Planray Oy:n ESD-suojauksen kartoitus ja parannus

Tämän insinöörityön tarkoituksena oli kartoittaa ESD-suojauksen taso Planray Oy:ssä ja selvittää siinä olevat puutteet. ESD (Electrostatic Discharge) tarkoittaa staattisen sähkön purkausta, jollaisia esiintyy jokapäiväisessä elämässä jatkuvasti. Elektroniikan kehittyessä komponentit monimutkaistuvat ja niiden koko sekä johdinleveydet pienentyvät. Tämän seurauksena ne ovat entistä herkempiä tuhoutumaan staattisen sähkön purkauksessa, ja ESD-suojaukseen tulisi kiinnittää erityistä huomiota. ESD-suojauksen kartoitus aloitettiin tutustumalla SFS-käsikirja 153:een, joka käsittelee staattisen sähkön hallintaa elektroniikkateollisuudessa. Planray Oy:n ESD-suojauksen taso kartoitettiin tekemällä yrityksessä auditointi, jossa ESD-suojaus käytiin kokonaisuudessaan läpi. Lisäksi käytiin tekemässä auditointi eräässä yrityksessä, joka on Planrayn asiakkaita. Näin saatiin tuloksille vertailupohjaa. ESD-suojausta oli tarkoitus kartoittaa myös resistanssimittauksilla, mutta aikataulullisista syistä sekä mittausvälineiden puuttuessa tästä jouduttiin luopumaan. Auditoinnin pohjalta tehtiin kaksi vaihtoehtoista parannusehdotusta. Lisäksi tehtiin valmiit mittauspöytäkirjat, joita voidaan käyttää tulevaisuudessa tehtävien mittauksien dokumentointiin.The purpose of this final year project was to map out and improvethe ESD protection of Planray Oy. The abbreviation ESD stands for Electrostatic Discharge, which is a common phenomenon in everyday life. In electronic industry many components have become smaller and more complex, which means that they can be destroyed more and more easily at ESD discharge. Studying ESD protection was done on the basis of the SFS handbook 153. This handbook handles the control of electrostatic discharge in electronic industry and includes the ESD protection standards IEC 61340-5-1 and IEC 61340-5-2. The level of the ESD protection was mapped out by making a survey in the company. In this survey the whole ESD protection was mapped out, trying to find possible failures. A comparison survey was also made in another company, which is one of Planray’s customers. Resistance measurements were also planned to be made, but unfortunately the schedule of this project and lack of proper measuring equipment made it impossible. On the basis of the survey results, two different solutions of improving ESD protection were made. A measurement report was also made, which Planray can use to document their ESD measurements in the future

Psychometric properties of the finnish version of the resilience scale and its short version

Aim: To investigate the psychometric properties of the Finnish version of the Resilience Scale (RS) and its short version (RS-14), as well as the relationship of resilience with demographic variables and self-perceived health. Method: A standard procedure was used for translation of the scale, and 243 participants (75% women, mean age = 41.0; SD = 17.8) were evaluated with the RS, the RS-14, and the EuroQol 5D. Results: The mean level of resilience was found to be moderate. Both the RS and the RS-14 showed good internal consistency reliability, .90 and .87, respectively. No clear factor structure was found. Both assessments correlated with age but there was no statistically significant association with education or gender. However, a relatively weak but statistically significant correlation between the RS and the RS-14 with self-reported health was found in women. Conclusion: The Finnish versions of the RS and RS-14 can be recommended to be used in clinical and scientific settings. Gender is suggested to be taken into account in further research of resilience

A novel CT‑based automated analysis method provides comparable results with MRI in measuring brain atrophy and white matter lesions

Purpose Automated analysis of neuroimaging data is commonly based on magnetic resonance imaging (MRI), but sometimes the availability is limited or a patient might have contradictions to MRI. Therefore, automated analyses of computed tomography (CT) images would be beneficial. Methods We developed an automated method to evaluate medial temporal lobe atrophy (MTA), global cortical atrophy (GCA), and the severity of white matter lesions (WMLs) from a CT scan and compared the results to those obtained from MRI in a cohort of 214 subjects gathered from Kuopio and Helsinki University Hospital registers from 2005 - 2016. Results The correlation coefficients of computational measures between CT and MRI were 0.9 (MTA), 0.82 (GCA), and 0.86 (Fazekas). CT-based measures were identical to MRI-based measures in 60% (MTA), 62% (GCA) and 60% (Fazekas) of cases when the measures were rounded to the nearest full grade variable. However, the difference in measures was 1 or less in 97-98% of cases. Similar results were obtained for cortical atrophy ratings, especially in the frontal and temporal lobes, when assessing the brain lobes separately. Bland-Altman plots and weighted kappa values demonstrated high agreement regarding measures based on CT and MRI. Conclusions MTA, GCA, and Fazekas grades can also be assessed reliably from a CT scan with our method. Even though the measures obtained with the different imaging modalities were not identical in a relatively extensive cohort, the differences were minor. This expands the possibility of using this automated analysis method when MRI is inaccessible or contraindicated.Peer reviewe

Radiological score of computed tomography scans predicts revision surgery for chronic rhinosinusitis

Objective. Evaluate computed tomography (CT) signs that predict need for revision endoscopic sinus surgery (ESS) of chronic rhinosinusitis (CRS). Methods. CRS patients (n = 48) underwent routine sinus CT scans and baseline ESS in 2006-2011. Lund-Mackay (LM) scores and 43 other CT signs were analysed blinded from both sides. Patients filled in a questionnaire during the day of CT scanning. Follow-up data were collected from hospital records until January 2018. Associations were analysed by Fisher's exact, Mann Whitney U, Kaplan-Meier method with logrank test and Cox's proportional hazard model. Results. Total LM score was not significantly associated with the need for revision ESS. The best predictive model was a sum of CT signs of non-detectable anatomy of inferior/middle turbinates, obstructed frontal recess, and previous sinus surgery. Using these CT findings, we formed a Radiological Score (RS) (min-max, 0-3 points). Having at least one RS point was significantly associated with the need for revision ESS during the average follow-up of 10.7 years (p = 0.008, Logrank test). Conclusion. We identified a radiologic score that was able to predict the need for revision ESS, which is probably useful in predicting CRS outcomes.Peer reviewe

Cluster Analysis of Finnish Population-Based Adult-Onset Asthma Patients

Background: Phenotypes of adult asthma have been identified in previous studies but rarely in population-based settings. Objective: To identify clusters of adult-onset asthma in a Finnish population-based study on subjects born before 1967. Methods: We used population-based data from 1350 asthmatics with adult-onset asthma (Adult Asthma in Finland) from Finnish national registers. Twenty-eight covariates were selected based on literature. The number of covariates was reduced by using factor analysis before cluster analysis. Results: Five clusters (CLU1-CLU5) were identified, 3 clusters with late-onset adult asthma (onset ≥40 years) and 2 clusters with onset at earlier adulthood (<40 years). Subjects in CLU1 (n = 666) had late-onset asthma and were nonobese, symptomatic, and predominantly female with few respiratory infections during childhood. CLU2 (n = 36) consisted of subjects who had earlier-onset asthma, were predominantly female, obese with allergic asthma, and had recurrent respiratory infections. Subjects in CLU3 (n = 75) were nonobese, older, and predominantly men with late-onset asthma, smoking history, comorbidities, severe asthma, least allergic diseases, low education, many siblings, and childhood in rural areas. CLU4 (n = 218) was a late-onset cluster consisting of obese females with comorbidities, asthma symptoms, and low education level. Subjects in CLU5 (n = 260) had earlier onset asthma, were nonobese, and predominantly allergic females. Conclusions: Our population-based adult-onset asthma clusters take into account several critical factors such as obesity and smoking, and identified clusters that partially overlap with clusters identified in clinical settings. Results give us a more profound understanding of adult-onset asthma phenotypes and support personalized management.publishedVersionPeer reviewe

Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus

To access publisher full text version of this article. Please click on the hyperlink in Additional Links fieldSystemic lupus erythematosus (SLE) is a complex systemic autoimmune disease caused by both genetic and environmental factors. Genome scans in families with SLE point to multiple potential chromosomal regions that harbor SLE susceptibility genes, and association studies in different populations have suggested several susceptibility alleles for SLE. Increased production of type I interferon (IFN) and expression of IFN-inducible genes is commonly observed in SLE and may be pivotal in the molecular pathogenesis of the disease. We analyzed 44 single-nucleotide polymorphisms (SNPs) in 13 genes from the type I IFN pathway in 679 Swedish, Finnish, and Icelandic patients with SLE, in 798 unaffected family members, and in 438 unrelated control individuals for joint linkage and association with SLE. In two of the genes--the tyrosine kinase 2 (TYK2) and IFN regulatory factor 5 (IRF5) genes--we identified SNPs that displayed strong signals in joint analysis of linkage and association (unadjusted P<10(-7)) with SLE. TYK2 binds to the type I IFN receptor complex and IRF5 is a regulator of type I IFN gene expression. Thus, our results support a disease mechanism in SLE that involves key components of the type I IFN system

Polymorphisms of the ITGAM Gene Confer Higher Risk of Discoid Cutaneous than of Systemic Lupus Erythematosus

Background Lupus erythematosus (LE) is a heterogeneous disease ranging from mainly skin-restricted manifestations (discoid LE [DLE] and subacute cutaneous LE) to a progressive multisystem disease (systemic LE [SLE]). Genetic association studies have recently identified several strong susceptibility genes for SLE, including integrin alpha M (ITGAM), also known as CD11b, whereas the genetic background of DLE is less clear. Principal findings To specifically investigate whether ITGAM is a susceptibility gene not only for SLE, but also for cutaneous DLE, we genotyped 177 patients with DLE, 85 patients with sporadic SLE, 190 index cases from SLE families and 395 population control individuals from Finland for nine genetic markers at the ITGAM locus. SLE patients were further subdivided by the presence or absence of discoid rash and renal involvement. In addition, 235 Finnish and Swedish patients positive for Ro/SSA-autoantibodies were included in a subphenotype analysis. Analysis of the ITGAM coding variant rs1143679 showed highly significant association to DLE in patients without signs of systemic disease (P-value = 4.73x10-11, OR = 3.20, 95% CI = 2.23-4.57). Significant association was also detected to SLE patients (P-value = 8.29x10-6, OR = 2.14, 95% CI = 1.52-3.00), and even stronger association was found when stratifying SLE patients by presence of discoid rash (P-value = 3.59x10-8, OR = 3.76, 95% CI = 2.29-6.18). Significance We propose ITGAM as a novel susceptibility gene for cutaneous DLE. The risk effect is independent of systemic involvement and has an even stronger genetic influence on the risk of DLE than of SLE.Peer reviewe

Antigenic Differences between AS03 Adjuvanted Influenza A (H1N1) Pandemic Vaccines : Implications for Pandemrix-Associated Narcolepsy Risk

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