interestingly, the observed exchange bias effect is
negative for along and perpendicular orientations of ring's asymmetry axis with
respect to the in-plane external magnetic field. This is in good quantitative
agreement with the random interface model proposed by Malozemoff et al. For the
application of inplane external magnetic field at 45 degree with respect to the
asymmetry axis, the exchange bias effect is positive. Unlike the exchange bias
effects in thin films, this is a very unusual observation indicating that
exchange bias phenomena of opposite natures can be manipulated by appropriate
combination of geometrical constraint and external magnetic field direction, in
addition to the interfacial interactions between ferromagnetic (FM) and
antiferromagnetic (AFM) layer.Comment: Asymmetric magnetic rings arrays; Exchange bias phenomen
Magnetic phases and reorientation transitions in antiferromagnetically coupled multilayers
In antiferromagnetically coupled superlattices grown on (001) faces of cubic
substrates, e.g. based on materials combinations as Co/Cu, Fe/Si, Co/Cr, or
Fe/Cr, the magnetic states evolve under competing influence of bilinear and
biquadratic exchange interactions, surface-enhanced four-fold in-plane
anisotropy, and specific finite-size effects. Using phenomenological
(micromagnetic) theory, a comprehensive survey of the magnetic states and
reorientation transitions has been carried out for multilayer systems with even
number of ferromagnetic sub-layers and magnetizations in the plane. In
two-layer systems (N=2) the phase diagrams in dependence on components of the
applied field in the plane include ``swallow-tail'' type regions of
(metastable) multistate co-existence and a number of continuous and
discontinuous reorientation transitions induced by radial and transversal
components of the applied field. In multilayers (N \ge 4) noncollinear states
are spatially inhomogeneous with magnetization varying across the multilayer
stack. For weak four-fold anisotropy the magnetic states under influence of an
applied field evolve by a complex continuous reorientation into the saturated
state. At higher anisotropy they transform into various inhomogeneous and
asymmetric structures. The discontinuous transitions between the magnetic
states in these two-layers and multilayers are characterized by broad ranges of
multi-phase coexistence of the (metastable) states and give rise to specific
transitional domain structures.Comment: Manuscript 34 pages, 14 figures; submitted for publicatio
On the growth mechanism of nickel and cobalt nanowires and comparison of their magnetic properties
Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy
BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to 300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m 2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years
Canagliflozin and renal outcomes in type 2 diabetes and nephropathy
BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years
- …