Ion collection by oblique surfaces of an object in a transversely-flowing strongly-magnetized plasma

The equations governing a collisionless obliquely-flowing plasma around an ion-absorbing object in a strong magnetic field are shown to have an exact analytic solution even for arbitrary (two-dimensional) object-shape, when temperature is uniform, and diffusive transport can be ignored. The solution has an extremely simple geometric embodiment. It shows that the ion collection flux density to a convex body's surface depends only upon the orientation of the surface, and provides the theoretical justification and calibration of oblique `Mach-probes'. The exponential form of this exact solution helps explain the approximate fit of this function to previous numerical solutions.Comment: Four pages, 2 figures. Submitted to Phys. Rev. Letter

Morphine activates neuroinflammation in a manner parallel to endotoxin

Opioids create a neuroinflammatory response within the CNS, compromising opioid-induced analgesia and contributing to various unwanted actions. How this occurs is unknown but has been assumed to be via classic opioid receptors. Herein, we provide direct evidence that morphine creates neuroinflammation via the activation of an innate immune receptor and not via classic opioid receptors. We demonstrate that morphine binds to an accessory protein of Toll-like receptor 4 (TLR4), myeloid differentiation protein 2 (MD-2), thereby inducing TLR4 oligomerization and triggering proinflammation. Small-molecule inhibitors, RNA interference, and genetic knockout validate the TLR4/MD-2 complex as a feasible target for beneficially modifying morphine actions. Disrupting TLR4/MD-2 protein–protein association potentiated morphine analgesia in vivo and abolished morphine-induced proinflammation in vitro, the latter demonstrating that morphine-induced proinflammation only depends on TLR4, despite the presence of opioid receptors. These results provide an exciting, nonconventional avenue to improving the clinical efficacy of opioids.Xiaohui Wang, Lisa C. Loram, Khara Ramos, Armando J. de Jesus, Jacob Thomas, Kui Cheng, Anireddy Reddy, Andrew A. Somogyi, Mark R. Hutchinson, Linda R. Watkins and Hang Yi

Space station stabilization and control study Final engineering report

Simulation of stabilization and control for spinning, manned space station to provide artificial gravity station environmen