1,330 research outputs found
From respect to reburial: negotiating pagan interest in prehistoric human remains in Britain, through the Avebury consultation
The recent Avebury Consultation on reburial has drawn considerable public and professional attention to the issue of pagan calls for respect towards the care of human remains. Our work has pointed to the importance of archaeologists and others engaging seriously and respectfully with pagans as significant stakeholders in our heritage. The Avebury Reburial Consultation suggests this dialogue is increasing in strength, but we identify problems in the process. We focus here on approaches to the prehistoric dead and worldviews enabling communication from which calls or âclaimsâ for the reburial of prehistoric pagan human remains, versus their retention for scientific study, are articulated; frameworks for assessing and adjudicating such âclaimsâ; and implications for the interest groups concerned. We argue that room must be made for philosophical debate and the emotional and spiritual views of pagans, in order to improve dialogue, develop common ground, and enable participatory decision-making and situational pragmatism
Fe65 Is Phosphorylated on Ser289 after UV-Induced DNA Damage
Fe65 undergoes a phosphatase-sensitive gel mobility shift after DNA damage, consistent with protein phosphorylation. A recent study identified Ser228 as a specific site of phosphorylation, targeted by the ATM and ATR protein kinases, with phosphorylation inhibiting the Fe65-dependent transcriptional activity of the amyloid precursor protein (APP). The direct binding of Fe65 to APP not only regulates target gene expression, but also contributes to secretase-mediated processing of APP, producing cytoactive proteolytic fragments including the APP intracellular domain (AICD) and cytotoxic amyloid ÎČ (AÎČ) peptides. Given that the accumulation of AÎČ peptides in neural plaques is a pathological feature of Alzheimerâs disease (AD), it is essential to understand the mechanisms controlling AÎČ production. This will aid in the development of potential therapeutic agents that act to limit the deleterious production of AÎČ peptides. The Fe65-APP complex has transcriptional activity and the complex is regulated by multiple post-translational modifications and other protein binding partners. In the present study, we have identified Ser289 as a novel site of UV-induced phosphorylation. Interestingly, this phosphorylation was mediated by ATM, rather than ATR, and occurred independently of APP. Neither phosphorylation nor mutation of Ser289 affected the Fe65-APP interaction, though this was markedly decreased after UV treatment, with a concomitant decrease in the protein levels of APP in cells. Using mutagenesis, we demonstrated that Fe65 Ser289 phosphorylation did not affect the transcriptional activity of the Fe65-APP complex, in contrast to the previously described Ser228 site
Pasts and pagan practices: moving beyond Stonehenge
Theorizing the past is not restricted to archaeology and interpretations of 'past' both influence and are themselves constituted within politicized understandings of self, community and in certain instances, spirituality. 'The past in the imagination of the present' is appropriated, variously, to give meaning to the present or to justify actions and interpret experiences. Summer solstice at Stonehenge, with an estimated 21,000 celebrants in 2005, is only the most publicized appropriation (by pagans and other adherents of alternative spirituality and partying) of a 'sacred site'; and conflicts and negotiations occurring throughout Britain are represented in popular and academic presentations of this 'icon of Britishness'. This paper presents work from the Sacred Sites, Contested Rites/Rights Project (http://www.sacredsites.org.uk) project, a collaboration of archaeology and anthropology informed by pagan and alternative approaches and standpoints investigating and theorizing discourse and practice of heritage management and pagan site users. Whether in negotiations around the Stonehenge solstice access or in dealing with numerous other sites, boundaries between groups or discourses are not clearly drawn - discursive communities merge and re-emerge. But clearly 'past' and 'site' are increasingly important within today's Britain, even as television archaeology increases its following, and pagan numbers continue to grow.</p
Detection of CO from SMM J16359+6612, The Multiply Imaged Submillimeter Galaxy Behind A2218
We report the detection of CO (=32) line emission from all three
multiple images (A,B and C) of the intrinsically faint ( 0.8 mJy)
submillimeter-selected galaxy SMM J16359+6612. The brightest source of the
submm continuum emission (B) also corresponds to the brightest CO emission,
which is centered at =2.5168, consistent with the pre-existing redshift
derived from \Ha. The observed CO flux in the A, B and C images is 1.2, 3.5 and
1.6 Jy \kms respectively, with a linewidth of \kms. After
correcting for the lensing amplification, the CO flux corresponds to a
molecular gas mass of \Msun, while the
extent of the CO emission indicates that the dynamical mass of the system
\Msun. Two velocity components are seen in the CO spectra;
these could arise from either a rotating compact ring or disk of gas, or
merging substructure. The star formation rate in this galaxy was previously
derived to be 100--500 \Msun \yr. If all the CO emission arises from the
inner few kpc of the galaxy and the galactic CO-to-H conversion factor
holds, then the gas consumption timescale is a relatively short 40 Myr, and so
the submm emission from SMM J16359+6612 may be produced by a powerful, but
short-lived circumnuclear starburst event in an otherwise normal and
representative high-redshift galaxy.Comment: Appearing in the 2004 October 10 issue of the Astrophysical Journal
Letters, Volume 614, L5-L
Phosphorylation of MCPH1 isoforms during mitosis followed by isoformâspecific degradation by APC/CâCDH1
Microcephalinâ1 (MCPH1) exists as 2 isoforms that regulate cyclinâdependent kinaseâ1 activation and chromosome condensation during mitosis, with MCPH1 mutations causing primary microcephaly. MCPH1 is also a tumor suppressor protein, with roles in DNA damage repair/checkpoints. Despite these important roles, there is little information on the cellular regulation of MCPH1. We show that both MCPH1 isoforms are phosphorylated in a cyclinâdependent kinaseâ1âdependent manner in mitosis and identify several novel phosphorylation sites. Upon mitotic exit, MCPH1 isoforms were degraded by the anaphaseâpromoting complex/cyclosomeâCDH1 E3 ligase complex. Anaphaseâpromoting complex/cyclosomeâCDH1 target proteins generally have DâBox or KENâBox degron sequences. We found that MCPH1 isoforms are degraded independently, with the long isoform degradation being DâBox dependent, whereas the short isoform was KENâBox dependent. Our research identifies several novel mechanisms regulating MCPH1 and also highlights important issues with several commercial MCPH1 antibodies, with potential relevance to previously published data.âMeyer, S. K., Dunn, M., Vidler, D. S., Porter, A., Blain, P. G., Jowsey, P. A. Phosphorylation of MCPH1 isoforms during mitosis followed by isoformâspecific degradation by APC/CâCDH1. FASEB J. 33, 2796â2808 (2019). www.fasebj.or
Submillimeter galaxies behind the Bullet Cluster (1E 0657-56)
Clusters of galaxies are effective gravitational lenses able to magnify
background galaxies and making it possible to probe the fainter part of the
galaxy population. Submillimeter galaxies, which are believed to be
star-forming galaxies at typical redshifts of 2 to 3, are a major contaminant
to the extended Sunyaev-Zeldovich (SZ) signal of galaxy clusters. For a proper
quantification of the SZ signal the contribution of submillimeter galaxies
needs to be quantified. The aims of this study are to identify submillimeter
sources in the field of the Bullet Cluster (1E 0657-56), a massive cluster of
galaxies at z~0.3, measure their flux densities at 870 micron, and search for
counterparts at other wavelengths to constrain their properties. We carried out
deep observations of the submillimeter continuum emission at 870 micron using
the Large APEX BOlometer CAmera (LABOCA) on the Atacama Pathfinder EXperiment
(APEX) telescope. Several numerical techniques were used to quantify the noise
properties of the data and extract sources. In total, seventeen sources were
found. Thirteen of them lie in the central 10 arcminutes of the map, which has
a pixel sensitivity of 1.2 mJy per 22 arcsec beam. After correction for flux
boosting and gravitational lensing, the number counts are consistent with
published submm measurements. Nine of the sources have infrared counterparts in
Spitzer maps. The strongest submm detection coincides with a source previously
reported at other wavelengths, at an estimated redshift z~2.7. If the submm
flux arises from two images of a galaxy magnified by a total factor of 75, as
models have suggested, its intrinsic flux would be around 0.6 mJy, consistent
with an intrinsic luminosity below 10^12 L_sun.Comment: Accepted by A&A, 15 pages, 11 figure
Repurposing the (super)crip: media representations of disability at the Rio 2016 Paralympic Games
Strangers in the night: Discovery of a dwarf spheroidal galaxy on its first Local Group infall
We present spectroscopic observations of the AndXII dwarf spheroidal galaxy
using DEIMOS/Keck-II, showing it to be moving rapidly through the Local Group
(-556 km/s heliocentric velocity, -281 km/s relative to Andromeda from the MW),
falling into the Local Group from ~115 kpc beyond Andromeda's nucleus. AndXII
therefore represents a dwarf galaxy plausibly falling into the Local Group for
the first time, and never having experienced a dense galactic environment. From
Green Bank Telescope observations, a limit on the H{I} gas mass of <3000 Msun
suggests that AndXII's gas could have been removed prior to experiencing the
tides of the Local Group galaxies. Orbit models suggest the dwarf is close to
the escape velocity of M31 for published mass models. AndXII is our best direct
evidence for the late infall of satellite galaxies, a prediction of
cosmological simulations.Comment: 4 pages 5 figures 1 table, accepted in ApJ, july issu
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