Temperature effects of Mach-Zehnder interferometer using a liquid crystal-filled fiber

We demonstrated a simple and cost-effective method to fabricate all fiber Mach-Zehnder interferometer (MZI) based on cascading a short section of liquid crystal (LC)-filled hollow-optic fiber (HOF) between two single mode fibers by using automatically splicing technique. The transmission spectra of the proposed MZI with different LC-infiltrated length were measured and the temperature-induced wavelength shifts of the interference fringes were recorded. Both blue shift and red shift were observed, depending the temperature range. Based on our experimental results, interference fringe was observed with a maximum interferometric contrast over 35dB. The temperature-induced resonant wavelength blue-shifts 70.4 nm for the MZI with an LC length of 9.79 mm and the wavelength temperature sensitivity of -1.55 nm/°C is easily achieved as the temperature increases from 25°C to 77°C

Multivariate Statistical Analysis of Dyeing Wastewater Organic Matter Indicators

Objectives Since 2016, TOC (Total Organic Carbon) has replaced COD (Chemical Oxygen Demand) as an organic indicator for effluent wastewater quality standards. However, the distribution of organic substances by process in wastewater treatment facilities is not properly identified, making it difficult to secure stable treated wastewater quality. Therefore, in this study, we identified the correlation between TOC and existing organic matter indicators in raw wastewater, primary treated, secondary treated, and effluent wastewater for dyeing wastewater. Methods Samples for each process were collected twice a week, a total of 24 times, from a dyeing wastewater treatment plant located in Y-city, Gyeonggi-do, and organic pollutant indicators (TOC, CODCr, CODMn, BOD5) were analyzed. TOC was analyzed by the NPOC (non-purgeable organic carbon) method using TOC-VCHP (Shimadzu, Japan). Using the analysis results, the characteristics of organic pollutants in dyeing wastewater were analyzed. In addition, multivariate statistical analysis was performed using SPSS to analyze correlations between organic pollutant indicators and principal component analysis. Results and Discussion As a result of multivariate statistical analysis, TOC was inflowed at an average of 574.9 mg/L and treated at 58.2mg/L. In the case of CODCr, CODMn, and BOD5, the inflow was 1,644, 448.9, and 440.7 mg/L and was treated at 98.2, 39.7, and 10.8mg/L. When evaluated based on effluent water quality standards, all of them satisfied the Region III standards, but were discharged at a relatively high level compared to the TOC concentration of sewage treatment plants effluent. As a result of comparing correlations between organic matter indicators through Pearson correlation analysis, the inflow raw water shows a high positive correlation with TOC:TCODCr (r=0.720), TOC:TCODMn (r=0.636), and TOC:TBOD5 (r=0.302) showed low correlation. This is reason to be due to the fact that most organic substances in dyeing wastewater are non-degradable substances and have low biodegradability. As a result of principal component analysis of influent, primary treated, and final treated, three main components each (two for final treated) were extracted, with cumulative contribution rates of 80.1%, 83.2%, and 95.6%. Conclusion Because the properties of wastewater differ greatly depending on the type of leather and chemicals handled at the dyeing factory, the correlation between influent water was low, but the correlation between treated water and treated water was relatively high. The correlation between processes in wastewater treatment facilities also tended to increase toward later processes. It is believed that the above statistical analysis can be used as basic data for effective organic matter management

Characteristics of Hearing Loss Among Older Adults in the Korean Genome and Epidemiology Study: A Community-Based Longitudinal Cohort Study With an 8-Year Follow-up

Objectives. This study investigated the 8-year incidence and progression of hearing loss (HL) and its types and examined the risk factors for changes in HL. Methods. This longitudinal cohort study analyzed data from the Korean Genome and Epidemiology Study (KoGES), an ongoing, prospective, community-based cohort study that has been conducted since 2001. Altogether, 1,890 residents of urban areas in Korea aged 45–75 years at time 1 (baseline) were included in the study. Pure-tone audiometry (PTA) testing was performed twice, at time 1 (2008–2009) and time 2 (2015–2018, follow-up), 8 years apart. HL grades were defined as seven mutually exclusive categories following the revised World Health Organization classification. Incidence was defined as PTA >20 dB HL in the better ear at time 2 among those without HL at time 1. Progression was defined as the progressive deterioration of HL among those with HL at time 1. The three types of HL constituted sensorineural (SNHL), conductive, and mixed HL. Results. At time 1, 36.40% of patients were diagnosed with HL, which increased to 51.64% at time 2. The 8-year incidence of HL was 27.20%, and progressive deterioration of HL occurred in 23.11% of those with HL. SNHL was the most common type of HL, and its prevalence markedly increased at time 2. Multivariate analysis demonstrated that the incidence of HL was significantly associated with increasing age, male sex (odds ratio [OR], 1.73; 95% confidence interval [CI], 1.07–2.81), and diabetes mellitus (OR, 1.43; 95% CI, 1.04–1.96). Alcohol consumption was a risk factor for HL deterioration among those with HL at time 1. Conclusion. The prevalence and deterioration of HL were extremely high among older adults, and age was the strongest risk factor for these changes. Therefore, timely screening and intervention are necessary to prevent HL and delay its deterioration among older adults

Egy tanúságtevő hitvalló, szolgáló, tudományos és papi pálya lezárult

Passed a Wittness of the Faith, Scientist, a Servant of The Lord, True Priest: Nicefor Petrashevich (1915–2013), canon of the Preshov Greek Catholic Eparchy. Abstract Decease of the witness of the Faith, a servant of the Lord and a famous researcher of the religious folklore: Nicefor Joseph Petrashevich (1915–2013) distinguished member of the Capitol of Preshov Greek Catholic Eparchy. Born in Čukalovce, East-Slovakia (then Csukalóc, Upper-Hungary) in 1915 as the sixth of the eleven children in the family of a Greek Catholic bishop, he was inspired by his father and elder brother who served the Lord. He studied in the high school (gymnasium) of the Cistercian Order in Eger (Northern Hungary) which provided its pupils with knowledge and deep faith. He became a choir-minister of the Uzghorod Bishopric Basilica where he turned to the examination of folklore traditions reflected in the liturgical chants. Apparently, it was his calling and his findings on the Byzantine chants contributed significantly to the understanding of religious folklore. He was known as a gift ed composer and singer, too. The Greek Catholic Church was banned in the Soviet Union which obtained Subcarpathia after the World War II, and this church was oppressed in Slovakia as well, so he faced a dilemma: to convert to the Ortodox (Pravoslav) Christianity and live free, or to remain faithful to the Catholic Church and be persecuted. Moreover, he was a coelebs, a priest who did not have a wife (despite the fact that Greek Catholic priests are allowed to have families). Consequently, he could have been elected as bishop, as the higher ranks in the Byzantine Churches are open for monks. The communist authorities offered Father Nicefor the episcopate of the Slovak Ortodox Church, if he converted to the Ortodoxy. He refused it: “my head does not accept the mithra (bishops’ crone) by leaving my Catholic faith” –he said. As a result, he was imprisoned for more than two years in Slovakia. Later he came to Hungary where could not serve as a parochial priest, but worked as cantor or helping pope in various places and in centres of pilgrimage where performed the liturgy in Church Slavonic which he sang excellently. Continuing his researches in the folk sings in the liturgy and the local traditions of the liturgical chants, he gained a small grant of the Soros Foundation in 1986 and delivered lectures for two semesters at the Department of the Folklore at the Eötvös University in Budapest in 1988–89. His papers have been partially published, but most of them are still preserved as manuscripts in the Institute of Musicology at the Hungarian Academy of Sciences, or even in unknown places worldwide, as he sent his works to his brothers-in-faith to the United States. In his eighties, instead of enjoying the golden days of ageing, he moved to Slovakia in order to serve as a pastor who spoke both Slovakian and Hungarian as mother tongues. He was buried in Szikszó, Hungary where the Greek Catholic Bishop of Preshov and approximately forty popes from Ukraine, Hungary and Slovakia commemorated him on 20 July 2013. Church historians and folklorists honored his memory as a researcher with a conference on 4 October 2013 in Szikszó. Proceedings are to be published next year. A memorial website about him is open for bloggers

Gene Expression Profiles in Genetically Different Mice Infected with Toxoplasma gondii: ALDH1A2, BEX2, EGR2, CCL3 and PLAU

Toxoplasma gondii can modulate host cell gene expression; however, determining gene expression levels in intermediate hosts after T. gondii infection is not known much. We selected 5 genes (ALDH1A2, BEX2, CCL3, EGR2 and PLAU) and compared the mRNA expression levels in the spleen, liver, lung and small intestine of genetically different mice infected with T. gondii. ALDH1A2 mRNA expressions of both mouse strains were markedly increased at day 1-4 postinfection (PI) and then decreased, and its expressions in the spleen and lung were significantly higher in C57BL/6 mice than those of BALB/c mice. BEX2 and CCR3 mRNA expressions of both mouse strains were significantly increased from day 7 PI and peaked at day 15-30 PI (P<0.05), especially high in the spleen liver or small intestine of C57BL/6 mice. EGR2 and PLAU mRNA expressions of both mouse strains were significantly increased after infection, especially high in the spleen and liver. However, their expression patterns were varied depending on the tissue and mouse strain. Taken together, T. gondii-susceptible C57BL/6 mice expressed higher levels of these 5 genes than did T. gondii-resistant BALB/c mice, particularly in the spleen and liver. And ALDH1A2 and PLAU expressions were increased acutely, whereas BEX2, CCL3 and EGR2 expressions were increased lately. Thus, these demonstrate that host genetic factors exert a strong impact on the expression of these 5 genes and their expression patterns were varied depending on the gene or tissue

Pure Epidural Cavernous Hemangioma of the Cervical Spine that Presented with an Acute Sensory Deficit Caused by Hemorrhage

Pure epidural cavernous hemangioma of the spine without vertebral involvement is rare. Due to the slow growth of this lesion, the most common symptoms are chronic pain, myelopathy, and radiculopathy. In our case, the patient complained of an acute onset sensory deficit of the C4 dermatome. An MRI revealed an epidural mass with an acute hematoma. Here, we report a case of a pure epidural cavernous hemangioma that presented with acute neurologic symptoms caused by intralesional hemorrhage and an acute epidural hematoma, which were demonstrated on the patient's MRI

Amifostine ameliorates recognition memory defect in acute radiation syndrome caused by relatively low-dose of gamma radiation

This study examined whether amifostine (WR-2721) could attenuate memory impairment and suppress hippocampal neurogenesis in adult mice with the relatively low-dose exposure of acute radiation syndrome (ARS). These were assessed using object recognition memory test, the terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling assay, and immunohistochemical markers of neurogenesis [Ki-67 and doublecortin (DCX)]. Amifostine treatment (214 mg/kg, i.p.) prior to irradiation significantly attenuated the recognition memory defect in ARS, and markedly blocked the apoptotic death and decrease of Ki-67- and DCX-positive cells in ARS. Therefore, amifostine may attenuate recognition memory defect in a relatively low-dose exposure of ARS in adult mice, possibly by inhibiting a detrimental effect of irradiation on hippocampal neurogenesis

Identification of MYC as an antinecroptotic protein that stifles RIPK1-RIPK3 complex formation

The underlying mechanism of necroptosis in relation to cancer is still unclear. Here, MYC, a potent oncogene, is an antinecroptotic factor that directly suppresses the formation of the RIPK1-RIPK3 complex. Gene set enrichment analyses reveal that the MYC pathway is the most prominently down-regulated signaling pathway during necroptosis. Depletion or deletion of MYC promotes the RIPK1-RIPK3 interaction, thereby stabilizing the RIPK1 and RIPK3 proteins and facilitating necroptosis. Interestingly, MYC binds to RIPK3 in the cytoplasm and inhibits the interaction between RIPK1 and RIPK3 in vitro. Furthermore, MYC-nick, a truncated form that is mainly localized in the cytoplasm, prevented TNF-induced necroptosis. Finally, down-regulation of MYC enhances necroptosis in leukemia cells and suppresses tumor growth in a xenograft model upon treatment with birinapant and emricasan. MYC-mediated suppression of necroptosis is a mechanism of necroptosis resistance in cancer, and approaches targeting MYC to induce necroptosis represent an attractive therapeutic strategy for cancer