A LEED structural analysis of the Co(100) surface

The structure of the clean Co(1010) surface has been analysed by LEED. Application of a recently developed computational scheme reveals the prevalence of the termination A in which the two topmost layers exhibit a narrow spacing of 0.62 Å, corresponding to a 12.8(±0.5)% contraction with respect to the bulk value, while the spacing between the second and third layer is slightly expanded by 0.8(±0.2)%

A COMPARISON OF RESISTED AND ASSISTED SPRINT TRAINING IN COLLEGIATE SPRINTERS

Sprint time (ST) is the product of stride length (SL) and stride rate (SR). Increases in either of these variables results in speed improvement. Purpose:  To compare resisted (RST) and assisted sprint training (AST) on sprint performance. Methods:  Twenty (10 male, 10 female) collegiate sprinters and hurdlers were randomly divided into two training groups: RST (age: 21.8±1.8yrs, height: 1.73±0.10m, mass: 69.5±12.8kg) and AST (age: 22.2±2.4yrs, height: 1.76±0.10m, mass: 69.1±9.9kg). Each group trained 3 days/week for 6 weeks. The RST group used a combination of weighted sled pulls, uphill sprinting and depth jumps. The AST group combined downhill running, towing, sprint ladders and single leg bounds. Prior to and following the training interventions SL and ST (10 meter sprint time) were recorded at sprint distances of 30m, 60m, and 120m during the last 10 meters of each sprint distance. Pre-post training ST and SL were compared within training groups at each sprint distance using paired t-tests. Additionally, a gain score was calculated by taking the difference between the post and pre test scores. The gain scores for SL and ST were compared between training groups via independent t-tests at each sprint distance. Results: For the RST 30m, ST (1.18±0.08s vs 1.14±0.08s, p<0.01) and SL (2.06±0.08m vs. 2.09±1.14m, p<0.01) were significantly improved. For the AST, 30m ST (1.19±0.08s vs. 1.18±0.08s, p<0.01) and SL (2.10±0.13m vs. 2.11±0.13, p=0.04) were significantly improved. No improvements in ST or SL were detected for either the RST or AST groups at the 60m sprint distance. For the RST 120m, ST (1.13±0.07s vs. 1.12±0.08s, p<0.01) was significantly improved. For the AST 120m, ST (1.12±0.07s vs. 1.11±0.07s, p<0.01) and SL (2.30±0.08 vs. 2.33±0.08, p<0.01) were significantly improved. At the 30M interval, the RST demonstrated significant improvements in SL and ST as compared to the AST (p<0.01). However, at the 120M interval, the AST demonstrated a significant improvement in SL as compared to the RST (p<0.01). Conclusion: Within the parameters of this study, RST and AST methods have proven effective at improving sprint performance. It appears that RST protocols may be of greatest benefit for improving sprint performance at shorter distances, while AST protocols may be of greater benefit at longer sprinting distances.  Article visualizations

The Pathobiology of TDP-43 C-Terminal Fragments in ALS and FTLD

During neurodegenerative disease, the multifunctional RNA-binding protein TDP-43 undergoes a vast array of post-translational modifications, including phosphorylation, acetylation, and cleavage. Many of these alterations may directly contribute to the pathogenesis of TDP-43 proteinopathies, which include most forms of amyotrophic lateral sclerosis (ALS) and approximately half of all frontotemporal dementia, pathologically identified as frontotemporal lobar degeneration (FTLD) with TDP-43 pathology. However, the relative contributions of the various TDP-43 post-translational modifications to disease remain unclear, and indeed some may be secondary epiphenomena rather than disease-causative. It is therefore critical to determine the involvement of each modification in disease processes to allow the design of targeted treatments. In particular, TDP-43 C-terminal fragments (CTFs) accumulate in the brains of people with ALS and FTLD and are therefore described as a neuropathological signature of these diseases. Remarkably, these TDP-43 CTFs are rarely observed in the spinal cord, even in ALS which involves dramatic degeneration of spinal motor neurons. Therefore, TDP-43 CTFs are not produced non-specifically in the course of all forms of TDP-43-related neurodegeneration, but rather variably arise due to additional factors influenced by regional heterogeneity in the central nervous system. In this review, we summarize how TDP-43 CTFs are generated and degraded by cells, and critique evidence from studies of TDP-43 CTF pathology in human disease tissues, as well as cell and animal models, to analyze the pathophysiological relevance of TDP-43 CTFs to ALS and FTLD. Numerous studies now indicate that, although TDP-43 CTFs are prevalent in ALS and FTLD brains, disease-related pathology is only variably reproduced in TDP-43 CTF cell culture models. Furthermore, TDP-43 CTF expression in both transgenic and viral-mediated in vivo models largely fails to induce motor or behavioral dysfunction reminiscent of human disease. We therefore conclude that although TDP-43 CTFs are a hallmark of TDP-43-related neurodegeneration in the brain, they are not a primary cause of ALS or FTLD

EFFECT OF WEIGHTED JUMP WARM-UP ON VERTICAL JUMP IN FEMALE VOLLEYBALL PLAYERS

Warm-ups which elicit a post activation potentiation (PAP) effect may increase performance in subsequent activities requiring strength and power. However, finding practical methods to best manipulate and exploit PAP remains elusive. Purpose: To determine if a warm-up that included weighted jumps would elicit a PAP effect and increase subsequent vertical jump (VJ) height. Methods: Ten female NCAA Division II volleyball players participated (age = 19.8 ± 1.8 yrs; mass = 71.7 ± 9.7 kg; ht = 167.8 ±23.9 cm). Two warm-up conditions were randomly employed: 1) light jogging, high knees, carioca, shuffling, ankle pops, pogos, and tuck jumps; and 2) an identical warm-up, plus 10 maximal VJs while wearing 20% of bodyweight. At 4-minutes post, VJ was randomly assessed in two conditions: 1) 2-hand standing block VJ (SBVJ), and 2) 1-hand 3-step approach VJ (AVJ). Paired Samples T-test determined if there was a significant difference (p < 0.05) in VJ height between the two conditions. Results: Results were mixed. No significant difference (p > 0.05) occurred in the SBVJ (262.1 vs. 263.0 cm, warm-up vs. warm-up with weight vest, respectively). However, the AVJ was significantly higher by 2.7±1.5 cm (p < 0.05; 275.1±13.2 vs. 277.8±13.2 cm) with the weight vest added to their warm-up. Conclusion: This study demonstrates that a dynamic warm-up with the addition of weighted jumps may increase 3-step AVJ ability in female collegiate volleyball players. However, no effect was seen in 2-hand SBVJ ability. Coaches may consider using a warm-up that includes weighted jumps to optimize performance in sports like volleyball where vertical jumps with an approach are key components of competition.  Article visualizations

CONTINUOUS WEIGHTED JUMPING: EFFECTS ON VERTICAL JUMP HEIGHT

High intensity, near maximal exercise is a conditioning activity which can cause neural hyper-stimulation and lead to acute enhanced power production known as post-activation potentiation (PAP). Investigations need to be conducted to better understand the duration and intensity of the conditioning activity and subsequent effects on the fatigue-potentiation relationship. Purpose: To investigate the effect of 30 seconds of continuous vertical jumping while wearing a vest loaded with 30% of body weight on power output as measured with a maximal vertical jump (VJ). Methods: 14 volunteers (8 weight trained males [23.0+2.9 yrs, 79.8+13.8 kg, 179.9+8.6 cm] and 6 weight trained females [23.0+2.9 yrs, 69.9+13.3 kg, 171.6+7.0 cm]) participated in the study. Pre-testing consisted of each participant performing 3 VJs. The highest VJ was recorded as baseline. A weighted vest was then loaded equaling 30% of the individual's body weight; while wearing the weighted vest, participants performed 30 seconds of continuous VJs. Immediately after jumping participants were seated in a chair for 3 minutes; at 3 minutes, they performed a maximal VJ without the weighted vest in the same manner as done during pre-testing. Two additional VJs were repeated at 4 and 5 minutes post weighted jumping. A mixed design ANOVA with repeated measures was performed. Results: Results showed main effects for each of the independent variables tested, gender and jump. The posttest values at all 3 intervals for both males and females were significantly different from the pretest scores (F [3, 36] = 21.74, p < 0.05). Post hoc analysis indicated that the pretest VJ scores (M = 280.1±18.6 cm) decreased significantly at the 3 minute interval (M = 278.1±18.3 cm), followed by a significant increase in height at the 4 minute interval (M = 281.1±18.7 cm), and another increase at the 5 minute interval (M = 283.0±19.2 cm). Males jumped significantly higher than the females across all trials (p<0.05), however there was no significant difference between male and female VJ gain scores between pre-PAP VJ and 3, 4 and 5 minute post weighted exercise VJ. Conclusion: Results suggest that 30 seconds of weighted VJs causes fatigue which decreases VJ at 3 minutes post exercise. However, a PAP effect was seen at 4 and 5 minutes post weighted exercise significantly increasing VJ above pre testing. From a practical perspective, coaches must be aware of the complex nature of the fatigue-potentiation relationship when attempting to elicit a PAP effect in the individual athlete.   Article visualizations

The effect of inhomogeneous compression on water transport in the cathode of a proton exchange membrane fuel cell

A three-dimensional, multicomponent, two-fluid model developed in the commercial CFD package CFX 13 (ANSYS Inc.) is used to investigate the effect of porous media compression on water transport in a proton exchange membrane fuel cell (PEMFC). The PEMFC model only consist of the cathode channel, gas diffusion layer, microporous layer, and catalyst layer, excluding the membrane and anode. In the porous media liquid water transport is described by the capillary pressure gradient, momentum loss via the DarcyForchheimer equation, and mass transfer between phases by a nonequilibrium phase change model. Furthermore, the presence of irreducible liquid water is taken into account. In order to account for compression, porous media morphology variations are specified based on the gas diffusion layer (GDL) through-plane strain and intrusion which are stated as a function of compression. These morphology variations affect gas and liquid water transport, and hence liquid water distribution and the risk of blocking active sites. Hence, water transport is studied under GDL compression in order to investigate the qualitative effects. Two simulation cases are compared; one with and one without compression

Hybrid FES-exoskeleton control: Using MPC to distribute actuation for elbow and wrist movements

IntroductionIndividuals who have suffered a cervical spinal cord injury prioritize the recovery of upper limb function for completing activities of daily living. Hybrid FES-exoskeleton systems have the potential to assist this population by providing a portable, powered, and wearable device; however, realization of this combination of technologies has been challenging. In particular, it has been difficult to show generalizability across motions, and to define optimal distribution of actuation, given the complex nature of the combined dynamic system.MethodsIn this paper, we present a hybrid controller using a model predictive control (MPC) formulation that combines the actuation of both an exoskeleton and an FES system. The MPC cost function is designed to distribute actuation on a single degree of freedom to favor FES control effort, reducing exoskeleton power consumption, while ensuring smooth movements along different trajectories. Our controller was tested with nine able-bodied participants using FES surface stimulation paired with an upper limb powered exoskeleton. The hybrid controller was compared to an exoskeleton alone controller, and we measured trajectory error and torque while moving the participant through two elbow flexion/extension trajectories, and separately through two wrist flexion/extension trajectories.ResultsThe MPC-based hybrid controller showed a reduction in sum of squared torques by an average of 48.7 and 57.9% on the elbow flexion/extension and wrist flexion/extension joints respectively, with only small differences in tracking accuracy compared to the exoskeleton alone.DiscussionTo realize practical implementation of hybrid FES-exoskeleton systems, the control strategy requires translation to multi-DOF movements, achieving more consistent improvement across participants, and balancing control to more fully leverage the muscles' capabilities

Pancreatic Polypeptide Controls Energy Homeostasis via Npy6r Signaling in the Suprachiasmatic Nucleus in Mice

SummaryY-receptors control energy homeostasis, but the role of Npy6 receptors (Npy6r) is largely unknown. Young Npy6r-deficient (Npy6r−/−) mice have reduced body weight, lean mass, and adiposity, while older and high-fat-fed Npy6r−/− mice have low lean mass with increased adiposity. Npy6r−/− mice showed reduced hypothalamic growth hormone releasing hormone (Ghrh) expression and serum insulin-like growth factor-1 (IGF-1) levels relative to WT. This is likely due to impaired vasoactive intestinal peptide (VIP) signaling in the suprachiasmatic nucleus (SCN), where we found Npy6r coexpressed in VIP neurons. Peripheral administration of pancreatic polypeptide (PP) increased Fos expression in the SCN, increased energy expenditure, and reduced food intake in WT, but not Npy6r−/−, mice. Moreover, intraperitoneal (i.p.) PP injection increased hypothalamic Ghrh mRNA expression and serum IGF-1 levels in WT, but not Npy6r−/−, mice, an effect blocked by intracerebroventricular (i.c.v.) Vasoactive Intestinal Peptide (VPAC) receptors antagonism. Thus, PP-initiated signaling through Npy6r in VIP neurons regulates the growth hormone axis and body composition

Experimental Investigation of the Classical Rayleigh-Taylor Instability

The evolution of the Rayleigh-Taylor (RT) instability in a compressible medium has been investigated at an accelerating embedded interface and at the ablation front in a series of experiments on the Nova laser. The x-ray drive generated in a gold hohlraum ablatively accelerated a planar target consisting of a doped plastic pusher backed by a higher density titanium payload with perturbations placed at the plastic-Ti interface. The targets were diagnosed by face-on and side-on radiography. In previous work focusing on single mode perturbations, wavelengths as short as 10 m have been observed to grow strongly at the embedded interface. Here multimode perturbations consisting of either 2, 10 or 20 modes superposed in phase have been investigated