Ring Expansion Of Alkylidenecarbenes Derived From Lactams, Lactones, And Thiolactones Into Strained Heterocyclic Alkynes: A Theoretical Study

Strained cycloalkynes are of considerable interest to theoreticians and experimentalists, and possess much synthetic value as well. Herein, a series of cyclic alkylidenecarbenes—formally obtained by replacing the carbonyl oxygen of four-, five-, and six-membered lactams, lactones, and thiolactones with a divalent carbon—were modeled at the CCSD(T)/cc-pVTZ//B3LYP/6-311+G** and CCSD(T)/cc-pVTZ//CCSD/6-311+G** levels of theory. The singlet carbenes were found to be more stable than the triplets. The strained heterocyclic alkynes formed by ring expansion of these singlet carbenes were also modeled. Interestingly, the C≡C bonds in the five-membered heterocycles, obtained from the rearrangement of β-lactam- and β-lactone-derived alkylidenecarbenes, displayed lengths intermediate between formal double and triple bonds. Furthermore, 2-(1-azacyclobutylidene)carbene was found to be nearly isoenergetic with its ring-expanded isomer, and 1-oxacyclopent-2-yne was notably higher in energy than its precursor carbene. In all other cases, the cycloalkynes were lower in energy than the corresponding carbenes. The transition states for ring-expansion were always lower for the 1,2-carbon shifts than for 1,2-nitrogen or oxygen shifts, but higher than for the 1,2-sulfur shifts. These predictions should be verifiable using carbenes bearing appropriate isotopic labels. Computed vibrational spectra for the carbenes, and their ring-expanded isomers, are presented and could be of value to matrix isolation experiments

Towards predicting post-editing productivity

Machine translation (MT) quality is generally measured via automatic metrics, producing scores that have no meaning for translators who are required to post-edit MT output or for project managers who have to plan and budget for transla- tion projects. This paper investigates correlations between two such automatic metrics (general text matcher and translation edit rate) and post-editing productivity. For the purposes of this paper, productivity is measured via processing speed and cognitive measures of effort using eye tracking as a tool. Processing speed, average fixation time and count are found to correlate well with the scores for groups of segments. Segments with high GTM and TER scores require substantially less time and cognitive effort than medium or low-scoring segments. Future research involving score thresholds and confidence estimation is suggested

Physical Processes in Star-Gas Systems

First we present a recently developed 3D chemodynamical code for galaxy evolution from the K**2 collaboration. It follows the evolution of all components of a galaxy such as dark matter, stars, molecular clouds and diffuse interstellar matter (ISM). Dark matter and stars are treated as collisionless N-body systems. The ISM is numerically described by a smoothed particle hydrodynamics (SPH) approach for the diffuse (hot) gas and a sticky particle scheme for the (cool) molecular clouds. Physical processs such as star formation, stellar death or condensation and evaporation processes of clouds interacting with the ISM are described locally. An example application of the model to a star forming dwarf galaxy will be shown for comparison with other codes. Secondly we will discuss new kinds of exotic chemodynamical processes, as they occur in dense gas-star systems in galactic nuclei, such as non-standard ``drag''-force interactions, destructive and gas producing stellar collisions. Their implementation in 1D dynamical models of galactic nuclei is presented. Future prospects to generalize these to 3D are work in progress and will be discussed.Comment: 4 pages, 4 figures, "The 5th Workshop on Galactic Chemodynamics" - Swinburne University (9-11 July 2003). To be published in the Publications of the Astronomical Society of Australia in 2004 (B.K. Gibson and D. Kawata, eds.). Accepted version, minor changes relative to origina

Human indoor climate preferences approximate specific geographies

Root mean square error analysis (between indoor and outdoor climates) and results for temperature and vapor pressur

The Obesity Epidemic: Survey of Current Physical Therapy Trends in North Dakota

Background and Purpose. Many different health professionals are involved in the prevention and treatment of obesity. The APTA believes that physical therapists should be in a leadership role among other health care providers in providing patient education and instruction regarding physical activity. The purpose of this study was to determine current practice trends among physical therapists in the state of North Dakota relating to patients who are overweight or obese. Subjects and Methods. Three hundred surveys were mailed to randomly selected physical therapists licensed in the State of North Dakota. The survey consisted of23 questions concerning level of training, referral rates, comfort level in treating patients who are overweight or obese, and interventions provided to these patients. Results. Of the 300 surveys sent out, 136 (45.3%) were completed and returned for inclusion in this study. Those physical therapists who indicated they had advanced training did not have significantly higher comfort level in treating patients who are overweight or obese. Similarly there was no significant difference between advanced training and discussion or recording of weight status. Seventy-five percent of therapists surveyed had not received any referrals for weight management in the past year. Appearance, weight/height measurements, body mass index (BMI), and patient opinion were the most commonly used methods to assess weight status. The most frequently used interventions included patient education, aerobic exercise, and strength training. Discussion and Conclusion. Physical therapists have appropriate education to identify at-risk patients and provide intervention to improve weight status, but are not currently active in promoting themselves as members of the weight management team. Additional training may be necessary in the areas of objective methods of assessing weight status and weight management programs for patients with other co-morbidities

Time-delayed feedback control in astrodynamics

In this paper we present time-delayed feedback control (TDFC) for the purpose of autonomously driving trajectories of nonlinear systems into periodic orbits. As the generation of periodic orbits is a major component of many problems in astodynamics we propose this method as a useful tool in such applications. To motivate the use of this method we apply it to a number of well known problems in the astrodynamics literature. Firstly, TDFC is applied to control in the chaotic attitude motion of an asymmetric satellite in an elliptical orbit. Secondly, we apply TDFC to the problem of maintaining a spacecraft in a periodic orbit about a body with large ellipticity (such as an asteroid) and finally, we apply TDFC to eliminate the drift between two satellites in low Earth orbits to ensure their relative motion is bounded

Dynamical Friction in a Gaseous Medium

Using time-dependent linear perturbation theory, we evaluate the dynamical friction force on a massive perturber M_p traveling at velocity V through a uniform gaseous medium of density rho_0 and sound speed c_s. This drag force acts in the direction -\hat V, and arises from the gravitational attraction between the perturber and its wake in the ambient medium. For supersonic motion (M=V/c_s>1), the enhanced-density wake is confined to the Mach cone trailing the perturber; for subsonic motion (M<1), the wake is confined to a sphere of radius c_s t centered a distance V t behind the perturber. Inside the wake, surfaces of constant density are hyperboloids or oblate spheroids for supersonic or subsonic perturbers, respectively, with the density maximal nearest the perturber. The dynamical drag force has the form F_df= - I 4\pi (G M_p)^2\rho_0/V^2. We evaluate I analytically; its limits are I\to M^3/3 for M>1. We compare our results to the Chandrasekhar formula for dynamical friction in a collisionless medium, noting that the gaseous drag is generally more efficient when M>1 but less efficient when M<1. To allow simple estimates of orbit evolution in a gaseous protogalaxy or proto-star cluster, we use our formulae to evaluate the decay times of a (supersonic) perturber on a near-circular orbit in an isothermal \rho\propto r^{-2} halo, and of a (subsonic) perturber on a near-circular orbit in a constant-density core. We also mention the relevance of our calculations to protoplanet migration in a circumstellar nebula.Comment: 17 pages, 5 postscript figures, to appear in ApJ 3/1/9

Effect of Human Exogenous Leukocyte Interferon in Cytomegalovirus Infections

Human leukocyte interferon was injected into nine patients with cytomegalovirus infections; four of these patients were congenitally infected, and five had acquired infections. In three patients viruria was completely inhibited. In five patients viral excretion in the urine was only transiently inhibited. Viremia was not significantly suppressed. The lymphocyte response to phytohemagglutinin was suppressed in two patient

A compact unc45b-promoter drives muscle-specific expression in zebrafish and mouse

Summary: Gene therapeutic approaches to cure genetic diseases require tools to express the rescuing gene exclusively within the affected tissues. Viruses are often chosen as gene transfer vehicles but they have limited capacity for genetic information to be carried and transduced. In addition, to avoid off-target effects the therapeutic gene should be driven by a tissue-specific promoter in order to ensure expression in the target organs, tissues, or cell populations. The larger the promoter, the less space will be left for the respective gene. Thus, there is a need for small but tissue-specific promoters. Here, we describe a compact unc45b promoter fragment of 195 bp that retains the ability to drive gene expression exclusively in skeletal and cardiac muscle in zebrafish and mouse. Remarkably, the described unc45b promoter fragment not only drives muscle-specific expression but presents heat-shock inducibility, allowing a temporal and spatial quantity control of (trans)gene expression. Here, we demonstrate that the transgenic expression of the smyd1b gene driven by the unc45b promoter fragment is able to rescue the embryonically lethal heart and skeletal muscle defects in smyd1b-deficient flatline mutant zebrafish. Our findings demonstrate that the described muscle-specific unc45b promoter fragment might be a valuable tool for the development of genetic therapies in patients suffering from myopathies. genesis 54:431–438, 2016. © 2016 The Authors. Genesis Published by Wiley Periodicals, Inc

OH-selected AGB and post-AGB stellar objects II.Blue versus red evolution off the AGB

Using objects found in a systematic survey of the galactic Plane in the 1612-MHz OH line, we discuss in detail two ``sequences'' of post-AGB evolution, a red and a blue. We argue that the red and the blue groups separate by initial mass at 4Msun, based on evolutionary-sequence turn-off colours, spectral energy distributions, outflow velocities and scaleheight. The higher-mass (blue) objects may have earlier AGB termination. The lower-mass (red) objects undergo very sudden reddening for IRAS colour R21\sim1.2; these sources must all undergo a very similar process at AGB termination. The transition colour corresponds to average initial masses of 1.7Msun. A combined IRAS-MSX colour proves a very sensitive tool to distinguish lower-mass, early post-AGB objects from sources still on the AGB and also to distinguish more evolved post-AGB objects from star-forming regions. The high-mass blue objects are the likely precursors of bipolar planetary nebulae, whereas the low-mass red objects will evolve into elliptical planetary nebulae.Comment: 12 pages, LaTex, 7 figures (1 colour), AJ (accepted