Evaluation of the Efficacy of Crude Extracts of Salix subserrata and Silene macroselen for the treatment of rabies in Ethiopia

A study was conducted between November, 2007 and April, 2008 to evaluate the anti-rabies activity of the leaf of Salix subserrata and root of Silene macroselen which are traditionally used for the treatment of rabies in Bereh-Aleltu Woreda, North Shewa, Central Ethiopia. The study involved oral administration of crude extracts of Salix subserrata and Silene macroselen to Pasteur Virus (PV) strain rabies virus infected mice which were assigned into three treatment and one negative control groups. Chloroform, methanol 80% and aqueous extracts of the study plants were prepared using maceration technique. Statistical analysis was performed by one-way analysis of variance tests coupled to least significant difference to compare result between treatment and positive control groups. Of the 6 crude extracts, chloroform and methanol 80% of Silene macroselen and chloroform and aqueous of Salix subserrata were found to increase the survival time of mice significantly (P< 0.05). Nevertheless, aqueous extract of Silene macroselen and methanol 80% extract of Salix subserrata did not exhibit a significant effect on the survival time. 1 day and 2 days treatment groups of the chloroform extract of S. macroselen indicated significant difference on the survival time from the positive control (P< 0.05). The chloroform and aqueous extracts of S. subserrata and the methanol 80 % extract of S. macroselen in their 1 day and 3 days treatment showed significant difference on survival time from the positive control group (P< 0.05). The results obtained from the present work suggest good correlation between traditional therapeutic uses and the in vivo anti-rabies activity. Further characterization of the active ingredients would reveal useful compounds. Keywords: Anti-rabies, Ethno-pharmaceutical, Mice model, PV strain, Salix subserrata, Silene macrosele

Systemic Review: Sexual Dysfunction in Women with type 2 Diabetes Mellitus

Diabetes would not just have a high blood glucose level in the individual body, yet these days diabetes likewise goes with numerous other organic issues like hypertension, feeble the myocardial layer working, sexual broke, and so on. These are some real issue which is these days joined by diabetes to a person’s body. Guys are for the most part being determined to have the sexual broke issue, guys, as well as experience a sexual broke issue. As similarly we may see less clinical examinations, including sexual broke issues looked for the sort two diabetic ladies. The primary goal of this article is to illuminate the situation that females proceed with much trouble with regards to the sexual broke Complication that might be physiological or neurotic if there should arise an occurrence of sorting two diabetes in ladies. It chiefly involves the useful extent of females like sexual drive, excitement, vaginal grease, Orgasm and general fulfilment space. Talking about the treatmentaccess of the ailment in the analyti way for it, Diabetes essentially hinders the sexual execution of Diabetic Women. Determinants of sexual ability incorporate age and extent of diabetes

NiCE Teacher Workshop: Engaging K-12 Teachers in the Development of Curricular Materials That Utilize Complex Networks Concepts

Our educational systems must prepare students for an increasingly interconnected future, and teachers require equipping with modern tools, such as network science, to achieve this. We held a Networks in Classroom Education (NiCE) workshop for a group of 21 K-12 teachers with various disciplinary backgrounds. The explicit aim of this was to introduce them to concepts in network science, show them how these concepts can be utilized in the classroom, and empower them to develop resources, in the form of lesson plans, for themselves and the wider community. Here we detail the nature of the workshop and present its outcomes - including an innovative set of publicly available lesson plans. We discuss the future for successful integration of network science in K-12 education, and the importance of inspiring and enabling our teachers.Comment: 11 pages, 4 figures, 2 table

Assessment of Marine Weather forecasts over the Indian Sector of Southern Ocean

The Southern Ocean (SO) is one of the important regions where significant processes and feedbacks of the Earth\u27s climate take place. Expeditions to the SO provide useful data for improving global weather/climate simulations and understanding many processes. Some of the uncertainties in these weather/climate models arise during the first few days of simulation/forecast and do not grow much further. NCMRWF issued real-time five day weather forecasts of mean sea level pressure, surface winds, winds at 500 hPa & 850 hPa and rainfall, daily to NCAOR to provide guidance for their expedition to Indian sector of SO during the austral summer of 2014–2015. Evaluation of the skill of these forecasts indicates possible error growth in the atmospheric model at shorter time scales. The error growth is assessed using the model analysis/reanalysis, satellite data and observations made during the expedition. The observed variability of sub-seasonal rainfall associated with mid-latitude systems is seen to exhibit eastward propagations and are well reproduced in the model forecasts. All cyclonic disturbances including the sub-polar lows and tropical cyclones that occurred during this period were well captured in the model forecasts. Overall, this model performs reasonably well over the Indian sector of the SO in medium range time scale

IMPROVEMENT OF OPERATIONAL EFFICIENCY OF EQUIPMENT THROUGH TPM: A CASE STUDY

ABSTRACT The productivity improvement of workforce, under Indian conditions, is a far cry. Therefore, the left out area is that of equipment and that can be significantly improved through Total Productive Maintenance (TPM). The various researchers have established that TPM is an important tool to improve equipment efficiency and achieving the organizational goals. This approach is to contribute on quality as well cost fronts. TPM is essentially a tool of Lean manufacturing where in the waste need to be identified for elimination. The present study pertains to spot welding workstation which clearly reveals the inherent problems associated with the process function. The various types of wastes on this workstation are bad design of tooling, long changeover time, unplanned machine breakdowns, and machine conditions. Therefore, elimination of these wastes is necessary to improve the equipment operating efficiency (OEE). TPM methodology has been assessed on the spot welding workstation for improvement in present level of 61 % to 68% in first stage, 68% to 75% in second stage and up to or above 85% in the third stage

Beyond bone biology: Lessons from team science

Today, research in biomedicine often requires the knowledge and technologies in diverse fields. Therefore, there is an increasing need for collaborative team science that crosses traditional disciplines. Here, we discuss our own lessons from both interdisciplinary and transdisciplinary teams, which ultimately ushered us to expand our research realm beyond bone biology. This article is protected by copyright. All rights reserved

The effects of iron fortification on the gut microbiota in African children: a randomized controlled trial in Cote d'Ivoire.

BACKGROUND: Iron is essential for the growth and virulence of many pathogenic enterobacteria, whereas beneficial barrier bacteria, such as lactobacilli, do not require iron. Thus, increasing colonic iron could select gut microbiota for humans that are unfavorable to the host. OBJECTIVE: The objective was to determine the effect of iron fortification on gut microbiota and gut inflammation in African children. DESIGN: In a 6-mo, randomized, double-blind, controlled trial, 6-14-y-old Ivorian children (n = 139) received iron-fortified biscuits, which contained 20 mg Fe/d, 4 times/wk as electrolytic iron or nonfortifoed biscuits. We measured changes in hemoglobin concentrations, inflammation, iron status, helminths, diarrhea, fecal calprotectin concentrations, and microbiota diversity and composition (n = 60) and the prevalence of selected enteropathogens. RESULTS: At baseline, there were greater numbers of fecal enterobacteria than of lactobacilli and bifidobacteria (P < 0.02). Iron fortification was ineffective; there were no differences in iron status, anemia, or hookworm prevalence at 6 mo. The fecal microbiota was modified by iron fortification as shown by a significant increase in profile dissimilarity (P < 0.0001) in the iron group as compared with the control group. There was a significant increase in the number of enterobacteria (P < 0.005) and a decrease in lactobacilli (P < 0.0001) in the iron group after 6 mo. In the iron group, there was an increase in the mean fecal calprotectin concentration (P < 0.01), which is a marker of gut inflammation, that correlated with the increase in fecal enterobacteria (P < 0.05). CONCLUSIONS: Anemic African children carry an unfavorable ratio of fecal enterobacteria to bifidobacteria and lactobacilli, which is increased by iron fortification. Thus, iron fortification in this population produces a potentially more pathogenic gut microbiota profile, and this profile is associated with increased gut inflammation. This trial was registered at controlled-trials.com as ISRCTN21782274