RB101-mediated Protection of Endogenous Opioids: Potential Therapeutic Utility?

The endogenous opioids met- and leu-enkephalin are inactivated by peptidases preventing the activation of opioid receptors. Inhibition of enkephalin-degrading enzymes increases endogenous enkephalin levels and stimulates robust behavioral effects. RB101, an inhibitor of enkephalin-degrading enzymes, produces antinociceptive, antidepressant, and anxiolytic effects in rodents, without typical opioid-related negative side effects. Although enkephalins are not selective endogenous ligands, RB101 induces these behaviors through receptor-selective activity. The antinociceptive effects of RB101 are produced through either the mu-opioid receptor alone or through activation of both mu- and delta-opioid receptors; the antidepressant-like and anxiolytic effects of RB101 are mediated only through the delta-opioid receptor. Although little is known about the effects of RB101 on other physiologically and behaviorally relevant peptides, these findings suggest that RB101 and other inhibitors of enkephalin-degrading enzymes may have potential as novel therapeutic compounds for the treatment of pain, depression, and anxiety.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75003/1/j.1527-3458.2007.00011.x.pd

Coaching efficacy and coaching effectiveness: examining their predictors and comparing coaches' and athletes' reports

Research on the conceptual model of coaching efficacy (Feltz, Chase, Moritz, & Sullivan, 1999) has increased dramatically over the past few years. Utilizing this model as the guiding framework, the current study examined: (a) coaching experience and sex as predictors of coaches' coaching efficacy; (b) sport experience, sex, and the match/mismatch in sex between coach and athlete as predictors of athletes' perceptions of their coach's effectiveness on the four coaching efficacy domains; and (c) whether coaches' reports of coaching efficacy and athletes' perceptions of coaching effectiveness differed. Coaches (N = 26) and their athletes (N = 291) from 8 individual and 7 team sports drawn from British university teams (N = 26) participated in the study. Coaches completed the Coaching Efficacy Scale (CES), while athletes evaluated their coach's effectiveness using an adapted version of the CES; coaches and athletes also responded to demographic questions. Results indicated that, in coaches, years of coaching experience positively predicted technique coaching efficacy, and males reported higher game strategy efficacy than females. In athletes, sport experience negatively predicted all perceived coaching effectiveness dimensions, and the mismatch in sex between athletes and their coach negatively predicted perceived motivation and character building coaching effectiveness. Finally, on average, coaches' ratings of coaching efficacy were significantly higher than their athletes' ratings of coaching effectiveness on A dimensions. The findings are discussed in terms of their implications for coaching effectiveness

Paradoks dystynkcji. Komiks na rynku kultury w Polsce

Artykuł stara się zinterpretować sytuację sztuki komiksowej w Polsce wykorzystując narzędzia wypracowane przez Pierre’a Bourdieu w Dystynkcji. Komiks był u nas od zaistnienia w obiegu kulturowym traktowany jako przykład kultury niskiej. W momencie wyłonienia się w latach osiemdziesiątych zwartej grupy społecznej fanów tego rodzaju sztuki, powstały liczne projekty mające na celu zwiększenie statusu powieści obrazkowych. W tekście omawiane są wybrane z nich i ich relacje z mechanizmami dystynkcji działającymi w obrębie rynku kultury.Jutkiewicz examines the state of Polish comic book art by drawing on Pierre Bourdieu’s Distinction. In Poland, this art form was initially seen as part of low-brow culture, but when a tight-knit social group of fans emerged in the 1980s, attempts were made to enhance the status of the graphic novel. Jutkiewicz discusses a selection of those projects and their relationship to the mechanisms of distinction at play in the cultural marketplace

Design, Synthesis, and Biological Activity of 5\u27-Phenyl-1,2,5,6-tetrahydro-3,3\u27-bipyridine Analogues as Potential Antagonists of Nicotinic Acetylcholine Receptors

Starting from a known non-specific agonist (1) of nicotinic acetylcholine receptors (nAChRs), rationally guided structural-based design resulted in the discovery of a small series of 5′-phenyl-1,2,5,6-tetrahydro-3,3′-bipyridines (3a – 3e) incorporating a phenyl ring off the pyridine core of 1. The compounds were synthesized via successive Suzuki couplings on a suitably functionalized pyridine starting monomer 4 to append phenyl and pyridyl substituents off the 3- and 5-positions, respectively, and then make subsequent modifications on the flanking pyridyl ring to provide target compounds. Compound 3a is a novel antagonist which is highly selective for α3β4 nAChR (Ki = 123 nM) over the α4β2, and α7 receptors

Tolerance to highâ internalizing δ opioid receptor agonist is critically mediated by arrestin 2

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/144602/1/bph14353.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/144602/2/bph14353_am.pd

Role of signalling molecules in behaviours mediated by the δ opioid receptor agonist SNC80

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142438/1/bph14131.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142438/2/bph14131-sup-0001-Supplementary-Data_S1.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142438/3/bph14131_am.pd