Electroweak Chiral Lagrangian for a Hypercharge-universal Topcolor Model

Electroweak chiral Lagrangian for a hypercharge-universal topcolor model is investigated. We find that the assignments of universal hypercharge improve the results obtained previously from K.Lane's prototype natural TC2 model by allowing a larger Z' mass resulting in a very small T parameter and the S parameter is still around the order of +1Comment: 12 pages, 7 figure

Dynamical Computation on Coefficients of Electroweak Chiral Lagrangian from One-doublet and Topcolor-assisted Technicolor Models

Based on previous studies deriving the chiral Lagrangian for pseudo scalar mesons from the first principle of QCD, we derive the electroweak chiral Lagrangian and build up a formulation for computing its coefficients from one-doublet technicolor model and a schematic topcolor-assisted technicolor model. We find that the coefficients of the electroweak chiral Lagrangian for the topcolor-assisted technicolor model are divided into three parts: direct TC2 interaction part, TC1 and TC2 induced effective Z' particle contribution part, and ordinary quarks contribution part. The first two parts are computed in this paper and we show that the direct TC2 interaction part is the same as that in the one-doublet technicolor model, while effective Z' contributions are at least proportional to the p^2 order parameter \beta_1 in the electroweak chiral Lagrangian and typical features of topcolor-assisted technicolor model are that it only allows positive T and U parameters and the T parameter varies in the range 0\sim 1/(25\alpha), the upper bound of T parameter will decrease as long as Z' mass become large. The S parameter can be either positive or negative depending on whether the Z' mass is large or small. The Z' mass is also bounded above and the upper bound depend on value of T parameter. We obtain the values for all the coefficients of the electroweak chiral Lagrangian up to order of p^4.Comment: 52 pages, 15 figure

Surgical analysis for 106 cases with A-V patterns strabismus

AIM: To analyze the causes and evaluate the surgical effect of A-V patterns strabismus.<p>METHODS: Clinical data of 106 caseswith A-V patterns strabismus in our hospital from January 2011 to December 2012 were retrospectively analyzed. Seventy patients with oblique muscle overaction were performed weakening oblique muscle surgery to treat A-V pattern. Twenty-six patients with no abnormality of oblique muscle and superior and inferior rectus muscle, and with >20^△between gaze up 25° and down 25° in V pattern and with >15^△between gaze up 25° and down 25° in A pattern were performed horizontal rectus muscle transposition to half to one muscle tendon. While ten patients with no obvious abnormality of oblique muscle and vertical rectus muscle, and with ≤20^△between gaze up 25° and down 25° in V pattern and with ≤15^△between gaze up 25°and down 25° in A pattern were only performed horizontal rectus muscle surgery.<p>RESULTS: No A-V patterns was defined asnormotopia and A-V patterns >10^△ was defined as overcorrection or undercorrection after surgery. In 106 cases, V pattern was corrected in 75 cases, overcorrected in 5 cases, undercorrected in 4 cases. A pattern was corrected in 15 cases, overcorrected in 3 cases, undercorrected in 4 cases. Horizontal strabismus >±10^△was defined as overcorrection or undercorrection after surgery. Eighty-five cases were corrected, 11 cases were undercorrected, and 10 cases were overcorrected.<p>CONCLUSION: A-V patterns strabismus was caused mainly by abnormal extraocular muscle. A-V patterns with abnormal oblique movement were treated by oblique surgery and A-V patterns with normal oblique and vertical rectus movement were treated by horizontal rectus muscle transposition, both which corrected A-V patterns. Patients had good distance and near stereopsis postoperation. Binocular weakening oblique muscle surgery can correct primary ocular position, so surgical design of horizontal deviation about A-V patterns strabismus with abnormal oblique muscle was considered

Leveraging syntactic and semantic graph kernels to extract pharmacokinetic drug drug interactions from biomedical literature

BACKGROUND: Information about drug-drug interactions (DDIs) supported by scientific evidence is crucial for establishing computational knowledge bases for applications like pharmacovigilance. Since new reports of DDIs are rapidly accumulating in the scientific literature, text-mining techniques for automatic DDI extraction are critical. We propose a novel approach for automated pharmacokinetic (PK) DDI detection that incorporates syntactic and semantic information into graph kernels, to address the problem of sparseness associated with syntactic-structural approaches. First, we used a novel all-path graph kernel using shallow semantic representation of sentences. Next, we statistically integrated fine-granular semantic classes into the dependency and shallow semantic graphs. RESULTS: When evaluated on the PK DDI corpus, our approach significantly outperformed the original all-path graph kernel that is based on dependency structure. Our system that combined dependency graph kernel with semantic classes achieved the best F-scores of 81.94 % for in vivo PK DDIs and 69.34 % for in vitro PK DDIs, respectively. Further, combining shallow semantic graph kernel with semantic classes achieved the highest precisions of 84.88 % for in vivo PK DDIs and 74.83 % for in vitro PK DDIs, respectively. CONCLUSIONS: We presented a graph kernel based approach to combine syntactic and semantic information for extracting pharmacokinetic DDIs from Biomedical Literature. Experimental results showed that our proposed approach could extract PK DDIs from literature effectively, which significantly enhanced the performance of the original all-path graph kernel based on dependency structure

Potential protective role of hydrogen against cisplatininduced side effects during chemotherapy: A mini-review of a novel hypothesis for antagonism of hydrogen

Purpose: To review the potential protective role of hydrogen against cisplatin-induced side effects during chemotherapy.Methods: We searched PubMed and SCOPUS using the following keywords and combinations in titles, keywords, abstracts and full texts: cisplatin; side effects; chemotherapy; tumor; toxicity; hydrogen; reactive oxidative species; and ischemic reperfusion.Results: The pathogenesis of cisplatin-induced side effects is suggested based on the increased level of reactive oxidative species (ROS). Cisplatin induces ROS-dependent platelet apoptosis via the extracellular signal-regulated kinase (ERK) signaling pathway, which might have contributed to cisplatininduced hematotoxicity, and in particular, thrombocytopenia. Molecular hydrogen has been shown to have therapeutic effects against damage to various organs (especially kidney, brain and liver) caused by ischemic reperfusion (IR) through selective elimination of the most cytotoxic ROS hydrogen radicals without affecting other types of ROS involved in signal transduction in vitro and in vivo.Conclusion: Hydrogen may not only alleviate hematotoxicity in patients with hemorrhagic tendencies during cisplatin-based chemotherapy, but also has a potential protective effect against other side effects induced by cisplatin.Keywords: Reactive oxygen species, Hydrogen radicals, Cisplatin, Hepatotoxicity, Chemotherapy, Side effects, Antagonis

Establishment and Characterization of an In Vitro Model for Cholesteatoma

ObjectivesExperimental models are of importance to study the pathogenesis of middle ear cholesteatoma, however, they were not established until now. We aimed to develop in vitro model of middle ear cholesteatoma using primary keratinocytes and fibroblasts isolated from cholesteatoma tissue. HaCaT cell line was used as a "skin equivalent" and to compare the grade of homogeneity between cholesteatoma keratinocytes and HaCaT cells.MethodsPrimary keratinocytes were isolated from cholesteatoma tissue, co-cultured with preliminary prepared feeder layer from cholesteatoma fibroblasts and subsequently air-exposed. The protein profile of cholesteatoma keratinocytes and HaCaT cells was evaluated by means of immunoblot using monoclonal antibody against cytokeratin (CK) 13 and 16. Tissue localization of CK 13 and 16 was accomplished with immunohistochemistry.ResultsDifferent protein profile and stronger expression of CK 13 and 16 were demonstrated in cholesteatoma keratinocytes in comparison with HaCaT cells. Bigger stratification was observed in the 3D-in vitro systems when both cholesteatoma keratinocytes and HaCaT cells were respectively co-cultured with fibroblasts in comparison with the corresponding control groups without fibroblasts.Conclusion3D-model demonstrates the significance of intercellular interaction between components of cholesteatoma tissue