A neonatal septic arthritis case caused by klebsiella pneumoniae: A case report

Septic arthritis is encountered very rarely during the neonatal period and its diagnosis can delay because of atypical symptoms, thus it may lead to serious sequelae. The sequale can be prevented by early diagnosis and concomitant treatment. In neonates, pain can be experienced as a result of pseudoparalysis and of movement of the effected joints. A 17-day-old neonatal patient was brought to our hospital with complaint of unrest and then diagnosed with septic arthritis due to propagation of Klebsiella pneumoniae in joint fluid culture was represented because of the rarity of such a case. © 2016, Journal of Clinical and Diagnostic Research. All rights reserved

Mechanıcal and fıre propertıes of orıental beech ımpregnated wıth fıre-retardants and coated wıth polyurea/polyurethane hybrıd and epoxy resıns

This study was performed to investigate some mechanical properties such as modulus of rupture and compression strength parallel to grain and some fire properties such as weight loss and temperature values of Oriental beech (Fagus orientalis) treated with fire-retardants  and coated with polyurethane/polyurea hybrid resin and epoxy resin were investigated. The coatings are based on epoxy and polyurethane\polyurea hybrid resins. Firstly,  an impregnation method was applied by using fire-retardants which are boron chemicals and ammonium sulfate before coating process. Oriental beech was impregnated with 3 % aqueous solution of boric acid, borax, boric acid and borax mixture (1:1), and ammonium sulfate. Oriental beech was primed with epoxy resin by using Sikafloor®-156, and then coated with Sikalastic®-851, a polyurethane/polyurea hybrid resin. Results showed that modulus of rupture and compression strength parallel to grain values of polyurethane/polyurea and epoxy resin coated Oriental beech wood were higher than that of un-treated and non-coated (control) group. Fire-retardants treatment before polyurethane/polyurea and epoxy resin coatings caused to decrease modulus of rupture and compression strength parallel to grain values of Oriental beech in some extent. Weight loss and temprature  values of polyurethane/polyurea and epoxy resin coated Oriental beech were higher than that of un-treated and non-coated (control) group. Hovewer, fire-retardants treatment before polyurethane/polyurea and epoxy resin coatings improved fire properties of Oriental beech wood

The protective effect of docosahexaenoic acid on the bilirubin neurotoxicity

Usually, all newborns demonstrate high serum unconjugated bilirubin (UCB) level. UCB may induce adverse effects in the central nervous system. We aimed to evaluate the cytotoxic effects of UCB and the protective effects of docosahexaenoic acid (DHA) on astrocyte cell cultures. The viability of astrocyte cells decreased after UCB treatment in a dose-dependent manner. Pre-incubation of DHA prevents the cells from UCB-mediated neurotoxicity. Our results shown that UCB leads to inhibition of antioxidant enzymes superoxide dismutase (SOD), catalase and GPx activity and induction of apoptosis. But only 4-h pretreatment of DHA can suppress of UCB-mediated inhibition of antioxidant enzymes SOD, catalase and GPx activity and induction of apoptosis in astrocytes. Our results strongly indicated that DHA has a protective effect on UCB-mediated neurotoxicity through inhibition apoptosis and antioxidant enzymes activity of SOD, CAT and GPx in rat primer astrocyte cell line © 2013 Informa UK, Ltd

The rate of weight gain ın preterm ınfants who were fed with enriched human milk

Bu çalışmada; eoprotinin prematüre bebeklerde vücut ağırlığı artış hızına etkisi incelendi. Pamukkale Üniversitesi Tıp Fakültesi Hastanesi'nde 1999-2000 tarihlerinde Yenidoğan Yoğun Bakım Ünitesinde yatan 26 prematüre bebek çalışmaya alındı. Onaltı prematüre bebeğe zenginleştirilmiş anne sütü, 10 bebeğe ise sadece anne sütü verildi. Eoprotin (milupa, 3 gram eoprotin; 0.6 gram protein, 11 kkal enerji içermektedir) bebekler tam oral olarak beslenmeye başladığında 100 ml anne sütüne 3 gram olarak eklendi. Günlük kilo alımı eoprotin verilen grupta kontrol grubuna göre anlamlı olarak yüksek bulundu. Vücut ağırlığı artış hızını arttırmak amacıyla prematüre bebeklerde eoprotin kullanılabilir.In this study; the effect of eoprotin on the weight gain rate of preterm babies were investigated. Twenty six preterm babies hospitalised in the Neonatal Intensive Care Unite of the Pamukkale University Hospital between 1999-2000 were evaluated. Enriched mothers milk was given to 16 babies, while the remaining 10 had only theirs mothers' milk. Eoprotin (milupa, 3 g eoprotin; 0.6 g protein, 11 kcal) was added in a dosage of 3 grams per 100 mililiters in expressed human milk when the preterm infants began to be fed fully enterally. Daily weight gain in the eoprotin group significantly increased compared to the control group. We suggest that eoprotin should be used in preterm babies to increase weight gain rate

Impaired Hemorheology in Exacerbations of COPD

Background. Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation. Cardiovascular-related comorbidities are established to contribute to morbidity and mortality especially during exacerbations. The aim of the current study was to determine alterations in hemorheology (erythrocyte aggregation, deformability) in newly diagnosed COPD patients and their response to medical treatment and to compare with values of COPD patients with exacerbations. Materials and Methods. The study comprised 13 COPD patients, 12 controls, and 16 COPD patients with exacerbations. The severity of COPD was determined according to Global Initiative for Chronic Obstructive Lung Disease guidelines. Red blood cell (RBC) deformability and aggregation were measured by an ektacytometer. Results. RBC deformability of COPD patients with exacerbations was decreased compared to the other groups. Erythrocyte aggregation and plasma fibrinogen of COPD patients determined during exacerbations were higher than control. Conclusion. Decreased RBC deformability and increased aggregation associated with exacerbations of COPD may serve as unfavorable mechanisms to worsen oxygenation and thus clinical symptoms of the patient. Treatment modalities that modify rheological parameters might be beneficial. © 2017 Erhan Ugurlu et al

Çocuklarda Akrep Zehirlenmeleri ve Yönetimi

Amaç: Akrep zehirlenmesi tanısı ile Çocuk Yoğun Bakım Ünitemize yatan hastaları geriye dönük olarak inceleyerek hastaların klinik ve laboratuvar bulgularını, tedavi yöntemlerini ve sonuçlarını değerlendirmek. Gereç ve yöntem: Ocak 2012-Ekim 2013 tarihleri arasında Çocuk Yoğun Bakım ve Yoğun Bakım Servislerinde akrep zehirlenmesi tanısı ile tedavi edilmiş olan 30 hasta çalışmaya dahil edildi. Bu hastaların klinik ve laboratuvar bulguları, tedavi yöntemleri incelendi. Bulgular: Hastaların yaşları ortalama 6,6±4 yıl olup, 12’ si %40 kız, 18’ i %60 erkek idi. Tüm hastalara antivenom tedavisi uygulandı. 9 hastaya prazosin, 8 hastaya dopamin, 3 hastaya dopamin ve dobutamin tedavisi uygulandı. Vakaların 5’ünde kalp yetmezliği ve 2’sinde akciğer ödemi gelişti. Laboratuvar sonuçları; hemoglobin 11,8±1 g/dl 9,6-13,1 , lökosit 10,5±3,1 bin/mm3 6,3-12,6 , trombosit 284±42 bin/mm3 , kan şekeri 135±50 mg/dL , kreatin kinaz miyokard izoenzimi CK-MB 40±22 U/

The retrospective evaluation of patientswith acute bronchiolitis

Amaç: Bronsiolit, küçük hava yollarının inflamatuar obstrüksiyonundan kaynaklanan ve özellikle 6 aydan küçük çocuklarda en sık hospitalizasyon nedeni olan bir hastalıktır. Bu çalısmada, klinigimize bronsiolit nedeniyle kabul edilen olguların demografik özellikleri, klinik bulguları, tedavisi ve prognozu analiz edildi. Bulgular: Olguların %59,7'si (n=40) erkek, %40,3'ü (n=37) kız olup, %40,3'ü kıs, %29,9'u ilkbahar, %23,9'u sonbahar, %6'sı yaz mevsiminde hastanemize kabul edildi. En büyük hasta gurubunu 3-6 aylık bebekler (%35,8) olusturmaktaydı. Ilk basvuru sikayetleri %85'inde öksürük, %53,7'sinde hırıltı ve %34,3'ünde atesti. Atopi öyküsü üç ve daha fazla atak geçirenlerde %41.6, bir ve iki atak geçirenlerde %20olarak saptandı. Sonuç: Ailede atopi öyküsü bulunmasının bronsiolitli olgularda atak sayısını ve steroid gereksinimini arttırdıgı görüldü.Aim: Bronchiolitis is an under respiratory tract disorder which is caused by the inflammatory obstruction of the small airways. It is also the most common reason for hospitalization of children younger than 6 months. In this study, demographic characteristics, clinical symptoms, treatment and prognoses of patients who had been admitted to our clinic due to bronchiolitis were investigated. Findings: 59.7% of patients were male, and 40.3% were female. 40.3% were admitted to our hospital in winter, 29.5% in spring, 23.6% in fall and 6% in summer. The largest group of patients consisted of infants between 3-6 months (35.9%). Initial complaints were coughing in 85%, wheezing in 53.7% and fever in 34.3%. Of the patients history of atopy was determined more frequently (41.6%) among those who suffered from three or more attacks compared with patients who experienced one to two attacks (20%). Result: A history of atopy in the patient's family increases the number of bronchiolitis attacks and the need for steroid

Henoch-Schonlein purpuralı hastaların analizi

Amaç: HSP'li hastalarımızın epidemiyolojik ve klinik özellikleri, laboratuar bulguları ve hastalıgın seyrinin incelenmesi amaçlandı. Yöntem: 2000-2006 yılları arasında, hastanemiz Çocuk Saglıgı ve Hastalıkları Klinigi'nde Henoch-Schonlein Purpurası tanısı alan ve izlenen 45 hasta retrospektif olarak incelendi. Bulgular: Hastaların 27 (%60,0)'si kız, 18 (%40,0)'i erkek, kız / erkek oranı 1.5 idi.Yas ortalaması 6 yas 9 ay (8 ay-14 yas) olarak saptandı. Basvuru sikayetleri sıklık sırasına göre döküntü (%100), yürüyememe ve/veya eklem agrısı (%71,1) ve karın agrısı (%40,0) idi. Hastaların % 57,7'inde ortalama 12 gün önce geçirilmis enfeksiyon öyküsü tespit edildi. Fizik muayenede purpurik döküntü (alt ekstremite ve gluteal bölgede %100, yaygın %11,1), artrit (32 hastada, %71,1, en sık ayak bilegi ve diz eklemlerinde), ates (9 hastada, %20,0) bulundu. Laboratuar bulguları anemi (8/45 hasta, %17,7), lökositoz (6/45 hasta, %13,3), trombositoz (16/45 hasta, %35,5), sedimentasyon yüksekligi (16/25 hasta, %64,0), CRP pozitifligi (33/34 hasta, %97,0), hematüri (4/45 hasta, %8,8), proteinüri (2/45 hasta, %,4,4), gaitada gizli kan pozitifligi (14/42 hasta, %33,3) bulundu. Hematüri ve proteinüri devam etmedigi için hiçbir hastada böbrek biyopsisine gerek duyulmadı. Gastrointestinal sistem tutulumu oldugu düsünülen 17 hastaya steroid tedavisi baslandı ve ortalama 9.1 gün kullanıldı. Perforasyon, invaginasyon gözlenmedi. Ortalama 15. günde 9 hastada relaps görüldü. Santral sinir sistemi tutulumu hiçbir hastada yoktu. Sonuç: Henoch-Schonlein Purpurası çocukluk çagında sık görülen benign karakterli bir hastalık olup komplikasyon ve sekel oranı oldukça düsüktür.Aim: The aim of this study was to investigate the clinical and epidemiologic features, laboratory finding and outcome of disease in our patients with Henoch-Schönlein purpura. Methods: Fourty-five patients with Henoch-Schönlein purpura who were diagnosed and observed in our department of pediatrics between 2000-2006 were retrospectively evaluated. Results: Twentyseven (60.0%) of the patients were female and 18 (40.0%) were male, female to male ratio was1.5. Mean age of the patients was 6 year 9 months (8 months-14 years). İnitial symptoms and findings in the time of admission with decreasing frequency were purpura (100%), disability to walk and/or arthralgia (71.1%) ve stomachache (40.0%). An infection history was present in 57.7% of the patients in the last 12 days. In physical examination, purpura (lower extremity and hips 100%, diffuse 11.1%), arhtritis (32 patients, 71.1%, mostly diffused on ankle and knee), fever (9 patients, 20,0%) were discovered. Anaemia (8/45 patients, 17.7%), leukocytosis (6/45 patients, 13.3%), trombocytosis (16/45 patients, 35.5%), increased erythrocyte sedimentation rate (16/25 patients, 64.0%), positive CRP (33/34 patients, 97.0%), hematuria (4/45 patients, 8.8%), proteinuria (2/45 patients, 4.4%), positive fecal blood tests (14/42 patients, 33.3%) were determined. Renal biopsy was not needed as there was no persistant hematuria and proteinuria. 17 patients who had gastrointestinal involvement were treated with steroid therapy for a mean period of 9.1 days. Perforation and invagination was not observed. Relapse was seen in 9 patients. (mean duration 15th day). There was no nervous system involvement in any patients. Conclusion: Henoch-Schonlein Purpura is a frequent benign disease of childhood. Complicatios and sequeles are infrequent

Congenital arterial thrombosis in newborn: A case report

Neonatal thrombosis is a serious event that can cause mortality or severe morbidity. Although catheters are the most common cause of neonatal thrombosis, spontaneous events can also occur. Arterial thrombosis is very rare and accounts for approximately half of all thrombotic events in neonates. Genetic prothrombotic risk factors may affect the occurence of neonatal thrombosis. In this report, a case of left brachial, radial, and ulnar arterial thrombosis associated with methylene-tetrahydrofolate reductase (MTHFR) gene C677T and A1298C polymorphism heterozygosity is presented. Plasma homocysteine level and other prothrombotic components were normal. Standard heparin, aspirin, vitamin B12, B6 and folic acid were initiated for treatment. However, the left arm of the patient was amputated at the shoulder because its capillary stream could not be observed. We suggest that MTHFR gene C677T and A1298C polymorphism heterozygosity might be investigated in neonates with congenital arterial thrombosis in spite of normal serum homocysteine levels. © Trakya University Faculty of Medicine

Characteristics of food allergy in children: National multicenter study

Conference: Congress of the European-Academy-of-Allergy-and-Clinical-Immunology (EAACI) Location: Lisbon, PORTUGAL Date: JUN 01-05, 2019Background : Food allergies impose a significant burden on the life of the child and the family. In this study, to determine the demographic characteristics of food allergies, we investigated the characteristics of patients with food allergies in different regions of Pediatric Allergy- Immunology departments in Turkey. Method : Turkey ' s National Study of Allergy and Clinical Immunology Society has conducted a Study Group on Food Allergies. 25 centers participated in this multicenter, cross- sectional and descriptive study.European Academy of Allergy and Clinical Immunolog