Safety and Usability Guidelines of Clinical Information Systems Integrating Clinical Workflow: A Systematic Review.

OBJECTIVES: The usability of clinical information systems (CISs) is known to be an essential consideration in ensuring patient safety as well as integrating clinical flow. This study aimed to determine how usability and safety guidelines of CIS consider clinical workflow through a systematic review in terms of the target systems, methodology, and guideline components of relevant articles. METHODS: A literature search was conducted for articles published from 2000 to 2015 in PubMed, Cochrane, EMBASE, Web of Science, and CINAHL. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement method was employed. Articles containing recommendations, principles, and evaluation items for CIS usability and safety were included. The selected articles were classified according to article type, methodology, and target systems. Taking clinical workflow into consideration, the components of guidelines were extracted and classified. RESULTS: A total of 7,401 articles were identified by keyword search. From the 76 articles remaining after abstract screening, 15 were selected through full-text review. Literature review (n = 7) was the most common methodology, followed by expert opinions (n = 6). Computerized physician order entry (n = 6) was the most frequent system. Four articles considered the entire process of clinical tasks, and two articles considered the principles of the entire process of user interface affecting clinical workflow. Only two articles performed heuristic evaluations of CISs. CONCLUSIONS: The usability and safety guidelines of CISs need improvement in guideline development methodology and with consideration of clinical workflow

Social Pressure-Induced Craving in Patients with Alcohol Dependence: Application of Virtual Reality to Coping Skill Training

OBJECTIVE: This study was conducted to assess the interaction between alcohol cues and social pressure in the induction of alcohol craving. METHODS: Fourteen male patients with alcohol dependence and 14 age-matched social drinkers completed a virtual reality coping skill training program composed of four blocks according to the presence of alcohol cues (x2) and social pressure (x2). Before and after each block, the craving levels were measured using a visual analogue scale. RESULTS: Patients with alcohol dependence reported extremely high levels of craving immediately upon exposure to a virtual environment with alcohol cues, regardless of social pressure. In contrast, the craving levels of social drinkers were influenced by social pressure from virtual avatars. CONCLUSION: Our findings imply that an alcohol cue-laden environment should interfere with the ability to use coping skills against social pressure in real-life situations.ope

Structural insights into the novel ARM-repeat protein CTNNBL1 and its association with the hPrp19-CDC5L complex

The hPrp19-CDC5L complex plays a crucial role during human pre-mRNA splicing by catalytic activation of the spliceosome. In order to elucidate the molecular architecture of the hPrp19-CDC5L complex, the crystal structure of CTNNBL1, one of the major components of this complex, was determined. Unlike canonical ARM-repeat proteins such as beta-catenin and importin-alpha, CTNNBL1 was found to contain a twisted and extended ARM-repeat structure at the C-terminal domain and, more importantly, the protein formed a stable dimer. A highly negatively charged patch formed in the N-terminal ARM-repeat domain of CTNNBL1 provides a binding site for CDC5L, a binding partner of the protein in the hPrp19-CDC5L complex, and these two proteins form a complex with a stoichiometry of 2:2. These findings not only present the crystal structure of a novel ARM-repeat protein, CTNNBL1, but also provide insights into the detailed molecular architecture of the hPrp19-CDC5L complex.open0

Recosiendo fragmentos metropolitanos: dispersión y desorientación urbana en el distrito de Yeongdeungpo de Seúl

Este estudio toma como base el área industrial de Yeongdeungpo, que es unos de los proyectos de regeneración urbana actuales en Seúl, como objetivo de la investigación. En este estudio, nos enfocamos en la revitalización urbana después de investigar y ana- lizar factores complejos de formación urbana e identificar problemas urbanos y luego, entretejer los principales elementos de esta importante zona de la ciudad de Seúl

Loosely Coupled Architecture for Bio-Network Reverse Engineering

Abstract Bio-network reverse engineering is inferring networks of biological entities with given observed data. In biology, our main concern is to find out the systematic architecture of biological entities and their functional role in living organisms. Thus it is very important to provide proper systematic approaches for such reverse engineering for bio-networks. Previously, we developed an information fusion platform for bio-network inference and analysis, named BioCAD. BioCAD provided a good workplace where various network inference and analysis techniques were integrated for user-specific variants of bio-network inference problems. The previous version of BioCAD has a tightly coupled architecture where the integrated usage of provided modules is available only in the form of given workflows. Even though it has provided good workplace for bio-network reverse engineering, there are some limitations in adding new modules and selective usage of provided modules. To overcome such limitations, we are designing and developing BioCAD 2.0 which has a loosely-coupled architecture. We propose our current approach of building new BioCAD 2.0 and BioCAD 2.0 will be a powerful workbench for bio-network reverse engineering.