221 research outputs found
Broadband compact microstrip patch antenna design loaded by multiple split ring resonator superstrate and substrate
We present microstrip patch antenna loaded with multiple split ring resonator substrate and superstrate. We analyze how the loading of split ring resonator superstrate and substrate can improve the bandwidth compared to the simple microstrip patch antenna and microstrip patch antenna loaded with split ring resonator superstrate. Another important observation is made for multiple split ring resonator loading in superstrate and substrate of microstrip patch antenna. The design is compared for two, three, and four-ring split ring resonator loading. The designs are also compared for different gap spacing between the rings. All three designs are compared for small gap and large gap between the rings. The design results in the form of reflection coefficient and bandwidth is presented in this manuscript. The design results are also compared with previously published designs
Broadband compact microstrip patch antenna design loaded by multiple split ring resonator superstrate and substrate
We present microstrip patch antenna loaded with multiple split ring resonator substrate and superstrate. We analyze how the loading of split ring resonator superstrate and substrate can improve the bandwidth compared to the simple microstrip patch antenna and microstrip patch antenna loaded with split ring resonator superstrate. Another important observation is made for multiple split ring resonator loading in superstrate and substrate of microstrip patch antenna. The design is compared for two, three, and four-ring split ring resonator loading. The designs are also compared for different gap spacing between the rings. All three designs are compared for small gap and large gap between the rings. The design results in the form of reflection coefficient and bandwidth is presented in this manuscript. The design results are also compared with previously published designs
The Elderly Poor in the EU’s New Member States. ENEPRI Research Reports No. 60, November 2008
To what extent is the financial position of the elderly in the NMS more vulnerable than that of the old member states (or the EU-15), due to a rather unfavourable starting point and the possible impact of pension reforms? This is the main issue of the current research report. It tries to delineate the vulnerability of the income position of elderly people in the NMS, in relation to the demographic, socio-economic and institutional context of these countries. More specifically, the report focuses on: - the current level of income of the elderly in the NMS, and the degree of relative poverty; - the way this position is related to the educational and labour market status of the elderly in the NMS, their retirement behaviour, institutional arrangements (notably the pension system), and demographic developments; - specific problems regarding the income position of possibly ‘marginal’ elderly groups in the NMS (such as single elderly female pensioners)
Effect of mebendazole on fibrosarcoma in hamsters
Purpose: To investigate the effect of mebendazole on an in vivo solid tumor model of fibrosarcoma in hamsters.Methods: 24 Syrian golden hamsters of both sexes with the approximate body weight of 100g were randomly distributed in 2 experimental and 2 control groups, with 6 animals in each group. BHK-21/C13 cells (2 x 106) in 1 mL Glasgow Minimum Essential Medium (GMEM) were injected subcutaneously into the back of each animal in 3 groups. The experimental groups were treated with mebendazole (460 mg/kg) via a gastric tube on a daily basis, immediately after tumor inoculation. In addition, one experimental group received deoxycholic acid 20 mg/kg once a day. After 2 weeks, when the tumors were approximately 1 - 2 cm in the control group, all the animals were sacrificed, and their blood collected for laboratory analysis. The tumors were excised, their weight and diameters measured, and the volumes calculated. The tumor samples were histopathologically assessed and the main organs toxicologically analyzed. Images were taken and processed by an imaging software, and Ki-67-positive cells in the tumor samples were quantified.Results: Mebendazole diminished tumor mitosis from 18.5 ± 3.02 to 13.5 ± 3.45 (p < 0.05), vasculature and tissue penetration, and increased necroses in tumor slices. Tumor volume and weight were insignificantly attenuated. Toxicity was not observed.Conclusion: Mebendazole might be an effective non-toxic agent in sarcoma therapy.Keywords: Mebendazole, Hamsters, BHK-21/C13 cells, Fibrosarcoma therapy, Tumor mitosi
Application of a widely-used tropical anti-worm agent, mebendazole, in modern oncology
Although clinical trials have not been completed, it has already been confirmed that mebendazole, a well-known anti-parasitic drug widely used in the tropical areas, inhibits cancer cell growth. Preclinical studies show that mebendazole notably impedes the growth of malignant and metastatic tumors such as osteosarcoma and soft tissue sarcoma, melanoma, carcinoma (lung, colorectal, breast, ovarian, hepatocellular and adrenocortical), acute myeloid leukaemia, glioblastoma multiforme and meduloblastoma. Mebendazole can induce the depolymerization of microtubules in neoplasms and newly formed vasculature, stopping tumor growth and neoangiogenesis, along with other proposed mechanisms of action.Keywords: Anthelmintic, Mebendazole, Cancer treatment, Antimicrotubullar effect, Antineoangiogenesi
Mapping between dynamic markings and performed loudness: a machine learning approach
This work was supported in part by UK EPSRC Platform Grant for Digital Music (EP/K009559/1), the Spanish TIN project TIMUL (TIN2013-48152- C2-2-R), and the European Unions Horizon 2020 research and innovation programme under grant agreement No 688269
How to determine local elastic properties of lipid bilayer membranes from atomic-force-microscope measurements: A theoretical analysis
Measurements with an atomic force microscope (AFM) offer a direct way to
probe elastic properties of lipid bilayer membranes locally: provided the
underlying stress-strain relation is known, material parameters such as surface
tension or bending rigidity may be deduced. In a recent experiment a
pore-spanning membrane was poked with an AFM tip, yielding a linear behavior of
the force-indentation curves. A theoretical model for this case is presented
here which describes these curves in the framework of Helfrich theory. The
linear behavior of the measurements is reproduced if one neglects the influence
of adhesion between tip and membrane. Including it via an adhesion balance
changes the situation significantly: force-distance curves cease to be linear,
hysteresis and nonzero detachment forces can show up. The characteristics of
this rich scenario are discussed in detail in this article.Comment: 14 pages, 9 figures, REVTeX4 style. New version corresponds to the
one accepted by PRE. The result section is restructured: a comparison to
experimental findings is included; the discussion on the influence of
adhesion between AFM tip and membrane is extende
Education for Sustainable Development: Towards the Sustainable University
We planned this conference in anticipation of the end of the UN Decade of Education for Sustainable Development (DESD), and the start of the next phase for those involved in ESD here and internationally. At Plymouth University, 2015 marks ten year anniversary since cross-‐institutional work on sustainability and sustainability education was spearheaded by the founding of the Centre for Sustainable Futures (CSF). Coincidentally, 2015 also marks a ten years since the influential HEFCE policy document ‘Sustainable Development in Higher Education’ was released. Holding the conference in January – named after the Roman god of doorways, of endings and beginnings – we sought to look at some of what has been achieved in sustainability education to date and explore its prospects as we move forward. Following an enthusiastic response to the call for abstracts, the conference featured a diverse range of research papers, posters, and roundtable presentations from academics and practitioners across the UK and beyond. The conference was arranged around three overarching themes: ESD Pedagogy: Criticality, Creativity, and Collaboration What are the teaching and learning processes that enable students to develop their own capacity to think critically and creatively in the face of global sustainability challenges and, secondly, to act collaboratively in ways that pursue more hopeful and sustainable futures? Innovative Learning Spaces for ESD What are the physical environments that provide opportunities for new forms of sustainability education to flourish? What lies beyond the lecture hall that is conducive to student learning through inquiry-‐based, active, participatory, interdisciplinary and experiential methods? Towards the Sustainable University What are effective approaches for leading institutional change, organisational learning, and staff CPD towards sustainability? This publication focuses on the last theme – Towards the Sustainable University. The previous PedRIO Occasional Paper 8 looks at the first theme ESD Pedagogy: Criticality, Creativity, and Collaboration
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