263 research outputs found
Flavoured resonant leptogenesis at sub-TeV scales
We consider sub-TeV scale flavoured resonant leptogenesis within the minimal type-I seesaw scenario with two right-handed singlet neutrinos N1,2forming a pseudo-Dirac pair, concentrating on the case of masses of the pseudo-Dirac pair having values M1,2100 GeV. The case when the CP violating asymme-tries in the individual lepton charges Ll, l=e, μ, τ, and in the total lepton charge Lof the Universe are generated in 1 ↔2 decay processes is investigated. We show that successful leptogenesis is possible for M1,2lying in the interval M1,2=(0.3 −100)GeV. Our results show also, in particular, that for vanishing initial N1,2abundance, flavour effects can play an important role in the generation of the baryon asymme-try, leading to an enhancement of the asymmetry by a factor up to ∼300 with respect to the “unflavoured” leptogenesis scenario
A Study on the Usage of Cross-Layer Power Control and Forward Error Correction for Embedded Video Transmission over Wireless Links
Cross-layering is a design paradigm for overcoming the limitations deriving from the ISO/OSI layering principle, thus improving the performance of communications in specific scenarios, such as wireless multimedia communications. However, most available solutions are based on empirical considerations, and do not provide a theoretical background supporting such approaches. The paper aims at providing an analytical framework for the study of single-hop video delivery over a wireless link, enabling cross-layer interactions for performance optimization using power control and FEC and providing a useful tool to determine the potential gain deriving from the employment of such design paradigm. The analysis is performed using rate-distortion information of an embedded video bitstream jointly with a Lagrangian power minimization approach. Simulation results underline that cross-layering can provide relevant improvement in specific environments and that the proposed approach is able to capitalize on the advantage deriving from its deployment
HVDC links between North Africa and Europe: Impacts and benefits on the dynamic performance of the European system
This document is the Accepted Manuscript version of the following article: Mokhtar Benasla, Tayeb Allaoui, Mostefa Brahami, Mouloud Denai, and Vijay K. Sood, ‘HVDC links between North Africa and Europe: Impacts and benefits on the dynamic performance of the European system’, Renewable and Sustainable Energy Reviews, November 2017. Under embargo. Embargo end date: 20 November 2018. The published version is available online at doi: DOI: https://doi.org/10.1016/j.rser.2017.10.075. Published by Elsevier Ltd. This manuscript version is distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.In the last decade, there have been several initiatives for the deployment of cross-Mediterranean HVDC (High Voltage Direct Current) links to enable the transmission of electrical power from renewable energy sources between North Africa and Europe. These initiatives were mainly driven by the potential economic, environmental and technical benefits of these HVDC interconnections. In previous studies on these projects, some technical aspects of critical importance have not been addressed or studied in sufficient detail. One of these key aspects relates to the impact and possible benefit of these HVDC links on the dynamic performance of the European system which is the major focus of this paper. Several issues relating to the dynamic performance of the system are addressed here. Based on the experience gained from existing AC/DC projects around the world, this paper shows that the HVDC links between North Africa and Europe can greatly improve the dynamic performance of the European system especially in the southern regions. In addition, some challenges on the operation and control of these HVDC links are highlighted and solutions to overcome these challenges are proposed. This review paper, therefore, serves as a preliminary study for further detailed investigation of specific impacts or benefits of these interconnections on the overall performance of the European system.Peer reviewe
Comprehensive screening and quantification of veterinary drugs in milk using UPLC–ToF-MS
Ultra-performance liquid chromatography combined with time-of-flight mass spectrometry (UPLC–ToF-MS) has been used for screening and quantification of more than 100 veterinary drugs in milk. The veterinary drugs represent different classes including benzimidazoles, macrolides, penicillins, quinolones, sulphonamides, pyrimidines, tetracylines, nitroimidazoles, tranquillizers, ionophores, amphenicols and non-steroidal anti-inflammatory agents (NSAIDs). After protein precipitation, centrifugation and solid-phase extraction (SPE), the extracts were analysed by UPLC–ToF-MS. From the acquired full scan data the drug-specific ions were extracted for construction of the chromatograms and evaluation of the results. The analytical method was validated according to the EU guidelines (2002/657/EC) for a quantitative screening method. At the concentration level of interest (MRL level) the results for repeatability (%RSD < 20% for 86% of the compounds), reproducibility (%RSD < 40% for 96% of the compounds) and the accuracy (80–120% for 88% of the compounds) were satisfactory. Evaluation of the CCβ values and the linearity results demonstrates that the developed method shows adequate sensitivity and linearity to provide quantitative results. Furthermore, the method is accurate enough to differentiate between suspected and negative samples or drug concentrations below or above the MRL. A set of 100 samples of raw milk were screened for residues. No suspected (positive) results were obtained except for the included blind reference sample containing sulphamethazine (88 μg/l) that tested positive for this compound. UPLC–ToF-MS combines high resolution for both LC and MS with high mass accuracy which is very powerful for the multi-compound analysis of veterinary drugs. The technique seems to be powerful enough for the analysis of not only veterinary drugs but also organic contaminants like pesticides, mycotoxins and plant toxins in one single method
The perfusion index derived from a pulse oximeter for predicting low superior vena cava flow in very low birth weight infants
Coordinated optimization for controlling short circuit current and multi-infeed DC interaction
Systemic Immune Activation in HIV Infection Is Associated with Decreased MDC Responsiveness to TLR Ligand and Inability to Activate Naive CD4 T-Cells
HIV infection is characterized by ineffective anti-viral T-cell responses and impaired dendritic cell (DC) functions, including response to Toll-Like Receptor (TLR) ligands. Because TLR responsiveness may affect a host's response to virus, we examined TLR ligand induced Myeloid and Plasmacytoid DC (MDC and PDC) activation of naïve T-cells in HIV+ subjects.Freshly purified MDC and PDC obtained from HIV+ subjects and healthy controls were cultured in the presence and absence of TLR ligands (poly I∶C or R-848). We evaluated indices of maturation/activation (CD83, CD86, and HLA-DR expression), cytokine secretion (IFN-alpha and IL-6), and ability to activate allogeneic naïve CD4 T-cells to secrete IFN-gamma and IL-2.MDC from HIV+ subjects had increased spontaneous IL-6 production and increased CD83 and CD86 expression when compared to MDC of controls. MDC IL-6 expression was associated with plasma HIV level. At the same time, poly I∶C induced HLA-DR up-regulation on MDC was reduced in HIV+ persons when compared to controls. The latter finding was associated with impaired ability of MDC from HIV+ subjects to activate allogeneic naïve CD4 T-cells. PDC from HIV+ persons had increased spontaneous and TLR ligand induced IL-6 expression, and increased HLA-DR expression at baseline. The latter was associated with an intact ability of HIV PDC to activate allogeneic naïve CD4 T-cells.These results have implications for the ability of the HIV+ host to form innate and adaptive responses to HIV and other pathogens
HIV and Mature Dendritic Cells: Trojan Exosomes Riding the Trojan Horse?
Exosomes are secreted cellular vesicles that can induce specific CD4+ T cell responses in vivo when they interact with competent antigen-presenting cells like mature dendritic cells (mDCs). The Trojan exosome hypothesis proposes that retroviruses can take advantage of the cell-encoded intercellular vesicle traffic and exosome exchange pathway, moving between cells in the absence of fusion events in search of adequate target cells. Here, we discuss recent data supporting this hypothesis, which further explains how DCs can capture and internalize retroviruses like HIV-1 in the absence of fusion events, leading to the productive infection of interacting CD4+ T cells and contributing to viral spread through a mechanism known as trans-infection. We suggest that HIV-1 can exploit an exosome antigen-dissemination pathway intrinsic to mDCs, allowing viral internalization and final trans-infection of CD4+ T cells. In contrast to previous reports that focus on the ability of immature DCs to capture HIV in the mucosa, this review emphasizes the outstanding role that mature DCs could have promoting trans-infection in the lymph node, underscoring a new potential viral dissemination pathway
Broad Antiviral Activity of Carbohydrate-Binding Agents against the Four Serotypes of Dengue Virus in Monocyte-Derived Dendritic Cells
BACKGROUND: Dendritic cells (DC), present in the skin, are the first target cells of dengue virus (DENV). Dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) is present on DC and recognizes N-glycosylation sites on the E-glycoprotein of DENV. Thus, the DC-SIGN/E-glycoprotein interaction can be considered as an important target for inhibitors of viral replication. We evaluated various carbohydrate-binding agents (CBAs) against all four described serotypes of DENV replication in Raji/DC-SIGN(+) cells and in monocyte-derived DC (MDDC). METHODOLOGY/PRINCIPAL FINDINGS: A dose-dependent anti-DENV activity of the CBAs Hippeastrum hybrid (HHA), Galanthus nivalis (GNA) and Urtica dioica (UDA), but not actinohivin (AH) was observed against all four DENV serotypes as analyzed by flow cytometry making use of anti-DENV antibodies. Remarkably, the potency of the CBAs against DENV in MDDC cultures was significantly higher (up to 100-fold) than in Raji/DC-SIGN(+) cells. Pradimicin-S (PRM-S), a small-size non-peptidic CBA, exerted antiviral activity in MDDC but not in Raji/DC-SIGN(+) cells. The CBAs act at an early step of DENV infection as they bind to the viral envelope of DENV and subsequently prevent virus attachment. Only weak antiviral activity of the CBAs was detected when administered after the virus attachment step. The CBAs were also able to completely prevent the cellular activation and differentiation process of MDDC induced upon DENV infection. CONCLUSIONS/SIGNIFICANCE: The CBAs exerted broad spectrum antiviral activity against the four DENV serotypes, laboratory-adapted viruses and low passage clinical isolates, evaluated in Raji/DC-SIGN(+) cells and in primary MDDC
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